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    ADENOVIRAL TARGETING, COMPOSITIONS AND METHODS THEREFOR
    73.
    发明申请
    ADENOVIRAL TARGETING, COMPOSITIONS AND METHODS THEREFOR 审中-公开
    ADENOVIRAL目标，其组成和方法

    公开(公告)号：WO2015161314A1

    公开(公告)日：2015-10-22

    申请号：PCT/US2015/026627

    申请日：2015-04-20

    申请人： WASHINGTON UNIVERSITY

    发明人： CURIEL, David ,  KALIBEROV, Sergey

    IPC分类号： C12N15/62 ,  C12N15/861 ,  A61P35/00 ,  C07K19/00

    CPC分类号： C07K16/3007 ,  C07K14/005 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/73 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10345 ,  C12N2810/859 ,  C12N2830/008 ,  C12N2830/85

    摘要： Polypeptides are disclosed comprising, in N-terminal-to-C-terminal order: an N-terminal segment of Ad5 fiber tail sequence; at least 2 pseudorepeats of an Ad5 fiber shaft domain sequence; a portion of a third Ad5 fiber shaft domain sequence; a carboxy-terminal segment of a T4 fibritin bacteriophage trimerization domain sequence; a linker sequence; and a camelid single chain antibody sequence. A camelid single chain antibody sequence can be against a human carcinoembryonic antigen. Also disclosed are nucleic acids encoding these polypeptides, and adenovirus vectors comprising the polypeptides. Methods are disclosed for treating a neoplastic disease. These methods can comprise administering an adenovirus vector comprising a disclosed polypeptide. Also disclosed are methods of targeting a vector to CEA-expressing cells. These methods comprise administering an adenovirus vector comprising a disclosed polypeptide. Methods can further comprise subjecting a subject to ionizing radiation in an amount effective for inducing CEA overexpression.

    摘要翻译： 公开了多肽，其包含N末端至C末端顺序：Ad5纤维尾序列的N末端片段; 至少2个伪距的Ad5纤维轴结构域序列; 第三个Ad5纤维轴域序列的一部分; T4纤维蛋白噬菌体三聚体结构域序列的羧基末端片段; 接头序列; 和骆驼单链抗体序列。 骆驼单链抗体序列可以针对人癌胚抗原。 还公开了编码这些多肽的核酸和包含多肽的腺病毒载体。 公开了治疗肿瘤性疾病的方法。 这些方法可以包括施用包含公开的多肽的腺病毒载体。 还公开了将载体靶向表达CEA的细胞的方法。 这些方法包括施用包含公开的多肽的腺病毒载体。 方法可以进一步包括使受试者以有效诱导CEA过表达的量进行电离辐射。

    SIGMA-2 RECEPTOR LIGAND DRUG CONJUGATES AS ANTITUMOR COMPOUNDS, METHODS OF SYNTHESIS AND USES THEREOF
    74.
    发明申请
    SIGMA-2 RECEPTOR LIGAND DRUG CONJUGATES AS ANTITUMOR COMPOUNDS, METHODS OF SYNTHESIS AND USES THEREOF 审中-公开
    SIGMA-2受体配体药物作为抗微生物化合物，其合成方法及用途

    公开(公告)号：WO2015153814A1

    公开(公告)日：2015-10-08

    申请号：PCT/US2015/023954

    申请日：2015-04-01

    申请人： WASHINGTON UNIVERSITY

    发明人： HAWKINS, William ,  MACH, Robert ,  SPITZER, Dirk ,  VANGVERAVONG, Suwanna

    IPC分类号： C07D403/14 ,  A61P35/00

    CPC分类号： C07D451/14 ,  A61K31/496 ,  A61K31/517 ,  A61K45/06 ,  C07D471/08

    摘要： Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC 50 value below 5 μΜ against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.

    摘要翻译： 公开了治疗癌症如胰腺癌和滑膜肉瘤的方法和组合物。 描述了包含σ-2受体结合部分和诱导铁诱发部分的化合物。 至少一种所述的分子物质在体外显示低于5μM的IC 50值对人胰腺癌细胞。 这种物种的管理促进了体内鼠模型系统中胰腺癌肿瘤的收缩，并且导致实验动物的100％存活时间过程，其中对照治疗仅提供30％或40％的存活率。 还公开了合成分子种类的方法。

    RADIOLABELED TRACERS FOR POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1), METHODS AND USES THEREFOR
    75.
    发明申请
    RADIOLABELED TRACERS FOR POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1), METHODS AND USES THEREFOR 审中-公开
    聚（ADP-RIBOSE）聚合酶-1（PARP-1）的放射性跟踪器，其方法和用途

    公开(公告)号：WO2015103526A1

    公开(公告)日：2015-07-09

    申请号：PCT/US2015/010129

    申请日：2015-01-05

    申请人： WASHINGTON UNIVERSITY

    发明人： MACH, Robert ,  CHU, Wenhua ,  ZHOU, Dong ,  MICHEL, Loren ,  CHEN, Delphine

    IPC分类号： C07D243/24 ,  C07D235/26 ,  A61K36/55 ,  C07D263/62 ,  C07D277/62 ,  C07D411/04 ,  A01N43/52 ,  A01N43/76 ,  A01N43/78

