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    Treatment of Respiratory Diseases
    4.
    发明公开
    Treatment of Respiratory Diseases 审中-公开

    公开(公告)号：US20230146291A1

    公开(公告)日：2023-05-11

    申请号：US18087672

    申请日：2022-12-22

    申请人： The University of Melbourne

    发明人： Alastair Stewart ,  Christine Keenan ,  Trudi Harris

    IPC分类号： A61K31/519 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/58 ,  A61K31/573 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

    CPC分类号： A61K31/519 ,  A61K31/58 ,  A61K31/444 ,  A61K31/506 ,  A61K31/573 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D487/04

    摘要： The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs. The present invention also provides a method of treating or preventing a condition of the airway or lung involving fibrosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1 or an inhibitor of ALK5, thereby treating or preventing a condition of the airway or lung involving fibrosis in a subject.

    MEDICAL DEVICE FOR SENSING AND OR STIMULATING TISSUE
    10.
    发明申请
    MEDICAL DEVICE FOR SENSING AND OR STIMULATING TISSUE 有权

    公开(公告)号：US20220331129A1

    公开(公告)日：2022-10-20

    申请号：US17810189

    申请日：2022-06-30

    申请人： The University of Melbourne

    发明人： Sam Emmanuel JOHN ,  Nicholas Lachlan OPIE ,  Thomas James OXLEY

    IPC分类号： A61F2/68 ,  A61B5/00 ,  A61N1/36 ,  A61F2/86 ,  A61F2/72 ,  A61B5/24 ,  B25J9/00 ,  G06F3/01

    摘要： Devices, methods and systems for transmitting signals through a device located in a blood vessel of an animal for stimulating and/or sensing activity of media proximal to the devices. The media can include tissue and/or fluid. A method of controlling an apparatus in communication with a brain machine interface. The method can include measuring a first neural activity in a first neural area and measuring a second neural activity in a second neural area. The first neural activity can be associated with a first intent. The method can include creating and delivering, via the processor, one or more first control signals to the apparatus upon comparing the second neural activity with the first neural activity, and confirming, based on this comparison, that the second neural activity is associated with the first intent.