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    Identification of novel disease states using viscoelastic analysis in the presence of a thrombolytic agent
    4.
    发明授权
    Identification of novel disease states using viscoelastic analysis in the presence of a thrombolytic agent 有权

    公开(公告)号：US11137409B2

    公开(公告)日：2021-10-05

    申请号：US15524095

    申请日：2015-11-05

    申请人： The Regents of the University of Colorado, a body corporate

    发明人： Michael P. Chapman ,  Hunter B. Moore ,  Eduardo Gonzalez Barreda ,  Ernest E. Moore

    IPC分类号： G01N33/86 ,  A61K38/36 ,  C12Q1/56

    摘要： In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis. In some embodiments, the invention also provides a container adapted for detecting an aberrant fibrinolysis condition in a blood sample using viscoelastic analysis comprising an interior having a coating comprising a thrombolytic agent.

    Blood characteristic measurement
    5.
    发明授权
    Blood characteristic measurement 有权

    公开(公告)号：US11112400B2

    公开(公告)日：2021-09-07

    申请号：US15749116

    申请日：2016-03-07

    申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    发明人： Shameed Sait M A ,  Rachel M. White ,  Chantelle Domingue ,  Manish Giri

    IPC分类号： G01N33/49 ,  G01N27/02 ,  G01N33/561 ,  C12Q1/56 ,  G01N33/86

    摘要： Examples herein provide a method. The method includes applying an electrical potential difference over a blood sample in a testing cassette of a microfluidic device, the cassette including a microfluidic channel through which the blood sample flows. The method includes measuring, over a duration of time, an electrical signal passing through the blood sample as the blood sample flows from a first end and coagulates at a second end of the microfluidic channel to obtain a measurement function as a function of time. The method also includes correlating the measurement function to a characteristic of the blood sample.

    Characterization of blood hemostasis and oxygen transport parameters
    9.
    发明授权
    Characterization of blood hemostasis and oxygen transport parameters 有权

    公开(公告)号：US10962524B2

    公开(公告)日：2021-03-30

    申请号：US14687837

    申请日：2015-04-15

    申请人： HemoSonics LLC

    发明人： Francesco Viola ,  William F. Walker

    IPC分类号： C12Q1/68 ,  G01N15/06 ,  G01N21/00 ,  G01N33/00 ,  G01N31/12 ,  C12Q1/56 ,  G05B21/00 ,  G01N33/48 ,  G01N33/49 ,  G01N29/024 ,  G01N29/032 ,  G01N29/028 ,  G01N29/44

    摘要： An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.