公开(公告)号：US20240000964A1

公开(公告)日：2024-01-04

申请号：US18354256

申请日：2023-07-18

申请人： Ajinomoto Co., Inc.

发明人： Tomohiro FUJII ,  Kei YAMADA ,  Yutaka MATSUDA ,  Ryusuke HIRAMA ,  Noriko HATADA

IPC分类号： A61K47/68 ,  C07K16/32 ,  C07C247/16 ,  C07D271/113 ,  C07D213/71 ,  C07D225/08 ,  C07D403/12 ,  C07D401/12

CPC分类号： A61K47/6889 ,  C07K16/32 ,  A61K47/6855 ,  C07C247/16 ,  C07D271/113 ,  C07D213/71 ,  C07D225/08 ,  C07D403/12 ,  C07D401/12 ,  C07K2317/51 ,  C07K2317/52

摘要： A desired antibody or antibody composition may be obtained by modifying a thiol group chemically introduced to an antibody to obtain an antibody composition comprising



(A) an antibody intermediate or a salt thereof having a bioorthogonal functional group which may be protected, which is represented by the following formula (A):






AbS-L-R]n  (A)





wherein
Ab is a certain antibody,
S is a sulfur atom,
L is a divalent group,
R is a bioorthogonal functional group which may be protected, and
n is an integer from 1 to 8, and


(B) a thiol group-introduced antibody or a salt thereof, which is represented by the following formula (B):






AbSH]n  (B)





wherein
Ab and n are the same as formulae (A), and
SH is a thiol group; and the like.

公开(公告)号：US10954195B2

公开(公告)日：2021-03-23

申请号：US16566659

申请日：2019-09-10

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： John C. Jewett ,  Lindsay E. Guzman ,  Bereketab T. Mehari ,  Jie He

IPC分类号： C07C247/16 ,  C07D233/88 ,  C07D233/60

摘要： Triazabutadiene molecules, such as those according to Formula B, which can yield aryl diazonium species, and methods of use of triazabutadiene molecules, for example methods and compositions for yielding an aryl diazonium species from a triazabutadiene molecule, e.g., a protected aryl diazonium species in the form of a triazabutadiene. In some embodiments, an enzyme catalyzes the reaction yielding the aryl diazonium species from the triazabutadiene molecule. As an example, the methods and compositions herein may be used for delivery of drugs.

公开(公告)号：US10858306B2

公开(公告)日：2020-12-08

申请号：US16844077

申请日：2020-04-09

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE NANTES ,  UNIVERSITE D'ANGERS ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： François Guerard ,  Jean-François Gestin ,  Martin W. Brechbiel ,  Yong-Sok Lee

IPC分类号： C07C201/12 ,  C07C67/307 ,  C07C41/18 ,  C07B59/00 ,  C07C247/10 ,  C07C247/16 ,  C07D207/46 ,  C07C253/30 ,  C07C25/24 ,  C07C17/361 ,  C07C43/225 ,  C07C29/62 ,  C07C29/10 ,  C07C29/58 ,  C07C33/46

摘要： The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.

公开(公告)号：US20190322659A1

公开(公告)日：2019-10-24

申请号：US16399821

申请日：2019-04-30

申请人： Cortexyme, Inc.

发明人： Andrei W. Konradi ,  Stephen S. Dominy ,  Casey Crawford Lynch ,  Craig Coburn ,  Joseph Vacca

IPC分类号： C07D417/12 ,  C07D213/53 ,  C07D409/12 ,  C07D277/24 ,  C07C247/18 ,  C07D277/28 ,  C07D277/64 ,  C07C233/62 ,  C07C233/78 ,  C07C247/16 ,  C07D213/50

摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

公开(公告)号：US10301301B2

公开(公告)日：2019-05-28

申请号：US15996660

申请日：2018-06-04

申请人： Cortexyme, Inc.

发明人： Andrei Konradi ,  Stephen S. Dominy ,  Casey Crawford Lynch ,  Craig Coburn ,  Joseph Vacca

IPC分类号： C07D417/12 ,  C07D213/53 ,  C07D277/28 ,  C07D277/64 ,  C07C233/62 ,  C07C233/78 ,  C07C247/16 ,  C07D409/12 ,  C07D213/50 ,  C07C247/18 ,  C07D277/24

摘要： The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.

公开(公告)号：US20160155633A1

公开(公告)日：2016-06-02

申请号：US14903138

申请日：2014-06-30

申请人： BASF SE

发明人： Mi Zhou ,  Fulvio G. Brunetti ,  Emmanuel Martin ,  Stefan Becker ,  Iori Doi ,  Raissa Nathania Santoso ,  Mei Shan Lam

IPC分类号： H01L21/02 ,  C07D333/20 ,  C08K5/45 ,  C09D125/06 ,  C08K5/28 ,  C07C247/16 ,  C07D333/22

CPC分类号： H01L21/02118 ,  C07C247/16 ,  C07C2603/18 ,  C07D333/20 ,  C07D333/22 ,  C08J3/24 ,  C08J3/28 ,  C08J2325/06 ,  C08K5/28 ,  C08K5/45 ,  C09D125/06 ,  H01L51/0018 ,  H01L51/052 ,  H01L51/0541 ,  H01L51/0545

摘要： The present invention provides compounds of formula a process for their preparation, a solution comprising these compounds, a process for the preparation of a device using the solution, devices obtainable by the process and the use of the bis-azide-type compounds as cross-linkers.

