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    Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid
    6.
    发明授权
    Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid 有权
    制备包含无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US09265781B2

    公开(公告)日：2016-02-23

    申请号：US13980223

    申请日：2012-03-07

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/18 ,  A61K31/7048 ,  C07H17/04 ,  C12P19/60 ,  A61K9/16

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高到86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    Process for producing a particulate composition comprising an hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid
    8.
    发明授权
    Process for producing a particulate composition comprising an hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid 有权
    包含含水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US09186368B2

    公开(公告)日：2015-11-17

    申请号：US14295546

    申请日：2014-06-04

    申请人： Hayashibara Co., Ltd.

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C07H17/04 ,  A61K31/7048 ,  C12P19/18 ,  C12P19/60 ,  A61K9/16

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    Human T-cell population
    9.
    发明授权
    Human T-cell population 有权
    人类T细胞群体

    公开(公告)号：US08883495B2

    公开(公告)日：2014-11-11

    申请号：US12282977

    申请日：2007-03-15

    申请人： Shuji Nakamura ,  Ryuichi Motoda ,  Masayoshi Kibata ,  Kunzo Orita ,  Fumiyuki Yamasaki

    发明人： Shuji Nakamura ,  Ryuichi Motoda ,  Masayoshi Kibata ,  Kunzo Orita ,  Fumiyuki Yamasaki

    IPC分类号： C12N5/00 ,  A61K35/14 ,  C12N5/0783 ,  A61K35/12

    CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K2035/122 ,  A61K2300/00

    摘要： The present invention has objects to provide a novel human T-cell population having both cytotoxic and immunosuppressive activities, and to a method for preparing the same. The above objects are attained by providing a human T-cell population which is obtainable by coculturing mononuclear cells, collected from human blood, with stroma cells and which has the following features: (1) being positive for CD3, CD25, CD28 and T-cell antigen receptor αβ; (2) essentially consisting of three groups of a CD4 positive and CD8 positive (CD4+CD8+) T-cell group, a CD4 positive and CD8 dimly positive (CD4+CD8dim) T-cell group, and a CD4 negative and CD8 positive (CD4−CD8+) T-cell group; (3) exerting a cytotoxic activity against the cocultured stroma cells; and (4) exerting an immunosuppressive activity against activated T cells.

    摘要翻译： 本发明的目的是提供具有细胞毒性和免疫抑制活性两者的新型人T细胞群及其制备方法。 上述目的是通过提供通过共培养从人血液收集的单核细胞与基质细胞获得的人类T细胞群而获得的，并且具有以下特征：（1）对于CD3，CD25，CD28和T- 细胞抗原受体α＆bgr; （2）基本上由CD4阳性和CD8阳性（CD4 + CD8 +）T细胞组，CD4阳性和CD8阳性（CD4 + CD8dim）T细胞组和CD4阴性和CD8阳性（CD4 + CD4-CD8 +）T细胞组; （3）对共培养的基质细胞发挥细胞毒活性; 和（4）对活化的T细胞施加免疫抑制活性。

    Functional powdery product
    10.
    发明授权
    Functional powdery product 有权
    功能性粉状产品

    公开(公告)号：US08841261B2

    公开(公告)日：2014-09-23

    申请号：US10593264

    申请日：2005-03-14

    申请人： Hajime Kusano ,  Masato Takatori ,  Norio Oga

    发明人： Hajime Kusano ,  Masato Takatori ,  Norio Oga

    IPC分类号： A61K31/7028

    CPC分类号： A61K8/602 ,  A61K8/676 ,  A61K31/7016 ,  A61K31/7028 ,  A61K31/7042 ,  A61K31/7048 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

    摘要： The present invention has objects to provide a functional powdery product prepared by allowing carriers to support one or more members selected from vitamin glycosides, and to provide external dermatological agents having satisfactory usability, which contain the above functional powdery products and effectively exert the functions of vitamins. These objects are solved by providing a functional powdery product prepared by allowing carriers such as saccharides to support one or more members selected from vitamin glycosides, and by providing external dermatological agents incorporated with the functional powdery products.

    摘要翻译： 本发明的目的是提供通过使载体支持一种或多种选自维生素糖苷的成分制备的功能性粉末产品，并提供具有令人满意的用途的外用皮肤病药，其含有上述功能性粉末产品并有效发挥维生素的功能 。 通过提供通过使诸如糖类的载体支持选自维生素糖苷的一种或多种成分，并且通过提供掺入功能性粉末产品的外部皮肤病试剂而制备的功能性粉末产品来解决这些目的。