    CPC分类号： A61K51/0468 ,  A61B6/037 ,  C07D235/18 ,  C07D403/12 ,  C07D487/04

    摘要： Disclosed are PARP-1 inhibitors, which can be 18 F-labeled for use as tracers in positron emission tomographic (PET) imaging. Further disclosed are methods of synthesis. Of the compounds synthesized, 2-[p-(2-Fluoroethoxy)phenyl]-1.3.10-triazatricyclo[6.4.1.0 4,13 ]trideca-2,4(13),5,7-tetraen-9-one (12) had the highest inhibition potency for PARP-1 (IC 50 = 6.3 nM). Synthesis of [ 18 F]-12 is disclosed under conventional conditions in high specific activity with 40-50% decay-corrected yield. MicroPET imaging using [ 18 F]-12 in MDA-MB-436 tumor-bearing mice demonstrated accumulation of [ 18 F]-12 in a tumor. Binding can be blocked by olaparib. The compounds have utility for tumor imaging.

    摘要翻译： 公开了PARP-1抑制剂，其可以被18F标记用于正电子发射断层摄影（PET）成像中的示踪剂。 进一步公开的是合成方法。 在合成的化合物中，将2- [对 - （2-氟乙氧基）苯基] -1.3.10-三氮杂三环[6.4.1.04,13]十三烷-2,4（13），5,7-四烯-9-酮（12 ）对PARP-1具有最高的抑制效能（IC50 = 6.3nM）。 在具有40-50％衰变校正产率的高比活性的常规条件下公开了[18 F] -12的合成。 使用[18F] -12在MDA-MB-436肿瘤小鼠中的MicroPET成像显示[18F] -12在肿瘤中的积累。 结合可以被olaparib阻断。 该化合物可用于肿瘤成像。

    SYSTEMS AND METHODS FOR HYPERSPECTRAL ANALYSIS OF CARDIAC TISSUE
    77.
    发明申请
    SYSTEMS AND METHODS FOR HYPERSPECTRAL ANALYSIS OF CARDIAC TISSUE 审中-公开
    心脏组织超分析的系统与方法

    公开(公告)号：WO2015077474A1

    公开(公告)日：2015-05-28

    申请号：PCT/US2014/066660

    申请日：2014-11-20

    申请人： THE GEORGE WASHINGTON UNIVERSITY

    发明人： SARVAZYAN, Narine

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0075 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4836 ,  A61B18/1492 ,  A61B90/37 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2018/00351 ,  A61B2018/00357 ,  A61B2018/0212 ,  A61B2090/373 ,  A61B2090/3735

    摘要： Systems and methods for hyperspectral analysis of cardiac tissue are provided. In some embodiments, a method for visualizing ablation lesions includes illuminating at one or more illumination wavelengths a surface of tissue having an ablation lesion; collecting a spectral data set comprising spectral images of the illuminated tissue acquired at multiple spectral bands each at one or more acquisition wavelengths; distinguishing between the ablation lesion and an unablated tissue based on one or more spectral differences between the ablation lesion and unablated tissue; and creating a composite image of the tissue showing the ablation lesion and the unablated tissue.

    摘要翻译： 提供了心脏组织超光谱分析的系统和方法。 在一些实施例中，用于可视化消融损伤的方法包括在一个或多个照射波长处照射具有消融损伤的组织的表面; 收集包含在多个光谱带上以一个或多个采集波长获取的被照射组织的光谱图像的光谱数据集; 基于消融损伤和未消融组织之间的一个或多个光谱差异区分消融病变和未消融的组织; 以及创建显示消融损伤和未消融组织的组织的复合图像。

    SYSTEMS AND METHODS OF GRUENEISEN-RELAXATION PHOTOACOUSTIC MICROSCOPY AND PHOTOACOUSTIC WAVEFRONT SHAPING
    78.
    发明申请
    SYSTEMS AND METHODS OF GRUENEISEN-RELAXATION PHOTOACOUSTIC MICROSCOPY AND PHOTOACOUSTIC WAVEFRONT SHAPING 审中-公开
    松散光电显微镜和光电波形形状的系统和方法

    公开(公告)号：WO2015077355A1

    公开(公告)日：2015-05-28

    申请号：PCT/US2014/066437

    申请日：2014-11-19

    申请人： WASHINGTON UNIVERSITY

    发明人： WANG, Lihong ,  WANG, Lidai ,  ZHANG, Chi ,  LAI, Puxiang ,  TAY, Jian Wei

    IPC分类号： G02B21/00

    CPC分类号： G01N29/2418 ,  G01N2201/06113 ,  G02B21/0004 ,  G02B21/002 ,  G02B21/0028 ,  G02B21/008

    摘要： Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.

    摘要翻译： 本文公开了使用非线性光声波前整形（PAWS）在聚焦区域内聚焦光脉冲的系统和方法。 该方法包括基于Grueneisen-relaxation光声（GR-PA）反馈信号调制光脉冲波形的空间相位图。 此外，本文公开了用于执行Grueneisen-relaxation光声显微镜（GR-PAM）的系统和方法，其包括分析由两个紧密间隔的光脉冲照射聚焦区域而产生的光声信号。 还公开了使用Grueneisen-relaxation光声显微镜（GR-PAM）获得样品的吸收系数的方法。