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1.发明申请
公开(公告)号：WO2005115361A3
公开(公告)日：2006-03-16
申请号：PCT/US2005017143
申请日：2005-05-16
Applicant: ACADIA PHARM INC , SCHLIENGER NATHALIE , PAWLAS JAN , FEJZIC ALMA , OLSSON ROGER , LUND BIRGITTE WINTHER , BADALASSI FABRIZIO , LEWINSKY RASMUS , THYGESEN MIKKEL BOAS
Inventor： SCHLIENGER NATHALIE , PAWLAS JAN , FEJZIC ALMA , OLSSON ROGER , LUND BIRGITTE WINTHER , BADALASSI FABRIZIO , LEWINSKY RASMUS , THYGESEN MIKKEL BOAS
IPC: A61K31/00 , C07C255/58 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D211/22 , C07D211/32 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/24 , C07D221/20 , C07D295/073 , C07D295/155 , C07D451/02 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07F9/572 , C07F9/6561 , C07D211/52 , C07D211/56 , C07D295/06 , C07D295/14
CPC classification number: C07D207/08 , C07C255/58 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D211/22 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/70 , C07D215/20 , C07D215/40 , C07D215/48 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D221/20 , C07D221/22 , C07D237/34 , C07D241/42 , C07D285/14 , C07D295/06 , C07D295/073 , C07D295/096 , C07D295/155 , C07D451/00 , C07D451/02 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D491/10 , C07F9/5721 , C07F9/6561
Abstract: Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
Abstract translation: 本文公开了式（I）的双环芳基化合物，其选择性调节核受体，优选雄激素受体或其药学上可接受的盐，酯，酰胺或前药，以及治疗疾病的方法，包括给予式（I）化合物至 有需要的患者。
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2.发明申请
公开(公告)号：WO2006076317A2
公开(公告)日：2006-07-20
申请号：PCT/US2006000733
申请日：2006-01-09
Applicant: ACADIA PHARM INC , SCHLIENGER NATHALIE , THYGESEN MIKKEL BOAS , PAWLAS JAN , BADALASSI FABRIZIO , LEWINSKY RASMUS , LUND BIRGITTE WINTHER , OLSSON ROGER
Inventor： SCHLIENGER NATHALIE , THYGESEN MIKKEL BOAS , PAWLAS JAN , BADALASSI FABRIZIO , LEWINSKY RASMUS , LUND BIRGITTE WINTHER , OLSSON ROGER
IPC: C07D451/02 , A61K31/435 , A61P3/04 , A61P5/26 , A61P25/28
CPC classification number: C07D451/02 , C07D451/06
Abstract: Disclosed herein is a novel class of aminophenyl compounds having the structure (I) wherein R 1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
Abstract translation: 本文公开了一类具有结构（I）的新型氨基苯基化合物，其中R 1是氰基或硝基且环A是双环或三环桥连杂环及其作为雄激素受体调节剂的用途， 治疗或预防相关病症。
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Patent Agency Ranking
公开(公告)号：WO2006076317A9
公开(公告)日：2007-09-27
申请号：PCT/US2006000733
申请日：2006-01-09
Applicant: ACADIA PHARM INC , SCHLIENGER NATHALIE , THYGESEN MIKKEL BOAS , PAWLAS JAN , BADALASSI FABRIZIO , LEWINSKY RASMUS , LUND BIRGITTE WINTHER , OLSSON ROGER
Inventor： SCHLIENGER NATHALIE , THYGESEN MIKKEL BOAS , PAWLAS JAN , BADALASSI FABRIZIO , LEWINSKY RASMUS , LUND BIRGITTE WINTHER , OLSSON ROGER
IPC: C07D451/02 , A61K31/435 , A61P3/04 , A61P5/26 , A61P25/28
CPC classification number: C07D451/02 , C07D451/06
Abstract: Disclosed herein is a novel class of aminophenyl compounds having the structure (I) wherein R 1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
Abstract translation: 本文公开了具有结构（I）的新一类氨基苯基化合物，其中R 1是氰基或硝基，环A是双环或三环桥连杂环，并且它们用作雄激素受体的调节剂 治疗或预防与此相关的病症。
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4.发明申请ANDROGEN RECEPTOR MODULATORS AND METHODS OF TREATING DISEASE USING THE SAME 审中-公开雄激素受体调节剂和使用该方法治疗疾病的方法
公开(公告)号：WO2007092391A1
公开(公告)日：2007-08-16
申请号：PCT/US2007/003053
申请日：2007-02-05
Applicant: ACADIA PHARMACEUTICALS INC. , SCHLIENGER, Nathalie , PAWLAS, Jan , FEJZIC, Alma , OLSSON, Roger , LUND, Birgitte Winther , BADALASSI, Fabrizio , LEWINSKY, Rasmus , THYGESEN, Mikkel Boas , WEINER, David M. , FURLANO, David , BONHAUS, Douglas W. , VAN KAMMEN, Daniel
