公开(公告)号：US12030907B2

公开(公告)日：2024-07-09

申请号：US17514168

申请日：2021-10-29

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei Gryaznov ,  Jin Hong ,  Vivek Kumar Rajwanshi ,  Leonid Beigelman

IPC: C07H19/10 ,  C07H1/00 ,  C07H19/20

CPC classification number: C07H19/10 ,  C07H1/00 ,  C07H19/20

Abstract: A method of making a compound represented by Formula (I):




includes a reducing step, a protecting step, and a phosphitylating step, where X is NH; Y is OCF3, —O(CR42)aCR43, —O(CR42)bOCR43, or —O(CR42)b—CR4═CR42; Z is H; B is adenine (A), guanine (G), thymine (T), cytosine (C), uracil (U), 5-methylcytosine (5-me-C), or a protected version of A, G, T, C, U, or 5-me-C; each R1 is independently C1-6 alkyl or cycloalkyl; R2 is CH2CH2CN or C1-6 alkyl; or R1 and R2 together form an optionally substituted C1-6 cycloalkyl; R3 is H or PG; PG is a protecting group; R4 is independently in each instance H or F; a is 1 or 2; and b is 1, 2, or 3.

公开(公告)号：US20230250125A1

公开(公告)日：2023-08-10

申请号：US17995073

申请日：2021-03-31

Applicant: JANSSEN BIOPHARMA, INC.

Inventor： Sergei GRYAZNOV ,  Lakshmipathi PANDARINATHAN

IPC: C07H21/00 ,  A61P31/14

CPC classification number: C07H21/00 ,  A61P31/14

Abstract: Modified nucleic acid polymers comprising modifications at the 2′ and/or 3′ positions(s) along with methods of making and use, e.g., inhibiting viral activity are disclosed.

公开(公告)号：US20220033406A1

公开(公告)日：2022-02-03

申请号：US17413327

申请日：2019-12-04

Applicant: Janssen BioPharma, Inc.

Inventor： Minghong ZHONG ,  Guangyi WANG

IPC: C07D487/04 ,  C07D239/10 ,  C07F9/6561 ,  C07F9/6512 ,  A61K45/06 ,  A61K31/685 ,  A61K31/513 ,  A61K31/519 ,  A61K31/522 ,  C07D239/22 ,  A61P31/20

Abstract: Described herein are cyclopentyl nucleoside analogs of Formula (I), pharmaceutical compositions that include one or more cyclopentyl nucleoside analogs and methods of using the same to treat HBV, HDV and/or HIV. (I)

公开(公告)号：US20210015884A1

公开(公告)日：2021-01-21

申请号：US17040029

申请日：2019-03-21

Applicant: Janssen BioPharma, Inc.

Inventor： Christian Andreas JEKLE ,  Ali R. Ozes

IPC: A61K38/00 ,  C07H21/02 ,  A61K31/7088

Abstract: Methods and compositions for reducing drug resistance are described. Agents for decreasing m6A RNA methylation are described. Also described are compositions comprising the agents, methods of making the agents, and methods of using the agents to reduce drug resistance in a subject in need thereof, or to stimulate an immune response.

公开(公告)号：US20230002409A1

公开(公告)日：2023-01-05

申请号：US17694757

申请日：2022-03-15

Applicant: Janssen BioPharma, Inc.

Inventor： Robert Than HENDRICKS ,  Antitsa Dimitrova STOYCHEVA ,  Jean-François BONFANTI ,  Pierre Jean-Marie Bernard RABOISSON ,  Jérôme Michel Claude FORTIN ,  Guillaume Jean Maurice MERCEY

IPC: C07D498/22 ,  A61P31/16 ,  C07D471/18 ,  C07D471/22 ,  C07D495/22 ,  C07D498/18

Abstract: The present invention relates to macrocyclic pyridotriazine derivatives and the prodrugs thereof, and the pharmaceutically acceptable salts, solvates or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.

公开(公告)号：US11312727B1

公开(公告)日：2022-04-26

申请号：US17284162

申请日：2019-10-09

Applicant: Janssen BioPharma, Inc.

Inventor： Robert Than Hendricks ,  Antitsa Dimitrova Stoycheva ,  Jean-François Bonfanti ,  Pierre Jean-Marie Bernard Raboisson ,  Jérôme Michel Claude Fortin ,  Guillaume Jean Maurice Mercey

IPC: C07D498/22 ,  A61P31/16 ,  C07D495/22 ,  C07D498/18 ,  C07D471/22 ,  C07D471/18

Abstract: The present invention relates to macrocyclic pyridotriazine derivatives of formula (I) and the pharmaceutically acceptable salts, solvates or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.

公开(公告)号：US20210139523A1

公开(公告)日：2021-05-13

申请号：US17063545

申请日：2020-10-05

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  David Bernard SMITH

IPC: C07H19/10 ,  C07H19/06 ,  C07H19/20 ,  C07H19/173 ,  C07H19/213 ,  A61P31/14 ,  C07H19/16 ,  C07H19/207

Abstract: Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.

公开(公告)号：US10905767B2

公开(公告)日：2021-02-02

申请号：US16179786

申请日：2018-11-02

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei Gryaznov ,  Leonid Beigelman ,  Theodore Yun

IPC: A61K47/54 ,  A61P31/20 ,  A61P35/00 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  C12Q1/6876 ,  A61K47/14 ,  A61K9/00 ,  A61K31/7088 ,  A61K39/00

Abstract: Oligodeoxynucleotide-based immunostimulatory Toll-Like Receptor 9 (TLR9) agonists are described. Also described are compositions comprising the TLR9 agonists, methods of making the TLR9 agonists, and methods of using the TLR9 agonists to treat immune diseases, disorders or conditions, such as viral infections or cancer.

公开(公告)号：US10696708B2

公开(公告)日：2020-06-30

申请号：US15895872

申请日：2018-02-13

Applicant: Janssen BioPharma, Inc.

Inventor： Natalia Dyatkina ,  Guangyi Wang ,  Leonid Beigelman ,  Vivek Kumar Rajwanshi

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/06 ,  C07H19/20 ,  C07H19/16 ,  C07H19/10 ,  A61K31/7072 ,  A61K31/7068 ,  A61K31/708 ,  A61K45/06 ,  A61K31/7076

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US10683320B2

公开(公告)日：2020-06-16

申请号：US16203409

申请日：2018-11-28

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid Beigelman ,  Guangyi Wang ,  David Bernard Smith

IPC: C07H19/207 ,  C07H19/10 ,  C07H19/06 ,  C07H19/20 ,  C07H19/173 ,  C07H19/213 ,  A61P31/14 ,  C07H19/16

Abstract: Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.