公开(公告)号：US06527738B1

公开(公告)日：2003-03-04

申请号：US09559692

申请日：2000-04-27

申请人： Eugene C. Jones ,  Michael A. Taylor

发明人： Eugene C. Jones ,  Michael A. Taylor

IPC分类号： A61M3700

CPC分类号： A61M5/1409 ,  A61M2202/064

摘要： Several improvements are disclosed for a drug delivery pack with dry reagent in a housing, each of which can be employed independently or in conjunction with others of the improvements. A novel spring is provided with two spring columns extending in parallel between a spring top and a spring bottom. The spring is particularly designed for fitting within the housing and compacting a dry reagent bed. A plunger mechanism to ratchet housing portions between two positions. In one position, a compression component adjacent the reagent bed is relatively uncompressed, such that it does not “set” over time. When the user is about to use the drug delivery device, the plunger is slid to compress the compression component so that it exerts pressure on the reagent bed. A similar sliding mechanism can also divert a stream of diluent through the housing from a priming path, where diluent bypasses the reagent bed, to a functional path passing through and eroding the reagent bed. Additionally, a method is provided for lyophilizing a liquid form of reagent within the housing from which it is to be delivered, thereby avoiding separate lyophilization and separate loading of dry form of the reagent.

摘要翻译： 在壳体中公开了具有干试剂的药物递送包的各种改进，每个可以独立地或与其他改进一起使用。 一个新的弹簧设有两个在弹簧顶部和弹簧底部之间平行延伸的弹簧柱。 弹簧特别设计用于安装在外壳内并压实干试剂床。 一种用于在两个位置之间棘轮收纳部分的柱塞机构。 在一个位置，邻近试剂床的压缩部件相对未压缩，使得其随着时间不“设定”。 当使用者即将使用药物输送装置时，柱塞被滑动以压缩压缩部件，从而对试剂床施加压力。 类似的滑动机构还可以将稀释剂流通过壳体从灌注路径转移到通过并侵蚀试剂床的功能路径上。 此外，提供了一种用于将液体形式的试剂冻结在壳体内以从其被输送的方法，从而避免单独的冻干和干燥形式的试剂的分离加载。

公开(公告)号：US06916305B2

公开(公告)日：2005-07-12

申请号：US10339715

申请日：2003-01-08

申请人： Eugene C. Jones ,  Michael A. Taylor

发明人： Eugene C. Jones ,  Michael A. Taylor

IPC分类号： A61J3/00 ,  A61J1/00 ,  A61M5/14 ,  A61M37/00

CPC分类号： A61M5/1409 ,  A61M2202/064

摘要： Several improvements are disclosed for a drug delivery pack with dry reagent in a housing, each of which can be employed independently or in conjunction with others of the improvements. A novel spring is provided with two spring columns extending in parallel between a spring top and a spring bottom. The spring is particularly designed for fitting within the housing and compacting a dry reagent bed. A plunger mechanism to ratchet housing portions between two positions. In one position, a compression component adjacent the reagent bed is relatively uncompressed, such that it does not “set” over time. When the user is about to use the drug delivery device, the plunger is slid to compress the compression component so that it exerts pressure on the reagent bed. A similar sliding mechanism can also divert a stream of diluent through the housing from a priming path, where diluent bypasses the reagent bed, to a functional path passing through and eroding the reagent bed. Additionally, a method is provided for lyophilizing a liquid form of reagent within the housing from which it is to be delivered, thereby avoiding separate lyophilization and separate loading of dry form of the reagent.

摘要翻译： 在壳体中公开了具有干试剂的药物递送包的各种改进，每个可以独立地或与其他改进一起使用。 一个新的弹簧设有两个在弹簧顶部和弹簧底部之间平行延伸的弹簧柱。 弹簧特别设计用于安装在外壳内并压实干试剂床。 一种用于在两个位置之间棘轮收纳部分的柱塞机构。 在一个位置，邻近试剂床的压缩部件相对未压缩，使得其随着时间不“设定”。 当使用者即将使用药物输送装置时，柱塞被滑动以压缩压缩部件，从而对试剂床施加压力。 类似的滑动机构还可以将稀释剂流通过壳体从灌注路径转移到通过并侵蚀试剂床的功能路径上。 此外，提供了一种用于将液体形式的试剂冻结在壳体内以从其被输送的方法，从而避免单独的冻干和干燥形式的试剂的分离加载。

