公开(公告)号：US4256631A

公开(公告)日：1981-03-17

申请号：US131539

申请日：1980-03-18

申请人： Nobuo Yokoo ,  Toshihito Mori

发明人： Nobuo Yokoo ,  Toshihito Mori

IPC分类号： C07K16/00 ,  A61K39/395 ,  C07K1/22 ,  C07K14/435 ,  C07K16/06

CPC分类号： C07K16/065 ,  Y10S530/831

摘要： The specification describes an economical process for the preparation of immunoglobulin for intravenous administration. An immunoglobulin can be, in accordance with the process, purified by a combination of a fractional precipitation method and an affinity chromatography. As a precipitant, divalent or trivalent metal salts are used and a complex of human IgG and a polyhydroxy polymeric compound is employed as an adsorbent. Purified immunoglobulin contains little or no aggregated or partially denatured globulin which is believed to cause anaphylaxis when administered intravenously. Prior art techniques cannot economically provide immunoglobulin in such a purified form and only intramuscular injections were feasible. Intravenous administrations allow immunoglobulin to be dosed in a larger amount and to act much faster than intramuscular injections.

摘要翻译： 该说明书描述了用于制备用于静脉内施用的免疫球蛋白的经济方法。 根据该方法，免疫球蛋白可以通过分级沉淀法和亲和色谱法的组合进行纯化。 作为沉淀剂，使用二价或三价金属盐，使用人IgG和多羟基聚合物的复合物作为吸附剂。 纯化的免疫球蛋白含有很少或没有聚集或部分变性的球蛋白，当被静脉内施用时被认为引起过敏反应。 现有技术不能经济地提供这种纯化形式的免疫球蛋白，只有肌内注射是可行的。 静脉内给药允许免疫球蛋白以更大量的剂量给药，并且比肌内注射快得多。

公开(公告)号：US5575285A

公开(公告)日：1996-11-19

申请号：US355516

申请日：1994-12-14

申请人： Satohiko Takanashi ,  Tetsuya Yamamoto ,  Tsuyoshi Watanabe ,  Muneharu Ishikawa

发明人： Satohiko Takanashi ,  Tetsuya Yamamoto ,  Tsuyoshi Watanabe ,  Muneharu Ishikawa

IPC分类号： G01N21/31 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/7253 ,  A61B5/7257

摘要： An apparatus for non-invasively measuring the oxygen saturation in the blood of a subject comprises light sources for irradiating a sample of blood in tissue with at least a first light beam and a second light beam having different wavelengths. A switching device drives the light sources and sequentially switches the irradiation of the sample of blood between the first and second laser beams. A photoelectric detector detects light transmitted through or reflected from the sample of blood and provides an electrical output signal indicative of the intensity of the detected light. A converter converts the electrical output signal of the photoelectric detecting device to a power spectrum, and a processor processes the power spectrum and calculates the oxygen saturation of the sample of blood. The blood oxygen saturation in the blood can be measured with high accuracy based on the detection of the light intensity transmitted through or reflected from the blood, regardless of the presence or absence of a pulsed blood flow. Additionally, by irradiating the subject by switching between laser beams of two wavelengths, the subject receives less irradiation than when two lasers are used at the same time. Thus even if the amount of irradiation at each wavelength is slightly increased, the accuracy measurement can be improved without adversely affecting the subject.

摘要翻译： 用于非侵入性地测量受试者的血液中的氧饱和度的装置包括用至少第一光束和具有不同波长的第二光束照射组织中的血液样本的光源。 切换装置驱动光源并顺序地切换第一和第二激光束之间的血液样本的照射。 光电检测器检测透过血液样本或从血液样本反射的光，并提供指示检测到的光的强度的电输出信号。 A转换器将光电检测装置的电输出信号转换为功率谱，并且处理器处理功率谱并计算血液样本的氧饱和度。 可以基于通过血液透过或反射的光强度的检测，以高精度测量血液中的血氧饱和度，而不管脉搏血流的存在与否。 此外，通过在两个波长的激光束之间切换来照射被摄体，与同时使用两个激光时相比，受检者的照射少。 因此，即使各波长的照射量稍微增加，也可以提高精度测量，而不会对被摄体造成不利影响。

公开(公告)号：US4443603A

公开(公告)日：1984-04-17

申请号：US381443

申请日：1982-05-24

申请人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Hiroshi Ishihama

发明人： Setsuro Fujii ,  Eizou Hattori ,  Mitsuteru Hirata ,  Koichiro Watanabe ,  Hiroshi Ishihama

IPC分类号： C07D295/18 ,  A61K31/495 ,  A61P43/00 ,  C07D207/24 ,  C07D209/18 ,  C07D295/088 ,  C07D295/13 ,  C07D295/15 ,  C07D295/185 ,  C07D403/12 ,  C07D241/04

