公开(公告)号：US20180346619A1

公开(公告)日：2018-12-06

申请号：US15611423

申请日：2017-06-01

Applicant: International Business Machines Corporation

Inventor： Sarah K. Czaplewski ,  Brandon M. Kobilka ,  Joseph Kuczynski ,  Jason T. Wertz ,  Jing Zhang

IPC: C08F130/02 ,  C08G79/04 ,  C09J9/00 ,  C09J143/02 ,  C09J185/02 ,  H05K1/03 ,  H01B3/30

CPC classification number: C08F130/02 ,  C07C69/003 ,  C07C69/07 ,  C07F9/091 ,  C07F9/093 ,  C07F9/113 ,  C07F9/1411 ,  C07F9/1412 ,  C08G79/04 ,  C08K5/0066 ,  C08K5/521 ,  C08K5/524 ,  C08L2201/02 ,  C08L2666/84 ,  C09J9/00 ,  C09J143/02 ,  C09J185/02 ,  C09J2203/326 ,  H01B3/307 ,  H05K1/0326 ,  H05K1/0373 ,  H05K2201/012

Abstract: A flame-retardant aconitic acid-derived monomer, a process for forming a flame-retardant polymer, and an article of manufacture comprising a material that contains a flame-retardant aconitic acid-derived monomer are disclosed. The flame-retardant aconitic acid-derived monomer can have at least one phosphoryl or phosphonyl moiety with functional groups that can participate in a polymerization reaction, such as allyl, epoxy, or propylene carbonate functional groups. The process for forming the flame-retardant polymer can include forming an aconitic acid derivative, forming a phosphorus-based flame-retardant molecule, and reacting the aconitic acid derivative with the phosphorus-based flame-retardant molecule to form a flame-retardant aconitic acid-derived monomer, which is then polymerized. The aconitic acid derivative can be synthesized from aconitic acid obtained from a bio-based source. The material in the article of manufacture can be a resin or adhesive, and the article of manufacture can further comprise an electronic component.

公开(公告)号：US09718753B2

公开(公告)日：2017-08-01

申请号：US14889858

申请日：2014-05-05

Applicant: FIRMENICH SA

Inventor： Brinda Indradas ,  Gilbert Virtucio ,  Gary Womack

IPC: A61K8/00 ,  C07C43/166 ,  C07C29/50 ,  C07C45/36 ,  C11B9/00 ,  C07C43/215 ,  C11D3/50 ,  C07C43/23 ,  C07C45/37

CPC classification number: C11B9/0061 ,  C07C29/50 ,  C07C43/166 ,  C07C43/215 ,  C07C43/23 ,  C07C45/36 ,  C07C45/37 ,  C07C2601/08 ,  C07C2601/16 ,  C11B9/0003 ,  C11B9/0015 ,  C11B9/0019 ,  C11D3/001 ,  C11D3/507 ,  C07C67/39 ,  C07C69/06 ,  C07C69/07 ,  C07C33/025 ,  C07C47/54 ,  C07C47/232 ,  C07C47/575 ,  C07C31/125 ,  C07C33/02 ,  C07C33/03 ,  C07C35/06 ,  C07C47/542 ,  C07C33/20

Abstract: A compound is provided of Formula (I), wherein R1 represents a C3 to C20 hydrocarbon group derived from an alcohol of formula R1OH, from a formate of formula R1OCH═O, or a cinnamyl aldehyde of Formula (II) wherein a compound of Formula I is capable of releasing a compound, when oxidized, selected from the group consisting of a fragrant alcohol of formula R1OH, a fragrant formate ester of formula R1OCH=0 and aryl aldehyde of Formula (III), wherein R2 is, independently, hydrogen atom, hydroxyl group, optionally substituted C1-C6 alkyl group, C1-C6 alkoxy group, or -0(C=0)CH(CH3)2 wherein any two of R2 may form an optionally substituted 5 or 6 membered ring. The compounds are useful for example as a precursor for the prolonged delivery or release of fragrant compounds such as fragrant alcohols, fragrant aldehydes or fragrant formates.

公开(公告)号：US09517988B2

公开(公告)日：2016-12-13

申请号：US14936310

申请日：2015-11-09

Applicant: Sichuan Haisco Pharmaceutical Co., Ltd.

