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    PANCREATIC INSULIN-PRODUCING BETA-CELL LINES DERIVED FROM HUMAN PLURIPOTENT STEM CELLS
    52.
    发明申请
    PANCREATIC INSULIN-PRODUCING BETA-CELL LINES DERIVED FROM HUMAN PLURIPOTENT STEM CELLS 审中-公开
    胰岛素生产胰岛素干细胞衍生的细胞系

    公开(公告)号：WO2014130887A1

    公开(公告)日：2014-08-28

    申请号：PCT/US2014/017823

    申请日：2014-02-21

    申请人： CEDARS-SINAI MEDICAL CENTER

    发明人： TALAVERA-ADAME, Dodanim ,  DAFOE, Donald C.

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0676 ,  A61K35/39 ,  C12N5/0677 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/117 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/30 ,  C12N2501/385 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2501/999 ,  C12N2502/28 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2533/90

    摘要： Production of beta-cells from stem cells from pluripotent stem cells have always been significantly lacking in at least one of the following properties: 1) functional properties related to insulin-production and glucose signaling response, 2) mature phenotype such as biochemical markers or cell structures, 3) efficiency in production of differentiated cells. Described herein is multistep differentiation protocol which substantially overcomes all of the existing limitations. Pluripotent stem cells, including induced pluripotent stem cells (iPSCs), and embryonic stem cells (ESCs) can be differentiated using an embryoid body (EB) formation step, followed by B maturation via endothelial cells (EC) co-culturing and incubation with a sequential series of bone morphogenic protein (BMP)-related growth factor cocktails. The resulting cells displayed functional properties, including insulin-production and glucose signaling response, and mature phenotype of C-peptide expression.

    摘要翻译： 从多能干细胞的干细胞中产生β-细胞一直在以下性质中至少存在一个缺点：1）与胰岛素生成和葡萄糖信号传导反应相关的功能特性，2）成熟表型如生化标记物或细胞 结构，3）分化细胞生产的效率。 本文描述了基本上克服了所有现有限制的多步差异化方案。 可以使用胚状体（EB）形成步骤来分化多能干细胞，包括诱导多能干细胞（iPSCs）和胚胎干细胞（ESCs），然后通过内皮细胞（EC）共培养并与 连续系列的骨形态发生蛋白（BMP）相关生长因子鸡尾酒。 所得细胞显示功能性质，包括胰岛素生产和葡萄糖信号传导反应，以及C肽表达的成熟表型。

    BI-FUNCTIONAL COMPOSITIONS FOR TARGETING CELLS TO DISEASED TISSUES AND METHODS OF USING SAME
    55.
    发明申请
    BI-FUNCTIONAL COMPOSITIONS FOR TARGETING CELLS TO DISEASED TISSUES AND METHODS OF USING SAME 审中-公开
    用于将细胞靶向疾病组织的双功能组合物及其使用方法

    公开(公告)号：WO2013166281A1

    公开(公告)日：2013-11-07

    申请号：PCT/US2013/039255

    申请日：2013-05-02

    申请人： CEDARS-SINAI MEDICAL CENTER

    发明人： MARBÁN, Eduardo ,  CHANG, Ke

    IPC分类号： A61K33/00

    CPC分类号： A61K49/1875 ,  A61K47/6923 ,  B82Y5/00

    摘要： Disclosed herein are compositions and methods for the targeted delivery of therapeutic cells to a target tissue. In several embodiments, the therapeutic cells are captured by an antibody that is coupled to a magnetic particle, which is in turn coupled to an antibody directed against a specific marker expressed by a target tissue. In some embodiments, the therapeutic cells comprise the target tissue is damaged or diseased cardiac tissue. In several embodiments, in conjunction with an applied magnetic field, the methods, in combination with the compositions, yield enhanced delivery, of the therapeutic cells to the target tissue, thereby resulting in repair and/or regeneration of the target tissue. Also disclosed are methods for the non-invasive detection of immune responses to transplanted cells or organs.

