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    FLUORESCENCE READER
    3.
    发明申请
    FLUORESCENCE READER 审中-公开
    荧光读数器

    公开(公告)号：WO2007108752A1

    公开(公告)日：2007-09-27

    申请号：PCT/SE2007/000275

    申请日：2007-03-21

    Applicant: ÅMIC AB ,  LINDSTRÖM, Tomas ,  MENDEL-HARTVIG, Ib ,  ÖHMAN, Ove ,  BACKLUND, Johan ,  VILHELMSSON, Kennet

    Inventor： LINDSTRÖM, Tomas ,  MENDEL-HARTVIG, Ib ,  ÖHMAN, Ove ,  BACKLUND, Johan ,  VILHELMSSON, Kennet

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N2021/6465

    Abstract: Fluorescence reader (10) for an optical assay arrangement comprising a polymeric sample substrate (1) having a reaction site-surface and a substrate surface (3) , the fluorescence reader comprising a light source (5) arranged to illuminate the reaction site-surface through the substrate surface, and a detector device (6) arranged to detect fluorescent light emitted from said reaction site-surface and transmitted through the substrate surface, the substrate surface provided with total-internal-reflection suppressing means (15) .

    Abstract translation: 用于光学测定装置的荧光读取器（10）包括具有反应位点表面和基底表面（3）的聚合物样品基底（1），所述荧光读取器包括光源（5），其被布置成照亮反应位点表面 通过基板表面，以及检测器装置（6），其被配置为检测从所述反应位置表面发射并透过所述基板表面的荧光，所述基板表面设置有全内反射抑制装置（15）。

    METHOD OF MAKING NOZZLE PLATES AND STRUCTURES COMPRISING SUCH NOZZLE PLATES
    5.
    发明申请
    METHOD OF MAKING NOZZLE PLATES AND STRUCTURES COMPRISING SUCH NOZZLE PLATES 审中-公开
    制造喷嘴板的方法和包括这种喷嘴板的结构

    公开(公告)号：WO2003024719A1

    公开(公告)日：2003-03-27

    申请号：PCT/SE2002/001695

    申请日：2002-09-19

    Applicant: ÅMIC AB ,  HOLLMAN, Patrik ,  ÖHMAN, Ove

    Inventor： HOLLMAN, Patrik ,  ÖHMAN, Ove

    IPC: B41J2/16

    CPC classification number: B41J2/1637 ,  B41J2/1433 ,  B41J2/162 ,  B41J2/1626 ,  B41J2/1643

    Abstract: A method of making a nozzle plate structure with miniature nozzles, said nozzles having an accurately defined geometry and an upper and a lower surface, and said nozzle plate structure comprising a stable base plate (14) provided with holes and each hole containing a moulded structure forming the miniature nozzles (22). The method comprising the steps of providing a positive lower half of a mould (10) having protrusions (12) defining the size and shape of the said miniature nozzle, in which the protrusion mate with the holes of the stable base plate, and inserting the stable base plate in the mould, closing the mould with a lid (16) and applying a curable polymer (18) to the mould and exposing the curable resin to curing conditions. A nozzle plate structure (20) made according to the method is also disclosed.

    Abstract translation: 一种制造具有微型喷嘴的喷嘴板结构的方法，所述喷嘴具有精确限定的几何形状和上表面和下表面，并且所述喷嘴板结构包括设置有孔的稳定基板（14），并且每个孔包含模制结构 形成微型喷嘴（22）。 该方法包括以下步骤：提供具有限定所述微型喷嘴的尺寸和形状的突起（12）的模具（10）的正下半部，其中所述突起与所述稳定基板的孔配合，并且将 在模具中具有稳定的基板，用盖子（16）封闭模具并将可固化聚合物（18）施加到模具上并将可固化树脂暴露于固化条件。 还公开了根据该方法制造的喷嘴板结构（20）。

    NOZZLES FOR ELECTROSPRAY IONIZATION AND METHODS OF FABRICATING THEM
    8.
    发明申请
    NOZZLES FOR ELECTROSPRAY IONIZATION AND METHODS OF FABRICATING THEM 审中-公开
    静电放电喷嘴及其制作方法

    公开(公告)号：WO2004075241A1

    公开(公告)日：2004-09-02

    申请号：PCT/SE2004/000229

    申请日：2004-02-19

    Applicant: ÅMIC AB ,  LARSSON, Olle ,  SIGMUNDSSON, Toni ,  READ, Michael ,  ÖHMAN, Ove

    Inventor： LARSSON, Olle ,  SIGMUNDSSON, Toni ,  READ, Michael ,  ÖHMAN, Ove

    IPC: H01J49/04

    CPC classification number: H01J49/167 ,  H01J49/0018

    Abstract: A nozzle chip (3') for ejecting a liquid such as in an electrospray device is built from a substrate chip having grooves (5, 7) on a top surface. A lid (25) is attached to the top surface closing the grooves to form channels one of which has an open outlet end (9). At the outlet end a nozzle is formed at or attached and it has an outlet opening from which the liquid is to be ejected. Alignment recesses (13, 15) are made at edges of the substrate chip and they are accurately positioned in relation to the outlet opening, the alignment recesses allowing an accurate mounting of nozzle chip giving the outlet opening of the nozzle a reproducible position in the device where it is to be used. At the outlet end a recess (17) in the substrate chip can be provided and the nozzle can then be located in the recess to mechanically protect it.

