公开(公告)号：US20060126064A1

公开(公告)日：2006-06-15

申请号：US11351054

申请日：2006-02-09

申请人： Shabbir Bambot ,  Mark Faupel ,  Glenn Arche

发明人： Shabbir Bambot ,  Mark Faupel ,  Glenn Arche

IPC分类号： G01N21/00

CPC分类号： A61B5/0071 ,  A61B5/0084 ,  G01N21/474 ,  G01N21/49 ,  G01N21/6486 ,  G01N2021/6484

摘要： An apparatus and method embodying the invention include utilizing a device with a limited number of interrogation devices to accomplish a large number of measurements on a target tissue (50). An instrument embodying the invention includes a plurality of detection devices (54) that are arranged in a predetermined pattern on a tissue contacting face of the instrument. The face of the instrument is located adjacent the target tissue (50), and a plurality of tissue characteristic measurement are simultaneously conducted. The detection devices (54) are moved to a new position, preferably without moving the tissue contacting face, and a second plurality of tissue characteristic measurements are simultaneously conducted. By conducting a series of measurements cycles in this manner, the ultimate resolution of the device is increased, while still obtaining a given resolution, which reduces potential cross-talk errors. Further, a plurality of tissue characteristics are simultaneously obtained from locations spaced across the target tissue (50) during each measurement cycle.

摘要翻译： 体现本发明的装置和方法包括利用具有有限数量的询问装置的装置来在目标组织（50）上完成大量的测量。 实施本发明的仪器包括在仪器的组织接触面上以预定图案布置的多个检测装置（54）。 仪器的表面位于目标组织（50）附近，同时进行多个组织特征测量。 检测装置（54）移动到新的位置，优选地不移动组织接触面，同时进行第二组织特征测量。 通过以这种方式进行一系列测量周期，设备的最终分辨率得到提高，同时仍然获得给定的分辨率，这降低了潜在的串扰误差。 此外，在每个测量周期期间，跨越目标组织（50）间隔开的位置同时获得多个组织特征。

公开(公告)号：US6002482A

公开(公告)日：1999-12-14

申请号：US124090

申请日：1998-07-29

申请人： Robert Rothfritz ,  Scott Kerr ,  Glenn Steven Arche ,  Scott Kellogg ,  Gregory J. Newman ,  Mark A. Samuels ,  Richard Lachlan Fowler ,  Shabbir Bambot

发明人： Robert Rothfritz ,  Scott Kerr ,  Glenn Steven Arche ,  Scott Kellogg ,  Gregory J. Newman ,  Mark A. Samuels ,  Richard Lachlan Fowler ,  Shabbir Bambot

IPC分类号： A61B5/00 ,  A61B6/00 ,  G01B9/02 ,  G01D18/00 ,  G01N3/62 ,  G01N21/27 ,  G01N21/64

CPC分类号： A61B5/0059 ,  A61B5/1495 ,  G01N21/276 ,  G01N21/278 ,  G01N21/645 ,  A61B2560/0233 ,  G01N2201/0221

摘要： A combined infection shield and calibration or reference target for use with a measuring instrument includes a removable calibration/reference layer. The removable calibration/reference layer has predetermined optical characteristics that can be utilized to calibrate or reference the instrument. The calibration/reference layer may have predetermined reflectance or scattering properties, a predetermined transmissivity to light, or it may have predetermined fluorescence properties. When the calibration/reference layer is removed from the remaining portions of the device, the portion of the calibration/reference layer having the predetermined optical characteristics is irrevocably altered such that the calibration/reference layer cannot be reused. The combined infection shield and target may be attached to a shield holder, which in turn is attached to an instrument. Alternatively, the infection shield and target may be attached directly to an instrument.

摘要翻译： 与测量仪器一起使用的组合感染屏蔽和校准或参考目标包括可移除的校准/参考层。 可拆卸的校准/参考层具有可用于校准或参考仪器的预定光学特性。 校准/参考层可以具有预定的反射率或散射特性，对光的预定透射率，或者可以具有预定的荧光特性。 当校准/参考层从设备的其余部分移除时，具有预定光学特性的校准/参考层的部分不可逆转地改变，使得校准/参考层不能被重复使用。 组合的感染屏蔽物和靶标可以附着到屏蔽保持器上，屏蔽保持器又连接到仪器上。 或者，感染屏蔽物和靶标可以直接附着在仪器上。

公开(公告)号：US07384396B2

公开(公告)日：2008-06-10

申请号：US10435221

申请日：2003-05-08

申请人： Mark A. Samuels ,  Jonathan A. Eppstein ,  Michael R. Hatch ,  Alan Smith ,  Mark Faupel

发明人： Mark A. Samuels ,  Jonathan A. Eppstein ,  Michael R. Hatch ,  Alan Smith ,  Mark Faupel

IPC分类号： A61B5/00

CPC分类号： A61B5/14514 ,  A61B5/00 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/150862 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15134 ,  A61B5/155 ,  A61B5/157 ,  A61B10/0045 ,  A61B2010/008

摘要： A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.