    摘要翻译： 本文公开了将靶向组织靶向递送治疗细胞的组合物和方法。 在几个实施方案中，治疗细胞被与偶联到磁性颗粒的抗体捕获，抗体依次与针对靶组织表达的特异性标记的抗体偶联。 在一些实施方案中，治疗性细胞包含靶组织被损坏或患病的心脏组织。 在几个实施方案中，结合施加的磁场，与组合物组合的方法产生治疗细胞到目标组织的增强的递送，从而导致靶组织的修复和/或再生。 还公开了用于非侵入性检测对移植的细胞或器官的免疫应答的方法。

    ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER
    56.
    发明申请
    ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER 审中-公开
    抗氧化剂，包含治疗药物的神经保护和抗原性纳米颗粒在AMPHIPHILIC间隔剂或AMPHIPHILIC聚合物

    公开(公告)号：WO2013016696A1

    公开(公告)日：2013-01-31

    申请号：PCT/US2012/048703

    申请日：2012-07-27

    申请人： CEDARS-SINAI MEDICAL CENTER ,  YU, John ,  LEE, Bong Seop

    发明人： YU, John ,  LEE, Bong Seop

    IPC分类号： A61K9/14 ,  C07D339/02 ,  C07D405/00 ,  A01N43/26

    CPC分类号： A61K47/48869 ,  A61K9/5123 ,  A61K38/00 ,  A61K47/55 ,  A61K49/0032 ,  A61K49/0052

    摘要： This invention relates to antioxidant, neuroprotective and antineoplastic nanoparticles comprising a therapeutic agent on an amphiphilic spacer or an amphiphilic polymer. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, NSAIDs and statins, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant, neuroprotective and anti-neoplastic nanoparticles comprising a therapeutic agent on an amphiphilic spacer or an amphiphilic polymer and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these neuroprotective and anti-neoplastic nanoparticles for the preparation of delivery devices of other pharmaceuticals and/or drugs.

    摘要翻译： 本发明涉及包含在两亲性间隔物或两亲性聚合物上的治疗剂的抗氧化剂，神经保护和抗肿瘤纳米颗粒。 合成喜树碱抗氧化剂衍生物和喜树碱类似物抗氧化剂衍生物，NSAIDs和他汀类药物的方法，自发乳化或纳米沉淀，以产生抗氧化剂，神经保护和抗肿瘤纳米颗粒，其包含两亲性间隔基或两亲性聚合物上的治疗剂及其用途 还提供治疗癌性疾病。 本发明的另一方面是这些神经保护和抗肿瘤纳米颗粒在制备其它药物和/或药物的递送装置中的用途。

    EARPHONES AND HEARING AIDS
    57.
    发明申请
    EARPHONES AND HEARING AIDS 审中-公开
    耳鸣和听力艾滋病

    公开(公告)号：WO2012167234A1

    公开(公告)日：2012-12-06

    申请号：PCT/US2012/040699

    申请日：2012-06-04

    申请人： CEDARS-SINAI MEDICAL CENTER ,  PEDEMONTE, Marisa ,  DREXLER, Daniel ,  BIANCO, Andres ,  GEISINGER, Dario

    发明人： PEDEMONTE, Marisa ,  DREXLER, Daniel ,  BIANCO, Andres ,  GEISINGER, Dario

    IPC分类号： H04R25/00

    CPC分类号： H04R1/1041 ,  H04R3/007 ,  H04R25/305 ,  H04R25/75 ,  H04R2225/39 ,  H04R2225/61 ,  H04R2430/01

    摘要： An earphones system providing insert detection, volume limiting, and equalization features for use with audio players or systems, including systems that provide external sound treatment to individuals suffering from tinnitus, is described. The earphones system may include an audio player or may be useable with an audio player operative to provide audio signals (e.g., for the treatment of tinnitus). Also described is a hearing aid system providing insert detection that operates by sensing changes in temperature, skin conductance, pressure or strain, or changes in sound. The hearing aid system is operative to send insert detection information to an external device such as a computer or mobile phone. The external device is configured to generate an alarm or other notification alerting a user that the hearing aid has come out the ear. Data concerning the insertion of the hearing aid may also be collected for further analysis.

