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    SYSTEMS, DEVICES, METHODS FOR DELIVERING HYDROGEL COMPOSITIONS WITH SELF-PURGING TO PREVENT CLOGGING
    1.
    发明申请
    SYSTEMS, DEVICES, METHODS FOR DELIVERING HYDROGEL COMPOSITIONS WITH SELF-PURGING TO PREVENT CLOGGING 有权
    系统，装置，用于自给自足的水凝胶组合物的预防方法

    公开(公告)号：US20140148791A1

    公开(公告)日：2014-05-29

    申请号：US14170759

    申请日：2014-02-03

    申请人： Neomend, Inc.

    发明人： Peter BARKER, Jr. ,  William Jerome MEZGER

    IPC分类号： A61M35/00

    CPC分类号： A61B17/00491 ,  A61B17/12186 ,  A61B2017/00495 ,  A61B2017/00942 ,  A61M5/003 ,  A61M35/003

    摘要： A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.

    摘要翻译： 通过将经过选择性施加的施加压力P（A）的分离的第一和第二液体组分输送到用于混合和排出的出口路径中来形成水凝胶组合物。 当中断P（A）的施加时，液体冲洗剂被自动地输送到出口路径中，经受基本上恒定地施加的清除压力P（P），以从出口路径连续冲洗剩余的水凝胶组合物。

    Biocompatible material composition adaptable to diverse therapeutic indications
    3.
    发明申请
    Biocompatible material composition adaptable to diverse therapeutic indications 有权
    适用于多种治疗适应症的生物相容性材料组合物

    公开(公告)号：US20100099779A1

    公开(公告)日：2010-04-22

    申请号：US12455561

    申请日：2009-06-03

    申请人： Olexander Hnojewyj ,  Charles F. Milo ,  Gregory M. Cruise

    发明人： Olexander Hnojewyj ,  Charles F. Milo ,  Gregory M. Cruise

    IPC分类号： A61K47/30 ,  C08L89/00 ,  A61K47/42

    CPC分类号： A61K9/0024 ,  A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00495 ,  A61K47/34 ,  A61L24/043 ,  A61L31/041 ,  Y10S530/815 ,  C08L89/00

    摘要： A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form. The polymer includes a degradation control region selected to achieve a desired degradation period and a cross-linking group selected to achieve a desired cross-linking period. The kit provides instructions for forming a mixture of the protein solution and polymer solution and for applying the mixture. The mixture serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.

    摘要翻译： 用于形成生物相容性材料的试剂盒提供蛋白质溶液和包含官能度至少为3的亲水性聚合物的衍生物的聚合物溶液。 混合后 蛋白质溶液和聚合物溶液交联以形成非液体三维网络，随着时间的推移而退化成液体形式。 聚合物包括选择以实现期望的降解期的降解控制区域和选择用于实现期望的交联期的交联基团。 该试剂盒提供了形成蛋白质溶液和聚合物溶液的混合物并施加混合物的说明书。 该混合物用作多种材料组合物种的基础，每种物质组合物种类适合特定的治疗适应症。

    Tissue adhering compositions
    5.
    发明申请
    Tissue adhering compositions 有权
    组织粘附组合物

    公开(公告)号：US20080108577A1

    公开(公告)日：2008-05-08

    申请号：US12004964

    申请日：2007-12-21

    申请人： Olexander Hnojewyj

    发明人： Olexander Hnojewyj

    IPC分类号： A61K38/00

    CPC分类号： A61K38/38 ,  A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00495 ,  A61B2017/0065 ,  A61K38/363 ,  A61K38/39 ,  A61L24/046 ,  C08L71/02

    摘要： A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic material comprising a natural or synthetic protein at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material includes tris-hydroxymethylaminomethane having a pH within the reaction pH range. The method applies the mixture to adhere to a tissue region.

    摘要翻译： 方法混合第一组分，第二组分和缓冲材料。 第一组分包括具有至少三个官能度的聚（乙二醇）的亲电子聚合物材料。 第二组分包括亲核材料，其包含浓度为约25％或更低的天然或合成蛋白质，当在反应pH范围内与第一组分混合时，与第一组分交联以形成非液体， 三维屏障。 缓冲材料包括pH在反应pH范围内的三羟甲基氨基甲烷。 该方法应用混合物粘附到组织区域。

    Method and apparatus for percutaneous wound sealing
    7.
    发明申请
    Method and apparatus for percutaneous wound sealing 审中-公开
    用于经皮伤口密封的方法和装置

    公开(公告)号：US20060161110A1

    公开(公告)日：2006-07-20

    申请号：US11319317

    申请日：2005-12-28

    申请人： Jay Lenker ,  William Mezger

    发明人： Jay Lenker ,  William Mezger

    IPC分类号： A61M5/178

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00637 ,  A61B2017/0065 ,  A61B2017/00672

