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公开(公告)号:US20230113202A1
公开(公告)日:2023-04-13
申请号:US17649752
申请日:2022-02-02
发明人: Shaun ABBOTT , Mylène DeLESELEUC , Julien MARTEL , Elyse BOURQUE , Jeremy GREEN , Alexandre LARIVÉE , Jean-Benoìt GIGUÈRE , Elodie LANDAGARAY , Claudio STURINO , Nadia Michel NASSER
IPC分类号: C07D405/06 , C07D405/14 , C07D413/06 , C07D409/14 , C07D405/12 , C07D249/06 , C07D487/10 , C07D471/10 , C07D471/08 , C07D401/14 , C07D491/056 , C07D409/06
摘要: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.
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公开(公告)号:US20230111853A1
公开(公告)日:2023-04-13
申请号:US17786161
申请日:2020-12-16
发明人: Nikolai KLEY , Riccardo SABATINI , Edward SUH
IPC分类号: C07D401/04 , C07D417/04 , C07D211/40 , C07D471/04 , C07D401/14 , C07D495/04 , C07D491/056 , C07D487/04 , C07D491/048 , C07D405/14 , A61P43/00
摘要: The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.
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公开(公告)号:US20230024283A1
公开(公告)日:2023-01-26
申请号:US17790080
申请日:2020-12-24
IPC分类号: C07D231/12 , C07D213/84 , C07C255/55 , C07D277/587 , C07C255/53 , C07D271/06 , C07D239/26 , C07D213/64 , C07D213/57 , C07C323/31 , C07D491/056 , C07D317/60 , C07C317/14 , C07D213/71 , C07D333/24 , C07D213/69 , C07D333/28 , C07D249/08 , C07D275/02 , C07D263/32 , C07D241/12 , C07D237/08 , C07D285/08 , C07D307/54 , C07D249/06 , A01P13/00 , A01N43/56 , A01N43/40 , A01N37/34 , A01N43/78 , A01N43/82 , A01N43/54 , A01N43/90 , A01N43/30 , A01N37/52 , A01N43/10 , A01N43/653 , A01N43/76 , A01N43/80 , A01N43/60 , A01N43/58 , A01N43/647 , A01N43/08
摘要: The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.
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公开(公告)号:US11479559B2
公开(公告)日:2022-10-25
申请号:US16968793
申请日:2019-01-25
发明人: Qiang Zhang , Shannan Yu , Zhongxiang Wang , Shouye Feng , Yansheng Liu , Xingfu Li , Hongbo Zhang , Leifu Yang , Hailong Yang , Likai Zhou , Nanqiao Zheng , Chenming Hu , Zhanqiang Xu
IPC分类号: C07D491/056 , A61K31/4741 , A61K31/496 , A61K31/5377 , A61K31/54 , A61K45/06
摘要: The present invention relates to an urea-substituted aromatic ring-linked dioxinoquinoline compound of formula (I), or a pharmaceutically acceptable salt or a hydrate thereof. The invention also provides a preparation method of the compound of formula (I) and a pharmaceutically acceptable salt thereof, as well as uses thereof as a drug, wherein the drug acting as a tyrosine kinase (i.e. VEGFR-2, C-RAF, B-RAF, and RET) inhibitor is used for treating disorders related to tyrosine kinase.
