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    Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f[quinoline complexes of cobalt and chromium
    1.
    发明申请
    Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f[quinoline complexes of cobalt and chromium 失效
    抗癌2,3-二氢-1H-吡咯并[3,2-f]喹啉配合物的钴和铬

    公开(公告)号：US20040138195A1

    公开(公告)日：2004-07-15

    申请号：US10470155

    申请日：2004-01-29

    Inventor： William Alexander Denny ,  William Robert Wilson ,  David Charles Ware ,  Graham John Atwell ,  Jared Bruce Milbank ,  Ralph James Stevenson

    IPC: A61K031/555 ,  C07F015/06 ,  C07F011/00

    CPC classification number: C07D471/04 ,  C07D257/00 ,  C07F11/005 ,  C07F15/065

    Abstract: This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.

    Abstract translation: 本发明涉及一类杂环及其金属络合物，特别涉及这些化合物在制备前体药物中的用途，或作为可在缺氧条件下通过酶或通过治疗电离辐射活化的前药，用于治疗 癌症。 本发明还涉及这些杂环和相应的金属络合物在制备药物中的用途以及包括杂环或其金属络合物的组合物以及制备这些化合物的方法。

    Nirtic oxide donors based on metallic centres
    2.
    发明申请
    Nirtic oxide donors based on metallic centres 失效
    基于金属中心的氧化氮供体

    公开(公告)号：US20040029854A1

    公开(公告)日：2004-02-12

    申请号：US10399408

    申请日：2003-04-23

    Inventor： Luigi Casella ,  Marina Ziche

    IPC: A61K031/555 ,  C07F003/08 ,  C07F015/06

    CPC classification number: C07D213/53 ,  A61K47/52 ,  C07D213/70 ,  C07D295/30 ,  C07F1/005

    Abstract: The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate re-endothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.

    Abstract translation: 本发明涉及配位体配合物，其特征在于存在具有金属阳离子的哌嗪壬酸酯残基，其中阳离子源自稳定氧化态的过渡金属或锌。 这些复合物是一氧化氮供体，并对冠状动脉区域发挥内皮保护作用，并刺激内皮再生和血管生成过程。 本发明包括所述化合物的制备方法和治疗用途。

    Catalyst composition II
    5.
    发明申请
    Catalyst composition II 失效
    催化剂组合物II

    公开(公告)号：US20040266961A1

    公开(公告)日：2004-12-30

    申请号：US10855585

    申请日：2004-05-27

    Inventor： Gregory Adam Solan ,  Christopher James Davies

    IPC: C08F004/44 ,  B01J031/00 ,  C07F015/02 ,  C07F015/06

    CPC classification number: C07C2/32 ,  B01J31/143 ,  B01J31/146 ,  B01J31/1805 ,  B01J31/1815 ,  B01J2231/122 ,  B01J2231/20 ,  B01J2531/0258 ,  B01J2531/16 ,  B01J2531/72 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C2531/26 ,  C07F13/005 ,  C07F15/025 ,  C07F15/045 ,  C07F15/065 ,  C08F10/00 ,  C08F110/02 ,  C07C11/02 ,  C08F2500/02 ,  C08F4/60089 ,  C08F4/7042 ,  C08F4/50 ,  C08F4/7081

    Abstract: This invention relates to a transition metal catalyst compound represented by the formula: LMX2 or (LMX2)2 wherein each M is independently a Group 7 to 11 metal, preferably a Group 7, 8, 9, or 10 metal; each L is, independently, a tridentate or tetradentate neutrally charged ligand that is bonded to M by three or four nitrogen atoms, (where at least one of the nitrogen atoms is a central nitrogen atom and at least two of the nitrogen atoms are terminal nitrogen atoms), and at least two terminal nitrogen atoms are substituted with one C3-C50 hydrocarbyl and one hydrogen atom or two hydrocarbyls wherein at least one hydrocarbyl is a C3-C50 hydrocarbyl, and the central nitrogen atom is bonded to three different carbon atoms or two different carbon atoms and one hydrogen atom; X is independently a monoanionic ligand, or two X may join together to form a bidentate dianionic ligand.