Inventor： Linlin Qin ,  Fangqiong Li ,  Shixu Yi ,  Huadong Luo ,  Xinfeng Luo ,  Songlin Wan ,  Lei Ren ,  Guoliang Liu ,  Yonggang Wei ,  Jianyu Liu ,  Peng Cho Tang

IPC: C07C43/00 ,  C07C39/00 ,  C07D213/00 ,  C07F9/00 ,  C07C39/17 ,  C07C39/42 ,  C07C69/96 ,  C07C43/21 ,  C07C43/23 ,  C07C69/157 ,  C07C69/24 ,  C07C69/82 ,  C07D207/16 ,  C07F9/6574 ,  C07F9/09 ,  C07F9/12 ,  C07F9/24 ,  C07D213/80 ,  C07C271/22 ,  C07C271/44 ,  C07C229/08 ,  C07C229/36 ,  C07C37/00 ,  C07C37/62 ,  C07C41/18 ,  C07C67/10 ,  C07C68/00 ,  C07C69/07 ,  C07C69/78 ,  C07C227/04 ,  C07C269/00 ,  C07D213/803 ,  C07F9/06

CPC classification number: C07C39/17 ,  C07C37/00 ,  C07C37/001 ,  C07C37/62 ,  C07C39/42 ,  C07C41/18 ,  C07C43/21 ,  C07C43/23 ,  C07C67/10 ,  C07C68/00 ,  C07C69/07 ,  C07C69/157 ,  C07C69/24 ,  C07C69/78 ,  C07C69/82 ,  C07C69/96 ,  C07C227/04 ,  C07C229/08 ,  C07C229/36 ,  C07C269/00 ,  C07C271/22 ,  C07C271/44 ,  C07C2601/02 ,  C07C2601/04 ,  C07D207/16 ,  C07D213/80 ,  C07D213/803 ,  C07F9/06 ,  C07F9/091 ,  C07F9/094 ,  C07F9/12 ,  C07F9/242 ,  C07F9/2458 ,  C07F9/65744

Abstract: The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a cocrystal thereof, a preparation method thereof, a pharmaceutical composition comprising the same, and use of the compound or composition of the present invention in the field of the central nervous system; wherein the definitions of substituents in general formula (A) are the same as those in the Description.

Abstract translation: 本发明涉及一种酚衍生物及其药物的制备方法和用途，特别涉及通式（A）表示的苯酚衍生物或立体异构体，溶剂合物，代谢物，前药，药学上可接受的盐或 其共结晶体，其制备方法，包含其的药物组合物，以及本发明化合物或组合物在中枢神经系统领域中的用途; 其中通式（A）中的取代基的定义与说明书中的相同。

公开(公告)号：US20070032667A1

公开(公告)日：2007-02-08

申请号：US10571261

申请日：2004-09-02

Applicant: Werner Bonrath ,  Manfred Breuninger ,  Gregroy Malaise ,  Thomas Netscher

Inventor： Werner Bonrath ,  Manfred Breuninger ,  Gregroy Malaise ,  Thomas Netscher

IPC: C07D311/02

CPC classification number: C07C69/017 ,  C07C67/08 ,  C07C67/28 ,  C07C67/29 ,  C07C67/293 ,  C07C67/475 ,  C07C69/157 ,  C07D311/72 ,  C07C69/16 ,  C07C69/145 ,  C07C69/07 ,  C07C69/78 ,  C07C69/007

Abstract: The present invention is concerned with a novel process for the manufacture of 4alkanoyloxy-2,3,5-trimethylphenyl (E/Z)-phytyl ethers, precursors of α-tocopheryl alkanoates, by cross-metathesis reaction of alkenyl ethers of 1-alkanoyloxy-2,3,6-trimethylhydroquinone with 2,6,10,14-tetramethylpentadecene or a phytol derivative, e.g. an ester, an ether or a silyl ether, in the presence of a cross-metathesis catalyst. As the crossmetathesis catalyst especially ruthenium metal carbene complexes are suitable which possess (a) ruthenium metal center(s), have an electron count of 16 or 18 and are penta- or hexa-coordinated. A further object of the invention is a process for the manufacture of atocopheryl alkanoates comprising this reaction.

