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公开(公告)号：US20230241012A1
公开(公告)日：2023-08-03
申请号：US18101258
申请日：2023-01-25
发明人： Yao-Ling Qiu , Xuri Gao , Jorden Kass , Hui Cao , Wei Li , Xiaowen Peng , Byung-Chul Suh , Yat Sun Or
IPC分类号： A61K31/167 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20 , A61K31/401 , C07C303/00 , C07C317/44
CPC分类号： A61K31/167 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20 , A61K31/401 , C07C303/00 , C07C317/44 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:
X-A-Y-L-R (I)
which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US20220350243A1
公开(公告)日：2022-11-03
申请号：US17716256
申请日：2022-04-08
发明人： Jun Hatakeyama , Masaki Ohashi
IPC分类号： G03F7/004 , G03F7/038 , G03F7/039 , C07C205/57 , C07C381/12 , C07D333/76 , C07C317/44 , C07D327/08 , C07C233/54 , C07C311/09 , C07D333/54
摘要： A resist composition comprising a sulfonium salt of a carboxylic acid having a nitro-substituted benzene ring is provided. The carboxylic acid is free of iodine and bromine, and when the benzene ring is fluorinated, the number of fluorine atoms is up to 3. The resist composition offers a high sensitivity, reduced LWR and improved CDU independent of whether it is of positive or negative tone.
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公开(公告)号：US11220477B2
公开(公告)日：2022-01-11
申请号：US16418858
申请日：2019-05-21
发明人： Peter Walter , Carmela Sidrauski , Diego Acosta Alvear , Michelle R. Arkin , Christopher G. Wilson , Kean Hooi Ang , Brian R. Hearn , Punitha Vedantham , Adam R. Renslo , Mervyn Maze , Susana Vacas
IPC分类号： C07C235/14 , C07F7/08 , A61K31/4192 , C07D403/12 , C07D495/04 , C07C255/54 , C07C257/14 , C07C271/24 , C07C271/52 , C07C211/29 , C07C317/22 , C07C317/44 , C07C323/60 , C07C235/20 , C07C235/22 , C07C235/24 , A61K31/165
摘要： Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
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公开(公告)号：US20210364917A1
公开(公告)日：2021-11-25
申请号：US17386440
申请日：2021-07-27
申请人： FUJIFILM Corporation
IPC分类号： G03F7/004 , G03F7/038 , G03F7/039 , C07C381/12 , C07C317/28 , C07C317/44 , C07D327/06 , C07C255/17 , C07D333/46 , C07C311/16 , C07C25/02 , C07D317/72
摘要： The present invention provides an actinic ray-sensitive or radiation-sensitive resin composition having excellent storage stability during long-term storage. In addition, also provided are a resist film, a pattern forming method, and a method for manufacturing an electronic device, each relating to the actinic ray-sensitive or radiation-sensitive resin composition. The actinic ray-sensitive or radiation-sensitive resin composition of an embodiment of the present invention includes a compound represented by General Formula (I) and an acid-decomposable resin. M1+A−-L-B−M2+ (I)
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公开(公告)号：US11130726B2
公开(公告)日：2021-09-28
申请号：US16685335
申请日：2019-11-15
IPC分类号： C07C62/38 , C07C62/34 , C07C229/48 , C07D211/22 , C07C317/44 , C07C323/61 , C07C69/757 , A61P25/00 , A61P29/00 , A61P17/04 , C07C313/04
摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US11091414B2
公开(公告)日：2021-08-17
申请号：US16506573
申请日：2019-07-09
申请人： AGROFRESH INC.
发明人： Nazir Mir
IPC分类号： C07C7/12 , C07C7/10 , C07C317/14 , C07C55/02 , C07C53/06 , C07C317/44 , C07D251/12 , C07F15/06 , C07F15/02 , C07F3/02 , C07F1/08 , C07F3/06 , A01N27/00 , A01N25/10 , A01N3/00 , B01J20/22
摘要： Disclosed are adsorption complexes that include 1-methylcyclopropene (1-MCP) and a metal coordination polymer network (MCPN), wherein the MCPN is a porous material, and the 1-MCP is adsorbed into the MCPN. Also disclosed are kits for containing 1-MCP that include the adsorption complex in a 1-MCP-impermeable package. Also disclosed are methods of releasing 1-methylcyclopropene (1-MCP) from the kit that include the application of aqueous fluids, heat, and/or pressure.