    Abstract translation: 本发明涉及由下式表示的过渡金属催化剂化合物：LMX2或（LMX2）2，其中每个M独立地是7-11族金属，优选第7,8,9或10族金属; 每个L独立地是三齿或四齿中性带电的配体，其通过三个或四个氮原子（其中至少一个氮原子是中心氮原子，并且至少两个氮原子是末端氮）键合到M上 原子），并且至少两个末端氮原子被一个C 3 -C 50烃基和一个氢原子或两个烃基取代，其中至少一个烃基是C 3 -C 50烃基，并且中心氮原子键合到三个不同的碳原子或 两个不同的碳原子和一个氢原子; X独立地是单阴离子配体，或两个X可以连接在一起以形成二齿二离子配体。

    Olefin polymerization catalyst system
    6.
    发明申请
    Olefin polymerization catalyst system 有权
    烯烃聚合催化剂体系

    公开(公告)号：US20040230015A1

    公开(公告)日：2004-11-18

    申请号：US10436741

    申请日：2003-05-13

    Inventor： Paul Veinbergs Hinkle ,  Francis Charles Rix

    IPC: C08F004/72 ,  C07F015/06

    CPC classification number: C07F15/04 ,  C08F10/00 ,  C08F10/02 ,  C08F110/02 ,  C08F210/02 ,  C08F210/16 ,  C08F232/08 ,  C08F2500/03 ,  C08F2500/09 ,  C08F2500/10 ,  C08F4/80 ,  C08F232/00 ,  C08F216/04 ,  C08F210/14 ,  C08F2500/05 ,  C08F4/7031 ,  C08F4/7022

    Abstract: This invention relates to a compound represented by the formula: 1 wherein M is selected from groups 3-11 of the periodic table; 2 L1 represents a formal anionic ligand, L2 represents a formal neutral ligand, a is an integer greater than or equal to 1; b is greater than or equal to 0; c is greater than or equal to 1, E is nitrogen or phosphorus, Ar0 is arene, R1-R4 are, each independently, selected from hydrogen, hydrocarbyl, substituted hydrocarbyl or functional group, provided however that R3 and R4 do not form a naphthyl ring, N is nitrogen and O is oxygen. This invention further relates to a process to oligomerize and/or polymerize unsaturated monomers using the above compositions, optionally combined with an activator.

    Abstract translation: 本发明涉及由下式表示的化合物：其中M选自周期表的第3-11组; L 1表示正式的阴离子配体，L 2表示正式的中性配体，a是大于或等于1的整数; b大于或等于0; c大于或等于1，E是氮或磷，Ar 0是芳烃，R 1 -R 4各自独立地选自氢，烃基，取代的烃基或官能团 R 3和R 4不形成萘环，N为氮，O为氧。 本发明还涉及使用上述组合物任选与活化剂组合来使不饱和单体低聚和/或聚合的方法。

    Alkyl cobalt (III) dioximates and process for forming the same
    8.
    发明申请
    Alkyl cobalt (III) dioximates and process for forming the same 失效
    烷基钴（III）二肟酸盐及其形成方法

    公开(公告)号：US20030149275A1

    公开(公告)日：2003-08-07

    申请号：US10371890

    申请日：2003-02-21

    Inventor： Alexei A. Gridnev ,  Gregorii A. Nikiforov

    IPC: C07F015/06

    CPC classification number: C07F15/06

    Abstract: This invention is directed to alkyl cobalt (II) dioximates and methods for making these dioximates. The alkyl cobalt (III) dioximate has the following structural formula: 1 wherein R1, and R2 are individually selected from the following group: H, alkyl having at least 2 carbon atoms, substituted alkyl, aryl, substituted aryl, COOR5, CONR6R7, SR7, SO2R7, SO2NR5R6, SOR5, SO3R5, halogen, CCl3, CF3, COR5, CHO, CR6R7OR5, CH(OR5)(OR6), CR5(OR6)(OR7); where R5, R6, and R7 are independently selected from the following group: H, alkyl, substituted alkyl, aryl or substituted aryl and A is a substituted alkyl derived from an olefinic component and B is a component of a Lewis base and where the substituents of the substituted alkyl are individually selected from the group of ester, ether, amide, halogen, ketone, hydroxy, aryl, SO2-alkyl, sulfamido, and amino groups and the substituents for the substituted aryl are individually selected from the group of ester, ether, amide, halogen, ketone, hydroxy, alkyl, SO2-alkyl, sulfamido, and amino groups.

    Abstract translation: 本发明涉及二肟烷基钴（II）和制备这些二肟酸盐的方法。 二卤代烷基钴（III）具有以下结构式：其中R1和R2分别选自以下基团：H，具有至少2个碳原子的烷基，取代的烷基，芳基，取代的芳基，COOR 5，CONR 6 R 7，SR 7， SO2R7，SO2NR5R6，SOR5，SO3R5，卤素，CCl3，CF3，COR5，CHO，CR6R7OR5，CH（OR5）（OR6），CR5（OR6）（OR7）; 其中R 5，R 6和R 7独立地选自下列基团：H，烷基，取代的烷基，芳基或取代的芳基，A是衍生自烯属成分的取代的烷基，B是路易斯碱的组分， 取代的烷基的取代基分别选自酯，醚，酰胺，卤素，酮，羟基，芳基，SO 2 - 烷基，氨磺酰氨基和氨基，取代芳基的取代基分别选自酯， 醚，酰胺，卤素，酮，羟基，烷基，SO 2 - 烷基，氨磺酰氨基和氨基。

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