公开(公告)号：US11873288B2

公开(公告)日：2024-01-16

申请号：US17112713

申请日：2020-12-04

申请人： The Regents of the University of California

发明人： Bruce Hammock ,  Sean Kodani

IPC分类号： C07D401/06 ,  C07C275/28 ,  C07D271/10 ,  C07C275/34 ,  A61P35/00 ,  C07C275/36 ,  C07D211/16 ,  C07D211/46 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/04

CPC分类号： C07D401/06 ,  A61P35/00 ,  C07C275/28 ,  C07C275/34 ,  C07C275/36 ,  C07D211/16 ,  C07D211/46 ,  C07D271/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/04 ,  C07C2601/14

摘要： The present invention provides compounds that are dual inhibitors of soluble epoxide hydrolase and fatty acid amide hydrolase. The present invention also provides methods of using the compounds to inhibit soluble epoxide hydrolase and fatty acid amide hydrolase, and to treat cancer.

公开(公告)号：US11814698B2

公开(公告)日：2023-11-14

申请号：US17810138

申请日：2022-06-30

申请人： EXCIR WORKS CORP.

发明人： Stephen Foley ,  Hiwa Salimi ,  Loghman Moradi

IPC分类号： C22B11/00 ,  C22B3/16 ,  C22B3/06 ,  C22B3/26 ,  C22B3/28 ,  C22B3/34 ,  C22B3/36 ,  C22B3/40 ,  C22B3/44 ,  C07C335/26 ,  C07D207/06 ,  C07D211/16 ,  C07D295/215 ,  C22B1/00 ,  C25C1/20 ,  C25C7/06

CPC分类号： C22B11/04 ,  C07C335/26 ,  C07D207/06 ,  C07D211/16 ,  C07D295/215 ,  C22B1/00 ,  C22B3/06 ,  C22B3/16 ,  C22B3/1608 ,  C22B3/1616 ,  C22B3/1625 ,  C22B3/1666 ,  C22B3/26 ,  C22B3/28 ,  C22B3/282 ,  C22B3/284 ,  C22B3/34 ,  C22B3/36 ,  C22B3/406 ,  C22B3/44 ,  C25C1/20 ,  C25C7/06 ,  Y02P10/20

摘要： The present application relates to methods for the simultaneous leaching and extraction of precious metals. For example, the present application relates to methods of leaching and extracting gold and/or palladium from a substance comprising gold and/or palladium such as a gold and/or palladium-containing ore in one step using a compound of Formula I: (I).

公开(公告)号：US20230098847A1

公开(公告)日：2023-03-30

申请号：US17867233

申请日：2022-07-18

申请人： California Institute of Technology

发明人： Brian M. Stoltz ,  Scott C. Virgil ,  David E. White ,  Taiga Yurino ,  Yiyang Liu ,  Douglas C. Behenna ,  Douglas Duquette ,  Christian Eidamshaus

IPC分类号： C07D211/78 ,  C07D265/32 ,  C07D211/60 ,  C07D207/16 ,  C07D223/10 ,  C07D309/04 ,  C07D223/04 ,  C07D241/04 ,  C07D241/08 ,  C07D241/52 ,  C07D207/06 ,  C07D265/30 ,  C07D207/08 ,  C07D207/10 ,  C07D207/26 ,  C07D207/263 ,  C07D207/27 ,  C07D207/46 ,  C07D211/16 ,  C07D211/18 ,  C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/76 ,  C07D211/88 ,  C07D211/94 ,  C07D211/96 ,  C07D309/30 ,  C07D207/267 ,  C07D207/273 ,  C07D207/277 ,  C07D211/90

摘要： The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.

公开(公告)号：US20220411426A1

公开(公告)日：2022-12-29

申请号：US17318672

申请日：2021-05-12

申请人： President and Fellows of Harvard College

发明人： Juan Pablo Maianti ,  David R. Liu

IPC分类号： C07D487/04 ,  C07D295/185 ,  C07D295/26 ,  C07D413/06 ,  C07D493/10 ,  C07D413/12 ,  C07D405/06 ,  C07D211/14 ,  C07D211/16 ,  C07D401/06 ,  C07D401/12 ,  C07D205/04 ,  C07D211/96 ,  C07D487/08 ,  C07D405/12 ,  A61K45/06 ,  A61P3/00 ,  C07C311/16 ,  C07D241/44

摘要： Provided herein are compounds of Formulae (RL), (I), (II), (HI), (IV), and (V), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, prodrugs, and isotopically labeled derivatives thereof. Also provided are pharmaceutical compositions, kits, and methods involving the inventive compounds for the treatment of metabolic disorders (e.g., diabetes, hyperglycemia, impaired glucose tolerance, insulin resistance, obesity). The compound are useful as substrate selective inhibitors of insulin-degrading enzyme (IDE).

