公开(公告)号：WO9958955A9

公开(公告)日：2000-03-02

申请号：PCT/US9910316

申请日：1999-05-13

申请人： LUMINEX CORP

发明人： CHANDLER VAN S

IPC分类号： G01N15/14 ,  G01N21/05 ,  G01N21/53 ,  G01N21/64 ,  G01N33/483

CPC分类号： G01N15/1456 ,  G01N21/05 ,  G01N21/53 ,  G01N21/645 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2015/1493 ,  G01N2021/0346 ,  G01N2021/4707 ,  G01N2021/4726 ,  G01N2021/6441 ,  G01N2021/6482 ,  Y10T436/11 ,  Y10T436/2575

摘要： A multi-analyte diagnostic system for use with a computer (900). The diagnostic system includes a flow analyzer (25) including a co-planar light source-optical detector array (120), the flow analyzer being communicatable with the computer (900). The diagnostic system also includes a memory medium readable by the computer (900) and storing computer instructions. The instructions include the following steps. A biological sample is run through the flow analyzer (25). The identity and quantity of at least one analyte of interest in the biological fluid is determined substantially simultaneously to the sample-running step.

摘要翻译： 用于计算机的多分析物诊断系统（900）。 诊断系统包括流量分析器（25），其包括共面光源 - 光学检测器阵列（120），该流量分析器可与计算机（900）通信。 诊断系统还包括可由计算机（900）读取并存储计算机指令的存储介质。 说明包括以下步骤。 生物样品通过流量分析仪（25）。 生物流体中至少一种感兴趣的分析物的身份和数量基本上与样品运行步骤同时确定。

公开(公告)号：WO99042608A1

公开(公告)日：1999-08-26

申请号：PCT/US1999/004039

申请日：1999-02-24

IPC分类号： B01L3/00 ,  B01L9/00 ,  C40B60/14 ,  C12Q1/00 ,  A01N1/02

CPC分类号： B01L3/5085 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01L9/523 ,  B01L2300/0829 ,  C40B60/14 ,  G01N2021/0346 ,  Y10S435/968 ,  Y10S435/975

摘要： One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic. A further aspect of the present invention is a method of testing a therapeutic for therapeutic activity and toxicology by identifying a therapeutic using a method of the present invention and monitoring the toxicology and efficacy of the therapeutic in an in vivo model. The figures depict a cross section of two embodiments of a multi-well platform.

摘要翻译： 本发明的一个方面是用于荧光测量的多孔平台，其包括框架内的多个孔，其中所述多孔平台具有低荧光背景。 本发明的另一方面是用于光谱测量的系统，其包括用于测定的试剂和用于荧光测量的多孔平台。 本发明的另一方面是通过检测从样品发射的光来检测多孔平台中包含的样品中分析物的存在的方法。 本发明的另一方面是通过检测从样品发射的光来识别多孔平台中包含的样品中生物过程或靶的调节剂的方法。 本发明的另一方面是通过该方法鉴定的组合物。 本发明的另一方面是鉴定治疗剂的方法。 本发明的另一方面是通过使用本发明的方法鉴定治疗剂并监测治疗剂在体内模型中的毒理学和功效来测试治疗活性和毒理学治疗剂的方法。 附图示出了多井平台的两个实施例的横截面。

