公开(公告)号：US20240360179A1

公开(公告)日：2024-10-31

申请号：US18568212

申请日：2022-06-08

申请人： FOG PHARMACEUTICALS, INC.

发明人： Brian Halbert White ,  Daniel Seungduk La ,  Lorenzo Josue Alfaro-Lopez ,  Paula Cristina Ortet ,  Sarah Isabelle Cappucci ,  Zhi Li ,  John Hanney McGee ,  Martin Robert Tremblay ,  Gregory L. Verdine ,  Yaguang Si ,  Kevin Ling ,  Peicheng Du ,  Jonathan Barry Hurov

IPC分类号： C07K7/56 ,  A61K38/00 ,  A61K45/06 ,  A61P35/00 ,  C07K1/107

CPC分类号： C07K7/56 ,  A61K45/06 ,  A61P35/00 ,  C07K1/1077 ,  A61K38/00

摘要： Among other things, the present disclosure provides various useful agents. In some embodiments, provided agents can bind to beta-catenin. In some embodiments, the present disclosure provides technologies for modulating beta-catenin functions. In some embodiments, the present disclosure provides technologies for preventing and/or treating conditions, disorders or diseases associated with beta-catenin. In some embodiments, the present disclosure provides designed amino acids and agents which can provide improved properties and/or activities.

公开(公告)号：US20240336664A1

公开(公告)日：2024-10-10

申请号：US18294862

申请日：2022-08-04

申请人： Adarsha Koirala

发明人： Adarsha Koirala ,  Karen Ellen Petra De Ceunynck

IPC分类号： C07K14/47 ,  A61K9/00 ,  A61K38/00 ,  A61K48/00 ,  C07K1/107 ,  C12N15/87

CPC分类号： C07K14/4708 ,  A61K9/0019 ,  A61K48/005 ,  C07K1/1077 ,  C12N15/87 ,  A61K38/00 ,  C07K2319/09 ,  C07K2319/33 ,  C07K2319/35 ,  C07K2319/70 ,  C07K2319/80

摘要： The present disclosure includes, among other things, methods and compositions for systemic (e.g., intravenous) delivery of sulfated polypeptide agents. In various embodiments, the present disclosure includes methods and compositions that reduce toxicity of systemic administration of polypeptide agents. In various embodiments, the present disclosure includes methods and compositions that cause or increase delivery of polypeptide agents to target cells, tissues, or organs (e.g., muscle, e.g., skeletal muscle, cardiac muscle, and/or diaphragm) following systemic (e.g., intravenous) delivery. In various embodiments, the present disclosure provides promoter sequences that achieve advantageous expression of operably linked coding sequences in muscle, e.g., in skeletal muscle, cardiac muscle, and/or diaphragm.

公开(公告)号：US20240327464A1

公开(公告)日：2024-10-03

申请号：US18289027

申请日：2023-02-10

申请人： C-BIOMEX CO., LTD.

发明人： Song Gil Lee ,  Hye Sook Ha ,  Jin Hwi Park ,  Se Won Kim ,  Yoo Joung Oh ,  Seo Hyun Park ,  Shin Young Park ,  Jun Hoe Cha

IPC分类号： C07K7/64 ,  A61K47/64 ,  A61K49/00 ,  A61K51/08 ,  A61P35/00 ,  C07K1/107

CPC分类号： C07K7/64 ,  A61K47/64 ,  A61K49/0056 ,  A61K51/088 ,  A61P35/00 ,  C07K1/1077

摘要： The present invention relates to a peptide ligand that specifically binds to carbonic anhydrase IX (CAIX), a peptide construct comprising the ligand, and a use thereof. The CAIX-binding peptide ligand of the present invention includes D-amino acids, so it is stable in the body and has high binding specificity to CAIX. And the linear or cyclic CAIX-binding peptide construct comprising the ligand can bind to CAIX with high affinity in the body. Therefore, it is useful for diagnosis, prevention, suppression or treatment of diseases mediated by CAIX.

公开(公告)号：US20240327457A1

公开(公告)日：2024-10-03

申请号：US18434662

申请日：2024-02-06

申请人： Wisconsin Alumni Research Foundation

发明人： Shaoqin Gong ,  Min Zhu ,  Xianghui Xu

IPC分类号： C07K5/02 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/711 ,  C07K1/107

CPC分类号： C07K5/0215 ,  A61K9/5123 ,  A61K31/7105 ,  A61K31/711 ,  C07K1/1077

摘要： The present technology provides disulfide-containing lipopeptides of Formula I. Such lipids may be incorporated into lipid nanoparticles for delivery of nucleic acids, nucleotides (e.g., NAD+ or NADH), polypeptides (including proteins), and complexes of proteins and nucleic acids, e.g., Cas9 RNP. The present technology also provides methods for delivering the nanoparticles to a cell and methods of treating a condition or disorder using the lipid nanoparticles.

