利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.01 秒)

    Biologically relevant methods for the rapid determination of sterility
    5.
    发明授权
    Biologically relevant methods for the rapid determination of sterility 失效
    用于快速测定不育的生物相关方法

    公开(公告)号：US5486459A

    公开(公告)日：1996-01-23

    申请号：US380195

    申请日：1995-01-30

    申请人： Jeffrey C. Burnham ,  George J. Hageage ,  Douglas Jambard-Sweet ,  Judy Hendricks

    发明人： Jeffrey C. Burnham ,  George J. Hageage ,  Douglas Jambard-Sweet ,  Judy Hendricks

    IPC分类号： C12M1/12 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/22 ,  G01N21/00

    CPC分类号： C12Q1/22 ,  Y10S435/81 ,  Y10S435/832 ,  Y10S435/842 ,  Y10S435/92

    摘要： The invention is directed to biological processes and apparatus for determining the efficacy of a sterilization cycle based upon the recovery of activity of interactive enzyme systems comprising enzymes, coenzymes, catalysts, cofactors, substrates or any other necessary reagents. The invention provides a vital process for expediting sterility verification before utilization of the articles thought to be sterilized. The invention involves the rapid detection of any surviving interactive enzymatic activity which directly relates to the probability of any biological spores surviving in a test sample. An absence of a change indicates that the sterilization process had inactivated the enzyme system thereby preventing the interactive reaction from taking place which is a rapid equivalent to directly detecting the survivability of bacterial spores in a similar test. The methods and apparatus of the invention are useful in the health care industry such as in hospitals, laboratories, and research institutions, in food and environmental technology, and in all technologies which utilize sterilization in manufacturing, production or waste disposal.

    摘要翻译： 本发明涉及用于基于包含酶，辅酶，催化剂，辅因子，底物或任何其它必需试剂的相互作用的酶系统的活性的恢复来确定灭菌循环的功效的生物过程和装置。 本发明提供了在使用被认为消毒的物品之前加速无菌验证的重要过程。 本发明涉及快速检测任何存活的互动酶活性，其直接涉及在测试样品中存活的任何生物孢子的概率。 没有变化表明灭菌过程已经使酶系统失活，从而防止相互作用反应的发生，其在类似试验中快速等同于直接检测细菌孢子的生存性。 本发明的方法和装置在医疗保健行业如医院，实验室和研究机构，食品和环境技术以及在制造，生产或废物处理中利用灭菌的所有技术中都是有用的。

    2-halo-4-(1-piperazinyl)-benzaldehydes and related compounds
    8.
    发明授权
    2-halo-4-(1-piperazinyl)-benzaldehydes and related compounds 失效
    2-羟基-4-（1-哌嗪基） - 苯并恶唑及其相关化合物

    公开(公告)号：US3558629A

    公开(公告)日：1971-01-26

    申请号：US3558629D

    申请日：1967-08-31

    申请人： STERLING DRUG INC

    发明人： ARCHER SYDNEY ,  ROSI DAVID

    IPC分类号： C07D295/096 ,  C12P17/12 ,  C07D51/70

    CPC分类号： C07D295/096 ,  C12P17/12 ,  Y10S435/897 ,  Y10S435/911 ,  Y10S435/913 ,  Y10S435/917 ,  Y10S435/92 ,  Y10S435/933

    摘要： 4 - (AMINO-(POLYCARBON-LOWER-ALKYL)-AMINO) - 2-HALOBENZYL ALCOHOLS AND LOWER-ALKYL ETHERS THEREOF HAVE SCHISTOSOMOACIDAL ACTIVITY. THE BENZYL ALCOHOLS ARE PREPARED: BY REDUCTION OF THE CORRESPONDING BENZALDEHYDES OR LOWER ALKYL BENZOATES; BY MICROBIOLOGICAL OXIDATION OF THE CORRESPONDING 4-SUBSTITUED-AMINO-2-HALOTOLUENES; OR, FOR THE COMPOUNDS WHERE POLYCARBON-LOWER-ALKYL IS ETHYLENE, BY REDUCING THE CORRESPONDING LOWER-ALKYL 4 - (AMINOACETYLAMINO)-2-HALOBENZOATES OR BY REDUCING THE CORRESPONDING 4 - (AMINOACETYLAMINO)-2-HALOBENZYL ALCOHOLS. THE ETHERS ARE PREPARED BY HEATING THE BENZYL ALCOHOLS WITH A LOWER-ALKANOL IN THE PRESENCE OF AN ACID. NOVEL INTERMEDIATE 2-HALO-4-(1-PIPERAZINYL)-BENZALDEHYDES ARE PREPARED BY FORMYLATION OF 3 - (1-PIPERAZINYL)-HALOBENZENES WITH AN N,N-DISTRIBUTED-FORMAMIDE, E.G., DIMETHYLFORMAMIDE, IN THE PRESENCE OF A PHOSPHORUS OXYHALIDE.