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    TREATING OR PREVENTING HOT FLASHES USING PRODRUGS OF GABA ANALOGS
    1.
    发明申请
    TREATING OR PREVENTING HOT FLASHES USING PRODRUGS OF GABA ANALOGS 审中-公开
    使用GABA模拟原理处理或防止热水闪烁

    公开(公告)号：WO2004089289A3

    公开(公告)日：2005-03-10

    申请号：PCT/US2004010137

    申请日：2004-03-31

    申请人： XENOPORT INC ,  BARRETT RONALD W ,  GALLOP MARK A

    发明人： BARRETT RONALD W ,  GALLOP MARK A

    IPC分类号： A61K20060101 ,  A61K31/195

    CPC分类号： A61K31/195

    摘要： Disclosed herein are methods of using prodrugs of GABA analogs and pharmaceutical compositions thereof to treat or prevent hot flashes in humans and pharmaceutical compositions of prodrugs of GABA analogs useful in treating or preventing hot flashes.

    摘要翻译： 本文公开了使用GABA类似物的前药和其药物组合物的方法来治疗或预防人类中的热潮红和用于治疗或预防潮热的GABA类似物的前药药物组合物。

    SPATIALLY-ADDRESSABLE IMMOBILIZATION OF ANTI-LIGANDS ON SURFACES
    4.
    发明申请
    SPATIALLY-ADDRESSABLE IMMOBILIZATION OF ANTI-LIGANDS ON SURFACES 审中-公开
    防辐射对表面的空间化处理

    公开(公告)号：WO1991007087A1

    公开(公告)日：1991-05-30

    申请号：PCT/US1990006607

    申请日：1990-11-13

    申请人： AFFYMAX TECHNOLOGIES, N.V. ,  BARRETT, Ronald, W. ,  PIRRUNG, Michael, C. ,  STRYER, Lubert ,  HOLMES, Christopher, P. ,  SUNDBERG, Steven, A.

    发明人： AFFYMAX TECHNOLOGIES, N.V.

    IPC分类号： A01N01/02

    CPC分类号： C07D495/04 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00722 ,  C07D233/38 ,  C40B40/06 ,  G01N33/54353 ,  G01N33/552 ,  Y02P20/55

    摘要： Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise protecting groups capable of being removed upon application of a suitable energy source. Spatially addressed irradiation of predefined regions on the surface permits immobilization of anti-ligands at the activated regions on the surface. Cycles of irradiation on different regions of the surface and immobilization of different anti-ligands allows formation of an immobilized matrix of anti-ligands at defined sites on the surface. The immobilized matrix of anti-ligands permits simultaneous screenings of a liquid sample for ligands having high affinities for certain anti-ligands of the matrix. A preferred embodiment of the invention involves attaching photoactivatable biotin derivatives to a surface. Photolytic activation of the biotin derivatives forms biotin analogs having strong binding affinity for avidin. Biotinylated anti-ligands can be immobilized on activated regions of the surface previously treated with avidin.

    摘要翻译： 描述了用于在固体底物的表面上固定抗配体如抗体或抗原，激素或激素受体，寡核苷酸和多糖的方法和组合物用于各种用途。 这些方法提供了覆盖有笼式结合构件的表面，其包括在施加合适的能量源时能够被去除的保护基团。 表面上预定区域的空间照射辐射允许在表面上的活化区域上固定抗配体。 表面不同区域的照射周期和不同抗配体的固定允许在表面上限定的位点形成固定的抗配体基团。 抗配体的固定化基质允许对基质的某些抗配体具有高亲和力的配体的液体样品的同时筛选。 本发明的优选实施方案涉及将可光活化的生物素衍生物连接到表面。 生物素衍生物的光解活化形成对抗生物素蛋白具有强结合亲和力的生物素类似物。 生物素化的抗配体可以固定在先前用抗生物素蛋白处理的表面的活化区上。

    COMPOUNDS DISPLAYED ON ICOSAHEDRAL PHAGE AND METHODS OF USING SAME
    7.
    发明申请
    COMPOUNDS DISPLAYED ON ICOSAHEDRAL PHAGE AND METHODS OF USING SAME 审中-公开
    在ICOSAHEDRAL PHAGE上显示的化合物及其使用方法

    公开(公告)号：WO2002077182A2

    公开(公告)日：2002-10-03

    申请号：PCT/US2002/009095

    申请日：2002-03-21

    申请人： XENOPORT, INC. ,  BARRETT, Ronald, W. ,  DOWER, William, J. ,  GALLOP, Mark ,  WOIWODE, Thomas, F. ,  CWIRLA, Steven, E.

    发明人： BARRETT, Ronald, W. ,  DOWER, William, J. ,  GALLOP, Mark ,  WOIWODE, Thomas, F. ,  CWIRLA, Steven, E.

    IPC分类号： C12N

    CPC分类号： C40B40/02 ,  C12N15/1037 ,  G01N33/6845

    摘要： Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.

    摘要翻译： 提供显示各种化合物的二十面体噬菌体及其收集物。 在一些情况下，二十面体噬菌体包括用于记录附着于噬菌体的化合物或化合物的特征的核酸标签。 还提供了许多用于使用二十面体噬菌体筛选化合物文库以获得所需生物学活性的不同方法，特别是用于受体介导的转运过程例如内吞作用和转胞吞作用的底物的化合物的测定。