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    CARBON-BASED COMPOSITE MATERIALS WITH ENHANCED DYNAMIC PERFORMANCE
    1.
    发明申请
    CARBON-BASED COMPOSITE MATERIALS WITH ENHANCED DYNAMIC PERFORMANCE 有权

    公开(公告)号：US20230134231A1

    公开(公告)日：2023-05-04

    申请号：US17516113

    申请日：2021-11-01

    申请人： Wisconsin Alumni Research Foundation

    发明人： Ramathasan Thevamaran ,  Jizhe Cai

    IPC分类号： C01B32/21 ,  C01B32/158 ,  D01F6/60 ,  D01F1/10

    摘要： Carbon-based composite materials are provided, such as those comprising at least 80 weight % of graphitic carbon comprising functional groups capable of forming hydrogen bonds, the graphitic carbon in the form of a mat of randomly entangled elongated structures; not more than 20 weight % of a polymer or a nanofiber thereof, dispersed within the graphitic carbon, the polymer or the nanofiber thereof comprising corresponding functional groups capable of forming hydrogen bonds with the functional groups of the graphitic carbon; and a plurality of hydrogen bonds at an interface formed between the graphitic carbon and the polymer or the nanofiber thereof, the plurality of hydrogen bonds formed between the functional groups of the graphitic carbon and the corresponding functional groups of the polymer or the nanofiber thereof.

    TOILET, TESTING, AND MONITORING SYSTEMS
    6.
    发明申请
    TOILET, TESTING, AND MONITORING SYSTEMS 有权

    公开(公告)号：US20230096779A1

    公开(公告)日：2023-03-30

    申请号：US18074060

    申请日：2022-12-02

    申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

    发明人： JOSHUA COON ,  MICHAEL WESTPHALL ,  IAN MILLER ,  LLOYD SMITH ,  KEATON MERTZ

    IPC分类号： G01N33/493 ,  G01N30/72 ,  E03D13/00 ,  E03D11/11 ,  G01N1/20

    摘要： Systems for monitoring metabolites may include a sample collection system and a urinalysis system of or for a toilet. The sample collection system may be automated to collect sample urine from a toilet or toilet area, transport the sample to the urinalysis system, and/or the sample urine for analysis at a later time or after analysis by the urinalysis system. The urinalysis system may be automated by proactively providing test material on which a subject may provide a urine sample. Once the urine sample has been provided the urinalysis system may provide the test material to an analyzer for analysis. Results of the analysis of the test material and sample urine may be provided to a mobile device of the subject and/or a remote server. The urinalysis system may provide a urine sample to a mass spectrometry unit for analysis.

    Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors
    7.
    发明申请
    Simplified Structural Mimetics of AIPS as Quorum Sensing Inhibitors 有权

    公开(公告)号：US20230094587A1

    公开(公告)日：2023-03-30

    申请号：US17823053

    申请日：2022-08-29

    申请人： Wisconsin Alumni Research Foundation

    发明人： Helen BLACKWELL ,  Joseph VASQUEZ ,  Yiftah TAL GAN

    IPC分类号： C07D291/02 ,  C07D285/00 ,  C07D273/00 ,  A61P31/04 ,  C07D417/12 ,  C07D413/12 ,  C07D419/12

    摘要： Compounds that regulate quorum sensing in Staphylococcal bacteria and in particular in Staphylococcus aureus are provided. Compounds provided are racemic, non-racemic or substantially enantiomerically pure cyclic peptides of formula I: or salts or solvates thereof, where variables R, W, X1, X2, and Z and are as described in the specification and L1 is a divalent linker which contains 1-12 carbon atoms, optionally 1-4 oxygen atoms, optionally one or two carbon-carbon double bonds, and hydrogen atoms to satisfy valency. Certain dimers of the cyclic peptides are also provided. One or more cylic peptides or dimers thereof herein can be employed to inhibit QS and to thus inhibit virulence in Staphylococcus bacteria. Compounds herein and pharmaceutical compositions containing one or more of these compounds are useful in treating infections of Staphylococcus bacteria. Methods for treating such bacterial infections are also provided.