公开(公告)号：US12053487B2

公开(公告)日：2024-08-06

申请号：US17719674

申请日：2022-04-13

申请人： Purina Animal Nutrition LLC

发明人： Kay Russo ,  Theodore Karnezos

IPC分类号： A61K39/002 ,  A23K10/14 ,  A23K20/163 ,  A23K20/22 ,  A23K50/10 ,  A23K50/60 ,  A61K31/7004 ,  A61K33/40 ,  A61K38/44 ,  A61P33/02

CPC分类号： A61K33/40 ,  A23K10/14 ,  A23K20/163 ,  A23K20/22 ,  A23K50/10 ,  A23K50/60 ,  A61K31/7004 ,  A61K38/443 ,  A61P33/02

摘要： Compositions for preventing or decreasing cryptosporidiosis in animals are disclosed herein. The compositions include sources of hydrogen peroxide and are fed to animals. The animals may be neonatal calves and the cryptosporidiosis may be caused by Cryptosporidium parvum. Methods of preventing or decreasing cryptosporidiosis in animals by feeding the hydrogen peroxide-generating compositions to the animals are also disclosed. Some disclosed methods reduce the number of Cryptosporidium oocysts shed by an infected animal or reduce the infectivity of Cryptosporidium oocysts shed by an infected animal. Some methods include feeding the hydrogen peroxide-generating compositions to animals ultimately afflicted with cryptosporidiosis, and the animals gain weight despite the infection.

公开(公告)号：US11969465B2

公开(公告)日：2024-04-30

申请号：US17692333

申请日：2022-03-11

申请人： Alpha-O Peptides AG ,  Emergent Travel Health Inc.

发明人： Rima McLeod ,  Kamal El Bissati ,  Ying Zhou ,  Jeff Alexander ,  Steve Reed ,  Peter Burkhard ,  Mariane Melo ,  Darrel Irvine ,  Ron Weiss ,  Yuan Zhang

IPC分类号： A61K39/002 ,  A61K9/00 ,  A61K39/00 ,  A61K39/012 ,  A61P33/02

CPC分类号： A61K39/002 ,  A61K9/0009 ,  A61K9/0019 ,  A61K39/012 ,  A61P33/02 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/70 ,  C07K2319/00

摘要： Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

公开(公告)号：US11945845B2

公开(公告)日：2024-04-02

申请号：US17595894

申请日：2020-05-30

申请人： Whitehead Institute for Biomedical Research

发明人： Ben Waldman ,  Sebastian Lourido

IPC分类号： A61K39/002 ,  A61P33/02 ,  A61P37/04 ,  C07K14/45 ,  C12N1/10 ,  C12N15/74 ,  A61K39/00

CPC分类号： C07K14/45 ,  A61K39/002 ,  A61P33/02 ,  A61P37/04 ,  C12N1/10 ,  C12N15/74 ,  A61K2039/52 ,  A61K2039/523 ,  A61K2039/585

摘要： The present disclosure provides genetically altered protozoan parasites comprising a mutation in a bradyzoite formation deficient 1 (BFD1) gene, wherein the mutation inhibits differentiation of the parasite into a bradyzoite. The genetically altered protozoan parasites can be utilized in vaccine compositions and in methods of treating apicomplexan parasite infection.

公开(公告)号：US11785949B2

公开(公告)日：2023-10-17

申请号：US17813065

申请日：2022-07-18

申请人： BASF CORPORATION

发明人： Damian Curtis ,  Brian Thompson

IPC分类号： A61K39/002 ,  A01N63/50 ,  C07K14/32 ,  A01N37/46 ,  A01N63/22 ,  A01N63/23 ,  A01N37/00 ,  C07K14/00

CPC分类号： A01N63/50 ,  A01N37/46 ,  A01N63/22 ,  A01N63/23 ,  C07K14/32 ,  A01N37/00 ,  C07K14/00 ,  A01N63/50 ,  A01N63/22 ,  A01N63/50 ,  A01N63/23 ,  A01N63/22 ,  A01N2300/00 ,  A01N63/50 ,  A01N63/23 ,  A01N2300/00 ,  A01N63/50

摘要： The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US11779639B2

公开(公告)日：2023-10-10

申请号：US17054872

申请日：2019-05-10

申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH ,  THE UNIVERSITY OF MELBOURNE