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公开(公告)号:US20220315534A1
公开(公告)日:2022-10-06
申请号:US17620065
申请日:2020-06-30
发明人: Anthony P. Ford , Jiaxin Yu , David Scott Carter , Wei Chen
IPC分类号: C07D213/73 , C07D237/20 , C07D241/20 , C07D213/64 , C07D215/227 , C07D309/38 , C07D471/04 , C07D491/056 , C07D498/04 , C07D265/36 , C07D215/14 , C07D231/56 , C07D261/20 , C07D209/86 , C07D263/58 , C07D235/14 , C07D223/16 , C07D277/68 , C07D209/08
摘要: The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
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公开(公告)号:US11377451B2
公开(公告)日:2022-07-05
申请号:US17475144
申请日:2021-09-14
发明人: David A. Nathanson , Michael E. Jung , Jonathan Tsang , Lorenz Urner , Peter M. Clark , Timothy F. Cloughesy , Gyudong Kim
IPC分类号: C07D491/14 , C07D491/056 , C07D239/95 , C07D239/94 , C07D405/04
摘要: The present disclosure relates to compounds, compositions and methods for treating cancer, including compounds that are capable of penetrating the blood brain barrier to modulate the activity of EGFR tyrosine kinase. The disclosure further relates to methods of treating cancer in the brain, including glioblastoma and other EGFR mediated cancers. The disclosure further relates to methods of treating cancers such as glioblastoma and other EGFR mediated cancers that have been determined to have altered glucose metabolism in the presence of inhibitors. The present disclosure also provides methods of administering to a subject a glucose metabolism inhibitor and a cytoplasmic p53 stabilizer.
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公开(公告)号:US11345672B2
公开(公告)日:2022-05-31
申请号:US16688469
申请日:2019-11-19
申请人: Valo Health, Inc.
发明人: Jennifer Lee , Nicholas Barczak , Jaime A. Escobedo , Chiara Conti , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Xiaozhang Zheng
IPC分类号: C07D263/58 , A61P35/00 , A61K31/403 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4192 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/437 , A61K31/438 , A61K31/4439 , A61K31/4709 , A61K31/4985 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07C53/06 , C07D209/40 , C07D209/54 , C07D221/20 , C07D235/30 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D473/00 , C07D487/04 , C07D491/056 , C07D491/107 , C07D498/04
摘要: The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.
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公开(公告)号:US20220162198A1
公开(公告)日:2022-05-26
申请号:US17602989
申请日:2020-04-09
发明人: Melissa SPENCER , Varghese JOHN , Irina KRAMEROVA , Jian LIU , Jesus CAMPAGNA , Barbara JAGODZINSKA
IPC分类号: C07D405/12 , C07D405/14 , C07D491/056 , A61P21/00
摘要: Compositions and methods of use for a compound having a chemical structure of Formula (I) and/or Formula (VII), or a pharmaceutically acceptable salt or solvate thereof, to increase muscle mass, muscle oxidative capacity, and muscle function and to treat muscular dystrophy, in particular limb girdle muscular dystrophy type 2A/R1/D1 are disclosed.
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公开(公告)号:US20220153752A1
公开(公告)日:2022-05-19
申请号:US17499048
申请日:2021-10-12
申请人: TORQUR AG , UNIVERSITÄT BASEL
发明人: Vladimir CMILJANOVIC , Paul HEBEISEN , Florent BEAUFILS , Thomas BOHNACKER , Denise RAGEOT , Alexander SELE , Matthias WYMANN , Jean-Baptiste LANGLOIS
IPC分类号: C07D498/08 , A61K31/53 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D239/48 , C07D491/048 , C07D491/056 , C07D491/20 , C07D519/00 , A61P35/00 , C07D417/14 , C07D491/107 , C07D491/18
摘要: The invention relates to novel phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR) and PI3K-related kinase (PIKKs) inhibitor compounds of formula (I), wherein X1, X2 and X3 are N or CH, with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.
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公开(公告)号:US20220135598A1
公开(公告)日:2022-05-05
申请号:US17515758
申请日:2021-11-01
发明人: Brahmam Pujala , Amantullah Ansari , Shreya Sapra , Pradeep S. Jadhavar , Dhananjay Pendharkar , Sreekanth A. Ramachandran , Uzma Saeed , Abhinandan Danodia , Farha Khan , Sagar Patni , Sanjeev Soni , Ashu Gupta , Sarvajit Chakravarty , Balaji Dashrath Sathe
IPC分类号: C07F5/02 , C07D403/04 , C07D471/04 , C07D487/04 , C07D491/056 , C07F9/6558 , C07D401/14 , C07D403/14
摘要: The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.
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