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    Powered sterile solution device
    2.
    发明授权
    Powered sterile solution device 失效
    电源无菌溶液装置

    公开(公告)号：US07250619B2

    公开(公告)日：2007-07-31

    申请号：US10478908

    申请日：2002-05-14

    申请人： Michael A. Taylor ,  Mark L. Sizelove ,  Tralance O. Addy

    发明人： Michael A. Taylor ,  Mark L. Sizelove ,  Tralance O. Addy

    IPC分类号： B01D61/08

    CPC分类号： B01D61/145 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1672 ,  A61M1/1674 ,  A61M1/287 ,  B01D61/147 ,  B01D61/18 ,  C02F1/444

    摘要： The disclosure below relates to apparatus and methods for producing medicament using sub-optimal water sources. One embodiment of the disclosure is directed to an apparatus comprising a preliminary purification component, a disinfection component, a pharmaceutical grade water preparation (PGW) component, and a drug pack. Another disclosed embodiment relates to a method for producing a peritoneal dialysis solution, comprising, passing diluent through a preliminary purification component, passing diluent through a disinfection component, passing diluent through a PGW preparation component, passing diluent through a drug pack, and collecting solute produced by the drug pack.

    摘要翻译： 下面的公开涉及使用次优水源生产药物的装置和方法。 本公开的一个实施方案涉及包含初步净化组分，消毒组分，药物级水制剂（PGW）组分和药物组合的装置。 另一个公开的实施方案涉及一种生产腹膜透析溶液的方法，其包括使稀释剂通过预净化组分，使稀释剂通过消毒组分，使稀释剂通过PGW制备组分，使稀释剂通过药物包装，并收集产生的溶质 由药包。

    Reagent/drug cartridge
    4.
    发明授权
    Reagent/drug cartridge 失效
    试剂/药筒

    公开(公告)号：US5725777A

    公开(公告)日：1998-03-10

    申请号：US149319

    申请日：1993-11-09

    申请人： Michael A. Taylor

    发明人： Michael A. Taylor

    IPC分类号： A61L2/02 ,  B01D61/04 ,  B01D61/08 ,  B01D61/10 ,  B01F1/00 ,  B01J4/00 ,  B01J8/02 ,  C02F1/44 ,  B01D61/00

    CPC分类号： C02F1/441 ,  A61L2/022 ,  B01D61/025 ,  B01D61/04 ,  B01D61/08 ,  B01D61/10 ,  B01D61/147 ,  B01F1/00 ,  B01F1/0033 ,  B01D2311/04 ,  B01F2001/0077 ,  C02F1/444

    摘要： A reagent cartridge for reacting a soluble reagent with a fluid diluent is disclosed having a fluid inlet for accepting a diluent and fluid outlet for expelling a solution. The cartridge casing also has fluid manifolds adjacent to the inlet and the outlet for directing fluid in a radial direction from the inlet to the outlet. The casing further defines a receptacle for a soluble reagent. A volumetric compensation means for volumetrically compensating for dissolution of the reagent upon introduction of the diluent into the fluid inlet is provided. The volumetric compensation means can take the form of a resilient sponge material having a compressed volume and an expanded volume, wherein the expanded volume is up to at least 500% of the compressed volume. The volumetric compensation means can also take the form of resilient coil springs. In other embodiments, a fluid permeable pressure plate is positioned adjacent to a free end of the coil spring and the reagent is positioned against the pressure plate. A method for obtaining injectable quality intravenous solutions in the field using the reagent cartridge is also disclosed.

    摘要翻译： 公开了一种用于使可溶性试剂与流体稀释剂反应的试剂盒，其具有用于接受用于排出溶液的稀释剂和流体出口的流体入口。 筒壳体还具有邻近入口和出口的流体歧管，用于将流体沿径向从入口引导到出口。 壳体还限定了可溶性试剂的容器。 提供了体积补偿装置，用于体积补偿试剂在将稀释剂引入流体入口时的溶解。 体积补偿装置可以采取具有压缩体积和膨胀体积的弹性海绵材料的形式，其中膨胀体积至多为压缩体积的至少500％。 体积补偿装置也可以采取弹性螺旋弹簧的形式。 在其它实施例中，流体可渗透的压力板被定位成与螺旋弹簧的自由端相邻，并且试剂抵靠压力板定位。 还公开了使用试剂盒在现场获得可注射质量静脉内溶液的方法。

    Modular Water Purification and Delivery System
    5.
    发明申请
    Modular Water Purification and Delivery System 审中-公开
    模块化水净化和输送系统

    公开(公告)号：US20090008318A1

    公开(公告)日：2009-01-08

    申请号：US12173636

    申请日：2008-07-15

    申请人： John M. Anes ,  Jeffrey Brian Godfrey ,  Amanda A. Wise ,  Michael A. Taylor ,  Stephen E. Pazian

    发明人： John M. Anes ,  Jeffrey Brian Godfrey ,  Amanda A. Wise ,  Michael A. Taylor ,  Stephen E. Pazian

    IPC分类号： C02F1/42 ,  C02F9/00

    CPC分类号： C02F9/00 ,  B01D61/18 ,  B01D63/02 ,  C02F1/283 ,  C02F1/42 ,  C02F1/44 ,  C02F2201/006 ,  C02F2301/08

    摘要： A modular filter system is provided with one or more modules that can be interchangeable, depending upon the specific application or specific health or environmental issue presented. Disclosed combinations can include one or more of any of the following modules in any relative position to one another: (a) a microbiological contaminant mitigation module, preferably in the form of an inverted u-shaped hollow fiber filter module wherein the fibers have ends potted on the downstream side and that consists essentially of hydrophilic fibers for water filtration with a small amount of hydrophobic fibers for venting of entrapped air; (b) a first chemical mitigation module, preferably in the form of an adsorption module comprising carbon or the combination of carbon and a deionization resin; and (c) a second chemical mitigation module, preferably in the form of a deionization resin module. Modules including a carbon bed or a resin bed may be equipped with a pair of hydrophobic foam bed restraints that apply opposing axial pressure to the bed in all operating conditions.