Abstract translation: 本发明涉及一种制备4-烷酰氧基-2,3,5-三甲基苯基（E / Z） - 萜醚的方法，通过1-烷酰氧基的链烯基醚的交错复分解反应制备α-生育酚链烷酸酯的前体 -2,3,6-三甲基氢醌与2,6,10,14-四甲基十五碳烯或植醇衍生物，例如 酯，醚或甲硅烷基醚，在交叉复分解催化剂存在下进行。 由于交叉分析催化剂特别是钌金属卡宾配合物，其具有（a）钌金属中心，具有16或18的电子数，并且是五元或六配位的。 本发明的另一个目的是制备包含该反应的链烷酸生育基酯的方法。

公开(公告)号：US06187964B1

公开(公告)日：2001-02-13

申请号：US09353311

申请日：1999-07-14

Applicant: Kazuo Tanaka ,  Yukio Sakai ,  Yasuhiro Shoji ,  Takafumi Yoshimura ,  Masatoshi Yoshimura

Inventor： Kazuo Tanaka ,  Yukio Sakai ,  Yasuhiro Shoji ,  Takafumi Yoshimura ,  Masatoshi Yoshimura

IPC: C07C3700

CPC classification number: C07C51/255 ,  C07C37/0555 ,  C07C51/285 ,  C07C67/39 ,  C07C67/54 ,  C07C63/04 ,  C07C69/017 ,  C07C69/07 ,  C07C39/07

Abstract: A method of producing a phenol compound comprising a step of oxidizing an aromatic aldehyde to an aryl formate and an aromatic carboxylic acid with an oxygen-containing gas, and a step of decomposing the aryl formate to the phenol compound. To facilitate the separation of the aryl formate and the unreacted aromatic aldehyde, a mixture of the aryl formate and the unreacted aromatic aldehyde is recycled to the oxidation process to concentrate the aryl formate in the oxidation mixture. Alternatively, the oxidation process is carried out in an organic solvent having substantially no ability of dissolving water to increase the conversion of the aromatic aldehyde and the selectivity of the aryl formate, thereby producing the aryl formate in a high yield. In another method, the aryl formate is produced by oxidizing the aromatic aldehyde in the organic solvent having substantially no ability of dissolving water with performic acid generated in situ in the reaction system from the reaction between formic acid and hydrogen peroxide. Since the oxidation proceeds in the organic solvent, hydrogen peroxide in aqueous phase contact the aromatic aldehyde. This significantly reduces the amount of explosive cyclic perther and a high-boiling product.

Abstract translation: 一种生产酚化合物的方法，包括用含氧气体将芳族醛氧化为芳基甲酸酯和芳族羧酸的步骤，以及将芳基甲酸酯分解成酚化合物的步骤。 为了促进甲酸芳基酯和未反应的芳族醛的分离，将甲酸芳基酯和未反应的芳族醛的混合物循环到氧化过程中以将甲酸芳基酯浓缩在氧化混合物中。 或者，氧化方法在基本上没有溶解水的能力的有机溶剂中进行，以增加芳族醛的转化率和甲酸芳基酯的选择性，从而以高产率生产甲酸芳基酯。 在另一种方法中，通过氧化芳族醛在有机溶剂中氧化芳族醛，通过在反应体系中原位产生的甲酸与甲酸和过氧化氢之间的反应基本上不溶解水的能力来进行氧化。 由于在有机溶剂中进行氧化，水相中的过氧化氢与芳族醛接触。 这显着地减少了爆炸性环状花药和高沸点产物的量。

公开(公告)号：US3344171A

公开(公告)日：1967-09-26

申请号：US39874764

申请日：1964-09-23

Applicant: INT FLAVORS & FRAGRANCES INC

Inventor： SEYMOUR LEMBERG

IPC: B01J27/06 ,  C07C5/25

CPC classification number: C07C5/255 ,  B01J27/06 ,  C07C5/2556 ,  C07C67/293 ,  C07C11/21 ,  C07C69/145 ,  C07C69/24 ,  C07C69/07

公开(公告)号：US2797234A

公开(公告)日：1957-06-25

申请号：US49178255

申请日：1955-03-02

Applicant: HOFFMANN LA ROCHE

Inventor： BIRBIGLIA JAMES A ,  CHASE GEORGE O ,  JULIUS GALENDER

IPC: C11B9/00

CPC classification number: C11B9/0019 ,  C07C67/283 ,  C07C69/07 ,  C07C69/145 ,  C07C69/24

