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公开(公告)号:US20230128765A1
公开(公告)日:2023-04-27
申请号:US17842495
申请日:2022-06-16
IPC分类号: C07D401/04 , C12N9/00 , A61P25/00 , A61P25/16 , A61P35/00 , C07D213/56 , C07D233/64 , C07D235/16 , C07D257/04 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D498/04
摘要: The present disclosure relates to compounds for activating the enzymatic activity of an E3 ubiquitin ligase and methods for treating a disease or disorder in a subject with diminished E3 ubiquitin ligase enzymatic activity. In some embodiments, the present disclosure provides a compound of Formula I or a compound of Formula II. or pharmaceutically acceptable salts thereof.
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2.
公开(公告)号:US20230116770A1
公开(公告)日:2023-04-13
申请号:US17875216
申请日:2022-07-27
IPC分类号: A61K31/4409 , A61K31/196 , A61K31/245 , A61K31/415 , A61K31/4155 , A61K31/417 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4355 , A61K31/437 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , A61K31/5386 , C07C275/42 , C07D213/40 , C07D213/56 , C07D213/643 , C07D213/73 , C07D213/74 , C07D231/12 , C07D233/64 , C07D237/08 , C07D239/26 , C07D249/04 , C07D261/08 , C07D263/32 , C07D277/28 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D498/08
摘要: Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.
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公开(公告)号:US20230114304A1
公开(公告)日:2023-04-13
申请号:US17634645
申请日:2020-08-14
IPC分类号: C07D207/09 , C07D487/04 , C07D233/64 , C07D311/80 , C07D277/04 , C07C309/54
摘要: Disclosed herein, inter alia, are depalmitoylating compounds, compositions, and methods of use thereof.
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公开(公告)号:US11578052B2
公开(公告)日:2023-02-14
申请号:US17162157
申请日:2021-01-29
发明人: Michael Downes , Ronald M. Evans , Arthur Kluge , Bharat Lagu , Masanori Miura , Sunil Kumar Panigrahi , Michael Patane , Susanta Samajdar , Ramesh Senaiar , Taisuke Takahashi
IPC分类号: C07D233/64 , C07D401/04 , C07D405/10 , A61P21/00 , A61P25/00
摘要: Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
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公开(公告)号:US20220348586A1
公开(公告)日:2022-11-03
申请号:US17765856
申请日:2020-10-02
发明人: SIAWASH AHMAR , JUNG YUN KIM , PING SHAN LAI , JEFFREY ALAN OMEARA , QUANG HUY TO , PETER MARTIN DOVE
IPC分类号: C07D487/04 , C07C235/60 , C07C235/58 , C07C235/88 , C07C235/62 , C07C235/64 , C07D239/26 , C07D261/08 , C07D263/32 , C07D233/64 , C07D213/40 , C07D257/04 , C07D295/192 , C07D295/26 , C07D207/16 , C07D207/24 , C07D209/44 , C07D209/08 , C07D203/18 , C07D205/04 , C07C255/29 , C07C271/16 , C07C271/34 , C07C271/48 , C07C271/24 , C07C233/60 , C07C233/18 , C07D261/14 , C07D271/10
摘要: This disclosure relates to cannabinoid derivatives of Formula (I), wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds and methods of using the cannabinoid derivatives. These compounds are potential cannabinoid receptor inhibitors, including CB1 and CB2 receptors.
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公开(公告)号:US20220306587A1
公开(公告)日:2022-09-29
申请号:US17636464
申请日:2020-08-20
申请人: AC BIOSCIENCE SA
发明人: Christian AUCLAIR , Annette IVES
IPC分类号: C07D233/64 , C07D263/32 , C07D277/28 , C07D413/04 , C07D417/04
摘要: The invention provides the imidazole, oxazole and thiazole compounds and use thereof in methods for treating a disease or a disorder, such as infectious diseases and cancer, wherein inhibition of sphingosine-1-phosphate lyase is beneficial to treat the disease or the disorder.
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公开(公告)号:US11420943B2
公开(公告)日:2022-08-23
申请号:US16958336
申请日:2018-12-19
申请人: FLAMMA S.P.A.
发明人: GianPaolo Negrisoli , Stefania Gagliardi , Almin Silnovic , Clelia Dallanoce , Marco De Amici , Renato Canevotti
IPC分类号: C07D233/64
摘要: Disclosed are peptide or pseudopeptide derivatives containing a nitrogenous heterocyclic residue with blocking activity against the by-products of lipid oxidative stress, and in particular of unsaturated aldehydes such as malondialdehyde and 4-hydroxy-trans-2-nonenal (HNE).
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公开(公告)号:US11420935B2
公开(公告)日:2022-08-23
申请号:US16849728
申请日:2020-04-15
IPC分类号: C07C235/66 , C07C311/51 , C07D217/24 , C07D217/26 , C07D401/12 , C07D213/40 , C07C255/24 , C07D333/70 , C07D305/08 , C07D305/06 , C07D241/12 , C07D233/64 , C07D257/04 , C07D213/73 , C07D213/61
摘要: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating deseases, such as cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.
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公开(公告)号:US11377425B1
公开(公告)日:2022-07-05
申请号:US16765143
申请日:2019-12-19
申请人: LEO Pharma A/S
发明人: Kevin Neil Dack , Xifu Liang , Mogens Larsen , Mark Andrews , Alan Stuart Jessiman , Mia Nørreskov Burhardt , Patrick Stephen Johnson , Peter Andersen , Lars Jørgensen
IPC分类号: C07D231/12 , C07D403/12 , C07D249/06 , C07D271/10 , C07D263/32 , C07D413/12 , C07D233/64 , C07D231/14 , C07D233/68 , C07D233/70 , C07D261/08
摘要: The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
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公开(公告)号:US20220202718A1
公开(公告)日:2022-06-30
申请号:US17556316
申请日:2021-12-20
申请人: Translate Bio, Inc.
IPC分类号: A61K9/19 , C07D233/64 , A61K9/127 , C07C323/25 , C07C323/44 , C12N15/88 , A61K38/45 , A61K38/46 , A61K38/47 , A61K38/50 , A61K31/7088 , C07C323/27 , C07J41/00 , C07J43/00
摘要: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent iransfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
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