    摘要： Devices and methods are disclosed for achieving hemostasis at a wound site following an endovascular procedure. Such wound sealing is necessary generally following a percutaneous procedure where a percutaneous cannula is withdrawn from the vasculature leaving an entry site to the vessel that could bleed if steps are not taken to stop said bleeding. The devices and methods disclosed herein are especially useful in the catheterization laboratory following interventional cardiology or interventional neuroradiology procedures. The devices utilize the introduction sheath that was originally used for the procedure as a guide for the closure. The closure device is inserted through the introduction sheath once any therapeutic or diagnostic devices have been removed. The closure device comprises a two-part sealing material housed in a reservoir system, a mixing chamber, a delivery cannula, exit ports, and a vessel location device. The sealing material generally comprises materials such as albumin and polyethylene glycol, or the like. The sealing device works in conjunction with the already placed sheath to eliminate the step of replacing said sheath, an action that increases procedural time and may contribute to further wound damage and reduced sealing effectiveness.

    摘要翻译： 公开了用于在血管内手术后在伤口部位止血的装置和方法。 这种伤口密封通常需要经皮操作，其中经皮插管从脉管系统中取出，留下进入血管的进入部位，如果不采取步骤来停止所述出血，则可能出血。 本文公开的装置和方法在介入心脏病学或介入性神经放射学程序之后在导管实验室中特别有用。 这些装置使用最初用于该过程的引入护套作为关闭的指导。 一旦任何治疗或诊断装置被去除，封闭装置就插入导入鞘中。 闭合装置包括容纳在储存器系统中的两部分密封材料，混合室，输送套管，出口和容器定位装置。 密封材料通常包括诸如白蛋白和聚乙二醇的材料等。 密封装置与已经放置的护套一起工作以消除更换所述护套的步骤，增加程序时间的作用并且可能有助于进一步的伤口损伤和降低的密封效果。

    Centrifugal mixing spray nozzle
    9.
    发明授权
    Centrifugal mixing spray nozzle 有权

    公开(公告)号：US10144017B2

    公开(公告)日：2018-12-04

    申请号：US14213162

    申请日：2014-03-14

    申请人： NEOMEND, INC.

    发明人： Peter G. Davis ,  Tina L. McArthur ,  Andrew J. Basilio ,  Kristina L. Clampitt

    IPC分类号： B05B1/34 ,  B01F5/00 ,  B01F13/00 ,  B01F15/02 ,  A61B17/00

    摘要： A nozzle tip assembly comprises a nozzle housing and a break-up insert. The nozzle assembly is adapted for receiving multiple pre-cursor fluids from multiple lumen. The pre-cursor fluids are kept substantially separate and forced around the break-up insert into a channel formed between the insert and the nozzle housing. Fluid is forced into fluted channels on a distal end of the break-up insert into a swirl chamber where mixing occurs prior to being expelled through an exit orifice in the nozzle housing.

    PLEURAL AIR LEAK TEST SYSTEM
    10.
    发明申请
    PLEURAL AIR LEAK TEST SYSTEM 审中-公开
    PLEURAL空气泄漏测试系统

    公开(公告)号：US20150374936A1

    公开(公告)日：2015-12-31

    申请号：US14749867

    申请日：2015-06-25

    申请人： Neomend, Inc.

    发明人： Peter G. DAVIS

    IPC分类号： A61M13/00 ,  A61L24/10 ,  A61L24/00 ,  A61B5/03 ,  A61M16/08

    CPC分类号： A61M13/003 ,  A61B5/08 ,  A61B17/0057 ,  A61B2017/00495 ,  A61B2017/0065 ,  A61L24/001 ,  A61L24/0026 ,  A61L24/043 ,  A61L24/108 ,  A61M11/00 ,  A61M16/0816 ,  A61M2202/0488 ,  A61M2205/15 ,  A61M2205/584

    摘要： Disclosed are methods, apparatus, and systems useful for detecting leaks in pleural tissue. Also disclosed are methods of detecting and sealing such leaks. Indicator dye or stain is aerosolized and delivered to the lung via anesthetic equipment, oxygen tube, endoscope, or other suitable equipment, the dye is allowed to travel through the lung along the path or paths of least resistance emerging at the surface of the lung, staining the tissue indicative of a leak. Some embodiments include introducing one part of a two part sealant with the dye, and applying the second part of the sealant to the stain identified leak locations.

    摘要翻译： 公开了用于检测胸膜组织中的泄漏的方法，装置和系统。 还公开了检测和密封这种泄漏的方法。 指示剂染料或染色剂被雾化并通过麻醉设备，氧气管，内窥镜或其它合适的设备输送到肺中，使染料沿着在肺表面出现的最小阻力的路径或路径行进穿过肺， 染色指示泄漏的组织。 一些实施方案包括将一部分两部分密封剂与染料一起引入，并且将第二部分密封剂施加到污染物识别的泄漏位置。