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公开(公告)号：US20110059974A1
公开(公告)日：2011-03-10
申请号：US12991822
申请日：2009-05-07
IPC分类号： A61K31/4164 , C07D233/61 , C07D403/12 , C07D473/00 , C07D473/38 , A61K31/4196 , A61K31/41 , A61K31/53 , A61K31/52 , A61P35/00
CPC分类号： C07D233/56 , A61K31/41 , A61K31/4164 , A61K31/4196 , A61K31/519 , A61K31/53 , C07D233/60 , C07D249/02 , C07D251/02 , C07D487/04
摘要： Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods include reacting RAMBAs with terminal polar carboxylic acid group with a variety of amines in the presence of suitable coupling reagents. The retinamide RAMBAs are potent inhibitors of the growth of prostate and breast cancer cells and may be useful for the treatment of these diseases in humans.
摘要翻译： 视黄酸代谢阻断剂（RAMBA）。 RAMBAs可用于治疗癌症，包括乳腺癌和前列腺癌。 新型视黄醛RAMBA的制备方法。 所述方法包括在合适的偶联剂存在下使RAMBA与末端极性羧酸基团与多种胺反应。 视网膜酰胺RAMBAs是前列腺和乳腺癌细胞生长的有效抑制剂，可用于治疗人类中的这些疾病。
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公开(公告)号：US09436084B2
公开(公告)日：2016-09-06
申请号：US11792752
申请日：2006-03-22
申请人： Koichi Misumi , Toshiki Okui
发明人： Koichi Misumi , Toshiki Okui
IPC分类号： G03F7/004 , G03F7/039 , H01L21/027 , C08F220/18 , C07D251/02
CPC分类号： G03F7/0397 , C07D251/02 , C08F220/18 , G03F7/004 , G03F7/0392 , H01L21/0274
摘要： The invention provides a chemical-amplification positive-working photoresist composition suitable for forming a resist film of a relatively large thickness on a substrate in addition to other advantages. The inventive composition contains (A) a photoacid-generating agent, (B) an alkali-insoluble resin capable of being imparted with increased alkali-solubility by interaction with an acid, (C) an alkali-soluble resin and (D) an organic solvent, wherein the component (C) is (C1) a polyhydroxystyrene or a copolymer having at least 80% by mass of the hydroxystyrene units in an amount not exceeding 15 parts by mass relative to 100 parts by mass of the total amount of the components (B) and (C).
摘要翻译： 本发明提供了除了其它优点之外，还适用于在基片上形成厚度相对较大的抗蚀剂膜的化学放大正性光致抗蚀剂组合物。 本发明的组合物含有（A）光致酸产生剂，（B）能够通过与酸相互作用而赋予碱溶性增加的碱不溶性树脂，（C）碱溶性树脂和（D）有机 溶剂，其中组分（C）为（C1）聚羟基苯乙烯或共聚物，相对于100质量份的组分的总量，相对于100质量份，羟基苯乙烯单元的至少80质量％的量不超过15质量份 （B）和（C）。
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3.发明授权公开(公告)号：US09301912B2
公开(公告)日：2016-04-05
申请号：US14592461
申请日：2015-01-08
IPC分类号： A61K8/85 , A61Q1/00 , A61Q3/00 , A61Q5/00 , C07D249/12 , C08G59/22 , C08G59/42 , C08G63/12 , C08G63/685 , C07D233/36 , C07D233/40 , C07D251/02 , C07D253/02 , A61Q5/06 , C07D249/14 , A61K8/49 , A61K8/88 , A61Q5/02 , A61Q19/00 , C08G83/00 , A61K8/84 , C08G59/02 , A61Q1/02 , A61Q5/12
CPC分类号： A61K8/85 , A61K8/4946 , A61K8/496 , A61K8/4966 , A61K8/84 , A61K8/88 , A61K2800/544 , A61Q1/02 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q19/00 , C07D233/36 , C07D233/40 , C07D249/12 , C07D249/14 , C07D251/02 , C07D253/02 , C08G59/02 , C08G59/22 , C08G59/42 , C08G63/12 , C08G63/685 , C08G63/6854 , C08G83/003
摘要： The present invention relates to a material comprising dendritic molecules each constituted of fragments that are at least bifunctional and of fragments that are at least trifunctional joined together by ester or thioester bridges, alone or in combination with amide or urea bridges, said bridges being formed from two functions carried by different fragments, said molecules containing, on the fragments located at the ends of the dendritic branches, associative end groups capable of forming associations with one another by hydrogen bonds and joined covalently to the functions that are not involved in said bridges. It also relates to the method of production thereof, as well as to its uses and to compositions, notably cosmetic, containing this material.