CPC分类号： C07D295/185 ,  C07D207/24 ,  C07D209/18 ,  C07D295/088 ,  C07D295/13 ,  C07D295/15

摘要： A piperazine derivartive represented by the following formula: ##STR1## wherein R.sub.1 : an indolyl group which may optionally be substituted by one or more lower alkyl and/or lower alkoxy groups, naphthyl group which may optionally be saturated partially with 2 or 4 hydrogen atoms, or phenyl or cyclohexyl group which may optionally be substituted by one or more lower alkyl groups;A: a single bond or alkylene group;P: a single bond or vinylene group;Q: an -O-alkylene group or -NH-alkylene group when P is a single bond, or a single bond when P is a vinylene group; andR.sub.2 : a lower alkyl, morpholino-lower alkyl, morpholino-carbonyl lower alkyl, piperidinocarbonyl lower alkyl, piperazinocarbonyl lower alkyl or lower alkylaminocarbonyl lower alkyl group, or an acid addition salt thereof is a proteolytic enzyme inhibitor.

摘要翻译： 由下式表示的哌嗪衍生物：其中R 1：可任选被一个或多个低级烷基和/或低级烷氧基取代的吲哚基，可任选地被2或4个氢原子部分饱和的萘基 ，或可任意被一个或多个低级烷基取代的苯基或环己基; A：单键或亚烷基; P：单键或亚乙烯基; Q：当P为单键时为-O-亚烷基或-NH-亚烷基，或当P为亚乙烯基时为单键; R2为低级烷基，吗啉代低级烷基，吗啉代羰基低级烷基，哌啶子基羰基低级烷基，哌嗪基羰基低级烷基或低级烷基氨基羰基低级烷基，或其酸加成盐为蛋白水解酶抑制剂。

公开(公告)号：US4309414A

公开(公告)日：1982-01-05

申请号：US87574

申请日：1979-10-23

申请人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

发明人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

IPC分类号： A61K31/405 ,  A61K45/08 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K31/40 ,  A61K31/78

CPC分类号： A61K47/38 ,  A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K9/0014

摘要： An antiinflammatory analgesic gelled ointment is disclosed which comprises indomethacin, a medium consisting of a glycol, alcohol and water, a gelling agent selected from cellulose and a carboxyvinyl polymer which has been neutralized with an amine, and water sufficiently enough to make up the balance. Such gelled ointment has an excellent antiinflammatory activity.

摘要翻译： 公开了一种消炎止痛凝胶软膏，其包含吲哚美辛，由二醇，醇和水组成的培养基，选自纤维素和已用胺中和的羧基乙烯基聚合物的胶凝剂，以及足够足以构成平衡的水。 这种凝胶软膏具有优异的抗炎活性。

公开(公告)号：US5013146A

公开(公告)日：1991-05-07

申请号：US396639

申请日：1989-08-18

申请人： Koichi Akiyama

发明人： Koichi Akiyama

IPC分类号： A61B3/10 ,  A61B3/117 ,  A61B3/12 ,  A61B3/135 ,  A61B3/15

CPC分类号： A61B3/117 ,  A61B3/1225 ,  A61B3/135 ,  A61B3/152

摘要： Disclosed is an ophthalmological measurement apparatus in which a laser beam is directed into an eye under examination and a measurement value is output on the basis of the state of scattering of the laser beam within the eye. An alignment index projector is provided for forming an alignment index for use in judging alignment between the apparatus and the eye under examination, whose relative position is controlled to cause light scattering points produced at the eye by the laser beam and the light of the alignment index image to assume predetermined positions within the field of an observation. The apparatus can be used for measuring protein concentration in the anterior chamber of the eye or as a split lamp microscope and enables easy alignment between itself and the eye being examined.

公开(公告)号：US4525347A

公开(公告)日：1985-06-25

申请号：US468491

申请日：1983-02-22

申请人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

发明人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

IPC分类号： A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K31/40 ,  A61K31/78

CPC分类号： A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014

摘要： An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C.sub.1 -C.sub.5 alcohol ester of a C.sub.4 -C.sub.14 monocarboxylic acid and a C.sub.1 -C.sub.3 alcohol diester of a C.sub.4 -C.sub.10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.

摘要翻译： 一种抗炎止痛软膏，其包含：（a）抗炎剂量的吲哚美辛; （b）由15至85重量％的羟基化合物，30至55重量％的水和80至55重量％的水，和足以使所述软膏发生凝胶化的量的凝胶剂， 选自纤维素化合物和已经用氨水或胺中和的羧基乙烯基聚合物; （c）佐剂以0.5-5重量％的范围存在，并且选自C 4 -C 14单羧酸的C 1 -C 5醇酯和C 4 -C 10的C 1 -C 3醇二酯 二羧酸 和（d）足以构成软膏平衡的量的水，所述软膏的pH值从酸性至碱性水平调节至足以将所述吲哚美辛溶解于组合物中，但不过多碱性的pH值导致分解 的所述吲哚美辛。

公开(公告)号：US5184157A

公开(公告)日：1993-02-02

申请号：US530290

申请日：1990-05-30

申请人： Tadashi Ichihashi ,  Koichi Akiyama

发明人： Tadashi Ichihashi ,  Koichi Akiyama

IPC分类号： A61B3/10 ,  A61B3/117 ,  A61B3/12

CPC分类号： A61B3/1225

摘要： An ophthalmic measurement apparatus is provided in which a laser beam is converged at a selected point in a measurement zone within an eye and light scattered therefrom is photoelectrically detected via a measurement mask having an aperture of a prescribed size for ophthalmic measurement. During alignment the measurement zone is scanned at high speed by the laser beam with the same scanning width as the scanning width used during measurement. This makes it possible to observe any harmful light rays that will actually appear during measurement at those settings and to align the apparatus so that the harmful light rays do not come within the limiting aperture of the measurement mask, thereby enabling measurement to be conducted under optimum conditions.

