-
公开(公告)号：US08916380B2
公开(公告)日：2014-12-23
申请号：US12377493
申请日：2006-12-20
申请人： Jeong Mook Lim , Jae Yong Han , Hee Bal Kim , Seoung Tae Lee , Eun Ju Lee , Seung Pyo Gong
发明人： Jeong Mook Lim , Jae Yong Han , Hee Bal Kim , Seoung Tae Lee , Eun Ju Lee , Seung Pyo Gong
CPC分类号： C12N5/0696 , C12N2501/235 , C12N2502/03 , C12N2502/04 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394
摘要： Disclosed is a method for preparing an embryonic stem cell (ESC)-like cell, which includes the steps of: (a) obtaining a first cell population from a mammalian tissue or body fluid, wherein the first cell population comprises adult stem cells; (b) obtaining a second somatic cell population from a mammalian tissue, wherein the mammalian tissue is different from the mammalian tissue in step (a) and the second cell population is different from the first cell population; (c) coculturing the first cell population and the second cell population in a medium for a period of time sufficient to form a colony from either the first cell population or the second cell population; and (d) subculturing a cell from the colony in a medium for a period time sufficient to prepare the ESC-like cell.
摘要翻译： 公开了一种制备胚胎干细胞（ESC）样细胞的方法，其包括以下步骤：（a）从哺乳动物组织或体液获得第一细胞群，其中第一细胞群包含成体干细胞; （b）从哺乳动物组织获得第二体细胞群，其中所述哺乳动物组织在步骤（a）中不同于哺乳动物组织，而第二细胞群与第一细胞群不同; （c）在培养基中共培养第一细胞群体和第二细胞群体足以从第一细胞群体或第二细胞群体形成菌落的时间; 和（d）在培养基中将细胞从菌落中传代培养足以制备ESC样细胞的时间。
-
公开(公告)号：US08053220B2
公开(公告)日：2011-11-08
申请号：US11451986
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
-
公开(公告)号：US20070134223A1
公开(公告)日：2007-06-14
申请号：US11451986
申请日：2006-06-12
申请人： Ed Harlow , Roderick Hyde , Edward Jung , Robert Langer , Eric Leuthardt , Lowell Wood
发明人： Ed Harlow , Roderick Hyde , Edward Jung , Robert Langer , Eric Leuthardt , Lowell Wood
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
-
公开(公告)号：US09982238B2
公开(公告)日：2018-05-29
申请号：US13983701
申请日：2011-07-07
申请人： Koh-ei Toyoshima , Takashi Tsuji
发明人： Koh-ei Toyoshima , Takashi Tsuji
CPC分类号： C12N5/0697 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3886 , A61L2430/18 , C12N5/0627 , C12N5/0633 , C12N2502/13 , C12N2502/1376 , C12N2533/54
摘要： A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ.
-
公开(公告)号：US08900865B2
公开(公告)日：2014-12-02
申请号：US11389268
申请日：2006-03-24
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/00 , C12N5/02 , C12N11/00 , C12N11/16 , A61F2/00 , A61L27/36 , C12N5/077 , A61K47/48 , C12N5/079 , A61L27/38 , A61K9/00 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
-
6.发明申请METHOD FOR PRODUCING REGENERATIVE ORGAN PRIMORDIUM PROVIDED WITH GUIDE FOR TRANSPLANTATION, COMPOSITION CONTAINING REGENERATIVE ORGAN PRIMORDIUM PROVIDED WITH GUIDE FOR TRANSPLANTATION PRODUCED THEREBY, AND METHOD FOR TRNSPLANTING REGENERATIVE ORGAN PRIMORDIUM PROVIDED WITH GUIDE FOR TRANSPLANTATION 有权用于生产提供用于移植指南的再生原液的方法，含有生产的转运指南的含有再生原料的组合物的方法，以及用于转运提供的再生原料原料的方法公开(公告)号：US20140037592A1
公开(公告)日：2014-02-06
申请号：US13983701
申请日：2011-07-07
申请人： Koh-ei Toyoshima , Takashi Tsuji
发明人： Koh-ei Toyoshima , Takashi Tsuji
IPC分类号： C12N5/071
CPC分类号： C12N5/0697 , A61K35/12 , A61L27/3813 , A61L27/3834 , A61L27/3886 , A61L2430/18 , C12N5/0627 , C12N5/0633 , C12N2502/13 , C12N2502/1376 , C12N2533/54
摘要： A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ.