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公开(公告)号：US20210230176A1
公开(公告)日：2021-07-29
申请号：US17143326
申请日：2021-01-07
发明人： Yao-Ling Qiu , Xuri Gao , Wei Li , Hui Cao , Meizhong Jin , Jorden Kass , Xiaowen Peng , Yat Sun Or
IPC分类号： C07D493/08 , C07C317/44 , C07C323/62 , A61K31/167 , A61K31/18 , A61K31/196 , A61K31/215 , A61K31/223 , A61K31/277 , A61K31/325 , A61K31/335 , A61K31/336 , A61K31/341 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/39 , A61K31/401 , A61K31/41 , A61K31/415 , A61K31/416 , A61K31/4164 , A61K31/421 , A61K31/426 , A61K31/439 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4425 , A61K31/445 , A61K31/4545 , A61K31/5377 , A61K31/655 , C07B59/00 , C07C235/56 , C07C311/53 , C07C317/32 , C07C323/42 , C07D207/16 , C07D211/54 , C07D213/52 , C07D213/81 , C07D213/89 , C07D231/12 , C07D233/64 , C07D257/04 , C07D261/02 , C07D261/08 , C07D261/20 , C07D263/52 , C07D277/26 , C07D295/088 , C07D303/26 , C07D303/34 , C07D307/32 , C07D307/33 , C07D309/08 , C07D313/04 , C07D317/72 , C07D327/10 , C07D401/04 , C07D451/04 , C07D493/04
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20210130281A1
公开(公告)日：2021-05-06
申请号：US17149170
申请日：2021-01-14
申请人： XWPHARMA LTD.
发明人： JIA-NING XIANG , XUESONG XU , XUAN ZHANG
IPC分类号： C07C69/78 , C07C255/57 , C07D213/79 , C07D213/80 , C07D309/12 , C07C271/22 , C07C271/34 , C07C69/612 , C07D317/64 , C07D333/38 , C07C229/08 , C07C233/47 , C07D207/16 , C07D307/68 , C07B59/00 , C07C69/76 , C07C69/24 , C07C229/36 , C07C69/608 , C07C317/44 , C07D277/56 , C07D211/46 , C07C69/738 , C07C69/28 , C07C69/22 , C07C69/34 , C07C69/618 , C07C69/74 , C07C69/96 , C07C229/34 , C07C317/14 , C07D207/12 , C07D211/44 , C07D277/30
摘要： Provided are prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
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公开(公告)号：US10952978B2
公开(公告)日：2021-03-23
申请号：US16114842
申请日：2018-08-28
发明人： Yao-Ling Qiu , Xuri Gao , Jorden Kass , Hui Cao , Wei Li , Xiaowen Peng , Byung-Chul Suh , Yat Sun Or
IPC分类号： A61K31/167 , A61K31/4164 , A61K31/34 , A61K31/357 , A61K31/4409 , A61K31/426 , A61K31/4015 , A61K31/4439 , A61K31/415 , A61K31/421 , A61K31/4192 , A61K31/351 , A61K31/397 , A61K31/337 , A61K31/47 , A61K31/513 , A61K31/7028 , A61P31/20 , A61K31/401 , C07C303/00 , C07C317/44 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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10.发明授权公开(公告)号：US10913711B2
公开(公告)日：2021-02-09
申请号：US16282894
申请日：2019-02-22
IPC分类号： C07C323/60 , A61K45/06 , A61K31/135 , C07C317/44 , C07C317/28 , C07C323/25 , C07D295/08 , C07D295/088 , C07D295/108 , C07D295/185
摘要： Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.
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