公开(公告)号：US5288646A

公开(公告)日：1994-02-22

申请号：US720531

申请日：1991-06-21

Applicant: Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

Inventor： Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

IPC: G01N33/49 ,  G01N21/03 ,  G01N21/11 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76 ,  G01N21/77 ,  G01N21/80 ,  G01N21/84 ,  G01N33/48 ,  G01N33/497 ,  G01N33/84 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N21/03 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N21/05 ,  G01N21/80 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: A sampling device for photometric determination of the content of an analyte in a sample of whole blood has at least one measuring chamber having locally transparent wall parts, at least one wall part being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber, with a transparent body having a radiation transmission characteristic dependent upon the concentration of a predetermined analyte in the whole blood sample disposed between the wall parts. The sampling device is employed in an analyzer for photometric determination of the content of analyte in a sample of whole blood and in a method of photometric in vitro determination of the content of an analyte in a sample of whole blood. In the method, a sample of whole blood is transferred directly from an in vivo locality to the sampling device, the measuring chamber therein is deformed in a controlled manner to substantially drain the whole blood from the measuring chamber, radiation is transmitted through the substantially drained measuring chamber, detected, and the analyte content determined. A measuring chamber for photometric determination of an analyte in a sample of whole blood has locally transparent wall parts, at least one being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber, and a transparent body disposed between the wall parts. The measuring chamber is employed in an analyzer and in a method for the photometric determination of an analyte in a sample of whole blood.

Abstract translation: PCT No.PCT / DK89 / 00301 Sec。 371日期1991年6月21日 102（e）1991年6月21日PCT 1989年12月21日PCT PCT。 公开号WO90 / 07109 日本1990年6月28日。用于光度测定全血样品中分析物含量的采样装置具有至少一个具有局部透明壁部分的测量室，至少一个壁部分可充分变形， 来自测量室的全血样本，具有取决于设置在壁部之间的全血样品中的预定分析物的浓度的透射特性的透明体。 采样装置用于测量全血样品中分析物含量的光度测定仪和全血样品中分析物含量的光度测定方法。 在该方法中，将全血样品直接从体内局部转移到采样装置，其中的测量室以受控的方式变形，从而从测量室基本上排出全部血液，辐射通过基本排出的 测量室，检测，并确定分析物含​​量。 用于光度测定全血样品中的分析物的测量室具有局部透明的壁部分，至少一个可充分变形以促进全血样品从测量室排出，以及设置在壁部之间的透明体。 测量室用于分析仪和全血样品中的分析物的光度测定方法。

公开(公告)号：US5116122A

公开(公告)日：1992-05-26

申请号：US669467

申请日：1991-03-14

Applicant: Toshiaki Fukuma

Inventor： Toshiaki Fukuma

IPC: G01N21/25

CPC classification number: G01N21/253 ,  G01N2201/0476

Abstract: A spectrophotometer provided with: a sample changer for holding a plurality of samples to be analyzed, each of which is given an identification code, and positioning a selected one of the samples for measurement; means for setting a measuring wavelength for each of the identification codes of the samples; means for setting an identification code for the measured data of each of the samples; means for setting a coefficient to be used for processing the measured data of each of the samples together with an identification code; means for setting an operation expression composed of the identification codes of the measured data of the samples and the identification code of the coefficient; means for storing the data obtained by measuring each of the samples with the corresponding one of the wavelengths set for the sample held by the sample changer in correspondence with the corresponding one of the identification codes of the measured data; and means for reading out the data stored in the storing means and the coefficient set in the setting means in accordance with the identification codes of the measured data and the coefficient which constitute the operation expression set in the setting means, and performing an operation for data processing in accordance with the operation expression.