Inventor： SCHLIENGER, Nathalie , PAWLAS, Jan , FEJZIC, Alma , OLSSON, Roger , LUND, Birgitte Winther , BADALASSI, Fabrizio , LEWINSKY, Rasmus , THYGESEN, Mikkel Boas , WEINER, David M. , FURLANO, David , BONHAUS, Douglas W. , VAN KAMMEN, Daniel
IPC: A61K31/40 , A61K31/439 , A61K31/445 , A61K31/504 , A61K31/5375 , A61P25/00 , A61P25/16 , A61P15/16 , A61P27/02 , A61P17/02 , A61P29/00
CPC classification number: A61K31/40 , A61K31/439 , A61K31/445 , A61K31/504 , A61K31/5375 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/40 , C07D215/48 , C07D217/02 , C07D217/22 , C07D221/20 , C07D221/22 , C07D237/34 , C07D241/42 , C07D285/14 , C07D295/06 , C07D295/155 , C07D451/02 , C07D451/04 , C07D451/06 , C07D471/08 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
Abstract translation: 本文公开了式（I）的双环芳基化合物，其选择性调节核受体，优选雄激素受体或其药学上可接受的盐，酯，酰胺或前药，以及治疗疾病的方法，包括将式（I）化合物 有需要的患者。
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公开(公告)号：WO2006076317A3
公开(公告)日：2006-07-20
申请号：PCT/US2006/000733
申请日：2006-01-09
Applicant: ACADIA PHARMACEUTICALS INC. , SCHLIENGER, Nathalie , THYGESEN, Mikkel Boas , PAWLAS, Jan , BADALASSI, Fabrizio , LEWINSKY, Rasmus , LUND, Birgitte Winther , OLSSON, Roger
Inventor： SCHLIENGER, Nathalie , THYGESEN, Mikkel Boas , PAWLAS, Jan , BADALASSI, Fabrizio , LEWINSKY, Rasmus , LUND, Birgitte Winther , OLSSON, Roger
IPC: C07D451/02 , A61K31/435 , A61P5/26 , A61P3/04 , A61P25/28
Abstract: Disclosed herein is a novel class of aminophenyl compounds having the structure (I) wherein R 1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
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公开(公告)号：WO2007092400A1
公开(公告)日：2007-08-16
申请号：PCT/US2007/003070
申请日：2007-02-06
Applicant: ACADIA PHARMACEUTICALS INC. , SCHLIENGER, Nathalie , THYGESEN, Mikkel Boas , PAWLAS, Jan , BADALASSI, Fabrizio , LEWINSKY, Rasmus , LUND, Birgitte Winther , OLSSON, Roger
Inventor： SCHLIENGER, Nathalie , THYGESEN, Mikkel Boas , PAWLAS, Jan , BADALASSI, Fabrizio , LEWINSKY, Rasmus , LUND, Birgitte Winther , OLSSON, Roger
IPC: C07D451/02 , C07D451/06 , A61K31/46 , A61P3/04 , A61P5/26 , A61P25/28
CPC classification number: C07D451/06 , C07D451/02
Abstract: Disclosed herein is a novel class of aminophenyl compounds having the structure: Formula (I) wherein R 1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.
Abstract translation: 本文公开了一类新的具有以下结构的氨基苯基化合物：式（I）其中R 1是氰基或硝基，环A是双环或三环桥环杂环，并且作为其作为雄激素调节剂的用途 受体用于治疗或预防与之有关的病症。
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7.发明申请
公开(公告)号：WO2005115361A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/017143
申请日：2005-05-16
Applicant: ACADIA PHARMACEUTICALS INC. , SCHLIENGER, Nathalie , PAWLAS, Jan , FEJZIC, Alma , OLSSON, Roger , LUND, Birgitte Winther , BADALASSI, Fabrizio , LEWINSKY, Rasmus , THYGESEN, Mikkel, Boas
Inventor： SCHLIENGER, Nathalie , PAWLAS, Jan , FEJZIC, Alma , OLSSON, Roger , LUND, Birgitte Winther , BADALASSI, Fabrizio , LEWINSKY, Rasmus , THYGESEN, Mikkel, Boas
IPC: A61K31/00
CPC classification number: C07D207/08 , C07C255/58 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D211/22 , C07D211/32 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/64 , C07D211/70 , C07D215/20 , C07D215/40 , C07D215/48 , C07D217/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D221/20 , C07D221/22 , C07D237/34 , C07D241/42 , C07D285/14 , C07D295/06 , C07D295/073 , C07D295/096 , C07D295/155 , C07D451/00 , C07D451/02 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D491/10 , C07F9/5721 , C07F9/6561
Abstract: Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.
Abstract translation: 本文公开了式（I）的双环芳基化合物，其选择性调节核受体，优选雄激素受体或其药学上可接受的盐，酯，酰胺或前药，以及治疗疾病的方法，包括给予式（I）化合物至 有需要的患者。
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