公开(公告)号：WO99036764A1

公开(公告)日：1999-07-22

申请号：PCT/SE1999/000040

申请日：1999-01-14

IPC分类号： B01F11/02 ,  B01F13/00 ,  G01N21/03 ,  B01L3/00

CPC分类号： B01F11/0266 ,  B01F13/0059 ,  G01N21/03 ,  G01N2021/0346

摘要： A photometer for determining the transmission of a liquid sample in a microcuvette (7, 20, 22) has a cavity for a capillary layer of the liquid sample with a free liquid surface extended transversely of the principal plane of the cavity. The cavity is initially prepared with a reagent to achieve a reaction, which affects the transmission of the liquid sample for indicating its contents of a predetermined substance. The photometer has a holder (6) for the microcuvette and measuring means (9, 10) for measuring the transmission of a bundle of rays directed towards the microcuvette. The cuvette holder (6) is mounted on bearings for vibration in a direction having a component, which extends in the plane of the free liquid surface and is parallel with the principal plane of the cavity, thereby achieving a mixing to accelerate the dissolution and the reaction. A method of carrying out mixing in a thin liquid layer, which is arranged between essentially parallel walls at a capillary distance from each other, is provided by subjecting the walls to a motion essentially in the plane of the liquid layer, balancing the motion against the capillary force exerted by the walls on the liquid, and selecting the interface between the liquid layer and the surrounding medium in such a manner that it functions as an elastic membrane.

摘要翻译： 用于确定液体样品在微型小瓶（7,20,22）中的透射的光度计具有用于液体样品的毛细管层的空腔，其具有横向于腔的主平面延伸的自由液体表面。 最初用试剂制备空腔以实现反应，其影响用于指示其预定物质的内容物的液体样品的透射。 光度计具有用于微型检测器的保持器（6）和测量装置（9,10），用于测量朝向微型检查器的射线束的透射。 将试管支架（6）安装在轴承上，以便在具有部分的方向上振动，该部件在自由液体表面的平面中延伸并与空腔的主平面平行，从而实现混合以加速溶解和 反应。 通过对壁进行基本上在液体层的平面中的运动来提供在薄液体层中进行混合的方法，所述薄液体层以彼此之间的毛细管距离布置在基本上平行的壁之间， 由壁施加在液体上的毛细管力，并且以这样的方式选择液体层和周围介质之间的界面，即其用作弹性膜。

公开(公告)号：WO99018422A1

公开(公告)日：1999-04-15

申请号：PCT/SE1998/001776

申请日：1998-10-02

IPC分类号： B01L3/00 ,  B29C51/00 ,  B29C51/10 ,  G01N21/03

CPC分类号： B01L3/502707 ,  B01F13/0059 ,  B01L2200/0684 ,  B01L2300/0825 ,  B01L2300/0887 ,  B29C51/10 ,  B29C2791/006 ,  G01N21/03 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/0357

摘要： The invention concerns a method for continuous production of disposable capillary plastic microcuvettes including the steps of providing a first and a second sheet; providing at least one depression having a predetermined depth at a predetermined place in at least one of the sheets; introducing at least one additive or reagent in at least one depression; joining the first sheet and the second sheet for obtaining a body member including at least one cavity, the inner walls of which are defined by the at least one depression and a predetermined area of the opposite sheet and cutting out microcuvettes including at least one cavity and having a predetermined size and configuration from the body member, in such a way that at least one cavity of the microcuvette is communicating with the exterior atmosphere of the microcuvette through a capillary sample inlet opening. The invention also concerns a cuvette prepared according to the new method.

摘要翻译： 本发明涉及连续生产一次性毛细管塑料微量储罐的方法，包括提供第一和第二片材的步骤; 在至少一个所述片材中的预定位置处提供具有预定深度的至少一个凹部; 在至少一个凹陷中引入至少一种添加剂或试剂; 接合第一片和第二片，用于获得包括至少一个腔的主体构件，其内壁由至少一个凹部和相对片的预定区域限定，并且切除包括至少一个空腔的微型储罐 具有来自本体构件的预定尺寸和构造，使得微型小瓶的至少一个空腔通过毛细管样品入口开口与微量储存器的外部气氛连通。 本发明还涉及根据新方法制备的比色皿。

公开(公告)号：WO99013986A1

公开(公告)日：1999-03-25

申请号：PCT/EP1998/005838

申请日：1998-09-15

IPC分类号： G01N21/64 ,  B01L3/00 ,  G01N21/03 ,  G01N21/25 ,  G01N21/59 ,  G01N21/65 ,  G01N21/76 ,  G01N35/00

CPC分类号： G01N21/253 ,  B01L9/065 ,  B01L2300/0893 ,  G01N21/03 ,  G01N2021/0346 ,  G01N2035/00237

摘要： There is provided according to the invention an apparatus for the performance of photometric assays comprising: 1. A housing; 2. A plurality of translucent capillaries each being sealed at one end; 3. Means to provide each capillary with photonic isolation from a neighbouring capillary; and 4. Optical instrumentation and circuitry adapted to read an optical response or event in each capillary.