Abstract translation: 一种分光光度计，其具有：用于保持多个要分析的样品的样品更换器，每个样品被赋予识别码，并且将所选择的一个样品定位以进行测量; 用于为样本的每个识别代码设置测量波长的装置; 用于设置每个样本的测量数据的识别码的装置; 用于设置用于处理每个样本的测量数据的系数与识别码一起的装置; 用于设置由样本的测量数据的识别码和系数的识别码组成的运算表达的装置; 用于存储通过对应于测量数据的相应的一个识别代码来测量每个采样所获取的数据的装置，所述数据与由样本更换器保存的样本设置的对应的一个波长相对应; 以及用于根据测量数据的识别码和构成在设定装置中设置的操作表达式的系数读出存储在存储装置中的数据和设置装置中设置的系数的装置，并且执行数据操作 按照操作表达进行处理。

公开(公告)号：US5525518A

公开(公告)日：1996-06-11

申请号：US720530

申请日：1991-06-21

Applicant: Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

Inventor： Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

IPC: G01N33/49 ,  G01N21/03 ,  G01N21/11 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76 ,  G01N21/77 ,  G01N21/80 ,  G01N21/84 ,  G01N33/48 ,  G01N33/497 ,  G01N33/84 ,  G01N35/00 ,  G01N35/10 ,  G01N33/50

CPC classification number: G01N21/03 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N21/05 ,  G01N21/80 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: A method of photometric in vitro determination of at least one blood gas parameter in a sample of whole blood. The whole blood sample is obtained by connecting an at least partially transparent sample container to an in vivo locality and transferring whole blood into the sample container, then breaking the connection. The sample container is arranged in an optical system which has a radiation source and a means for detecting radiation to locate the sample container between the radiation source and the radiation detection means. Radiation is transmitted to the sample from the radiation source and radiation emitted from the sample is transmitted to the radiation detection means. The detected radiation is used to determine the blood gas parameter of the sample. A system for use in this method has a radiation source, a radiation detection means, an at least partially transparent sample container, and a sample container station.

Abstract translation: PCT No.PCT / DK89 / 00302 Sec。 371日期1991年6月21日 102（e）1991年6月21日PCT 1989年12月21日PCT PCT。 公开号WO90 / 07106 日期：1990年6月28日。全血样品中至少一种血气参数的光度测定方法。 通过将至少部分透明的样品容器连接到体内局部并将全血转移到样品容器中，然后断开连接而获得全血样品。 样品容器布置在具有辐射源的光学系统和用于检测辐射的装置以将样品容器定位在辐射源和辐射检测装置之间的光学系统中。 辐射从辐射源发射到样品，并且从样品发射的辐射被传输到辐射检测装置。 检测到的辐射用于确定样品的血气参数。 用于该方法的系统具有辐射源，辐射检测装置，至少部分透明的样品容器和样品容器台。

公开(公告)号：US5366903A

公开(公告)日：1994-11-22

申请号：US199858

申请日：1994-02-22

Applicant: Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

Inventor： Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

IPC: G01N33/49 ,  G01N21/03 ,  G01N21/11 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/64 ,  G01N21/76 ,  G01N21/77 ,  G01N21/80 ,  G01N21/84 ,  G01N33/48 ,  G01N33/497 ,  G01N33/84 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N21/03 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/78 ,  G01N33/4925 ,  G01N33/497 ,  G01N2021/0346 ,  G01N2021/036 ,  G01N2021/0364 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6417 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N21/05 ,  G01N21/80 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288

Abstract: A sampling device for photometric determination of the content of an analyte in a sample of whole blood has at least one measuring chamber having two wall parts, at least one wall part being locally transparent, at least one wall part being sufficiently deformable to facilitate displacement of the whole blood sample from the measuring chamber. The measuring chamber also contains a transparent body having a radiation transmission characteristic dependent upon the concentration of a predetermined analyte in the whole blood sample. The sample device is employed in an analyzer for photometric determination of the content of an analyte in a sample of whole blood and in a method of photometric in vitro determination of the content of an analyte in a sample of whole blood. In the method, a sample of whole blood is transferred directly from an in vivo locality to the sampling device, the measuring chamber therein is deformed in a controlled manner to substantially drain the whole blood from the measuring chamber, radiation is transmitted through the substantially drained measuring chamber, detected, and the analyte content determined.

