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公开(公告)号：US09896702B2
公开(公告)日：2018-02-20
申请号：US14740554
申请日：2015-06-16
IPC分类号： C12P7/62 , C12P13/00 , C12P7/42 , C12N9/18 , C12P7/44 , C12P7/18 , C12P11/00 , C12N9/16 , C12N9/10 , C12N9/02 , C07C69/533 , C12P7/24 , C12P7/40 , C12P17/10
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
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公开(公告)号：US09777302B2
公开(公告)日：2017-10-03
申请号：US14741259
申请日：2015-06-16
IPC分类号： C07C47/02 , C12P13/00 , C12P7/64 , C12N9/10 , C12N9/02 , C12P7/24 , C07C59/01 , C08G63/06 , C12P7/40 , C12P7/42 , C07C47/12 , C07C59/325 , C07C223/02 , C12P7/44 , C12P7/62
CPC分类号： C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
摘要： This document describes biochemical pathways for producing 5-hydroxypentanoate methyl ester and pentanoic acid pentyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 5-hydroxypentanoate methyl esters and pentanoic acid pentyl esters can be enzymatically converted to glutaric acid, 5-aminopentanoate, 5-hydroxypentanoate, cadaverine, or 1,5-pentanediol.
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3.发明申请公开(公告)号：US20190078103A1
公开(公告)日：2019-03-14
申请号：US16199704
申请日：2018-11-26
IPC分类号： C12N15/81 , C12N9/16 , C12N9/80 , C12P7/18 , C12P13/00 , C12N15/52 , C12P17/10 , C12P7/42 , C12N9/02 , C12N9/10 , C12N9/86 , C12P7/44
CPC分类号： C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
摘要： This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
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公开(公告)号：US20180002729A1
公开(公告)日：2018-01-04
申请号：US15642269
申请日：2017-07-05
IPC分类号： C12P13/00 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/02 , C12P7/64 , C12P7/62 , C12P7/44 , C07C47/02 , C12P7/40 , C12P7/24 , C12N9/10 , C12P7/42
CPC分类号： C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
摘要： This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
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公开(公告)号：US20150361463A1
公开(公告)日：2015-12-17
申请号：US14740749
申请日：2015-06-16
IPC分类号： C12P13/00 , C12P7/40 , C12P7/24 , C07C69/533 , C12N9/16 , C12N9/10 , C12N9/02 , C12N9/18 , C12P7/44 , C12P11/00
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.
摘要翻译： 该文献描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，辅酶A转移酶和辅酶A连接酶从前体如2-氧戊二酸生产2,3-脱氢阿迪普基-CoA甲酯的生化途径，以及 表达一种或多种此类酶的重组宿主。 可以使用反式-2-烯酰辅酶A还原酶将2,3-脱氢脱苄基-CoA甲酯酶促转化为己二酰CoA，甲酯酶又可以酶促转化为己二酸，6-氨基己酸6-羟基己酸酯 ，己内酰胺，六亚甲基二胺或1,6-己二醇。
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6.发明授权Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage 有权通过与碳储存相关的CoA依赖性碳链延长生产6碳化学品的方法公开(公告)号：US09102960B2
公开(公告)日：2015-08-11
申请号：US14106124
申请日：2013-12-13
CPC分类号： C12N15/81 , C12N9/0008 , C12N9/0077 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/80 , C12N9/86 , C12N15/52 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/01002 , C12Y102/99006 , C12Y114/15001 , C12Y203/01032 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/02 , C12Y305/01062
摘要： This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes or analogs enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.
摘要翻译： 该文献描述了通过在C6脂肪族骨架中形成由羧基，胺或羟基组成的两个末端官能团来生产己二酸，己内酰胺，6-氨基己酸，6-羟基己酸，六亚甲基二胺或1,6-己二醇的生化途径 基质。 本文描述的这些途径，代谢工程和培养策略依赖于CoA依赖性延伸酶或与聚羟基链烷酸酯累积细菌的碳储存途径相关的类似物酶。
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公开(公告)号：US20230357807A1
公开(公告)日：2023-11-09
申请号：US18006728
申请日：2021-06-25
发明人： Christof Niemeyer , Kersten Rabe , Maximilian Groesche , Patrick Bitterwolf , Laurenz Walkowsky
CPC分类号： C12P13/008 , C12N9/0006 , C12N9/0028 , C12N9/1096 , C12N9/88 , C12N11/14 , C12N11/18 , C12P7/22 , C12Y101/01001 , C12Y101/01047 , C12Y105/01 , C12Y206/01029 , C12Y401/01
摘要： Catalytically active protein foams and methods for producing same by coupling catalytically active fusion proteins with connectors, and the use of catalytically active protein foams in biocatalysis and microfluidics.
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公开(公告)号：US09988654B2
公开(公告)日：2018-06-05
申请号：US14740749
申请日：2015-06-16
IPC分类号： C12P7/62 , C12P7/44 , C12P13/00 , C12P7/42 , C12P7/18 , C12P11/00 , C12N9/16 , C12N9/10 , C12N9/02 , C12N9/18 , C07C69/533 , C12P7/24 , C12P7/40 , C12P17/10
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.
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公开(公告)号：US20150361467A1
公开(公告)日：2015-12-17
申请号：US14741259
申请日：2015-06-16
IPC分类号： C12P13/00 , C12N9/10 , C12P7/24 , C07C47/02 , C07C59/01 , C07C59/325 , C07C223/02 , C07C47/12 , C12P7/42 , C12N9/02
CPC分类号： C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
摘要： This document describes biochemical pathways for producing 5-hydroxypentanoate methyl ester and pentanoic acid pentyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 5-hydroxypentanoate methyl esters and pentanoic acid pentyl esters can be enzymatically converted to glutaric acid, 5-aminopentanoate, 5-hydroxypentanoate, cadaverine, or 1,5-pentanediol.
摘要翻译： 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，醇O-乙酰转移酶和单加氧酶来生产5-羟基戊酸甲酯和戊酸戊酯的生物化学途径，以及表达一种或多种这样的一种或多种 外源酶。 5-羟基戊酸甲酯和戊酸戊酯可以酶促转化成戊二酸，5-氨基戊酸，5-羟基戊酸，尸胺或1,5-戊二醇。
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公开(公告)号：US20150361458A1
公开(公告)日：2015-12-17
申请号：US14740554
申请日：2015-06-16
IPC分类号： C12P7/62 , C12P13/00 , C12P7/42 , C12N9/18 , C12P11/00 , C12N9/16 , C12N9/10 , C12N9/02 , C12P7/44 , C12P7/18
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
摘要翻译： 本文件描述了使用一种或多种脂肪酸O-甲基转移酶，硫酯酶，硫酸酯酶等从前体例如2-氧代 - 戊二酸，乙酰辅酶A或琥珀酰-CoA制备2（E） - 庚二酰辅酶A甲酯的生化途径， CoA转移酶，CoA连接酶，以及表达一种或多种这样的酶的重组宿主。 2（E） - 庚二酰辅酶A甲酯可以使用反式-2-烯酰辅酶A还原酶和甲酯酶酶转化为双甲酰基-CoA。 可将Pimeloyl-CoA酶促转化成庚二酸，7-氨基庚酸酯，7-羟基庚酸酯，七亚甲基二胺或1,7-庚二醇。
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