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公开(公告)号：US20240285834A1
公开(公告)日：2024-08-29
申请号：US18638964
申请日：2024-04-18
发明人： Erez ILAN , Omri FAINGOLD , Eve MONTIA
CPC分类号： A61L33/08 , A61K9/1682 , A61K31/717 , A61K45/06 , A61L33/0047 , A61P41/00 , A61L2400/04
摘要： Compositions comprised of oxidized cellulose (OC) in the form of a powder, wherein the carboxyl content of the OC is about 9% to about 18%, by weight, are disclosed. Optionally, the powder is in an aggregated form. Uses of the compositions for preventing tissue adhesion in the presence of bleeding are further disclosed.
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公开(公告)号：US11993797B2
公开(公告)日：2024-05-28
申请号：US17546447
申请日：2021-12-09
发明人： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
CPC分类号： C12N9/96 , A61K9/19 , A61K38/4833 , A61K47/26 , A61K47/42 , C12N9/6429 , C12Y304/21005
摘要： Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
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公开(公告)号：US11426483B2
公开(公告)日：2022-08-30
申请号：US16195898
申请日：2018-11-20
发明人： Erez Ilan , Omri Faingold
摘要： The invention provides a wound dressing made by an ex vivo formed combination of fibrinogen and/or fibrin containing-liquid formulation and an oxidized cellulose (OC) backing; and use thereof.
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公开(公告)号：US20220054527A1
公开(公告)日：2022-02-24
申请号：US17518415
申请日：2021-11-03
发明人： James Galloway , Tamara BYK-TENNENBAUM , Erez ILAN , Lior WEISSMAN , Sivan DORON , Eve MONTIA , Niels-Derrek Schmitz
IPC分类号： A61K31/717 , A61K31/704 , A61L24/00 , A61L15/28 , A61L24/08 , A61L15/44
摘要： Provided are implants and a glycolytic dependent compound for use in enhancing toxicity of the glycolytic dependent compound towards a cell, tissue and/or organ e.g., a diseased cell, tissue and/or organ, wherein the implant and the glycolytic dependent compound are contacted with the cell, tissue and/or organ in a non-blended form.
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公开(公告)号：US11246579B2
公开(公告)日：2022-02-15
申请号：US16910698
申请日：2020-06-24
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Lior Erez , Ashley DeAnglis
摘要： The invention relates to syringes for storing and mixing components.
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公开(公告)号：US11229688B2
公开(公告)日：2022-01-25
申请号：US16166510
申请日：2018-10-22
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Tamara Byk-Tennenbaum
IPC分类号： A61K38/48 , C12N9/74 , C12N15/115 , A61K38/36 , A61K47/26 , A61M5/19 , C12N15/113 , G01N33/53
摘要： The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
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7.发明申请公开(公告)号：US20210316048A1
公开(公告)日：2021-10-14
申请号：US17345728
申请日：2021-06-11
发明人： Eve Montia , Dwayne Looney , Theresa Scheuble , Ronen Eavri , Roi Mashiach
IPC分类号： A61L31/16 , A61P31/04 , A01N1/00 , A61L27/54 , C12N5/00 , A61L27/20 , A61K31/717 , A61K31/65 , A61L15/28 , A61L15/44 , A61L26/00
摘要： Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.
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公开(公告)号：US20210154358A1
公开(公告)日：2021-05-27
申请号：US17167492
申请日：2021-02-04
发明人： Erez ILAN , Omri Faingold , Nataly Freizus , Ronen Eavri , Dwayne Looney , Sridevi Dhanaraj , James Galloway , Walter Danker
摘要： The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.
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公开(公告)号：US20210038757A1
公开(公告)日：2021-02-11
申请号：US16945990
申请日：2020-08-03
发明人： EREZ ILAN , OMRI FAINGOLD , TAMAR AUERBACH-NEVO , TALI NEGREANU-GILBOA , HADAS ALPERIN , Yi-Lan Allen Wang , Dwayne Looney
摘要： An expandable biodegradable hemostatic matrix comprised of oxidized cellulose, and having a density ranging from about 0.8 to about 1.2 gr/cm3 is disclosed herein. The matrix may be expandable to at least 3 times its original volume within 4 sec upon contact with an aqueous solution room temperature. Further disclosed are methods for making the hemostatic matrix as well as method of treating a wound.
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公开(公告)号：US10479987B2
公开(公告)日：2019-11-19
申请号：US14935743
申请日：2015-11-09
发明人： Roberto Meidler , Oleg Belyaev , Liliana Bar , Israel Nur
摘要： Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
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