摘要翻译： 根据本发明提供了一种用于执行光度测定的装置，包括：1.壳体; 多个半透明毛细管分别在一端被密封; 3.提供每个毛细管与相邻毛细管的光子隔离的方法; 和4.适用于读取每个毛细管中的光学响应或事件的光学仪器和电路。

公开(公告)号：WO1997046866A1

公开(公告)日：1997-12-11

申请号：PCT/US1997009494

申请日：1997-06-02

申请人： IN USA, INC.

发明人： IN USA, INC. ,  DOSORETZ, Victor, J. ,  BEHR, Daniel ,  KELLER, Scott

IPC分类号： G01N21/59

CPC分类号： G01N21/33 ,  G01N21/03 ,  G01N21/05 ,  G01N21/31 ,  G01N21/3504 ,  G01N2021/0346

摘要： A gas detection and measurement system includes a light source (10), a light sensor (18), a test cell body (12) having a first fluid port (28) and a second fluid port (30), and first and second optical paths (34, 36) from the light source (10) to the light sensor (18) through the test cell (12). The first and second optical paths (34, 36) have different lengths. As fluid flows through the test cell body (12), light intensity measurements are taken along the first and second optical paths (34, 36) so that the concentration of a target gas within the fluid can be calculated.

摘要翻译： 气体检测和测量系统包括光源（10），光传感器（18），具有第一流体端口（28）和第二流体端口（30）的测试电池体（12），以及第一和第二光学 通过测试电池（12）从光源（10）到光传感器（18）的路径（34,36）。 第一和第二光路（34,36）具有不同的长度。 当流体流过测试电池体（12）时，沿着第一和第二光路（34,36）获得光强度测量值，以便可以计算流体内目标气体的浓度。

公开(公告)号：WO1996027785A1

公开(公告)日：1996-09-12

申请号：PCT/US1996002845

申请日：1996-02-28

申请人： ABBOTT LABORATORIES

发明人： ABBOTT LABORATORIES ,  WU, Xiaomao ,  JOU, Yi-Her ,  HUANG, Tung-Ming ,  STROUPE, Stephen, D. ,  LI, Conan, K., N. ,  ALCOCK, Alan, J. ,  GUTIERREZ, Edward, J.

IPC分类号： G01N21/76

CPC分类号： G01N21/05 ,  G01N21/76 ,  G01N2021/0346

摘要： A method and article for conducting a chemiluminescent reaction in which a reaction conduit is provided having a unique configuration for enhanced chemiluminescent signal production and detection. The conduit is preferably provided with a plurality of folds defining multiple substantially different flow paths for reactants flowing therethrough. The method and article are suitable for use in diagnostic assays employing chemiluminescent labels.

摘要翻译： 用于进行化学发光反应的方法和制品，其中提供具有用于增强的化学发光信号产生和检测的独特配置的反应导管。 导管优选地设置有多个折痕，其限定用于流过其中的反应物的多个基本不同的流动路径。 该方法和制品适用于采用化学发光标记的诊断测定。

公开(公告)号：WO1994017556A1

公开(公告)日：1994-08-04

申请号：PCT/US1994000368

申请日：1994-01-10

申请人： FCI-FIBERCHEM, INC.

发明人： FCI-FIBERCHEM, INC. ,  KLAINER, Stanley, M. ,  SAINI, Devinder, P., S. ,  DANDGE, Dileep, K.

IPC分类号： H01L27/14

CPC分类号： H01L51/5012 ,  G01N21/05 ,  G01N21/7703 ,  G01N2021/0346 ,  G01N2021/7763 ,  G01N2201/061 ,  H01L27/305 ,  H01L51/0035 ,  H01L51/0036 ,  H01L51/0038 ,  H01L51/0041 ,  H01L51/4206 ,  H01L51/4213 ,  Y02E10/549

摘要： An optical sensor (10) is produced with a polymer based light source (18) and/or polymer based light detector (28). An electroluminescent source (18) has a conducting polymer layer (20) or alternatively a phosphor layer (20). A detector (28), of either Schottky or heterojunction/hybrid type, has a photoconducing polymer layer (64) or adjacent conducting polymer (76) and semiconductor (78) layers where at least one is photoconducting.