摘要翻译： 本发明提供式Ⅰ化合物的方法，其制备方法，包含这些化合物的溶液，制备使用该溶液的装置的方法，通过该方法可获得的装置和双叠氮化物型化合物的用途， 接头。

公开(公告)号：US20150141378A1

公开(公告)日：2015-05-21

申请号：US14492741

申请日：2014-09-22

申请人： John P. Toscano ,  Christopher M. Pavlos ,  Preeya Kapur Boppana

发明人： John P. Toscano ,  Christopher M. Pavlos ,  Preeya Kapur Boppana

IPC分类号： C07C247/16 ,  C07C247/18 ,  C07D207/50

CPC分类号： C07C247/16 ,  C07C247/18 ,  C07C291/08 ,  C07D207/50 ,  C07D209/42

摘要： Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.

摘要翻译： 本文描述的是硝酰氧基祖细胞化合物，以及其组合物，包括其化合物的方法或产生，以及使用该化合物和组合物治疗或预防疾病和疾病症状的方法。

公开(公告)号：US08946302B2

公开(公告)日：2015-02-03

申请号：US13707418

申请日：2012-12-06

申请人： Wisconsin Alumni Research Foundation

发明人： Arnold E. Ruoho ,  Abdol R. Hajipour ,  Uyen B. Chu ,  Dominique A. Fontanilla

IPC分类号： A01N33/02 ,  A61K31/135 ,  A01N33/26 ,  A61K31/655 ,  C07C247/00 ,  C07J41/00 ,  C07C211/00 ,  C12N5/00 ,  C12N5/02 ,  C07C247/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/49

CPC分类号： C07C247/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/49

摘要： The invention provides compounds of the formulas described herein and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.

摘要翻译： 本发明提供了本文所述的化合物及其组合物。 本发明还提供了使用化合物和组合物的方法。 本发明的化合物可以提供与哺乳动物中σ-1受体的高亲和力结合。 该化合物可显示σ-2受体超过σ-2受体的选择性。 本发明的化合物和组合物还可用于治疗涉及σ-1受体的病症，例如成瘾，心血管病症和癌症，例如乳腺癌，肺癌，前列腺癌，卵巢癌，结肠直肠癌或 中枢神经系统

公开(公告)号：US20100179111A1

公开(公告)日：2010-07-15

申请号：US12621246

申请日：2009-11-18

申请人： Arnold E. Ruoho ,  Abdol R. Hajipour ,  Uyen B. Chu ,  Dominique A. Fontanilla

发明人： Arnold E. Ruoho ,  Abdol R. Hajipour ,  Uyen B. Chu ,  Dominique A. Fontanilla

IPC分类号： A61K31/655 ,  C07C211/29 ,  A61K31/137 ,  C07C247/16 ,  A61P35/00

CPC分类号： C07C247/16 ,  C07C211/27 ,  C07C211/29 ,  C07C211/49

摘要： The invention provides compounds of formula I and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.

摘要翻译： 本发明提供式I化合物及其组合物。 本发明还提供了使用化合物和组合物的方法。 本发明的化合物可以提供与哺乳动物中σ-1受体的高亲和力结合。 该化合物可显示σ-2受体超过σ-2受体的选择性。 本发明的化合物和组合物还可用于治疗涉及σ-1受体的病症，例如成瘾，心血管病症和癌症，例如乳腺癌，肺癌，前列腺癌，卵巢癌，结肠直肠癌或 中枢神经系统

公开(公告)号：US07378446B2

公开(公告)日：2008-05-27

申请号：US10563089

申请日：2004-07-09

申请人： Masayuki Sudoh ,  Takuo Tsukuda ,  Miyako Masubuchi ,  Kenichi Kawasaki ,  Takeshi Murata ,  Fumio Watanabe ,  Hiroshi Fukuda ,  Susumu Komiyama ,  Tadakatsu Hayase

发明人： Masayuki Sudoh ,  Takuo Tsukuda ,  Miyako Masubuchi ,  Kenichi Kawasaki ,  Takeshi Murata ,  Fumio Watanabe ,  Hiroshi Fukuda ,  Susumu Komiyama ,  Tadakatsu Hayase

IPC分类号： A61K31/194 ,  A61K31/381 ,  A61K31/4192 ,  A61K31/4406 ,  A61K31/4412 ,  A61K31/45 ,  A61K31/495 ,  A61K31/505 ,  A61K31/513 ,  A61K31/5375 ,  C07D249/06 ,  C07D333/20 ,  C07D211/46 ,  C07D213/46 ,  C07D213/64 ,  C07D213/65 ,  C07D213/38 ,  C07D241/04 ,  C07D239/26 ,  C07D265/30 ,  C07C229/36 ,  C07C247/16

CPC分类号： A61K31/195 ,  A61K31/216 ,  A61K31/405 ,  C07C235/76

摘要： The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV, its production method, an intermediate compound useful for its production and a pharmaceutical composition containing these compounds, and the present invention relates to a compound represented by the formula (I): (wherein A represents —(CH2)n—, etc.; B represents —(C═O)—, etc.; D represents —(CH2)m—R′, etc.; E represents a hydrogen atom, etc.; G represents —(CH2)p-J, etc.; bond Q represents a single bond or double bond; and R1, R2 and R3 may be the same or different and each represent a hydrogen atom, etc.), a prodrug thereof or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明的目的是提供一种可用于预防和治疗病毒感染性疾病的化合物，特别是由于其对HCV具有高复制抑制活性的HCV感染引起的肝脏疾病，其制备方法，中间体 可用于其生产的化合物和含有这些化合物的药物组合物，本发明涉及由式（I）表示的化合物：其中A表示 - （CH 2 2）n < /等等; B表示 - （CO） - 等; D表示 - （CH 2 2）m -R 1等; E表示 氢原子等; G表示 - （CH 2 CH 2）n -J等;键Q表示单键或双键; R' R 1，R 2和R 3可以相同或不同，各自表示氢原子等），其前药或药学上可接受的盐 其中。