公开(公告)号：US20180057518A1

公开(公告)日：2018-03-01

申请号：US15804427

申请日：2017-11-06

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC分类号： C07H15/10 ,  C07H1/00 ,  C12N5/078

摘要： A construct of the structure F—S1-S2 where: F—S1 is an aminoalkylglycoside where F is α-D-galactopyranosyl-(1→4)-B-D-galactopyranosyl-(1→4)-β-D-glucopyranoside and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.

公开(公告)号：US20130280746A1

公开(公告)日：2013-10-24

申请号：US13765314

申请日：2013-02-12

申请人： Kode Biotech Limited

发明人： Cristina-Simona Weinberg ,  Nicolai Bovin ,  Stephen Michael Henry

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  A61K47/543 ,  A61K47/544 ,  C07F9/091 ,  C07F9/572 ,  C07K5/1008 ,  C07K14/47 ,  C07K17/08 ,  C12N5/0006 ,  C12N5/0641 ,  C12N2503/00 ,  G01N33/5304 ,  G01N33/554 ,  G01N33/555 ,  G01N33/6854 ,  G01N33/80 ,  G01N2405/00

摘要： Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glyccrolipid (including glyccrophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells.

摘要翻译： 公开了结构L-S-F的肽 - 脂质构建体，其中F是肽，S是通过乙二醇的低聚物共价连接F与L的间隔基，L是二酰基或二烷基 - glyccrolipid（包括Glycrophospholipids）。 间隔物理想地具有6至14个乙二醇重复，对应于分子量为约250至600的PEG。还公开了通过使血清与修饰以掺入肽 - 脂质构建体的细胞接触来检测血清中的反应性抗体的方法，其中 肽是抗体的表位，并确定细胞的凝集程度。

公开(公告)号：US10082515B2

公开(公告)日：2018-09-25

申请号：US13765314

申请日：2013-02-12

申请人： Kode Biotech Limited

发明人： Cristina-Simona Weinberg ,  Nicolai Bovin ,  Stephen Micheal Henry

IPC分类号： G01N33/92 ,  C07F9/09 ,  C07F9/572 ,  C07K5/103 ,  C07K14/47 ,  C07K17/08 ,  C12N5/00 ,  C12N5/078 ,  G01N33/555 ,  G01N33/68 ,  G01N33/53 ,  G01N33/554 ,  G01N33/80 ,  A61K47/54

CPC分类号： G01N33/92 ,  A61K47/543 ,  A61K47/544 ,  C07F9/091 ,  C07F9/572 ,  C07K5/1008 ,  C07K14/47 ,  C07K17/08 ,  C12N5/0006 ,  C12N5/0641 ,  C12N2503/00 ,  G01N33/5304 ,  G01N33/554 ,  G01N33/555 ,  G01N33/6854 ,  G01N33/80 ,  G01N2405/00

摘要： Method of incorporating a water soluble construct of the structure L-S-F into the lipid bi-layer of cells by contacting a suspension of the cells with a solution of the construct at a concentration and for a time and temperature sufficient to allow the construct to insert into the lipid bi-layer. In the structure L-S-F, F is a peptide, S is a spacer containing an oligomer of ethylene glycol covalently linking F to L and the number of ethylene oxide repeats in the oligomer of ethylene glycol is 6 to 14, and L is a phosphatidylethanolamine.

公开(公告)号：US20140186950A1

公开(公告)日：2014-07-03

申请号：US14108749

申请日：2013-12-17

申请人： Kode Biotech Limited

发明人： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC分类号： C12N5/078

CPC分类号： C07H15/10 ,  A61K2035/124 ,  C07F9/10 ,  C07H1/00 ,  C07H15/04 ,  C12N5/0006 ,  C12N5/0604 ,  C12N5/0641

摘要： Cells incorporating a synthetic molecule construct of the structure F—S1—S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.