公开(公告)号：US20220380314A1

公开(公告)日：2022-12-01

申请号：US17760878

申请日：2020-09-17

申请人： Bial - R&D Investments, S.A. ,  Fondazione Istituto Italiano di Tecnologia

发明人： Renato T. Skerlj ,  Elyse Marie Josee Bourque ,  Soumya Ray ,  Rita Scarpelli ,  Vincenzo Cilibrasi

IPC分类号： C07D217/06 ,  C07D401/10 ,  C07D215/08 ,  C07D241/38 ,  C07D471/04 ,  C07D265/36 ,  C07D498/10 ,  C07D215/233 ,  C07D211/16 ,  C07D211/28 ,  C07D211/48 ,  C07D401/04 ,  C07D405/10 ,  C07D265/30 ,  C07D207/06 ,  C07D221/20 ,  C07D209/54 ,  C07D265/34 ,  C07D211/70 ,  C07C275/26 ,  C07D471/08 ,  C07D405/12 ,  C07D241/20 ,  C07D265/32 ,  C07C271/16 ,  C07D451/06

摘要： The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

公开(公告)号：US20220315549A1

公开(公告)日：2022-10-06

申请号：US17615659

申请日：2020-05-29

申请人： Hangzhou Westan Pharmaceutical Technology Co., Ltd

发明人： Yunfeng CHENG ,  Yongzhou HU

IPC分类号： C07D295/185 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D417/04 ,  C07D471/08 ,  C07D211/16 ,  C07D221/20 ,  C07D417/12 ,  C07D413/12 ,  C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D417/14 ,  C07D403/06 ,  C07D405/14 ,  C07D405/06 ,  A61P11/06

摘要： Provided in the present invention are a heteroaromatic acetamide derivative and the preparation and the use thereof, wherein the heteroaromatic acetamide derivative is a heteroaromatic acetamide compound as shown in general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. According to the present invention, experiments have confirmed that the heteroaromatic acetamide derivative of the present invention can specifically bind to transient receptor potential ankyrin 1 (TRPA1) and inhibit or reduce the activity thereof, and can be used for treating diseases mediated by TRPA1. The present invention further provides a method for preparing the heteroaromatic acetamide derivative, and a drug and pharmaceutical composition containing the heteroaromatic acetamide derivative.

公开(公告)号：US11420949B2

公开(公告)日：2022-08-23

申请号：US17068354

申请日：2020-10-12

申请人： Rutgers, The State University of New Jersey

发明人： Longqin Hu

IPC分类号： C07D295/185 ,  C07D211/16 ,  C07C323/60

摘要： Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: and pharmaceutically acceptable salts, solvates and prodrugs thereof, wherein each R and R′ pair are independently selected from (i) or (ii); (i) R and R′ are independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alcohol, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclic, and substituted or unsubstituted heteroaryl, or (ii) R and R′ together form a substituted or unsubstituted heterocyclic ring structure, or a substituted or unsubstituted heteroaryl ring structure; X is hydrogen, or an alkyl; and Y is O or S.

公开(公告)号：US20210387950A1

公开(公告)日：2021-12-16

申请号：US17419448

申请日：2019-12-26

申请人： Jing ZHANG

发明人： Jing ZHANG

IPC分类号： C07D211/16 ,  C07C235/78 ,  C07D203/18

摘要： An acetylsalicylic acid derivative and an application thereof. The present disclosure relates to the field of chemical pharmaceuticals, and in particular, to a compound shown in formula (I) or pharmaceutically acceptable salts thereof.

公开(公告)号：US11053195B2

公开(公告)日：2021-07-06

申请号：US16186275

申请日：2018-11-09

申请人： Global Blood Therapeutics, Inc.

发明人： Qing Xu ,  Zhe Li ,  Stephen L. Gwaltney, II

IPC分类号： C07D207/08 ,  C07D265/30 ,  C07D401/12 ,  C07D211/30 ,  C07D403/12 ,  C07C271/16 ,  C07D207/34 ,  C07D207/48 ,  C07D211/16 ,  C07D211/22 ,  C07D211/60 ,  C07D211/78 ,  C07D213/81 ,  C07D241/04 ,  C07D279/12 ,  C07D309/08 ,  C07D309/28 ,  C07D333/38 ,  C07D335/02 ,  C07D401/06 ,  C07D403/06

摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

公开(公告)号：US20210161829A1

公开(公告)日：2021-06-03

申请号：US16991196

申请日：2020-08-12

申请人： ModernaTX, Inc.

发明人： Kerry E. BENENATO ,  William BUTCHER

IPC分类号： A61K9/51 ,  C07D295/185 ,  C07D211/16 ,  C07D295/13 ,  C07D211/14 ,  A61K38/18 ,  A61K47/22 ,  A61K48/00 ,  C07D241/04

摘要： The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.