公开(公告)号：US11964941B2

公开(公告)日：2024-04-23

申请号：US16921856

申请日：2020-07-06

申请人： City of Hope

发明人： Sangkil Nam ,  David Horne ,  Jun Xie

IPC分类号： C07D209/40 ,  A61K31/404 ,  C07D209/34 ,  C07D403/04

CPC分类号： C07D209/40

摘要： Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.

公开(公告)号：US20220411373A1

公开(公告)日：2022-12-29

申请号：US17893399

申请日：2022-08-23

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks ,  Christopher Pulliam ,  Ryan M. Bain

IPC分类号： C07D213/04 ,  C07D209/40 ,  C07J41/00 ,  C07C45/72

摘要： The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.

公开(公告)号：US11306072B2

公开(公告)日：2022-04-19

申请号：US16790611

申请日：2020-02-13

申请人： City of Hope ,  National and Kapodistrian University of Athens

发明人： Richard Jove ,  Sangkil Nam ,  David Horne ,  Jun Xie ,  Alexios Leandros Skaltsounis ,  Marina Kritsanida ,  Nicolas Gaboriaud-Kolar

IPC分类号： C07D403/14 ,  C07D401/04 ,  C07D209/40 ,  C07D209/48 ,  A61K45/06 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/496 ,  C07D401/14

摘要： Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.

公开(公告)号：US11072583B2

公开(公告)日：2021-07-27

申请号：US16767389

申请日：2018-08-06

申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

发明人： Chandrasekhar Srivari ,  Prathama Satyendra Mainkar ,  Chada Raji Reddy ,  Srigiridhar Kotamraju ,  Pavan Kumar Togapur ,  Subbarao Mohan Venkata Muppidi ,  Somesh Sharma ,  Ashok Kumar Jha ,  Prem Kumar Arumugam

IPC分类号： C07D209/40 ,  B01J31/24

摘要： Sulfonyl hydroxamic acid compounds have the following general formula: Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R1, R2, R3, R4, R5, and R6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives.

公开(公告)号：US10774044B2

公开(公告)日：2020-09-15

申请号：US15613520

申请日：2017-06-05

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks ,  Christopher Pulliam ,  Ryan M. Bain

IPC分类号： C07D213/04 ,  C07D209/40 ,  C07J41/00 ,  C07C45/72

摘要： The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.

公开(公告)号：US20200039976A1

公开(公告)日：2020-02-06

申请号：US16298632

申请日：2019-03-11

申请人： NOVITA PHARMACEUTICALS, INC. ,  CORNELL UNIVERSITY

发明人： Xin-Yun HUANG ,  Christy Young SHUE

IPC分类号： C07D471/04 ,  C07D231/56 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D209/30 ,  C07D209/40 ,  C07D405/04

摘要： Provided are compounds, compositions and methods for inhibiting fascin activity or treating a condition or disorder mediated by fascin activity in a subject in need thereof.

公开(公告)号：US10538496B2

公开(公告)日：2020-01-21

申请号：US16202210

申请日：2018-11-28

申请人： FORMA Therapeutics, Inc. ,  H. Lee Moffitt Cancer Center and Research Institute, Inc.

发明人： Jennifer Lee ,  Pearlie Burnette ,  Srikumar Chellappan ,  Nicholas Barczak ,  Jaime A. Escobedo ,  Chiara Conti ,  Bingsong Han ,  David R. Lancia, Jr. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Xiaozhang Zheng

IPC分类号： C07D263/58 ,  A61P35/00 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  C07C53/06 ,  C07D209/40 ,  C07D209/54 ,  C07D221/20 ,  C07D235/30 ,  C07D277/82 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D473/00 ,  C07D487/04 ,  C07D491/056 ,  C07D491/107 ,  C07D498/04

摘要： The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.

公开(公告)号：US10428095B2

公开(公告)日：2019-10-01

申请号：US16148622

申请日：2018-10-01

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan Wiles ,  Avinash S. Phadke ,  Xiangzhu Wang ,  Dawei Chen ,  Akihiro Hashimoto ,  Venkat Rao Gadhachanda ,  Godwin Pais ,  Qiuping Wang ,  Atul Agarwal ,  Milind Deshpande

IPC分类号： C07D403/14 ,  C07F9/572 ,  C07D209/42 ,  C07D403/12 ,  C07D401/14 ,  C07D471/04 ,  C07D417/06 ,  C07D403/06 ,  C07D417/14 ,  C07F7/08 ,  C07D413/14 ,  C07D487/04 ,  C07D405/14 ,  C07D403/08 ,  C07D413/06 ,  C07F5/02 ,  C07F9/6561 ,  C07F9/6558 ,  A61K31/404 ,  A61K31/407 ,  A61K31/4162 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4192 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/506 ,  A61K31/549 ,  A61K31/55 ,  A61K31/675 ,  A61K31/683 ,  C07B59/00 ,  C07D209/14 ,  C07D209/40 ,  C07D405/12 ,  C07D417/12 ,  C07D487/14 ,  C07D491/113 ,  C07D495/04 ,  C07D513/04 ,  A61K9/00 ,  A61K31/4045 ,  A61K31/444 ,  A61K31/501 ,  A61K31/519 ,  C07D209/12 ,  C07D209/30 ,  C07D209/44 ,  C07D209/88 ,  C07D471/08

摘要： Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

公开(公告)号：US10385066B2

公开(公告)日：2019-08-20

申请号：US16240659

申请日：2019-01-04

申请人： GlaxoSmithKline LLC

发明人： Mui Cheung ,  Raghuram Tangirala

IPC分类号： C07D209/40 ,  C07D498/04 ,  C07D519/00

摘要： This invention relates to methods for the preparation of a compound which is an inhibitor of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1).

公开(公告)号：US10370341B2

公开(公告)日：2019-08-06

申请号：US16146894

申请日：2018-09-28

申请人： Neoculi Pty Ltd.

发明人： Stephen Page ,  Sanjay Garg ,  Martine Keenan ,  Adam McCluskey ,  Andrew Stevens

IPC分类号： A61K31/155 ,  A61K31/381 ,  A61K31/14 ,  A61K31/17 ,  A61K31/175 ,  A61K31/404 ,  A61K31/505 ,  C07D239/50 ,  C07D251/54 ,  C07D239/48 ,  C07D251/48 ,  C07C281/16 ,  C07D333/58 ,  C07D209/14 ,  C07D295/125 ,  C07C281/08 ,  C07C281/18 ,  A61K45/06 ,  C07C323/45 ,  C07C337/08 ,  C07D215/12 ,  C07D251/66 ,  C07D209/40 ,  C07D213/53 ,  C07D307/56 ,  A01N43/54 ,  A01N47/44 ,  C07F9/6512

摘要： The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.