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1.发明授权公开(公告)号：US10196657B2
公开(公告)日：2019-02-05
申请号：US14139072
申请日：2013-12-23
IPC分类号： C12P13/00 , C12P7/18 , C12N1/20 , C12N15/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/88 , C07H21/04 , C12P7/44 , C12P7/42 , C12N15/52
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded dicarboxylic acid substrates.
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2.发明授权公开(公告)号：US09920336B2
公开(公告)日：2018-03-20
申请号：US14139142
申请日：2013-12-23
IPC分类号： C12P37/02 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/16 , C12N9/10 , C12N15/00 , C07H21/04 , C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/00
CPC分类号： C12P7/46 , C12P7/18 , C12P7/42 , C12P7/44 , C12P13/001 , C12P13/005
摘要： This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.
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公开(公告)号：US09896702B2
公开(公告)日：2018-02-20
申请号：US14740554
申请日：2015-06-16
IPC分类号： C12P7/62 , C12P13/00 , C12P7/42 , C12N9/18 , C12P7/44 , C12P7/18 , C12P11/00 , C12N9/16 , C12N9/10 , C12N9/02 , C07C69/533 , C12P7/24 , C12P7/40 , C12P17/10
CPC分类号： C12P7/62 , C07C69/533 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/16 , C12N9/18 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P11/00 , C12P13/001 , C12P13/005 , C12P17/10 , C12Y102/99006 , C12Y203/01016 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082 , C12Y301/01085 , C12Y301/02
摘要： This document describes biochemical pathways for producing 2(E)-heptenedioyl-CoA methyl ester from precursors such as 2-oxo-glutarate, acetyl-CoA, or succinyl-CoA using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase, a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2(E)-heptenedioyl-CoA methyl ester can be enzymatically converted to pimeloyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
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公开(公告)号：US09777302B2
公开(公告)日：2017-10-03
申请号：US14741259
申请日：2015-06-16
IPC分类号： C07C47/02 , C12P13/00 , C12P7/64 , C12N9/10 , C12N9/02 , C12P7/24 , C07C59/01 , C08G63/06 , C12P7/40 , C12P7/42 , C07C47/12 , C07C59/325 , C07C223/02 , C12P7/44 , C12P7/62
CPC分类号： C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
摘要： This document describes biochemical pathways for producing 5-hydroxypentanoate methyl ester and pentanoic acid pentyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 5-hydroxypentanoate methyl esters and pentanoic acid pentyl esters can be enzymatically converted to glutaric acid, 5-aminopentanoate, 5-hydroxypentanoate, cadaverine, or 1,5-pentanediol.
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公开(公告)号：US20150361460A1
公开(公告)日：2015-12-17
申请号：US14741414
申请日：2015-06-16
CPC分类号： C12P7/62 , C07C69/42 , C07C229/08 , C12N9/0008 , C12N9/1007 , C12N9/1096 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/42 , C12P7/44 , C12P13/001 , C12Y102/99006 , C12Y201/01197 , C12Y206/01018 , C12Y206/01038 , C12Y301/01085
摘要： This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or hydroxyl group, in a C5 backbone substrate such as glutaryl-CoA, glutaryl-[acp] or glutarate methyl ester. 2,4-pentadienoyl-CoA can be enzymatically converted to 1,3-butadiene.
摘要翻译： 本文件描述了通过在C5主链基质如戊二酰辅酶A，戊二酰 - [acp]或戊二酸甲酯中形成一个或两个由羧基或羟基组成的末端官能团来生产2,4-戊二烯酰辅酶A的生化途径 。 2,4-戊二烯酰辅酶A可以酶促转化为1,3-丁二烯。
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公开(公告)号：US20150361459A1
公开(公告)日：2015-12-17
申请号：US14741392
申请日：2015-06-16
CPC分类号： C12P7/62 , C07C69/42 , C07C229/08 , C12N9/0008 , C12N9/1007 , C12N9/1096 , C12N9/16 , C12N9/18 , C12N15/52 , C12P7/42 , C12P7/44 , C12P13/001 , C12Y102/99006 , C12Y201/01197 , C12Y206/01018 , C12Y206/01038 , C12Y301/01085
摘要： This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as malonyl-CoA or malonyl-[acp].
