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    HIGH DENSITY PERMEABLE SUPPORTS FOR HIGH THROUGHPUT SCREENING
    83.
    发明申请
    HIGH DENSITY PERMEABLE SUPPORTS FOR HIGH THROUGHPUT SCREENING 审中-公开
    高密度渗透性支持用于高通量筛选

    公开(公告)号：WO2008005244A2

    公开(公告)日：2008-01-10

    申请号：PCT/US2007/014852

    申请日：2007-06-27

    Applicant: CORNING INCORPORATED ,  MARTIN, Gregory R ,  TANNER, Allison J

    Inventor： MARTIN, Gregory R ,  TANNER, Allison J

    CPC classification number: C12M25/04 ,  B01L3/50255 ,  B01L3/50857 ,  B01L2300/0681 ,  B01L2300/0829 ,  C12M23/24 ,  C12M23/38

    Abstract: A class of designs is provided for a permeable support where the design principle includes a permeable support layer, such as a membrane, bonded midway between two arrays of wells or multiwell plates, attached at their bottom portions, forming a double-sided multiwell plate. Thus, opposite facing wells on either side of the permeable support layer are accessible by inversion of the double-sided multiwell plate. Well fluid is held in place in the novel multiwell plate by capillary forces in the case of aligned upper and lower well arrays or by surface tension on patterned well regions on a permeable membrane layer. No additional components are necessary to form compartments for fluid retention. These new plate designs allow the surface area of the permeable support layer to be maximized, eliminate potential wicking and cross contamination issues that may arise from multiple component sidewalls, and take advantage of the small well diameters to retain fluid by utilizing the effects of surface tension or capillary forces.

    Abstract translation: 提供了一类用于可渗透支撑的设计，其中设计原理包括可渗透的支撑层，例如膜，粘合在两个孔阵列或多孔板之间的中间，连接在其底部，形成双面多孔板。 因此，可渗透支撑层的任一侧上的相对面对的孔可通过双面多孔板的倒置进入。 在新颖的多孔板中，在对准的上下阵列的情况下通过毛细作用力将液体保持在适当的位置，或者通过可渗透膜层上的图案化阱区域上的表面张力来保持良好的流体。 不需要额外的部件来形成用于流体保持的隔室。 这些新的板设计允许可渗透支撑层的表面积最大化，消除可能由多个部件侧壁产生的潜在芯吸和交叉污染问题，并利用小井直径利用表面张力的作用来保持流体 或毛细管力。

    METHOD AND DEVICE FOR THE COLLECTION AND ISOLATION OF NUCLEIC ACID
    85.
    发明申请
    METHOD AND DEVICE FOR THE COLLECTION AND ISOLATION OF NUCLEIC ACID 审中-公开
    用于收集和分离核酸的方法和装置

    公开(公告)号：WO2007022483A2

    公开(公告)日：2007-02-22

    申请号：PCT/US2006/032531

    申请日：2006-08-18

    Applicant: BIOVENTURES, INC. ,  DAWSON, Elliott P. ,  WOMBLE, Kristie E.

    Inventor： DAWSON, Elliott P. ,  WOMBLE, Kristie E.

    IPC: C12M3/00

    CPC classification number: B01L3/5085 ,  B01L3/50857 ,  B01L2300/069 ,  B01L2300/0819

    Abstract: A device for collecting and preserving nucleic acids in a sample, the device comprising: a) a support; b) one or more than one sample zone in the support for loading the sample onto the device; and c) a composition comprising i) one or more than one absorbent, and ii) one or more than one stabilizer; where the one or more than one sample zone on the support comprises a recess or space within the support extending from the top surface toward, but not through, the bottom surface, or comprises a space within the support and the composition is retained within the sample zone. A method for collecting and preserving nucleic acids in a sample, the method comprising a) providing a device for collecting and preserving nucleic acids in a sample according to the present invention; b) providing a sample potentially comprising one or more than one nucleic acid; and c) applying part or all of the sample to one or more than one of the sample zones on the device. A method of detecting and quantifying nucleic acids in a sample, the method comprising a) collecting and preserving nucleic acids in the sample according to a method of the present invention; b) removing the absorbent with sample from the sample zones of the device; and c) detecting, or detecting and quantifying the nucleic acids.

