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    High efficiency environmental sampling with rapidly cured peelable coatings
    4.
    发明授权
    High efficiency environmental sampling with rapidly cured peelable coatings 有权

    公开(公告)号：US10883901B1

    公开(公告)日：2021-01-05

    申请号：US15785295

    申请日：2017-10-16

    申请人： Los Alamos National Security, LLC

    发明人： Vladimir Henzl ,  Rollin Lakis ,  Sylvia Ann Junghans

    IPC分类号： G01N1/02 ,  C08F2/48 ,  B01J20/291 ,  G01N21/76 ,  B01J20/32 ,  C08L33/08 ,  B01J20/286

    摘要： A rapidly curable liquid gel for collecting an analyte from a sampling surface includes a polymer precursor mixture including a monomer and/or an oligomer; and an additive to enhance extraction of the analyte from the sampling surface. A kit for collecting an analyte from a sampling surface may include the rapidly curable liquid gel and a portable device for rapidly curing the gel. The rapidly curable liquid gel is cured to thereby form a peelable sampling film, and the sampling film is removed from the sampling surface, thereby collecting the analyte. In one embodiment, the rapidly curable liquid gel is UV-curable, the polymer precursor mixture further includes a photoinitiator compound, and the portable device includes a UV light source configured to emit UV light of a wavelength range absorbed by the photoinitiator compound.

    Productivity and bioproduct formation in phototropin knock/out mutants in microalgae
    5.
    发明授权
    Productivity and bioproduct formation in phototropin knock/out mutants in microalgae 有权

    公开(公告)号：US10590398B2

    公开(公告)日：2020-03-17

    申请号：US15831178

    申请日：2017-12-04

    申请人： NMC, INC. ,  LOS ALAMOS NATIONAL SECURITY, LLC

    发明人： Sangeeta Negi ,  Richard Thomas Sayre ,  Shawn Robert Starkenburg

    IPC分类号： C12N9/12 ,  C12P19/04 ,  C12P23/00 ,  C12N1/12 ,  C12P7/64 ,  C07K14/405 ,  C12N9/02 ,  C12N9/22 ,  C12N15/01 ,  C12N15/11

    摘要： Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii, phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures (500 μmol photons m−2 s−1). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.

    High-temperature, high pressure acoustic resonance cell
    6.
    发明授权
    High-temperature, high pressure acoustic resonance cell 有权

    公开(公告)号：US10352907B2

    公开(公告)日：2019-07-16

    申请号：US15039365

    申请日：2014-11-26

    申请人： Triad National Security, LLC

    发明人： Blake T. Sturtevant ,  Cristian Pantea ,  Dipen N. Sinha

    IPC分类号： G01N29/22 ,  G01N29/036

    摘要： A compact, rugged and portable measurement cell design for the determination of sound speed in fluids at temperatures up to 250° C. and pressures up to 3,000 psi is described. Swept Frequency Acoustic Interferometry measurement for liquid sound speed determinations in liquids up to 250° C. is of both fundamental interest, as in the case of basic equations of state, and applied interest, such as for characterizing geothermal or petroleum down hole environments. Representative sound speeds for water, as a function of temperature and pressure, are in agreement with an internationally accepted standard for the sound speed of water.

    USING NEW EDGES FOR ANOMALY DETECTION IN COMPUTER NETWORKS
    7.
    发明申请
    USING NEW EDGES FOR ANOMALY DETECTION IN COMPUTER NETWORKS 审中-公开

    公开(公告)号：US20180278641A1

    公开(公告)日：2018-09-27

    申请号：US16002870

    申请日：2018-06-07

    申请人： Los Alamos National Security, LLC

    发明人： Joshua Charles Neil

    IPC分类号： H04L29/06 ,  G06N7/00

    摘要： Creation of new edges in a network may be used as an indication of a potential attack on the network. Historical data of a frequency with which nodes in a network create and receive new edges may be analyzed. Baseline models of behavior among the edges in the network may be established based on the analysis of the historical data. A new edge that deviates from a respective baseline model by more than a predetermined threshold during a time window may be detected. The new edge may be flagged as potentially anomalous when the deviation from the respective baseline model is detected. Probabilities for both new and existing edges may be obtained for all edges in a path or other subgraph. The probabilities may then be combined to obtain a score for the path or other subgraph. A threshold may be obtained by calculating an empirical distribution of the scores under historical conditions.

    Using new edges for anomaly detection in computer networks
    9.
    发明授权
    Using new edges for anomaly detection in computer networks 有权

    公开(公告)号：US10015183B1

    公开(公告)日：2018-07-03

    申请号：US15637475

    申请日：2017-06-29

    申请人： Los Alamos National Security, LLC

    发明人： Joshua Charles Neil

    IPC分类号： H04L29/06 ,  G06N7/00

    CPC分类号： H04L63/1425 ,  G06F21/577 ,  G06N5/02 ,  G06N5/022 ,  G06N5/045 ,  G06N7/005 ,  H04L1/002 ,  H04L63/1408 ,  H04L63/1416 ,  H04L63/1433 ,  H04L2463/144

    摘要： Creation of new edges in a network may be used as an indication of a potential attack on the network. Historical data of a frequency with which nodes in a network create and receive new edges may be analyzed. Baseline models of behavior among the edges in the network may be established based on the analysis of the historical data. A new edge that deviates from a respective baseline model by more than a predetermined threshold during a time window may be detected. The new edge may be flagged as potentially anomalous when the deviation from the respective baseline model is detected. Probabilities for both new and existing edges may be obtained for all edges in a path or other subgraph. The probabilities may then be combined to obtain a score for the path or other subgraph. A threshold may be obtained by calculating an empirical distribution of the scores under historical conditions.