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    Production of homogeneous cell line highly permissive to porcine circovirus type 2 (PCV2) infection
    3.
    发明授权
    Production of homogeneous cell line highly permissive to porcine circovirus type 2 (PCV2) infection 有权
    生产对猪圆环病毒2型（PCV2）感染高度许可的均质细胞系

    公开(公告)号：US08518696B2

    公开(公告)日：2013-08-27

    申请号：US12599555

    申请日：2007-05-11

    Applicant: Adeline Hui Ling Lau ,  Jennifer Siew Kee Lau ,  Hwei-Sing Kwang

    Inventor： Adeline Hui Ling Lau ,  Jennifer Siew Kee Lau ,  Hwei-Sing Kwang

    IPC: C12N5/12 ,  C12Q1/68

    CPC classification number: C12N7/00 ,  C12N2750/10052

    Abstract: Continuous cell lines that are highly permissive to infection by porcine circovirus type 2 (“PCV2”) are described. PCV2 is the causal agent of post-weaning multi-systemic wasting syndrome (“PMWS”) in pigs. PMWS has emerged as a major disease that poses a significant threat to the economics of global swine industry. The highly permissive cell lines of this invention provide efficient and reliable sources of PCV2 for use in development of vaccines, therapies and diagnostic agents for PMWS.

    Abstract translation: 描述了对猪圆环病毒2型（“PCV2”）感染高度容许的连续细胞系。 PCV2是猪在断奶后多系统性消耗综合征（“PMWS”）的致病因子。 PMWS已经成为对全球猪业经济造成重大威胁的重大疾病。 本发明的高度允许的细胞系提供用于开发用于PMWS的疫苗，治疗和诊断剂的PCV2的有效和可靠的来源。

    SELF-REPLICATING DNA EXPRESSION SYSTEM AND IMMUNOGEN
    4.
    发明公开
    SELF-REPLICATING DNA EXPRESSION SYSTEM AND IMMUNOGEN 审中-公开

    公开(公告)号：US20240344100A1

    公开(公告)日：2024-10-17

    申请号：US18293736

    申请日：2022-08-04

    Applicant: University of Cape Town

    Inventor： Edward Peter Rybicki ,  Guy Louis Regnard ,  Warren Ralph Josephus De Moor

    IPC: C12P21/00 ,  C12N15/86

    CPC classification number: C12P21/00 ,  C12N15/86 ,  C12N2750/10043 ,  C12N2750/10052

    Abstract: The present invention relates to self-replicating DNA expression vectors comprising elements from Beak and Feather Disease Virus (BFDV), including a BFDV LIR element comprising an origin of replication (Ori), genes encoding a BFDV Rep protein and a heterologous polypeptide of interest under the control of a mammalian promoter, wherein the Rep protein is capable of binding to the Ori to initiate replication of the expression vector. Pharmaceutical compositions and cells comprising the self-replicating vectors are also provided. The self-replicating vectors may be used in methods of inducing an immune response or expressing a polypeptide in a subject, or as an expression system.

    Production of Homogeneous Cell Line Highly Permissive To Porcine Circovirus Type 2 (PCV2) Infection
    6.
    发明申请
    Production of Homogeneous Cell Line Highly Permissive To Porcine Circovirus Type 2 (PCV2) Infection 有权
    生产高度允许猪圆环病毒2型（PCV2）感染的均质细胞系

    公开(公告)号：US20110008871A1

    公开(公告)日：2011-01-13

    申请号：US12599555

    申请日：2007-05-11

    Applicant: Adeline Hui Ling Lau ,  Jennifer Siew Kee Lau ,  Hwei-Sing Kwang

    Inventor： Adeline Hui Ling Lau ,  Jennifer Siew Kee Lau ,  Hwei-Sing Kwang

    IPC: C12N7/00 ,  C12N5/071

    CPC classification number: C12N7/00 ,  C12N2750/10052

    Abstract: Continuous cell lines that are highly permissive to infection by porcine circovirus type 2 (“PCV2”) are described. PCV2 is the causal agent of post-weaning multi-systemic wasting syndrome (“PMWS”) in pigs. PMWS has emerged as a major disease that poses a significant threat to the economics of global swine industry. The highly permissive cell lines of this invention provide efficient and reliable sources of PCV2 for use in development of vaccines, therapies and diagnostic agents for PMWS.

    Abstract translation: 描述了对猪圆环病毒2型（“PCV2”）感染高度容许的连续细胞系。 PCV2是猪在断奶后多系统性消耗综合征（“PMWS”）的致病因子。 PMWS已经成为对全球猪业经济造成重大威胁的重大疾病。 本发明的高度允许的细胞系提供用于开发用于PMWS的疫苗，治疗和诊断剂的PCV2的有效和可靠的来源。

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