公开(公告)号：US06878338B2

公开(公告)日：2005-04-12

申请号：US10141501

申请日：2002-05-06

申请人： Michael A. Taylor ,  Carolyn Fitzgerald

发明人： Michael A. Taylor ,  Carolyn Fitzgerald

IPC分类号： G01N1/36 ,  A61M5/28 ,  A61M5/315 ,  B01F1/00 ,  B01F13/00 ,  B01F15/02 ,  B01J8/02 ,  B01J19/18 ,  B01J19/26 ,  G01N35/00 ,  B01L3/00

CPC分类号： B01J19/26 ,  A61M5/284 ,  A61M5/286 ,  A61M5/31596 ,  B01F1/00 ,  B01F13/002 ,  B01F13/0023 ,  B01F15/0205 ,  B01J8/0278 ,  B01J19/1812

摘要： A reagent dissolution device and methods of using the same, wherein the device comprises a housing (40), a diluent (25), and at least one reagent bed (35), wherein the diluent (25) and the at least one reagent bed (35) are separated by a friable barrier (50) and a flow distribution disk (100). Alternate embodiments include chambers with a plurality of reagent beds as well as chambers for the mixing of two or more liquid reagents.

摘要翻译： 一种试剂溶解装置及其使用方法，其中所述装置包括壳体（40），稀释剂（25）和至少一个试剂床（35），其中所述稀释剂（25）和所述至少一个试剂床 （35）由易碎屏障（50）和流量分配盘（100）分开。 替代实施方案包括具有多个试剂床的室以及用于混合两种或更多种液体试剂的室。

公开(公告)号：US06805685B2

公开(公告)日：2004-10-19

申请号：US10712747

申请日：2003-11-12

申请人： Michael A. Taylor

发明人： Michael A. Taylor

IPC分类号： A61M514

CPC分类号： A61M5/1409

摘要： An in-line drug delivery pack that connects in-line with an intravenous (IV) line and allows for the mixing of diluent with a drug reagent to be delivered to the patient. An internal drug bed bypass mechanism is tailored to apportion diluent flow between the bypass and the drug bed. The apportionment is selected to achieve a solution concentration suitable for IV administration as the dried reagent is dissolved. Thus, both dissolution and precisely tailored dilution are performed in the same simple device.

公开(公告)号：US06426056B2

公开(公告)日：2002-07-30

申请号：US09908785

申请日：2001-07-18

申请人： Michael A. Taylor

发明人： Michael A. Taylor

IPC分类号： B01D1102

CPC分类号： B01D67/0093 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/28 ,  B01D61/00 ,  B01D61/002 ,  B01D61/18 ,  B01F1/0022 ,  B01F1/0033 ,  B01F15/0254 ,  B01F2215/0034 ,  C02F1/283 ,  C02F1/42 ,  C02F1/444 ,  C02F1/688 ,  C02F9/005 ,  C02F2001/422 ,  C02F2001/425 ,  C02F2103/026 ,  C02F2103/04 ,  Y02A20/214 ,  Y10S210/90 ,  Y10S210/908

摘要： The invention provides an apparatus and method for storing and transporting peritoneal dialysate in dry or lyophilized form, and for forming a deliverable peritoneal dialysis solution therefrom. In one embodiment, a dry reagent bed, including reagents sufficient to produce a dialysis solution, is suspended in a diluent flow path through the apparatus housing. Continuous pressure on the reagent bed causes the bed to compact as it erodes when purified water is passed through the housing. The pressure ensures complete and even dissolution of the reagents. Through dry storage and simple dissolution, even in a home, the invention enables a wider variety of solution constituents, including reduced acid content and the use of bicarbonate as a stable buffer component. The latter is illustrated in a double-bed embodiment, where bicarbonate is stored separately from calcium or magnesium salts within a single housing.

摘要翻译： 本发明提供一种用于以干燥或冻干形式储存和输送腹膜透析液的装置和方法，并用于从其形成可递送的腹膜透析溶液。 在一个实施方案中，将干试剂床（包括足以产生透析溶液的试剂）悬浮在通过装置壳体的稀释剂流动路径中。 试剂床上的连续压力导致床被压缩，因为当净化水通过壳体时它被侵蚀。 压力确保试剂的完全均匀溶解。 通过干燥储存和简单溶解，即使在家中，本发明能够实现更多种类的溶液成分，包括降低酸含量和使用碳酸氢盐作为稳定的缓冲组分。 后者在双床实施例中示出，其中碳酸氢盐与单个壳体内的钙盐或镁盐分开储存。