摘要翻译： 一种用于从生物体提取生物流体并连续监测其特征的系统和方法。 该系统包括适于定位在生物体的生物膜的表面上或周围的组织界面装置以及耦合到组织界面装置的监测和控制单元。 组织接口装置包括定位在流体的流动路径中的传感器，用于在生物流体从形成在生物膜中的一个或多个人造开口流出时持续感测生物流体的特性。 传感器产生代表其的传感器信号。 监视器和控制单元以电或光学方式读取传感器，以连续的方式获得生物流体特性的浓度，例如特定分析物的浓度。

公开(公告)号：US20060189857A1

公开(公告)日：2006-08-24

申请号：US11412491

申请日：2006-04-27

申请人： Mark Faupel ,  Raulee Marcus ,  Alan Smith ,  Difei Yang

发明人： Mark Faupel ,  Raulee Marcus ,  Alan Smith ,  Difei Yang

IPC分类号： A61B5/00

CPC分类号： A61B5/145 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/441 ,  A61B5/4839

摘要： The present invention relates to a system and method for monitoring or treating a health condition. The method can include accessing a biological fluid, evaluating an analyte in the fluid, presenting a measurement parameter based on the evaluation, and/or administering a treatment based on the evaluation. The measurement parameter can prompt administering a treatment. The system can include a fluid handling device, a display and/or alert device, and/or an administration device. This abstract is provided for searching purposes only and is not meant for construing the claims.

摘要翻译： 本发明涉及一种用于监测或治疗健康状况的系统和方法。 该方法可以包括进入生物流体，评估流体中的分析物，基于评估呈现测量参数，和/或基于评估进行治疗。 测量参数可以促进治疗。 该系统可以包括流体处理装置，显示器和/或警报装置，和/或管理装置。 本摘要仅用于搜索目的，而不是用于解释权利要求。

公开(公告)号：US07041057B1

公开(公告)日：2006-05-09

申请号：US10130686

申请日：2000-11-17

申请人： Mark L. Faupel ,  Krishna Kumar ,  J. David Farquhar ,  Mark Vreeke ,  Alan Smith ,  Michael Hatch ,  Teresa Woods

发明人： Mark L. Faupel ,  Krishna Kumar ,  J. David Farquhar ,  Mark Vreeke ,  Alan Smith ,  Michael Hatch ,  Teresa Woods

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61B5/04

CPC分类号： A61B5/1486

摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

摘要翻译： 适于定位在生物体的生物膜中的一个或多个人造开口上或周围的组织界面装置（10），并用于耦合到监测和控制单元和真空源。 组织接口装置（10）包括壳体（100），传感器通道（130）和传感器（150）。 壳体（100）限定孔口（120），孔口（120）在壳体（100）的底端（102）上具有开放的入口端口（122）和远端（124），该远端端部 与传感器通道（130）连接。 孔口（120）与从生物膜中形成的人造开口流动的流体流体连通。 传感器通道（130）用于耦合到真空源并与之流体连通。 传感器（150）在流体的流动路径中位于传感器通道（130）中，用于感测流体从人造开口流出时的特性。 传感器产生代表其的传感器信号。

公开(公告)号：US06870620B2

公开(公告)日：2005-03-22

申请号：US10446857

申请日：2003-05-29

申请人： Mark L. Faupel ,  Shabbir B. Bambot ,  Tim Harrell ,  J. David Farquhar ,  Glenn S. Arche ,  Walter R. Sanders ,  Edward L. Kimbrell

发明人： Mark L. Faupel ,  Shabbir B. Bambot ,  Tim Harrell ,  J. David Farquhar ,  Glenn S. Arche ,  Walter R. Sanders ,  Edward L. Kimbrell

IPC分类号： A61B5/00 ,  G01N21/21 ,  G01N21/47 ,  G01N21/49 ,  G01N21/64 ,  G01N21/00

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4331 ,  A61B5/6843 ,  A61B2562/164 ,  G01N21/21 ,  G01N21/474 ,  G01N21/49 ,  G01N21/64