摘要翻译： 一种用于移植的再生器官胚芽的制备方法包括使用再生器官细菌进行移植，确保移植后接受者的连续性，并促进移植手术。 制备具有移植指南的再生器官细菌的方法包括通过紧密接触基本上由间充质细胞组成的第一细胞块和基本上由上皮细胞组成的第二细胞块来制备再生器官细菌，培养它们 支撑体内的细胞块，将引导件插入再生器官细菌。
-
公开(公告)号：US20070134224A1
公开(公告)日：2007-06-14
申请号：US11451994
申请日：2006-06-12
申请人： Ed Harlow , Roderick Hyde , Edward Jung , Robert Langer , Eric Leuthardt , Lowell Wood
发明人： Ed Harlow , Roderick Hyde , Edward Jung , Robert Langer , Eric Leuthardt , Lowell Wood
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
-
8.发明授权Producing human CD34+CD7+CD5+CD1a− progenitor T cells and method of treatment 有权生产人CD34 + CD7 + CD5 + CD1a祖细胞T细胞和治疗方法公开(公告)号：US09533009B2
公开(公告)日：2017-01-03
申请号：US14284533
申请日：2014-05-22
IPC分类号： C12N15/00 , A01K63/00 , A61K35/17 , C12N5/0783 , C12N5/0789 , G01N33/50 , A61K35/12 , C12N5/0775 , C12N5/077
CPC分类号： C12N5/0647 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N5/0646 , C12N5/0663 , C12N5/0669 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/42 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2502/99 , C12N2506/02 , C12N2506/11 , C12N2506/45 , G01N33/5005
摘要： Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described. The human progenitor T cells have the phenotype CD34+CD7+CD 1a−CD5− or CD34+CD7+CD1a−CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells by coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4). Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.
摘要翻译： 描述了能够成功移植鼠胸腺并分化成成熟的人T和NK细胞的人祖细胞T细胞。 人祖细胞T细胞具有表型CD34 + CD7 + CD 1a-CD5-或CD34 + CD7 + CD1a-CD5 +，并且通过与表达Notch受体的细胞共培养来源于人造血干细胞，胚胎干细胞和诱导的多能干细胞 配体（OP9-DL1或OP9-DL4）。 这样的细胞可用于各种应用，包括免疫重建，免疫缺陷的治疗和用于基因治疗的基因的载体。
-
9.发明授权公开(公告)号：US08993000B2
公开(公告)日：2015-03-31
申请号：US13510535
申请日：2010-11-16
IPC分类号： C12N5/0775 , A61K31/00 , A61K33/14 , A61K33/40 , A61K36/258 , A61K38/17 , C12N5/077 , A61K38/00
CPC分类号： A61K31/00 , A61K33/14 , A61K33/40 , A61K36/258 , A61K38/1709 , C12N5/0654 , C12N5/0664 , C12N2500/05 , C12N2501/00 , C12N2501/415 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , A61K2300/00
摘要： Provided is an efficient method of inducing differentiation of a pulp cell into an odontoblast. Also provided is an agent for inducing differentiation capable of inducing differentiation into an odontoblast efficiently. The method of inducing differentiation of a pulp cell into an odontoblast includes using a substance capable of activating a Wnt signaling pathway. Further, the agent for inducing differentiation includes a substance capable of activating a Wnt signaling pathway. Specifically, the substance capable of activating a Wnt signaling pathway is any one selected from sodium perchlorate, sodium perchlorate, lithium chloride, Norrin, and R-Spondin2.
摘要翻译： 提供了一种诱导牙髓细胞分化为成牙质细胞的有效方法。 还提供了用于诱导能够有效诱导成牙本质细胞分化的药剂。 诱导牙髓细胞分化为成牙质细胞的方法包括使用能够激活Wnt信号通路的物质。 此外，诱导分化的药剂包括能够激活Wnt信号通路的物质。 具体地，能够激活Wnt信号通路的物质是选自高氯酸钠，高氯酸钠，氯化锂，Norrin和R-斯朋素2中的任何一种。
-
公开(公告)号：US20150064146A1
公开(公告)日：2015-03-05
申请号：US14534459
申请日：2014-11-06
申请人： SEARETE LLC
发明人： Ed Harlow , Roderick A. Hyde , Edward K.Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, JR.
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.018 秒)