Abstract translation: 用于对全血样品中的分析物的含量进行光度测定的取样装置具有至少一个具有两个壁部分的测量室，至少一个壁部分局部透明，至少一个壁部分具有足够的可变形性， 来自测量室的全血样品。 测量室还包含具有取决于全血样品中预定分析物浓度的辐射透射特性的透明体。 样品装置用于用于光度测定全血样品中的分析物的含量的分析仪中，以及全血样品中分析物的含量的光度测定方法。 在该方法中，将全血样品直接从体内局部转移到采样装置，其中的测量室以受控的方式变形，从而从测量室基本上排出全部血液，辐射通过基本排出的 测量室，检测，并确定分析物含​​量。

公开(公告)号：US5564419A

公开(公告)日：1996-10-15

申请号：US269950

申请日：1994-06-30

Applicant: Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

Inventor： Finn C. Lundsgaard ,  Niels-Henrik Jensen ,  Willy Andersen

IPC: G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/64 ,  G01N21/80 ,  G01N21/84 ,  G01N33/49 ,  G01N33/497 ,  G01N35/00 ,  G01N35/10 ,  A61B5/00

CPC classification number: G01N33/4925 ,  G01N21/251 ,  G01N21/255 ,  G01N21/276 ,  G01N21/6428 ,  G01N33/497 ,  G01N2021/036 ,  G01N2021/3148 ,  G01N2021/3166 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/8405 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/1062 ,  G01N21/80 ,  G01N2201/0407 ,  G01N2201/0476 ,  G01N2201/0618 ,  G01N2201/1288 ,  Y10T436/207497

Abstract: In a method of photometric in vitro determination of the content of oxygen in a blood sample, a blood sample is transferred directly from an in vivo locality to an at least partially transparent sample container of a sampling device. The sample container has a measuring chamber containing a luminophor, the luminescence of which is quenched in the presence of oxygen. The luminophor is excited by irradiation with radiation from a radiation source. The luminescence emitted by the excited luminophor is detected by a radiation detector and the oxygen content determined on the basis of the radiation detected by the radiation detector. A sampling device and a system for photometric in vitro determination of oxygen in a blood sample are also described.

Abstract translation: 在光度测定血液样品中的氧含量的方法中，将血液样品直接从体内局部转移到采样装置的至少部分透明的样品容器中。 样品容器具有含有发光体的测量室，其发光在氧气存在下淬火。 发光体被来自辐射源的辐射照射而激发。 由激发的发光体发射的发光由辐射检测器检测，并且基于由辐射检测器检测的辐射确定的氧含量。 还描述了用于血液样品中的氧的体外测定的取样装置和系统。

公开(公告)号：US4936682A

公开(公告)日：1990-06-26

申请号：US084098

申请日：1987-08-11

Applicant: Joshua K. Hoyt

Inventor： Joshua K. Hoyt

IPC: G01N35/02 ,  G01N21/25 ,  G01N21/27

CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0476

Abstract: An analytic instrument for kinetically measuring light absorption characteristics of a plurality of independent samples contained in disposable test tubes arranged in a circular pattern about a single light source. The instrument is designed to be used with a host personal computer and is not specific to any particular type of assay. The instrument obtains and temporarily stores raw data in the form of digitized output signals from the plurality of photodetectors and periodically passes them to the host computer. An incubator has test tube wells arranged in a circular array equidistant from a single incandescent light source. The circular symmetry controls the thermal gradients in the incubator such that all of the samples are disposed on the same isotherm and all of the photodetectors are disposed on the same isotherm. The instrument is designed for use with disposable test tubes, and sources of error arising from optical variation in such test tubes are minimized by providing a separate detector for each tube and by holding the tube fixed with respect to the detector. The light output from the single light source is continuously monitored and is kept constant.