摘要： An apparatus embodying the invention includes a probe head with an interrogation surface that is intended to be positioned adjacent or pushed into contact with a target material or tissue. The probe head is constructed to have a plurality of interrogation devices arranged across the face of the interrogation surface. The probe head is also constructed so that the interrogation device can conform to a non-uniform or non-planar surface of the target tissue. In some embodiments, the interrogation surface may have a particular shape that conforms to the shape of a target material. In other embodiments, one or more portions of the interrogation surface could be movable with respect to the remaining portions so that the interrogation surface could be movable with respect to remaining portions so that the interrogation surface can thereby conform to a non-uniform surface. In still other embodiments, a plurality of separately moveable interrogation devices can be arranged across the interrogation surface. During a measurement process, the interrogation surface would be pressed into contact with the non-uniform surface to cause individual ones of the interrogation devices to move, thereby causing the probe head to conform to the non-uniform surface.

摘要翻译： 实施本发明的装置包括具有询问表面的探针头，该询问表面旨在被定位成与靶材料或组织相邻或被推动接触。 探头被构造成具有布置在询问表面的表面上的多个询问装置​​。 探头也被构造成使得询问装置能够符合目标组织的不均匀或非平面的表面。 在一些实施例中，询问表面可以具有符合目标材料的形状的特定形状。 在其他实施例中，询问表面的一个或多个部分可以相对于其余部分是可移动的，使得询问表面可以相对于剩余部分移动，使得询问表面因此可以符合不均匀的表面。 在其他实施例中，可以跨越询问表面布置多个可单独移动的询问装置。 在测量过程中，询问表面将被压制成与不均匀表面接触，以使单个询问装置​​移动，从而使探针头与非均匀表面一致。

公开(公告)号：US20040119976A1

公开(公告)日：2004-06-24

申请号：US10446857

申请日：2003-05-29

申请人： SpectRx, Inc.

发明人： Mark L. Faupel ,  Shabbir B. Bambot ,  Tim Harrell ,  J. David Farquhar ,  Glenn S. Arche ,  Walter R. Sanders ,  Edward L. Kimbrell

IPC分类号： G01N021/00

CPC分类号： A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4331 ,  A61B5/6843 ,  A61B2562/164 ,  G01N21/21 ,  G01N21/474 ,  G01N21/49 ,  G01N21/64

摘要： An apparatus embodying the invention includes a probe head with an interrogation surface that is intended to be positioned adjacent or pushed into contact with a target material or tissue. The probe head is constructed to have a plurality of interrogation devices arranged across the face of the interrogation surface. The probe head is also constructed so that the interrogation device can conform to a non-uniform or non-planar surface of the target tissue. In some embodiments, the interrogation surface may have a particular shape that conforms to the shape of a target material. In other embodiments, one or more portions of the interrogation surface could be movable with respect to the remaining portions so that the interrogation surface could be movable with respect to remaining portions so that the interrogation surface can thereby conform to a non-uniform surface. In still other embodiments, a plurality of separately moveable interrogation devices can be arranged across the interrogation surface. During a measurement process, the interrogation surface would be pressed into contact with the non-uniform surface to cause individual ones of the interrogation devices to move, thereby causing the probe head to conform to the non-uniform surface.

摘要翻译： 实施本发明的装置包括具有询问表面的探针头，该询问表面旨在被定位成与靶材料或组织相邻或被推动接触。 探头被构造成具有布置在询问表面的表面上的多个询问装置​​。 探头也被构造成使得询问装置能够符合目标组织的不均匀或非平面的表面。 在一些实施例中，询问表面可以具有符合目标材料的形状的特定形状。 在其他实施例中，询问表面的一个或多个部分可以相对于其余部分是可移动的，使得询问表面可以相对于剩余部分移动，使得询问表面因此可以符合不均匀的表面。 在其他实施例中，可以跨越询问表面布置多个可单独移动的询问装置。 在测量过程中，询问表面将被压制成与不均匀表面接触，以使单个询问装置​​移动，从而使探针头与非均匀表面一致。

公开(公告)号：US20030109773A1

公开(公告)日：2003-06-12

申请号：US10303832

申请日：2002-11-26

申请人： SpectRx, Inc.

