专利检索 ipc:C07D491/10 第 1 页

1.

发明授权
Substituted 4-aminoisoindoline-1,3-dione compounds, compositions thereof, and methods of treatment therewith 有权

公开(公告)号：US11945804B2

公开(公告)日：2024-04-02

申请号：US17743313

申请日：2022-05-12

申请人： Celgene Corporation

发明人： Matthew D. Alexander , Soraya Carrancio , Matthew D. Correa , Virginia Heather Sharron Grant , Joshua Hansen , Roy L. Harris , Dehua Huang , Timothy S. Kercher , Antonia Lopez-Girona , Mark A. Nagy , Veronique Plantevin-Krenitsky

IPC分类号： C07D403/14 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/04 , C07D401/14 , C07D407/14 , C07D417/14 , C07D491/08 , C07D491/10 , C07D491/107 , C07D498/08

CPC分类号： C07D403/14 , A61P35/00 , C07D407/14

摘要： Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure:

wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

2.

发明授权
Alpha-cinnamide compounds and compositions as HDAC8 inhibitors 有权

公开(公告)号：US11919839B2

公开(公告)日：2024-03-05

申请号：US17238529

申请日：2021-04-23

申请人： Valo Health, Inc.

发明人： Kenneth W. Bair , Nicholas Barczak , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Mary-Margaret Zablocki , Xiaozhang Zheng

IPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10

CPC分类号： C07C259/06 , A61K31/185 , A61K31/277 , A61K31/397 , A61K31/4035 , A61K31/407 , A61K31/417 , A61K31/4184 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/495 , A61K31/5377 , C07D207/10 , C07D207/267 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/46 , C07D211/16 , C07D211/58 , C07D213/56 , C07D213/65 , C07D213/75 , C07D213/81 , C07D215/12 , C07D221/20 , C07D231/14 , C07D231/18 , C07D233/36 , C07D233/38 , C07D233/68 , C07D235/14 , C07D235/30 , C07D239/20 , C07D239/22 , C07D241/08 , C07D241/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D277/56 , C07D295/155 , C07D295/192 , C07D307/68 , C07D317/68 , C07D333/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D493/08 , C07D495/10 , C07D498/04 , C07D513/10 , Y02A50/30

摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

3.

发明授权
Delayed fluorescent compound, and organic light emitting diode and organic light emitting display device including the same 有权

公开(公告)号：US11667647B2

公开(公告)日：2023-06-06

申请号：US16712159

申请日：2019-12-12

申请人： LG Display Co., Ltd. , Soulbrain Co., Ltd.

发明人： Suk-Young Bae , Tae-Ryang Hong , Jun-Yun Kim , Jin-Hee Kim , Ah-Rang Lee

IPC分类号： C07D491/10 , C07D491/107 , C07D495/10 , H01L51/00 , H01L51/50

CPC分类号： C07D491/107 , C07D495/10 , H01L51/0054 , H01L51/0067 , H01L51/0072 , H01L51/0073 , H01L51/0074 , H01L51/5004

摘要： The disclosure provides a delayed fluorescent compound of the Formula

and an organic light emitting diode including a first electrode, a second electrode and an organic emitting layer between the first and second electrodes, where the delayed fluorescent compound is included in the organic emitting layer, and an organic light emitting display device including the organic emitting layer.

4.

发明授权
Methods of use of cyclopamine analogs 有权

公开(公告)号：US11602527B2

公开(公告)日：2023-03-14

申请号：US17035611

申请日：2020-09-28

申请人： Infinity Pharmaceuticals, Inc.

发明人： Alfredo C. Castro , Michael J. Grogan , Karen J. McGovern , Martin R. Tremblay

IPC分类号： A61K31/4355 , C07D307/94 , C07D471/04 , C07D471/10 , A61K31/58 , C07D491/04 , C07D491/10 , C07J69/00 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , C07D491/107 , A61K45/06 , C07D491/048 , A61K9/00 , A61N5/10

摘要： The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:

5.

发明申请
NUCLEAR RECEPTOR MODULATORS 有权

公开(公告)号：US20230066771A1

公开(公告)日：2023-03-02

申请号：US17443264

申请日：2021-07-23

申请人： AbbVie Inc.

发明人： Maria A. Argiriadi , Eric C. Breinlinger , Kevin P. Cusack , Adrian D. Hobson , Dominique Potin , Martine Barth , Jerome Amaudrut , Olivia Poupardin , Laurent Mounier , Michael E. Kort

IPC分类号： C07D209/08 , C07D401/10 , C07D403/10 , C07D401/14 , C07D405/12 , C07D401/06 , C07D491/107 , C07D405/14 , C07D235/06 , C07D471/04 , C07D487/04 , C07D231/56 , C07D235/16 , C07D405/10 , C07D491/10 , C07D209/14 , C07D209/18

摘要： The invention provides compounds of Formula (I) pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.

6.

发明申请
MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO 有权

公开(公告)号：US20220396579A1

公开(公告)日：2022-12-15

申请号：US17726807

申请日：2022-04-22

申请人： Arena Pharmaceuticals, Inc.

发明人： Thuy-Anh Tran , Brett Ullman , Bryan Aubrey Kramer , Quyen-Quyen Thuy Do , Young-Jun Shin

IPC分类号： C07D491/048 , C07D491/10 , A61P9/04

摘要： The present invention relates to compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the beta-3 adrenergic receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of a beta-3 adrenergic receptor-mediated disorder, such as, heart failure and related disorders thereto

7.

发明申请
COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES 有权

公开(公告)号：US20220340581A1

公开(公告)日：2022-10-27

申请号：US17719653

申请日：2022-04-13

申请人： Galapagos NV

发明人： Luke Jonathan ALVEY , Denis Maurice ANNOOT , Florence Marie-Emilie BONNATERRE , Denis BUCHER , Béranger DUTHION , Hélène Marie JARY , Christophe PEIXOTO , Taoues TEMAL-LAIB , Amynata TIRERA , Nicolas DESROY

IPC分类号： C07D487/04 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D471/04 , C07D491/10 , C07D495/10

摘要： The present invention discloses compounds according to Formula I: wherein R1, R2, R3a, R3b, X, Y1, Y2, Y3, and Z are as defined herein.
The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of TNFα, interferons, IL-6, IL-12 and/or IL-23, respiratory diseases, endocrine and/or metabolic diseases, cardiovascular diseases, dermatological diseases, and/or abnormal angiogenesis associated diseases by administering the compound of the invention.

8.

发明授权
Azaspiro[4.5]decane derivatives and use thereof 有权

公开(公告)号：US11180502B2

公开(公告)日：2021-11-23

申请号：US15869538

申请日：2018-01-12

申请人： Purdue Pharma L.P.

发明人： Mark A. Youngman , Laykea Tafesse , Jae Hyun Park

IPC分类号： C07D471/10 , C07D401/14 , C07D491/10 , C07D491/107 , A61K31/435 , A61K31/495

摘要： The invention provides azaspiro[4.5]decane derivatives of Formula (A): and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers thereof, wherein A1, X, A2, Rr, R2′, W1, W2, R3′, R4′, a, and b are defined in the disclosure. The invention also provides compounds of Formulae I, and B-G, and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers thereof. Further, the invention provides use of the compounds of Formulae A-G and I, and the pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers thereof, to treat pain. In certain embodiments, Compounds of the Disclosure are useful for treating a disorder responsive to blockade of one or more sodium channels.