Abstract:
There is set forth in one embodiment an apparatus and method for imparting a phase shift to an input waveform for output of a converted waveform. In one embodiment, a phase shift can be provided by four wave mixing of an input waveform and a pump pulse. In one embodiment, there is set forth an apparatus and method for generating a high resolution time domain representation of an input waveform comprising: dispersing the input waveform to generate a dispersed input waveform; subjecting the dispersed input waveform to four wave mixing by combining the dispersed input waveform with a dispersed pump pulse to generate a converted waveform; and presenting the converted waveform to a detector unit. In one embodiment a detector unit can include a spectrometer (spectrum analyzer) for recording of the converted waveform and output of a record representing the input waveform.
Abstract:
An angle-sensitive pixel (ASP) device that uses the Talbot effect to detect the local intensity and incident angle of light includes two local diffraction gratings stacked above a photodiode. When illuminated by a plane wave, the upper grating generates a self-image at a selected Talbot depth. The second grating, placed at this depth, blocks or passes light depending upon incident angle. Several such structures, tuned to different incident angles, are sufficient to extract local incident angle and intensity. Arrays of such structures are sufficient to localize light sources in three dimensions without any additional optics.
Abstract:
A method for detecting target nucleic acids such as SNPs is provided. The method comprises performing a ligase detection reaction (LDR), performing surface enhanced Raman scattering (SERS) on the LDR, and analyzing the outcome of the LDR using analysis and/or quantification of the SERS by detecting an emitted Raman signature. The LDR-SERS method can be used for sensitive and specific detection of any nucleic acid sequence of interest. A microfluidic SERS detection device is also provided. The device comprises electrokinetically active microwells for mixing and concentrating analytes and in which analytes can be quantified. The device can be used for performing the LDR-SERS method in optofluidic chip format.
Abstract:
A nucleic acid molecule encoding a mutant form of wild-type translation initiation factor elF4E is disclosed A mutation comprising one or more of I70N, I70E, L82R, DI12N, L48F, S68K, A77D or MI09I in SEQ ID NO 1 imparts virus resistance to potato Nucleic acid constructs, expression vectors, cells, plants, and plant seeds containing the nucleic acid sequence are also disclosed, as are methods of imparting virus resistance to plants
Abstract translation:公开了编码野生型翻译起始因子elF4E的突变形式的核酸分子,其包含SEQ ID NO 1中的I70N,I70E,L82R,DI12N,L48F,S68K,A77D或MI09I中的一个或多个的突变赋予对马铃薯的病毒抗性 还公开了含有核酸序列的核酸构建体,表达载体,细胞,植物和植物种子,以及赋予植物病毒抗性的方法
Abstract:
The present invention is directed to a CMOS integrated micromechanical device fabricated in accordance with a standard CMOS foundry fabrication process. The standard CMOS foundry fabrication process is characterized by a predetermined layer map and a predetermined set of fabrication rules. The device includes a semiconductor substrate formed or provided in accordance with the predetermined layer map and the predetermined set of fabrication rules. A MEMS resonator device is fabricated in accordance with the predetermined layer map and the predetermined set of fabrication rules. The MEMS resonator device includes a micromechanical resonator structure having a surface area greater than or equal to approximately 20 square microns. At least one CMOS circuit is coupled to the MEMS resonator member. The at least one CMOS circuit is also fabricated in accordance with the predetermined layer map and the predetermined set of fabrication rules.
Abstract:
A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.
Abstract:
Methods and compositions are provided for producing hydrogel nucleic acid structures using photo-crosslinking. Methods of using the photo-crosslmked hydrogels for cell-free protein production, and for encapsulating and delivering compounds, are also provided.
Abstract:
In one embodiment, there is provided in an ultrasound wave generating apparatus a low output impedance transistor based driver circuit that has the ability to apply a drive signal at a frequency corresponding to an ultrasound transducer's resonant frequency. The low output impedance of the driver circuit allows for a substantial portion of the energy to be delivered to the ultrasound transducer and converted to ultrasound energy. The power transfer efficiency of the presented circuit allows ultrasound drivers to be powered by portable battery packs, while still delivering high ultrasound acoustic power. The ultrasound driver can provide energy in sufficient amounts making it suitable for a range of ultrasound driving applications including but not limited to therapeutic low and high power clinical systems, high intensity focused ultrasound HIFU, acoustical welding, industrial inspection, and other various forms of low-to-high power acoustic devices. Other embodiments of ultrasound transducer drivers and of other components of portable ultrasound generator apparatus in various embodiments are set forth herein.
Abstract:
A device for evaluation of a tissue's biological or biomechanical character is disclosed. The device uses negative pressure to draw a portion of the tissue across one or more electrode pairs disposed within the device. By measuring one or more parameters associated with an electric or magnetic field defined by the electrode pairs, in vivo evaluation of the tissue's biological or biomechanical character may be achieved in a minimally invasive manner. The device may also include an indenter to apply a positive stress on the tissue within the sidewall to further evaluate its biological or biomechanical character. A method of using the device is also disclosed.
Abstract:
Methods of treating cancer in a patient are provided. In some embodiments the method comprises administering an antibody that is capable of binding to the extracellular domain of PSMA. In some embodiments, the method comprises restricting folate intake by the patient. Methods of monitoring cancer therapy are provided as well as kits for treating cancer and kits for monitoring cancer therapy.