    Abstract translation: 用于喷射诸如电喷雾装置中的液体的喷嘴芯片（3'）从在顶表面上具有凹槽（5,7）的衬底芯片构建。 盖（25）附接到顶表面，封闭沟槽以形成通道，其中一个具有开放的出口端（9）。 在出口处，喷嘴形成在或附接并且具有出口，液体从该出口开始喷出。 对准凹槽（13,15）在基片的边缘处形成，并且它们相对于出口开口精确地定位，所述对准凹槽允许精确地安装喷嘴芯片，使得喷嘴的出口开口在装置中是可再现的位置 在哪里使用。 在出口端，可以设置衬底芯片中的凹部（17），然后可以将喷嘴定位在凹部中以机械地保护其。

    IMMOBILISATION METHOD AND SURFACES PRODUCED USING SAID METHOD
    9.
    发明申请
    IMMOBILISATION METHOD AND SURFACES PRODUCED USING SAID METHOD 审中-公开
    使用方法生产的固定方法和表面

    公开(公告)号：WO2003023402A1

    公开(公告)日：2003-03-20

    申请号：PCT/SE2002/001635

    申请日：2002-09-12

    Applicant: OSCARSSON, Sven ,  QUIST, Arjan ,  PAVLOVIC, Elisabeth ,  ÖHMAN, Ove

    Inventor： OSCARSSON, Sven ,  QUIST, Arjan ,  PAVLOVIC, Elisabeth ,  ÖHMAN, Ove

    IPC: G01N33/543

    CPC classification number: B82B3/00 ,  G01N33/54353 ,  G01Q80/00

    Abstract: Objects, such as molecules, macormolecules, nanoparticles, cells and organelles are immobilised to a surface by covalent bonds and in a site-specific manner using an external source of energy, acting on the surface in the presence of said objects, when said surface and said objects have been chemically derivatised to present groups capable of forming reactive moieties when subjected to said source of energy. The exact location of the immobilisation is determined either by exposing the surface to said source of energy in a highly localised manner, or by creating site-specific defects or a pattern, to which groups capable of forming reactive moieties when subjected to said source of energy are first arranged. Said pattern may be in the form of electrodes, arranged on the surface.

    Abstract translation: 如分子，大分子，纳米颗粒，细胞和细胞器的物体通过共价键和位点特异性方式通过使用外部能量源固定在表面上，在所述物体存在时作用在表面上，当所述表面和 所述物体已被化学衍生化以呈现当经受所述能量源时能够形成活性部分的基团。 固定的确切位置是通过以高度局部化的方式将表面暴露于所述能量源或通过产生位点特异性缺陷或图案来确定，当经受所述能量源时能够形成反应性部分的基团 首先安排 所述图案可以是布置在表面上的电极的形式。

    DEVICE FOR SEPARATION AND MALDI ANALYSIS OF AN ANALYTE IN A SAMPLE
    10.
    发明申请
    DEVICE FOR SEPARATION AND MALDI ANALYSIS OF AN ANALYTE IN A SAMPLE 审中-公开
    样品中分析物的分离和MALDI分析装置

    公开(公告)号：WO2008062372A2

    公开(公告)日：2008-05-29

    申请号：PCT/IB2007/054736

    申请日：2007-11-21

    Applicant: PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  RIBBING, Carolina ,  ÖHMAN, Ove

    Inventor： RIBBING, Carolina ,  ÖHMAN, Ove

    CPC classification number: H01J49/0418

    Abstract: The present invention relates to a device for separating at least one analyte in a liquid sample and further analyzing said analyte by laser desorption/ionization (LDI) mass spectrometry. The invention is further concerned with the use of devices for separating at least one analyte in a liquid sample and subsequent determination of the presence and/or amount of said at least one analyte by LDI mass spectrometry. The invention is also concerned with a method for separating at least one analyte in a liquid sample and subsequent determination of the presence and/or amount of said at least one analyte by LDI mass spectrometry.

    Abstract translation: 本发明涉及一种用于分离液体样品中的至少一种分析物并且通过激光解吸/电离（LDI）质谱法进一步分析所述分析物的装置。 本发明进一步涉及使用用于分离液体样品中的至少一种分析物并且随后通过LDI质谱法确定所述至少一种分析物的存在和/或量的装置的使用。 本发明还涉及用于分离液体样品中的至少一种分析物并随后通过LDI质谱法确定所述至少一种分析物的存在和/或量的方法。

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