摘要翻译： 本发明涉及包含树枝状分子的材料，每个树枝状分子由至少双功能的片段和至少三官能的片段组成，所述片段通过酯或硫酯桥单独或与酰胺或脲桥结合在一起，所述桥由 两个功能由不同的片段携带，所述分子在位于树枝状分枝末端的片段上包含能够通过氢键彼此形成缔合的缔合端基，并且共价连接到不涉及所述桥的功能。 它还涉及其生产方法，以及其用途和组合物，特别是包含该材料的化妆品。
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公开(公告)号：US20150132239A1
公开(公告)日：2015-05-14
申请号：US14592461
申请日：2015-01-08
IPC分类号： A61K8/84 , A61Q5/02 , C08G59/02 , C07D233/36 , A61K8/49
CPC分类号： A61K8/85 , A61K8/4946 , A61K8/496 , A61K8/4966 , A61K8/84 , A61K8/88 , A61K2800/544 , A61Q1/02 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q19/00 , C07D233/36 , C07D233/40 , C07D249/12 , C07D249/14 , C07D251/02 , C07D253/02 , C08G59/02 , C08G59/22 , C08G59/42 , C08G63/12 , C08G63/685 , C08G63/6854 , C08G83/003
摘要： The present invention relates to a material comprising dendritic molecules each constituted of fragments that are at least bifunctional and of fragments that are of least trifunctional joined together by ester or thioester bridges, alone or in combination with amide or urea bridges, said bridges being formed from two functions carried by different fragments, said molecules containing, on the fragments located at the ends of the dendritic branches, associative end groups capable of forming associations with one another by hydrogen bonds and joined covalently to the functions that are not involved in said bridges. It also relates to the method of production thereof, as well as to its uses and to compositions, notably cosmetic, containing this material.
摘要翻译： 本发明涉及包含树枝状分子的材料，每个树枝状分子由至少双功能的片段和至少三官能的片段组成，所述片段通过酯或硫酯桥单独或与酰胺或脲桥结合在一起，所述桥由 两个功能由不同的片段携带，所述分子在位于树枝状分枝末端的片段上包含能够通过氢键彼此形成缔合的缔合端基，并且共价连接到不涉及所述桥的功能。 它还涉及其生产方法，以及其用途和组合物，特别是包含该材料的化妆品。
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公开(公告)号：US09156792B2
公开(公告)日：2015-10-13
申请号：US12991822
申请日：2009-05-07
IPC分类号： A61K31/4164 , A61K31/53 , A61K31/4196 , A61K31/41 , A61K31/519 , C07D233/60 , C07D487/04 , C07D251/02 , C07D221/04 , C07D249/02 , C07D233/56
CPC分类号： C07D233/56 , A61K31/41 , A61K31/4164 , A61K31/4196 , A61K31/519 , A61K31/53 , C07D233/60 , C07D249/02 , C07D251/02 , C07D487/04
摘要： Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods include reacting RAMBAs with terminal polar carboxylic acid group with a variety of amines in the presence of suitable coupling reagents. The retinamide RAMBAs are potent inhibitors of the growth of prostate and breast cancer cells and may be useful for the treatment of these diseases in humans.