公开(公告)号：US4854694A

公开(公告)日：1989-08-08

申请号：US59736

申请日：1987-06-08

申请人： Takashi Hirano ,  Atsushi Kojima

发明人： Takashi Hirano ,  Atsushi Kojima

IPC分类号： A61B3/00 ,  A61B3/024 ,  A61B3/14

CPC分类号： A61B3/024

摘要： An eye fixation monitor for ophthalmological examination is provided which is capable of automatically monitoring the eye fixation without the ophthalmologist being required to initialize the eye fixation value. The eye fixation is monitored using deviation signals derived on the basis of the eye image formed on photoelectric transducers. The eye fixation monitor is provided with means for inducing the patient to assume the eye fixation state, and to resume the monitoring automatically after the examination has been interrupted by excessive deviation of the line of sight from the eye fixation target.

摘要翻译： 提供一种用于眼科检查的眼睛固定监视器，其能够自动监视眼睛固定，而不需要眼科医生初始化眼睛固定值。 使用基于在光电传感器上形成的眼睛图像的偏差信号来监视眼睛固定。 眼睛固定监视器设置有用于诱导患者呈现眼睛固定状态的装置，并且在通过视线与眼睛固定目标的偏离过大而使检查中断之后自动恢复监视。

公开(公告)号：US4290954A

公开(公告)日：1981-09-22

申请号：US89403

申请日：1979-10-30

申请人： Kazuhiro Onogi ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Masami Shiratsuchi ,  Masahiko Nagakura ,  Naoki Machida, deceased ,  by Takayasu Miwa, heir

发明人： Kazuhiro Onogi ,  Hisashi Kunieda ,  Kiyoshi Kawamura ,  Masami Shiratsuchi ,  Masahiko Nagakura ,  Naoki Machida, deceased ,  by Takayasu Miwa, heir

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/41 ,  A61K31/495 ,  A61K31/535 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  C07D311/86 ,  C07D405/04 ,  C07D405/12 ,  C07D405/10 ,  C07D413/10

CPC分类号： C07D311/86

摘要： A tetrahydroxanthone derivative represented by the general formula: ##STR1## wherein R is a hydrogen atom, a hydroxyl, cyano, lower alkyl, lower alkoxy, lower acyloxy, benzoyloxy or tetrazolyl group, or ##STR2## (R.sub.3 is a hydrogen atom, R.sub.4 is a hydrogen atom, a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.3 and R.sub.4 commonly form a ring together with the adjacent nitrogen atom and another nitrogen atom or an oxygen atom); R.sub.1 is a hydrogen or halogen atom, a lower alkyl, cyano, carboxyl or tetrazolyl group, or ##STR3## (R.sub.5 is a hydrogen atom, R.sub.6 is a phenyl group which may be optionally substituted, or a tetrazolyl group; or R.sub.5 and R.sub.6 commonly form a ring together with the adjacent nitrogen atom and an oxygen atom); and R.sub.2 is a hydrogen or halogen atom, or a lower alkyl group; with the proviso that neither R nor R.sub.1 is a hydrogen atom; when R is --CONH.sub.2, R.sub.1 and R.sub.2 are not respectively a hydrogen atom nor a hydrogen or halogen atom, or a lower alkyl group; and R.sub.2 and R.sub.1 are not respectively a hydrogen atom nor a halogen atom or a lower alkyl group. Exhibits anti-allergic, anti-inflammatory, analgesic, inhibitory and asthma-treating activities.

摘要翻译： 其中R是氢原子，羟基，氰基，低级烷基，低级烷氧基，低级酰氧基，苯甲酰氧基或四唑基，或者是（R 3是氢原子，R 4 是氢原子，可以被任意取代的苯基或四唑基;或者R3和R4通常与相邻的氮原子和另一个氮原子或氧原子一起形成环）; R 1是氢或卤素原子，低级烷基，氰基，羧基或四唑基，或者R 5是氢原子，R 6是任选被取代的苯基或四唑基;或R 5和R 6 通常与相邻的氮原子和氧原子一起形成环）; 并且R 2是氢或卤原子或低级烷基; 条件是R和R1都不是氢原子; 当R为-CONH 2时，R 1和R 2不分别为氢原子或氢或卤素原子或低级烷基; R2和R1不分别为氢原子或卤素原子或低级烷基。 展示抗过敏，抗炎，镇痛，抑制和哮喘治疗活动。