公开(公告)号：US5349892A

公开(公告)日：1994-09-27

申请号：US788408

申请日：1991-11-06

申请人： Michael A. Taylor ,  Steven R. Chambers

发明人： Michael A. Taylor ,  Steven R. Chambers

IPC分类号： F42B5/188 ,  F42B3/20 ,  D03D23/00

CPC分类号： F42B5/188

摘要： A propellant stick kerfing apparatus includes a support frame, a conveyor mounted on the support frame and operable for conveying a succession of spaced propellant sticks along a path of travel with the sticks extending in transverse relation to the direction of travel, a drive arrangement mounted on the support frame and coupled to the conveyor for driving the conveyor to advance the succession of propellant sticks along the path of travel, and pairs of upper and lower blades mounted stationarily on the support frame and defining cutting edges for making transaxial kerfs in the propellant sticks from opposite upper and lower sides thereof as the succession of spaced sticks are advanced along the path of travel between the cutting edges. The upper and lower blades define the upper and lower cutting edges in an oppositely inclined orientation in which the upper and lower cutting edges converge forwardly toward one another, intersect the path of travel of the succession of sticks, and engage the sticks for making pairs of transaxial kerfs in the sticks as the succession of sticks are advanced along the path of travel between the cutting edges. Each pair of upper and lower blades is spaced from adjacent pairs in a direction transverse to the direction of travel and staggered in the direction of travel relative to adjacent pairs of blades.

摘要翻译： 推进剂棒切割装置包括支撑框架，安装在支撑框架上的输送器，可操作用于沿着行进路径传送一系列间隔的推进剂棒，其中杆与横向于行进方向延伸;驱动装置，安装在 支撑框架并且联接到输送机，用于驱动输送机以沿着行进路径推进推进剂棒的连续，并且成对的上和下叶片固定地安装在支撑框架上并且限定切割边缘，用于在推进剂棒中进行横轴切割 当间隔开的棒的连续沿着切割边缘之间的行进路径前进时，从其相对的上侧和下侧开始。 上刀片和下刀片以相反倾斜的方向限定上切削刃和下切削刃，其中上切削刃和下刀刃相互朝向彼此前进地相交，与连续杆的移动路径相交，并且接合棒以使成对 沿着棒的连续的棒中的横轴切口沿切割刃之间的行进路径前进。 每对上下叶片在相对于行进方向横向的方向上与相邻的对间隔开，并且在相对于相邻叶片对的行进方向上交错。

公开(公告)号：US4529753A

公开(公告)日：1985-07-16

申请号：US598927

申请日：1984-04-10

申请人： Michael A. Taylor

发明人： Michael A. Taylor

IPC分类号： C08F6/00 ,  C08F6/14 ,  C08L27/06

CPC分类号： C08F6/006 ,  C08F6/003

摘要： Residual monomer may be removed from a polymeric emulsion by subjecting it to pressure and temperature conditions so that the ambient vapor pressure is less than the vapor pressure in the emulsion and concurrently and continuously during the treatment adding a free radical initiator.

摘要翻译： 残余单体可以通过使其经受压力和温度条件从聚合物乳液中除去，使得环境蒸气压小于乳液中的蒸气压，并且在处理过程中同时且连续地加入自由基引发剂。

公开(公告)号：US4268510A

公开(公告)日：1981-05-19

申请号：US070492

申请日：1979-08-28

申请人： Francis T. Boyle ,  Michael A. Taylor

发明人： Francis T. Boyle ,  Michael A. Taylor

IPC分类号： A23K1/16 ,  A23K1/18 ,  C07D239/90 ,  C07D265/14 ,  C07D265/16 ,  C07D265/22 ,  A61K31/535

CPC分类号： C07D265/14 ,  C07D239/90 ,  C07D265/16 ,  C07D265/22

摘要： The invention relates to novel heterocyclic trichloromethyl derivatives, particularly 2-trichloromethyl-substituted quinazoline, benzo[d]-[1,3]-oxazine and benzo[e]-[1,3]-oxazine derivatives, for example 1,2-dihydro-2-trichloromethylquinazolin-4-one. The compounds of the invention are at least as effective as prior art trichloromethyl derivatives, which reduce the production of methane during the rumen metabolism of ruminant animals, and increase the formation of propionate at the expense of acetate, and hence improve the animals' rate of growth and their efficiency of food utilization.

