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    BACTERIA ENGINEERED TO TREAT DISORDERS INVOLVING THE CATABOLISM OF A BRANCHED CHAIN AMINO ACID
    2.
    发明申请
    BACTERIA ENGINEERED TO TREAT DISORDERS INVOLVING THE CATABOLISM OF A BRANCHED CHAIN AMINO ACID 审中-公开
    细菌设计用于治疗涉及分支链氨基酸的分解的病症

    公开(公告)号：WO2016201380A8

    公开(公告)日：2017-01-26

    申请号：PCT/US2016037098

    申请日：2016-06-10

    申请人： SYNLOGIC INC

    发明人： FALB DEAN ,  MILLER PAUL ,  MILLET YVES ,  ISABELLA VINCENT ,  KOTULA JONATHAN ,  TUCKER ALEX

    IPC分类号： C12N1/00 ,  A61K35/74

    CPC分类号： A61K35/74 ,  A61K9/0019 ,  A61K9/0053 ,  A61K38/44 ,  A61K38/443 ,  C07K14/245 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0016 ,  C12N9/0022 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12N15/70 ,  C12Y101/01 ,  C12Y101/01001 ,  C12Y101/01086 ,  C12Y104/01009 ,  C12Y104/03002 ,  C12Y206/01042 ,  C12Y401/01 ,  C12Y401/01001

    摘要： The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patient's internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding a branched chain amino acid catabolism enzyme. The disclosure further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders involving the catabolism of branched chain amino acids using the pharmaceutical compositions disclosed herein.

    摘要翻译： 本公开内容提供了已经用遗传电路工程化的重组细菌细胞，所述遗传电路允许重组细菌细胞感测患者的内部环境并且通过开启或关闭工程化的代谢途径来进行响应。 打开时，重组细菌细胞完成代谢途径中的所有步骤以在宿主受试者中实现治疗效果。 这些重组细菌细胞被设计为从微生物组的起源点驱动整个宿主体内的治疗效果。 具体而言，本公开提供了包含编码支链氨基酸分解代谢酶的异源基因的重组细菌细胞。 本公开还提供了包含重组细菌的药物组合物，以及使用本文公开的药物组合物治疗涉及支链氨基酸分解代谢的病症的方法。

    NOVEL RHTB PROTEIN VARIANTS AND THE METHOD OF PRODUCING O-PHOSPHOSERINE USING THE SAME
    8.
    发明申请
    NOVEL RHTB PROTEIN VARIANTS AND THE METHOD OF PRODUCING O-PHOSPHOSERINE USING THE SAME 审中-公开
    新型RHTB蛋白质变体和使用其生产O-磷酸酯的方法

    公开(公告)号：WO2014182119A1

    公开(公告)日：2014-11-13

    申请号：PCT/KR2014/004150

    申请日：2014-05-09

    申请人： CJ CHEILJEDANG CORPORATION

    发明人： KIM, Sol ,  KIM, Hye Won ,  CHANG, Jin Sook ,  YOO, In Hwa

    IPC分类号： C07K14/195 ,  C12N15/31 ,  C12N15/63 ,  C12P13/06

    CPC分类号： C07K14/245 ,  C12N9/0006 ,  C12N9/1096 ,  C12N9/16 ,  C12N15/52 ,  C12N15/63 ,  C12P13/005 ,  C12P13/06 ,  C12P13/12

    摘要： The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.

    摘要翻译： 本发明涉及具有增强作为L-半胱氨酸前体的O-磷酸丝氨酸（OPS）的能力的RhtB（高丝氨酸/高丝氨酸内酯输出转运蛋白）蛋白质，编码该蛋白质的多核苷酸，包含多核苷酸的载体， 包含蛋白质变体的OPS生成微生物，使用该微生物生产O-磷酸丝氨酸的方法，以及制备半胱氨酸或其衍生物的方法，其包括使上述方法制备的O-磷酸丝氨酸与硫化物在存在下反应 的O-磷酸丝氨酸巯基化酶（OPSS）或表达OPSS的微生物。