摘要翻译： 视黄酸代谢阻断剂（RAMBA）。 RAMBAs可用于治疗癌症，包括乳腺癌和前列腺癌。 新型视黄醛RAMBA的制备方法。 所述方法包括在合适的偶联剂存在下使RAMBA与末端极性羧酸基团与多种胺反应。 视网膜酰胺RAMBAs是前列腺和乳腺癌细胞生长的有效抑制剂，可用于治疗人类中的这些疾病。
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6.发明申请公开(公告)号：US20110003872A1
公开(公告)日：2011-01-06
申请号：US12746484
申请日：2008-12-02
IPC分类号： A61K31/4196 , A61K31/20 , A61Q90/00
CPC分类号： A61K8/85 , A61K8/4946 , A61K8/496 , A61K8/4966 , A61K8/84 , A61K8/88 , A61K2800/544 , A61Q1/02 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q19/00 , C07D233/36 , C07D233/40 , C07D249/12 , C07D249/14 , C07D251/02 , C07D253/02 , C08G59/02 , C08G59/22 , C08G59/42 , C08G63/12 , C08G63/685 , C08G63/6854 , C08G83/003
摘要： The present invention relates to a material comprising dendritic molecules each constituted of fragments that are at least bifunctional and of fragments that are at least trifunctional joined together by ester or thioester bridges, alone or in combination with amide or urea bridges, said bridges being formed from two functions carried by different fragments, said molecules containing, on the fragments located at the ends of the dendritic branches, associative end groups capable of forming associations with one another by hydrogen bonds and joined covalently to the functions that are not involved in said bridges. It also relates to the method of production thereof, as well as to its uses and to compositions, notably cosmetic, containing this material.
摘要翻译： 本发明涉及包含树枝状分子的材料，每个树枝状分子由至少双功能的片段和至少三官能的片段组成，所述片段通过酯或硫酯桥单独或与酰胺或脲桥结合在一起，所述桥由 两个功能由不同的片段携带，所述分子在位于树枝状分枝末端的片段上包含能够通过氢键彼此形成缔合的缔合端基，并且共价连接到不涉及所述桥的功能。 它还涉及其生产方法，以及其用途和组合物，特别是包含该材料的化妆品。
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公开(公告)号：US08795390B2
公开(公告)日：2014-08-05
申请号：US13884778
申请日：2011-10-25
申请人： Claus Reineking , Roberta Gamarino , Licia Trimarco , Maurizio Quaglierini , Markus Gisler , Rainer Nusser
发明人： Claus Reineking , Roberta Gamarino , Licia Trimarco , Maurizio Quaglierini , Markus Gisler , Rainer Nusser
IPC分类号： C14C3/26 , C07D253/02 , C14C3/00 , C14C3/02 , C14C3/04 , C07D253/00 , C07D251/00 , C07D251/02 , C07D251/04 , C07D251/44
CPC分类号： C14C3/00 , C07D251/00 , C07D251/02 , C07D251/04 , C07D251/44 , C07D253/00 , C07D253/02 , C07D403/10 , C14C3/02 , C14C3/04 , C14C3/26 , C14C3/28
摘要： Tanned leather, skin or pelt is produced by non-metal tanning, comprising the step of tanning a bated hide, skin or pelt with a tanning agent (A), the tanning agent (A) being at least one compound of formula (I), wherein Hal signifies chlorine or fluorine, X signifies N or CR, Y signifies hydrogen, C1-8-alkyl, C1-4-alkyl-carbonyl, C-1-4-alkyl-sulphonyl or a radical of formula (Ia), or (Ib) —(—C2-3 alkylene-O—)q—H (Ib), R signifies hydrogen or chlorine, q is 1 to 10 and M signifies hydrogen, an alkali metal cation or an ammonium cation being a protonated tertiary amine or a quaternary ammonium cation, in a tanning bath having a pH of from 6 to 10 at the beginning of the tanning step.