    摘要翻译： 描述了提供用于音频播放器或系统的插入检测，音量限制和均衡功能的耳机系统，包括为耳鸣患者提供外部声音治疗的系统。 耳机系统可以包括音频播放器，或者可以与可操作以提供音频信号（例如，用于治疗耳鸣）的音频播放器一起使用。 还描述了提供插入物检测的助听器系统，其通过检测温度，皮肤电导，压力或应变或声音变化的变化来操作。 助听器系统可操作以将插入检测信息发送到诸如计算机或移动电话的外部设备。 外部设备被配置为产生警报或其他通知，提醒用户助听器已经脱出耳朵。 关于助听器插入的数据也可以被收集用于进一步的分析。

    LIPOSOMAL VANCOMYCIN FOR THE TREATMENT OF MRSA INFECTIONS
    59.
    发明申请
    LIPOSOMAL VANCOMYCIN FOR THE TREATMENT OF MRSA INFECTIONS 审中-公开
    用于治疗MRSA感染的脂肪性血友病

    公开(公告)号：WO2012149116A2

    公开(公告)日：2012-11-01

    申请号：PCT/US2012035134

    申请日：2012-04-26

    申请人： CEDARS SINAI MEDICAL CENTER ,  LIU GEORGE Y ,  OMRI ABDEL ,  SANDE LINETTE

    发明人： LIU GEORGE Y ,  OMRI ABDEL ,  SANDE LINETTE

    IPC分类号： A61K9/127

    CPC分类号： A61K9/127 ,  A61K38/14

    摘要： The present invention discloses formulations of liposomal vancomycin that are highly effective in the treatment of bacterial infections, and particularly MRSA infections. The present invention further teaches methods of using the formulations disclosed herein for the treatment of bacterial infections. The inventors determined that certain formulations disclosed herein are likely to result in lower toxicity than what is normally associated with vancomycin treatment.

    摘要翻译： 本发明公开了在治疗细菌感染，特别是MRSA感染方面非常有效的脂质体万古霉素制剂。 本发明进一步教导了使用本文公开的制剂治疗细菌感染的方法。 发明人确定本文公开的某些制剂可能导致比通常与万古霉素处理相关的更低的毒性。

    DIAGNOSTIC BIOMARKER TO PREDICT WOMEN AT RISK FOR PRETERM DELIVERY
    60.
    发明申请
    DIAGNOSTIC BIOMARKER TO PREDICT WOMEN AT RISK FOR PRETERM DELIVERY 审中-公开
    诊断生物标志物预防妇女的风险预先提供

    公开(公告)号：WO2012125641A1

    公开(公告)日：2012-09-20

    申请号：PCT/US2012/028934

    申请日：2012-03-13

    申请人： CEDARS-SINAI MEDICAL CENTER ,  EQUILS, Ozlem O. ,  SIMMONS, Jr., Charles F.

    发明人： EQUILS, Ozlem O. ,  SIMMONS, Jr., Charles F.

    IPC分类号： G01N33/53 ,  G01N33/00

    CPC分类号： G01N33/689 ,  G01N33/6863 ,  G01N33/6866 ,  G01N33/6869 ,  G01N2800/368

    摘要： The invention relates to bioniarkers associated with preterm delivery. More specifically, the invention provides methods of measuring bioniarkers including but not limited to cytokines, cytokine receptors, cytokine receptor antagonists, chemokines, chemokine receptors, and/or chemokine receptor antagonists found in women thai are at risk for preterm delivery. The diagnostic methods may be performed on whole blood.

    摘要翻译： 本发明涉及与早产分娩相关的二硫代酸。 更具体地，本发明提供了测量生物标记物的方法，包括但不限于在早产的风险中的妇女中发现的细胞因子，细胞因子受体，细胞因子受体拮抗剂，趋化因子，趋化因子受体和/或趋化因子受体拮抗剂。 诊断方法可以在全血上进行。