摘要翻译： 本发明涉及新型杂环三氯甲基衍生物，特别是2-三氯甲基取代喹唑啉，苯并[d] - [1,3] - 恶嗪和苯并[e] - [1,3] 二氢-2-三氯甲基喹唑啉-4-酮。 本发明的化合物至少与现有技术的三氯甲基衍生物一样有效，其在反刍动物的瘤胃代谢期间减少甲烷的产生，并且以乙酸盐为代价增加丙酸盐的形成，因此改善动物的 增长及其食物利用效率。

公开(公告)号：US20130116598A1

公开(公告)日：2013-05-09

申请号：US13810326

申请日：2011-07-15

申请人： Julie C. Howell ,  Michael A. Taylor ,  John F. Higdon ,  Robert G. Rosenthal ,  Sanjiv Kumar

发明人： Julie C. Howell ,  Michael A. Taylor ,  John F. Higdon ,  Robert G. Rosenthal ,  Sanjiv Kumar

IPC分类号： A61B5/15 ,  A61M5/32

CPC分类号： A61B5/150641 ,  A61B5/1405 ,  A61B5/15003 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/15074 ,  A61B5/150916 ,  A61B5/153 ,  A61M5/158 ,  A61M5/3221 ,  A61M5/3271 ,  A61M25/0606 ,  A61M25/0631 ,  A61M25/0637 ,  A61M2005/1586 ,  A61M2005/3247

摘要： An I.V. infusion or blood collection apparatus comprises an I.V. infusion set (100) and a safety shield (200). The I.V. infusion set has a wing body (105) from which a pair of wings (140) extend outward there from and a grip (145) extending upward there from. One end of the wing body mounts a needle (120) or catheter and medical tubing (130) is connected to the opposite end. The wing body includes a bore so that fluid flows between the needle and the medical tubing. A safety shield has a top, a bottom and opposing side walls and defines a cavity (227) that is adapted to receive the I.V. infusion set. The safety shield has slots (250) in each of the side walls and a slot (255) in the top. The respective wings and grip are adapted to be positioned in the slots and to slidably move therein. The slot in the top includes a lock that is adapted to receive the grip so that when the needle is retracted into the cavity; the grip is permanently captured therein, thus locking the needle in the fully retracted safety position.

摘要翻译： 一个 输液或采血装置包括I.V. 输液器（100）和安全护罩（200）。 I.V. 输液器具有翼体（105），一对翼片（140）从该翼体向外延伸，并且从那里向上延伸的手柄（145）。 翼体的一端安装针（120）或导管，并且医疗管（130）连接到相对端。 翼体包括孔，使得流体在针和医疗管之间流动。 安全护罩具有顶部，底部和相对的侧壁并且限定适于接收I.V.的腔（227）。 输液器 安全护罩在每个侧壁中具有槽（250），在顶部具有槽（255）。 相应的翼和把手适于定位在槽中并且可滑动地移动在其中。 顶部的狭槽包括适于接收把手的锁，使​​得当针缩回到腔中时; 手柄被永久地夹在其中，从而将针锁定在完全缩回的安全位置。

公开(公告)号：US20120136508A1

公开(公告)日：2012-05-31

申请号：US13198334

申请日：2011-08-04

申请人： Michael A. Taylor ,  Jean-Jacques Clar ,  Thandava K. Edara ,  Timothy J. Felty ,  Troy K. Becicka

发明人： Michael A. Taylor ,  Jean-Jacques Clar ,  Thandava K. Edara ,  Timothy J. Felty ,  Troy K. Becicka

IPC分类号： G05D1/00 ,  G06F7/00

CPC分类号： G05D1/0274 ,  E02F9/2045 ,  E02F9/262 ,  G05D1/0278 ,  G05D2201/0202

摘要： A control system is disclosed for a mobile excavation machine operating at a worksite. The control system may have a locating device configured to generate a first signal indicative of a position of the mobile excavation machine, and a position sensor configured to generate a second signal indicative of a position of a work tool. The control system may also have an offboard planner configured to receive a first input indicative of a characteristic of an intended work area, a second input indicative of a characteristic of the mobile excavation machine, and a third input indicative of a desired change in the intended work area. The offboard planner may also be configured to generate an excavation plan based on the first, second, and third inputs. The control system may further have a controller configured to autonomously control the mobile excavation machine based on the first and second signals and based on the excavation plan.

摘要翻译： 公开了一种用于在现场操作的移动式挖掘机的控制系统。 控制系统可以具有定位装置，其被配置为产生指示移动式挖掘机的位置的第一信号，以及位置传感器，其配置成产生指示作业工具的位置的第二信号。 控制系统还可以具有被配置为接收指示预期工作区域的特性的第一输入的第二输入，指示移动式挖掘机的特性的第二输入，以及指示期望的变化的第三输入 工作区域。 离线计划器还可以被配置为基于第一，第二和第三输入产生挖掘计划。 控制系统还可以具有控制器，该控制器被配置为基于第一和第二信号自动地控制移动挖掘机，并且基于挖掘计划。