摘要翻译： 鞣制的皮革，皮肤或毛皮是通过非金属鞣制制成的，包括用鞣剂（A），鞣制剂（A）为至少一种式（I）化合物鞣制皮肤，皮肤或皮肤的步骤， 其中Hal表示氯或氟，X表示N或CR，Y表示氢，C1-8 - 烷基，C1-4 - 烷基 - 羰基，C 1-4 - 烷基 - 磺酰基或式（Ia）的基团， 或（Ib） - （ - C2-3亚烷基-O-）q-H（Ib），R表示氢或氯，q表示1至10，M表示氢，碱金属阳离子或铵阳离子为质子化三级 胺或季铵阳离子，在鞣制步骤开始时pH为6至10的鞣制浴中。
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公开(公告)号：US20130239340A1
公开(公告)日：2013-09-19
申请号：US13884778
申请日：2011-10-25
申请人： Claus Reineking , Roberta Gamarino , Licia Trimarco , Maurizio Quaglierini , Markus Gisler , Rainer Nusser
发明人： Claus Reineking , Roberta Gamarino , Licia Trimarco , Maurizio Quaglierini , Markus Gisler , Rainer Nusser
CPC分类号： C14C3/00 , C07D251/00 , C07D251/02 , C07D251/04 , C07D251/44 , C07D253/00 , C07D253/02 , C07D403/10 , C14C3/02 , C14C3/04 , C14C3/26 , C14C3/28
摘要： Tanned leather, skin or pelt is produced by non-metal tanning, comprising the step of tanning a bated hide, skin or pelt with a tanning agent (A), the tanning agent (A) being at least one compound of formula (I), wherein Hal signifies chlorine or fluorine, X signifies N or CR Y signifies hydrogen, C1-8-alkyl, C1-4-alkyl-carbonyl, C1-4-alkyl-sulphonyl or a radical of formula (Ia), or (Ib) —(—C2-3 alkylene-O—)q—H (Ib) R signifies hydrogen or chlorine, q is 1 to 10 and M signifies hydrogen or an alkali metal cation or an ammonium cation, the ammonium cation being a protonated tertiary amine or a quaternary ammonium cation, in a tanning bath, the tanning bath having a pH of from 6 to 10 at the beginning of the tanning step.
摘要翻译： 鞣制的皮革，皮肤或毛皮是通过非金属鞣制制成的，包括用鞣剂（A），鞣制剂（A）为至少一种式（I）化合物鞣制皮肤，皮肤或皮肤的步骤， 其中Hal表示氯或氟，X表示N或CRY表示氢，C1-8 - 烷基，C1-4 - 烷基 - 羰基，C1-4 - 烷基 - 磺酰基或式（Ia）的基团，或（Ib ） - （ - C2-3亚烷基-O-）qH（Ib）R表示氢或氯，q表示1〜10，M表示氢或碱金属阳离子或铵阳离子，铵阳离子为质子化叔胺或 在鞣制浴中，在鞣制步骤开始时，鞣制浴的pH为6至10。
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公开(公告)号：US20080026321A1
公开(公告)日：2008-01-31
申请号：US11792752
申请日：2006-03-22
申请人： Koichi Misumi
发明人： Koichi Misumi
IPC分类号： G03C1/00
CPC分类号： G03F7/0397 , C07D251/02 , C08F220/18 , G03F7/004 , G03F7/0392 , H01L21/0274
摘要： The invention provides a chemical-amplification positive-working photoresist composition suitable for forming a resist film of a relatively large thickness on a substrate in addition to other advantages. The inventive composition contains (A) a photoacid-generating agent, (B) an alkali-insoluble resin capable of being imparted with increased alkali-solubility by interaction with an acid, (C) an alkali-soluble resin and (D) an organic solvent, wherein the component (C) is (C1) a polyhydroxystyrene or a copolymer having at least 80% by mass of the hydroxystyrene units in an amount not exceeding 15 parts by mass relative to 100 parts by mass of the total amount of the components (B) and (C).
摘要翻译： 本发明提供了除了其它优点之外，还适用于在基片上形成厚度相对较大的抗蚀剂膜的化学放大正性光致抗蚀剂组合物。 本发明的组合物含有（A）光致酸产生剂，（B）能够通过与酸相互作用而赋予碱溶性增加的碱不溶性树脂，（C）碱溶性树脂和（D）有机 溶剂，其中组分（C）为（C 1）多羟基苯乙烯或具有至少80质量％的羟基苯乙烯单元的共聚物，相对于100份，不超过15份 组分（B）和（C）的总量的质量。
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