    Abstract translation: 一种用于收集和保存样品中的核酸的装置，所述装置包括：a）支撑件; b）支架中的一个或多于一个样品区用于将样品装载到装置上; 和c）包含i）一种或多于一种吸收剂，和ii）一种或多种稳定剂的组合物; 其中载体上的一个或多于一个样品区包括在载体内的从顶表面朝向底表面延伸但不穿过底表面的凹陷或空间，或者在载体内包含空间并且组合物保留在样品内 区。 一种用于收集和保存样品中的核酸的方法，所述方法包括：a）提供根据本发明的用于收集和保存样品中的核酸的装置; b）提供可能包含一种或多于一种核酸的样品; 和c）将部分或全部样品应用于装置上的一个或多于一个样品区。 一种检测和定量样品中核酸的方法，该方法包括：a）根据本发明的方法收集和保存样品中的核酸; b）从装置的样品区域除去带有样品的吸收剂; 和c）检测或检测和定量核酸。

    MICROFLUIDIC PACKAGING
    89.
    发明申请
    MICROFLUIDIC PACKAGING 审中-公开
    微流体包装

    公开(公告)号：WO2005032448A3

    公开(公告)日：2005-12-15

    申请号：PCT/US2004031833

    申请日：2004-09-28

    Applicant: IBM ,  HUMENIK JAMES N ,  NATARAJAN GOVINDARAJAN ,  BISHNOI SANDRA W ,  YOUNG ALBERT

    Inventor： HUMENIK JAMES N ,  NATARAJAN GOVINDARAJAN ,  BISHNOI SANDRA W ,  YOUNG ALBERT

    IPC: B01L3/00 ,  B01L9/00 ,  B01L99/00 ,  B01L3/02

    CPC classification number: B01L9/527 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/50857 ,  B01L2200/025 ,  B01L2300/0887

    Abstract: A plate (100) for use in mixing and testing materials in the pharmaceutical industry is formed by a method in which an array of sample cells (110) contain a U -shaped structure having two vertical apertures (121, 123) connected by a horizontal passage (126) in a bottom sheet; reagents are drawn in to the vertical passages by capillary action and react in the horizontal passage. An optional version of the invention includes a relatively large reservoir (680) for containing rinsing fluids.

    Abstract translation: 用于在制药工业中混合和测试材料的板（100）通过以下方法形成，其中，样品池（110）的阵列包含具有两个垂直孔（121,123）的U形结构，所述两个垂直孔通过水平 通道（126）在底部片材中; 试剂通过毛细作用被吸入垂直通道并在水平通道中反应。 本发明的可选形式包括用于容纳冲洗流体的相对较大的容器（680）。

    CONTAINER
    90.
    发明申请
    CONTAINER 审中-公开
    容器

    公开(公告)号：WO2005116612A1

    公开(公告)日：2005-12-08

    申请号：PCT/FI2005/000242

    申请日：2005-05-26

    Applicant: THERMO ELECTRON OY ,  VOHO, Marko

    Inventor： VOHO, Marko

    IPC: G01N21/03

    CPC classification number: B01L3/50855 ,  B01L3/0275 ,  B01L3/50857 ,  B01L9/06

    Abstract: The invention relates to a container for a liquid sample, which container (1) comprises an elongate casing and into which container a liquid sample may be taken and in which it may be examined. The container (1) comprises an open lower end and an open upper end and the sample in the container may be examined in the longitudinal direction of the container, especially from above.

    Abstract translation: 本发明涉及一种用于液体样品的容器，该容器（1）包括细长的壳体，并且可以在其中容纳液体样品并且可以在其中进行检查。 容器（1）包括敞开的下端和敞开的上端，并且容器中的样品可以沿容器的纵向方向，特别是从上方检查。

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