发明人： Mark A. Samuels ,  Keith D. Ignotz ,  Gregory J. Newman ,  Jonathan A. Eppstein ,  Fan Xu

IPC分类号： A61B005/00

CPC分类号： A61B5/0059 ,  A61B2560/0233 ,  A61B2562/247

摘要： A system and method embodying the invention can be used to detect a characteristic or condition of a patient. A method embodying the invention may include the steps of illuminating a portion of a skin of the patient with light, detecting a frequency spectrum of light scattered from the skin, determining, from first and second portions of the spectrum, a first parameter indicative of a blood content of the skin and a second parameter indicative of a melanin content of the skin, determining, from a third portion of the spectrum, a third parameter indicative of an uncorrected bilirubin concentration, and calculating a corrected bilirubin concentration based on the first, second and third parameters.

摘要翻译： 体现本发明的系统和方法可用于检测患者的特征或状况。 体现本发明的方法可以包括以下步骤：用光照射患者皮肤的一部分，检测从皮肤散射的光的频谱，从频谱的第一和第二部分确定指示一个 皮肤的血液含量和指示皮肤黑色素含量的第二参数，从光谱的第三部分确定指示未校正的胆红素浓度的第三参数，以及基于第一，第二 和第三个参数。

公开(公告)号：US6022316A

公开(公告)日：2000-02-08

申请号：US36169

申请日：1998-03-06

申请人： Jonathan A. Eppstein ,  Michael R. Hatch

发明人： Jonathan A. Eppstein ,  Michael R. Hatch

IPC分类号： A61N1/30 ,  A61N1/32 ,  A61B5/00

CPC分类号： A61N1/0416 ,  A61N1/30 ,  A61N1/325 ,  A61N1/327 ,  A61N1/0476

摘要： An apparatus and a method for electroporating tissue. At least one micropore is formed to a predetermined depth through a surface of the tissue, and electrical voltage is applied between an electrode electrically coupled to the micropore and another electrode spaced therefrom. By applying electroporation to tissue that has been breached by a micropore, the electroporation effects can be targeted at tissue structures beneath the surface, such as capillaries, to greatly enhance the withdrawal of biological fluid, and the delivery for uptake of compounds into the tissue. In a preferred embodiment, a device is provided having elements that are suitable for microporating the tissue and which serve as the electroporation electrodes.

摘要翻译： 一种用于电穿孔组织的装置和方法。 至少一个微孔通过组织的表面形成到预定深度，并且在电耦合到微孔的电极和与其间隔开的另一电极之间施加电压。 通过对已经被微孔破坏的组织进行电穿孔，电穿孔作用可以针对表面下方的组织结构，例如毛细管，以大大增强生物流体的抽出，以及将化合物吸收到组织中。 在优选的实施方案中，提供了一种装置，其具有适合于对组织进行微孔化并用作电穿孔电极的元件。

公开(公告)号：US5792049A

公开(公告)日：1998-08-11

申请号：US906969

申请日：1997-08-06

申请人： Jonathan A. Eppstein ,  Mark A. Samuels ,  Keith D. Ignotz ,  Gregory J. Newman

发明人： Jonathan A. Eppstein ,  Mark A. Samuels ,  Keith D. Ignotz ,  Gregory J. Newman

IPC分类号： A61B5/00 ,  G01N21/27

CPC分类号： G01N21/278 ,  A61B5/0059 ,  A61B5/1495 ,  G01J5/02 ,  G01J5/021 ,  G01J5/04 ,  G01J5/048 ,  G01J5/522 ,  A61B2560/0233

摘要： A disposable calibration device is used to calibrate a spectroscopic measurement system which transmits radiation to a material or tissue in order to effect measurements such as bilirubin measurements. The disposable calibration device includes a structure with a window through which radiation can be transmitted, as well as a removable calibration target arranged on the window and capable of returning a portion of the radiation for calibrating the spectrometer system. The removable calibration target can be peeled of the window to allow a measurement to be made on the material or tissue. Once a measurement is complete, the disposable calibration device can be discarded and a new calibration device can be inserted on the spectroscopic system.

摘要翻译： 一次性校准装置用于校准将辐射传输到材料或组织的光谱测量系统，以便进行诸如胆红素测量的测量。 一次性校准装置包括具有可以透射辐射的窗口的结构以及布置在窗口上并且能够返回一部分辐射以用于校准光谱仪系统的可移除校准目标。 可拆卸的校准目标物可以从窗户上剥离，以便对材料或组织进行测量。 一旦测量完成，可以丢弃一次性校准装置，并且可以在光谱系统上插入新的校准装置。