    摘要翻译： 模块化过滤器系统具有可以互换的一个或多个模块，这取决于具体应用或所呈现的特定健康或环境问题。 公开的组合可以包括彼此相对位置的任何以下模块中的一个或多个：（a）微生物污染物减轻模块，优选为倒U形中空纤维过滤器模块的形式，其中纤维具有端部盆 在下游侧，并且基本上由亲水纤维组成，用于用少量疏水纤维进行水过滤以排出被截留的空气; （b）第一化学缓解模块，优选为包含碳或碳与去离子树脂的组合的吸附模块的形式; 和（c）第二化学缓解模块，优选以去离子树脂模块的形式。 包括碳床或树脂床的模块可以配备一对疏水泡沫床限制器，其在所有操作条件下对床施加相反的轴向压力。

    Single dose delivery device
    7.
    发明授权
    Single dose delivery device 失效
    单剂量输送装置

    公开(公告)号：US06932791B2

    公开(公告)日：2005-08-23

    申请号：US10437412

    申请日：2003-05-12

    申请人： Michael A. Taylor

    发明人： Michael A. Taylor

    IPC分类号： A61M5/00 ,  A61M5/28 ,  A61M5/315 ,  A61M37/00

    CPC分类号： A61M5/282 ,  A61M5/284 ,  A61M5/288 ,  A61M5/31531 ,  A61M5/3294 ,  A61M2005/3142

    摘要： A microinjection system comprises a device for housing dried forms of medical reagents, such as vaccines, hormones, etc. in single doses. Within a single chamber, a dry reagent bed is provided adjacent a compression component that keeps the bed compacted. In operation, diluent flows through the chamber to carry the reagent out of the chamber in fluid form. In the illustrated embodiments, the fluid carrying reagent is directly delivered from the chamber via a needle. Integral or connectable diluent delivery devices are disclosed for providing an appropriate volume of diluent to the reagent chamber. Unstable formulations of drugs, for example, can be safely stored in dry form. When injection is needed, the drug can be delivered almost instantly in fluid form simply by releasing diluent through the chamber, where the reagent bed is dissolved or suspended while the remaining reagent is continually compacted. The resultant fluid contains a single dose of the reagent and is delivered directly to a patient, desirably without measurement of the fluid form.

    摘要翻译： 显微注射系统包括用于以单次剂量容纳干燥形式的药物试剂例如疫苗，激素等的装置。 在单个室内，在压缩部件附近设置干燥的试剂床，其保持床层压实。 在操作中，稀释剂流过室以将流体形式的试剂输送出室。 在所示实施例中，流体携带试剂通过针直接从腔室输送。 公开了用于向试剂室提供适当体积的稀释剂的整体或可连接的稀释剂输送装置。 不稳定的药物制剂，例如，可以安全地以干燥的形式储存。 当需要注射时，药物几乎可以以流体形式立即输送，简单地通过释放稀释剂通过室，其中试剂床溶解或悬浮，同时剩余的试剂持续压实。 所得流体含有单剂量的试剂，并且直接递送至患者，理想地不测量流体形式。

    Method of loading drug delivery pack
    8.
    发明授权
    Method of loading drug delivery pack 失效
    药物递送包装方法

    公开(公告)号：US06916305B2

    公开(公告)日：2005-07-12

    申请号：US10339715

    申请日：2003-01-08

    申请人： Eugene C. Jones ,  Michael A. Taylor

    发明人： Eugene C. Jones ,  Michael A. Taylor

    IPC分类号： A61J3/00 ,  A61J1/00 ,  A61M5/14 ,  A61M37/00

    CPC分类号： A61M5/1409 ,  A61M2202/064

    摘要： Several improvements are disclosed for a drug delivery pack with dry reagent in a housing, each of which can be employed independently or in conjunction with others of the improvements. A novel spring is provided with two spring columns extending in parallel between a spring top and a spring bottom. The spring is particularly designed for fitting within the housing and compacting a dry reagent bed. A plunger mechanism to ratchet housing portions between two positions. In one position, a compression component adjacent the reagent bed is relatively uncompressed, such that it does not “set” over time. When the user is about to use the drug delivery device, the plunger is slid to compress the compression component so that it exerts pressure on the reagent bed. A similar sliding mechanism can also divert a stream of diluent through the housing from a priming path, where diluent bypasses the reagent bed, to a functional path passing through and eroding the reagent bed. Additionally, a method is provided for lyophilizing a liquid form of reagent within the housing from which it is to be delivered, thereby avoiding separate lyophilization and separate loading of dry form of the reagent.

    摘要翻译： 在壳体中公开了具有干试剂的药物递送包的各种改进，每个可以独立地或与其他改进一起使用。 一个新的弹簧设有两个在弹簧顶部和弹簧底部之间平行延伸的弹簧柱。 弹簧特别设计用于安装在外壳内并压实干试剂床。 一种用于在两个位置之间棘轮收纳部分的柱塞机构。 在一个位置，邻近试剂床的压缩部件相对未压缩，使得其随着时间不“设定”。 当使用者即将使用药物输送装置时，柱塞被滑动以压缩压缩部件，从而对试剂床施加压力。 类似的滑动机构还可以将稀释剂流通过壳体从灌注路径转移到通过并侵蚀试剂床的功能路径上。 此外，提供了一种用于将液体形式的试剂冻结在壳体内以从其被输送的方法，从而避免单独的冻干和干燥形式的试剂的分离加载。