摘要翻译： 含有结构F-S1-S2-L的合成分子构建体的细胞其中：F-S1是氨基烷基糖苷，其中F是单，二，三或寡糖，S1是2-氨基乙基，3-氨基丙基 ，4-氨基丁基或5-氨基戊基; S2是-CO（CH 2）2 CO-，-CO（CH 2）3 CO-，-CO（CH 2）4 CO-或-CO（CH 2）5 CO-; L是磷脂酰乙醇胺。

公开(公告)号：US10858384B2

公开(公告)日：2020-12-08

申请号：US16571526

申请日：2019-09-16

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC分类号： C07H15/10 ,  C07H1/00 ,  C07H15/04 ,  C07F9/10 ,  C12N5/078 ,  C12N5/00 ,  C12N5/073 ,  A61K35/12

摘要： Synthetic molecule construct of the structure F-S1-S2-L where F-S1 is an aminoalkylglycoside and S2-L is a dicarboxylated, e.g. adipylated, phosphatidylethanolamide are disclosed. The two terminal sugars of the aminoalkylglycoside (Galα1-3Galβ-) are the two terminal sugars of the Galili antigen.

公开(公告)号：US10414786B2

公开(公告)日：2019-09-17

申请号：US15804427

申请日：2017-11-06

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC分类号： C07H15/10 ,  C07H1/00 ,  C07H15/04 ,  C07F9/10 ,  C12N5/078 ,  C12N5/073 ,  C12N5/00 ,  A61K35/12

摘要： A construct of the structure F—S1-S2 where: F—S1 is an aminoalkylglycoside where F is α-D-galactopyranosyl-(1→4)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranoside and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.

公开(公告)号：US20200123188A1

公开(公告)日：2020-04-23

申请号：US16571526

申请日：2019-09-16

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Norchagina

IPC分类号： C07H15/10 ,  C07H1/00 ,  C12N5/078 ,  C12N5/073 ,  C12N5/00 ,  C07H15/04 ,  C07F9/10

摘要： Synthetic molecule construct of the structure F-S1-S2-L where F—S1 is an aminoalkylglycoside and S2-L is a dicarboxylated, e.g. adipylated, phosphatidylethanolamide are disclosed. The two terminal sugars of the aminoalkylglycoside (Galα1-3Galβ-) are the two terminal sugars of the Galili antigen.

公开(公告)号：US09809614B2

公开(公告)日：2017-11-07

申请号：US15168144

申请日：2016-05-30

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC分类号： C07H15/10 ,  C07H1/00 ,  C07F9/10 ,  C07H15/04 ,  C12N5/00 ,  C12N5/073 ,  C12N5/078 ,  A61K35/12

CPC分类号： C07H15/10 ,  A61K2035/124 ,  C07F9/10 ,  C07H1/00 ,  C07H15/04 ,  C12N5/0006 ,  C12N5/0604 ,  C12N5/0641

摘要： Cells incorporating a synthetic molecule construct of the structure F—S1—S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.

公开(公告)号：US09353349B2

公开(公告)日：2016-05-31

申请号：US14108749

申请日：2013-12-17

申请人： KODE BIOTECH LIMITED

发明人： Nicolai Bovin ,  Lissa Gilliver ,  Stephen Henry ,  Elena Korchagina

IPC分类号： C12N5/078 ,  C07F9/10 ,  C07H15/04 ,  C12N5/00 ,  C12N5/073 ,  A61K35/12

CPC分类号： C07H15/10 ,  A61K2035/124 ,  C07F9/10 ,  C07H1/00 ,  C07H15/04 ,  C12N5/0006 ,  C12N5/0604 ,  C12N5/0641

摘要： Cells incorporating a synthetic molecule construct of the structure F—S1-S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.

摘要翻译： 含有结构F-S1-S2-L的合成分子构建体的细胞其中：F-S1是氨基烷基糖苷，其中F是单，二，三或寡糖，S1是2-氨基乙基，3-氨基丙基 ，4-氨基丁基或5-氨基戊基; S2是-CO（CH 2）2 CO-，-CO（CH 2）3 CO-，-CO（CH 2）4 CO-或-CO（CH 2）5 CO-; L是磷脂酰乙醇胺。

公开(公告)号：US20140371437A1

公开(公告)日：2014-12-18

申请号：US14202504

申请日：2014-03-10

申请人： Kode Biotech Limited

发明人： Nicola Lewell Carter ,  Deborah Adella Blake ,  Nicolai Bovin ,  Stephen Michael Henry ,  Elena Yurievna Korchagina ,  Eleanor Christine Williams ,  Alexander Tuzikov

IPC分类号： C08B37/08

CPC分类号： C08B37/0072 ,  C07H17/04 ,  C12N5/0006 ,  C12N5/0604 ,  C12N2533/80

摘要： A method of localizing reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.

摘要翻译： 公开了通过共价连接到脂质来将辅助透明质酸生殖辅助生殖细胞表面定位的方法。