摘要翻译： 用基于聚合物的光源（18）和/或基于聚合物的光检测器（28）制造光学传感器（10）。 电致发光源（18）具有导电聚合物层（20）或者可选地具有磷光体层（20）。 肖特基或异质结/杂化型的检测器（28）具有光电导聚合物层（64）或相邻的导电聚合物（76）和至少一个是光导的半导体（78）层。

公开(公告)号：WO1993020939A1

公开(公告)日：1993-10-28

申请号：PCT/US1993003361

申请日：1993-04-07

申请人： BIOTRACK, INC.

发明人： BIOTRACK, INC. ,  SUBRAMANIAN, Kumar ,  SUGARMAN, Jeffrey ,  STERLING, Bernhard, Boe ,  VOSS, Fred ,  SALTMAN, Marina

IPC分类号： B01L03/00

CPC分类号： G01N21/03 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/082 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0457 ,  G01N21/474 ,  G01N2021/0346 ,  G01N2021/035 ,  Y10S366/01

摘要： A diagnosis system, which comprises a monitor, comprising means for detecting multiple reflectance readings in an array of individual locations, means for registering an analytical cartridge in the monitor at a fixed location and orientation relative to the array, and means for determining and displaying analytical results from reflectance readings; and an analytical cartridge, comprising a liquid impervious housing, a sample application site in the housing located outside the monitor when the cartridge is registered in the monitor by the means for registering, one or more reflectance reading sites in the housing that register with one or more of the locations in the array, a capillary pathway in the housing leading from the sample application site to each of the reflectance reading sites, and a reflectance matrix located in at least one of the reflectance reading sites. In some embodiments of the invention, control features that optimize accuracy of measurement by controlling when and if sample reaches reflectance reading sites and by drawing excess sample away from undesirable locations in the cartridge are present. One control element balances the liquid-holding capacities of the application site, the sample-transporting capillary passageway that leads to the reflectance reading site, and the porous matrices from which the reflectance reading will be made, so that excess sample is excluded from entry into the cartridge while sample volumes that are below the minimum necessary for accurate operation do not reach the matrix, thereby avoiding false readings.

公开(公告)号：WO1993016372A1

公开(公告)日：1993-08-19

申请号：PCT/US1993001300

申请日：1993-02-12

申请人： PRECISION DETECTORS, INC.

发明人： PRECISION DETECTORS, INC. ,  FORD, Norman, C., Jr.

IPC分类号： G01N21/49

CPC分类号： G01N21/49 ,  G01N21/53 ,  G01N2021/0346 ,  G01N2021/0392 ,  G01N2021/4711 ,  G01N2021/4728 ,  G01N2201/064 ,  G01N2201/0642 ,  G01N30/74 ,  G01N21/05

摘要： A molecular characterization detector (8) includes a scattering cell (10) containing a sample for molecular characterization, a light source (20) for directing a light beam through the cell (10) so that the light beam is scattered by the sample, optical elements (30, 32, 50, 52) for selecting from the scattered light a measurement beam (40) comprising light that is scattered by the sample from a predetermined portion of the cell (10) in a predetermined range of angles relative to the optical axis (22), and a detector (44) for detecting the measurement beam and providing an output electrical signal representative of the measurement beam. The detector (44) typically selects light scattered from a central portion of the scattering cell at angles in the range of 14° to 16°. A single spherical lens (18) is preferably utilized. As a result, interference from stray scattered light is minimized. A beam dump (24) attenuates the light beam after it passes through the scattering cell (10). Additional detectors (62, 70, 80) detect light scattered at 90° to the light beam. The outputs of the detectors (44, 62, 70, 80) are processed to provide molecular characterization of the sample.