发明人： Chris Tonkin ,  Alessandro Uboldi ,  Malcolm McConville ,  Martin Blume

IPC分类号： A61K39/002 ,  A61P33/02 ,  C12N1/10 ,  C12N1/36 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  A61K39/00

CPC分类号： A61K39/002 ,  A61P33/02 ,  C12N1/10 ,  C12N1/36 ,  C12N9/1051 ,  C12N9/1205 ,  C12N9/16 ,  C12Y204/01015 ,  C12Y207/01001 ,  C12Y301/03012 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/552

摘要： The present disclosure provides mutant parasites, in particular protozoan parasites comprising a mutation of the trehalose-6-phosphate synthase/6-phosphate phosphatase (TPS/TPP)-like gene of Toxoplasma gondii (herein referred to as ‘Toxoplasma’) or a homologue thereof as well as vaccines comprising same.

公开(公告)号：US20220080040A1

公开(公告)日：2022-03-17

申请号：US17414156

申请日：2019-12-20

申请人： Intervet Inc.

发明人： Joseph Koumans ,  Petter Frost ,  Maria Forlenza

IPC分类号： A61K39/205 ,  A61K39/12 ,  A61K39/145 ,  A61K39/02 ,  A61K39/005 ,  A61K39/002 ,  A61K35/16 ,  A61P31/12 ,  A23K50/80 ,  A23K10/16 ,  A23K20/147 ,  A23K10/18 ,  A23K10/24

摘要： A vaccine composition comprising a virus antigen wherein the composition comprises less than 5% serum, wherein the virus antigen is a whole virus or derived from a whole virus, the vaccine composition reduces, prevents or avoids cross-stitch spinal deformity in the treated animal. Said vaccine composition for use in a method of treating a disease caused by the intracellular pathogen in an animal and reducing, preventing or avoiding cross-stitch spinal deformity in the treated animal. In cross-stitch vertebra the intervertebral space is completely collapsed. A vaccine composition for use as defined above wherein the animal is a fish. In an embodiment the pathogen is salmon alpha virus (SAV).

公开(公告)号：US11173198B2

公开(公告)日：2021-11-16

申请号：US16786350

申请日：2020-02-10

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Xingmin Sun

IPC分类号： A61K39/002 ,  A61K39/08 ,  A61P31/04 ,  A61K39/112 ,  A61K38/16 ,  C07K19/00 ,  C07K14/255 ,  C07K14/33 ,  A61K39/00

摘要： Described are immunogenic proteins against Clostridium difficile. Also described are compositions comprising the immunogenic proteins. Further described are methods of preventing or treating a Clostridium difficile infection in a subject in need thereof.

公开(公告)号：US20210284950A1

公开(公告)日：2021-09-16

申请号：US16338726

申请日：2017-10-04

申请人： Zoetis Services LLC

发明人： Rim Daoussi ,  Frederick H. Weber

IPC分类号： C12N1/04 ,  A61K39/002 ,  A61K9/19 ,  A61K9/16

摘要： An improved stabilization buffer for use in the lyophilization of Neospora and other protozoans is disclosed. Also disclosed is an improved lyophilization method, which includes controlling ice nucleation during the freezing step.

公开(公告)号：US20210139883A1

公开(公告)日：2021-05-13

申请号：US16628216

申请日：2018-07-03

申请人： UNIVERSITE DE TOURS ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

发明人： Anne-France BOUSSEMART-PROUVOST ,  Edouard SECHE ,  Thi Kim Chi NGUYEN

IPC分类号： C12N15/10 ,  C12N15/66 ,  A61K39/002 ,  C12N1/36

摘要： Disclosed is a mutant strain of Sarcocystidae in which the two genes mic1 and mic3 are deleted containing two specific recombination sites of an enzyme allowing a specific recombination, in particular Cre-recombinase, the specific recombination sites being at the respective locus of each of the deleted genes, the specific recombination site of the enzyme allowing specific recombination, in particular of the Cre-recombinase, at the locus of the deleted mic1 gene being different from that of the deleted mic3 gene.

公开(公告)号：US20210121545A1

公开(公告)日：2021-04-29

申请号：US17251121

申请日：2019-06-13

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION (WARF)

发明人： Laura Knoll ,  Bruno Martorelli Di Genova

IPC分类号： A61K39/002 ,  A01K67/027

摘要： Methods of preparing mammalian enteroids, and methods producing T. gondii oocysts in vitro and in vivo in heterologous systems, are provided.