公开(公告)号：US1963108A

公开(公告)日：1934-06-19

申请号：US62745932

申请日：1932-08-04

Applicant: DU PONT

Inventor： WERNTZ JAMES H

CPC classification number: C08F220/18 ,  C07C67/04 ,  C07C69/07 ,  C07C69/145 ,  C07C69/24 ,  C07C69/63

公开(公告)号：US4985403A

公开(公告)日：1991-01-15

申请号：US545623

申请日：1990-06-29

Applicant: Anubhav P. S. Narula ,  Charles E. J. Beck ,  Marie R. Hanna

Inventor： Anubhav P. S. Narula ,  Charles E. J. Beck ,  Marie R. Hanna

IPC: A24B15/34 ,  C07C35/37 ,  C07C43/18 ,  C07C43/188 ,  C07C43/196 ,  C07C45/49 ,  C07C45/50 ,  C07C45/75 ,  C07C47/267 ,  C07C49/453 ,  C07C49/653 ,  C07C69/00 ,  C07D311/00 ,  C11B9/00

CPC classification number: C07D311/00 ,  A24B15/345 ,  C07C35/37 ,  C07C43/18 ,  C07C43/188 ,  C07C43/196 ,  C07C45/49 ,  C07C45/50 ,  C07C45/75 ,  C07C47/267 ,  C07C49/453 ,  C07C49/653 ,  C07C67/08 ,  C07C69/00 ,  C07C69/07 ,  C11B9/0042 ,  C07C2103/00 ,  C07C2103/74

Abstract: Described are adamantane derivatives defined according to the structure: ##STR1## wherein R.sub.1 is hydrogen or acetyl; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen or methylene (CH.sub.2) and wherein the dashed line represents a carbon-hydrogen single bond or a carbon-methylene double bond with the provisos that when R.sub.2 is methyl R.sub.1 and R.sub.3 are both hydrogen and when R.sub.2 is hydrogen, R.sub.3 is methylene and the dashed line is a carbon-methylene double bond and uses thereof in augmenting or enhancing the aroma of consumable materials selected from the group consisting of perfume compositions, colognes and perfumed articles.

Abstract translation: 描述了根据以下结构定义的金刚烷衍生物：其中R 1是氢或乙酰基; R2是氢或甲基; 且R 3为氢或亚甲基（CH 2），并且其中虚线表示碳 - 氢单键或碳 - 亚甲基双键，条件是当R 2为甲基R 1且R 3均为氢时，并且当R 2为氢时，R 3为 亚甲基，虚线是碳 - 亚甲基双键，并用于增强或增强选自香水组合物，古龙水和香料制品的消耗材料的香气。

公开(公告)号：US4525298A

公开(公告)日：1985-06-25

申请号：US442676

申请日：1982-11-18

Applicant: Karl H. Schulte-Elte ,  Bernard L. Muller

Inventor： Karl H. Schulte-Elte ,  Bernard L. Muller

IPC: C07C31/125 ,  C07C33/02 ,  C07C33/048 ,  C07C45/30 ,  C07C47/02 ,  C07C49/04 ,  C07C69/025 ,  C07C69/07 ,  C07C69/145 ,  C11B9/00 ,  C11D3/50 ,  C07C69/24

CPC classification number: C11D3/50 ,  C07C31/125 ,  C07C33/02 ,  C07C33/048 ,  C07C45/305 ,  C07C47/02 ,  C07C49/04 ,  C07C69/06 ,  C07C69/07 ,  C07C69/14 ,  C07C69/145 ,  C07C69/24 ,  C11B9/0015

Abstract: There are disclosed compounds of formula ##STR1## having a single or a double bond in the position indicated by the dotted line and wherein:Z represents an ethylene, ethenyl or an ethynyl divalent radical;X represents a hydrogen atom or an acyl radical, derived from a linear or branched lower hydrocarbon of formula R--CO, wherein R designates a hydrogen atom or a lower alkyl group, andR.sup.1 and R.sup.2, identical or different, represent each a hydrogen atom or a linear or branched alkyl radical.Compounds (I) possess useful perfuming properties.

Abstract translation: 公开了在虚线表示的位置具有单键或双键的式（I）的化合物，其中：Z表示乙烯，乙烯基或乙炔基二价基; X表示衍生自式R-CO的直链或支链低级烃的氢原子或酰基，其中R表示氢原子或低级烷基，R 1和R 2相同或不同，表示氢原子 或直链或支链烷基。 化合物（I）具有有用的加香性质。