摘要翻译： 本文件描述了通过在C5主链基质中形成一个或两个由羧基，胺或羟基组成的末端官能团来生产戊二酸，5-氨基戊酸，5-羟基戊酸，尸胺或1,5-戊二醇的生化途径 例如丙二酰辅酶A或丙二酰 - [acp]。
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公开(公告)号：US09957535B2
公开(公告)日：2018-05-01
申请号：US14741342
申请日：2015-06-16
IPC分类号： C12P13/00 , C12P7/44 , C12P7/42 , C12P7/18 , C12N9/02 , C12N9/10 , C08G69/26 , C12P7/62 , C12P7/40 , C12N15/52 , C12P13/04 , C12N9/00
CPC分类号： C12P13/001 , C08G69/26 , C12N9/00 , C12N9/0008 , C12N9/1096 , C12N15/52 , C12P7/18 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P13/04 , C12Y102/99006 , C12Y206/01018
摘要： This document describes biochemical pathways for producing glutaric acid, 5-aminopentanoic acid, 5-hydroxypentanoic acid, cadaverine or 1,5-pentanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate.
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公开(公告)号：US09862973B2
公开(公告)日：2018-01-09
申请号：US14452201
申请日：2014-08-05
CPC分类号： C12P5/007 , C12N9/1029 , C12N9/1205 , C12N9/88 , C12N15/52 , C12N15/70 , C12P5/026 , C12Y203/01041 , Y02E50/343
摘要： This document describes biochemical pathways for producing isoprene by forming two vinyl groups in a central precursor produced from isobutyryl-CoA, 3-methyl-2-oxopentanoate, or 4-methyl-2-oxopentanoate as well as recombinant hosts for producing isoprene.
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公开(公告)号：US09816117B2
公开(公告)日：2017-11-14
申请号：US14741228
申请日：2015-06-16
IPC分类号： C12P13/00 , C12P7/64 , C12N9/10 , C12N9/02 , C12P7/24 , C07C59/01 , C08G63/06 , C12P7/40 , C12P7/42 , C07C47/02 , C07C47/12 , C07C59/325 , C07C223/02 , C12P7/44 , C12P7/62
CPC分类号： C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
摘要： This document describes biochemical pathways for producing 6-hydroxyhexanoate methyl ester and hexanoic acid hexyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase and a monooxygenase, as well as recombinant hosts expressing one or more of such enzymes. 6-hydroxyhexanoate methyl esters and hexanoic acid hexyl ester can be enzymatically converted to adipic acid, adipate semialdehyde, 6-aminohexanoate, 6-hydroxyhexanoate, hexamethylenediamine, and 1,6-hexanediol.
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公开(公告)号：US09738914B2
公开(公告)日：2017-08-22
申请号：US14741194
申请日：2015-06-16
IPC分类号： C12P13/00 , C12P7/64 , C12N9/10 , C12N9/02 , C12P7/24 , C07C59/01 , C08G63/06 , C12P7/40 , C12P7/42 , C07C47/02 , C07C47/12 , C07C59/325 , C07C223/02 , C12P7/44 , C12P7/62
CPC分类号： C12P13/001 , C07C47/02 , C07C47/12 , C07C59/01 , C07C59/325 , C07C223/02 , C08G63/06 , C12N9/0008 , C12N9/0077 , C12N9/1007 , C12N9/1096 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/62 , C12P7/6409 , C12P7/6436 , C12Y102/99006 , C12Y114/15001 , C12Y114/15003 , C12Y206/01018 , C12Y206/01019 , C12Y206/01029 , C12Y206/01048 , C12Y206/01082
摘要： This document describes biochemical pathways for producing 7-hydroxyheptanoate methyl ester and heptanoic acid heptyl ester using one or more of a fatty acid O-methyltransferase, an alcohol O-acetyltransferase, and a monooxygenase, as well as recombinant hosts expressing one or more of such exogenous enzymes. 7-hydroxyheptanoate methyl esters and heptanoic acid heptyl esters can be enzymatically converted to pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol.
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