公开(公告)号：US12097242B2

公开(公告)日：2024-09-24

申请号：US17721569

申请日：2022-04-15

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Gene M. Dubowchik ,  Olafur S. Gudmundsson ,  Xiaojun Han ,  R. Michael Lawrence ,  Dasa Lipovsek ,  Cort S. Madsen ,  Claudio Mapelli ,  Paul E. Morin ,  Michael C. Myers

IPC分类号： A61K38/22 ,  A61K38/18 ,  C07K1/107 ,  C07K14/64 ,  A61K38/00 ,  A61K45/06 ,  A61K47/64 ,  A61P9/00

CPC分类号： A61K38/18 ,  A61K38/2221 ,  C07K1/1077 ,  C07K14/64 ,  A61K38/00 ,  A61K45/06 ,  A61K47/64 ,  A61P9/00

摘要： The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.

公开(公告)号：US20240277859A1

公开(公告)日：2024-08-22

申请号：US18682046

申请日：2022-08-22

申请人： Genentech, Inc.

发明人： Rachel Hendricks ,  Matthew Henry Hutchinson ,  Mark Frederick Fedesco ,  Bejamin Phu Tran

IPC分类号： A61K47/68 ,  C07K1/107 ,  C07K1/18

CPC分类号： A61K47/68 ,  C07K1/1077 ,  C07K1/18

摘要： The present invention relates to a method of developing purification processes for antibody drug conjugates using cation-exchange chromatography in flow-through mode leveraging the purification conditions of the antibody intermediate without a change to the critical quality attributes (CQA) of the ADC.

公开(公告)号：US20240277795A1

公开(公告)日：2024-08-22

申请号：US18444009

申请日：2024-02-16

申请人： Pardes Biosciences, Inc.

发明人： Daniel J. Buzard ,  Walter Keung ,  Dange Vijay Kumar ,  Erik Verner ,  Lee D. Arnold

IPC分类号： A61K38/05 ,  A61K45/06 ,  A61P31/14 ,  C07K1/107

CPC分类号： A61K38/05 ,  A61K45/06 ,  A61P31/14 ,  C07K1/1077

摘要： The disclosure provides compounds with nitrile warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with nitrile warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20240209053A1

公开(公告)日：2024-06-27

申请号：US18285198

申请日：2022-03-31

申请人： Protagonist Therapeutics, Inc.

发明人： Gregory Thomas BOURNE ,  Ashok BHANDARI

IPC分类号： C07K14/575 ,  A61K38/00 ,  A61P3/12 ,  C07K1/107

CPC分类号： C07K14/575 ,  A61P3/12 ,  C07K1/1077 ,  A61K38/00

摘要： The present invention relates, inter alia, to certain hepcidin peptide analogues, including both peptide monomers and peptide dimers, and conjugates and derivatives thereof, as well as compositions comprising the peptide analogues, and to the use of the peptide analogues in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of erythrocytoses, such as polycytemia vera, iron overload diseases such as hereditary hemochromatosis, iron-loading anemias, and other conditions and disorders described herein.

公开(公告)号：US20240209029A1

公开(公告)日：2024-06-27

申请号：US18555201

申请日：2021-04-21

申请人： The University of Hong Kong

发明人： Yu WANG ,  Xuechen LI ,  Aimin XU ,  Hongxiang WU ,  Yiwei ZHANG ,  Yuanxin LI

IPC分类号： C07K14/00 ,  A61K38/00 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  B01J23/50 ,  C07K1/107 ,  C07K14/575

CPC分类号： C07K14/001 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  B01J23/50 ,  C07K1/1075 ,  C07K14/575 ,  A61K38/00

摘要： An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.

公开(公告)号：US20240182586A1

公开(公告)日：2024-06-06

申请号：US18287539

申请日：2022-05-11

申请人： Northeastern University

发明人： Zhaohui Sunny ZHOU ,  Amissi SADIKI

IPC分类号： C07K16/28 ,  A61K39/00 ,  C07K1/107 ,  C12N9/10 ,  C12N9/24

CPC分类号： C07K16/2863 ,  C07K1/107 ,  C12N9/1044 ,  C12N9/1051 ,  C12N9/2402 ,  A61K2039/505 ,  A61K2123/00 ,  C07K2317/732 ,  C07K2317/90 ,  C12Y204/01133 ,  C12Y302/01096 ,  C12Y302/01097

摘要： Methods for making a site-specific modification of a glycoprotein are provided which preserve the charge and glycoform of the glycoprotein. One or more glycans are trimmed from the glycoprotein, while keeping a core glycan attached to the glycoprotein. The removal of the one or more glycans provides access to a targeted amino acid for a site-specific reaction. The attached core glycan can optionally be utilized for modulation of the glycoprotein, or one or more glycans or reagents can be attached to the core.