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公开(公告)号：WO2012100198A3
公开(公告)日：2012-10-04
申请号：PCT/US2012022081
申请日：2012-01-20
Applicant: UNIV WASHINGTON CT COMMERCIALI , CHIU DANIEL T , FUJIMOTO BRYANT S , GANSEN ALEXANDER R , YEN GLORIA S , LORENZ ROBERT M
Inventor： CHIU DANIEL T , FUJIMOTO BRYANT S , GANSEN ALEXANDER R , YEN GLORIA S , LORENZ ROBERT M
CPC classification number: C12Q1/6851 , C12Q1/6806 , C12Q2527/146 , C12Q2531/113 , C12Q2545/114
Abstract: Methods, devices and systems for performing digital measurements are provided.
Abstract translation: 提供了用于执行数字测量的方法，设备和系统。
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公开(公告)号：WO2012054525A3
公开(公告)日：2012-08-16
申请号：PCT/US2011056768
申请日：2011-10-18
Applicant: UNIV WASHINGTON CT COMMERCIALIZATION , CHIU DANIEL T , WU CHANGFENG , ZHANG XUANJUN , YU JIANGBO , YE FANGMAO
Inventor： CHIU DANIEL T , WU CHANGFENG , ZHANG XUANJUN , YU JIANGBO , YE FANGMAO
CPC classification number: G01N33/588 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/126 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J3/11 , C08J2327/22 , C09K11/025 , C09K11/06 , C09K2211/1425 , H01L51/0039
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
Abstract translation: 除其他方面外，本发明提供了稳定的发色纳米粒子。 在某些实施方案中，本文提供的发色纳米粒子用预定数量的官能团合理官能化。 在某些实施方案中，本文提供的稳定的发色纳米粒子用低密度的官能团进行修饰。 在其他实施方案中，本文提供的发色纳米粒子与一个或多个分子缀合。 本文还提供了用于制造合理官能化的发色纳米粒子的方法。
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公开(公告)号：WO2010120818A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/030938
申请日：2010-04-13
Applicant: UNIVERSITY OF WASHINGTON , CHIU, Daniel T. , SCHIRO, Perry G. , KUO, Jason S.
Inventor： CHIU, Daniel T. , SCHIRO, Perry G. , KUO, Jason S.
CPC classification number: G01N33/6893 , G01N33/5302 , G01N33/5308 , G01N33/57407 , Y02A50/58
Abstract: Provided herein, among other aspects, are methods and apparatuses for ranking aliquots from a suspension containing bioparticles. In certain embodiments, the bioparticles may be cells, organelles, proteins, DNAs, debris of biological origin, microbeads coated with biological compounds, or viral particles. As such, the methods and apparatuses provided herein may be used to quantify rare cells such as circulating cancer cells, fetal cells and other rare cells present in bodily fluids for disease diagnosis, prognosis, or treatment.
Abstract translation: 除了其它方面之外，本文提供了用于从含有生物颗粒的悬浮液排列等分试样的方法和装置。 在某些实施方案中，生物颗粒可以是细胞，细胞器，蛋白质，DNA，生物来源的碎片，用生物化合物涂覆的微珠或病毒颗粒。 因此，本文提供的方法和装置可以用于定量罕见细胞，例如循环癌细胞，胎儿细胞和存在于体液中的其它稀有细胞用于疾病诊断，预后或治疗。
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4.发明申请METHOD AND APPARATUS FOR THE DISCRETIZATION AND MANIPULATION OF SAMPLE VOLUMES 审中-公开用于样品体积的分离和操作的方法和设备
公开(公告)号：WO2010019388A3
公开(公告)日：2010-05-14
申请号：PCT/US2009052299
申请日：2009-07-30
Applicant: UNIV WASHINGTON , CHIU DANIEL T , COHEN DAWN E , JEFFRIES GAVIN D M
Inventor： CHIU DANIEL T , COHEN DAWN E , JEFFRIES GAVIN D M
CPC classification number: B01L3/502 , B01L3/502784 , B01L7/52 , B01L2200/0642 , B01L2200/0673 , B01L2300/0877 , B01L2300/0883 , B01L2300/165 , B01L2300/1827 , B01L2300/1861 , B01L2400/0439 , B01L2400/0633 , G01N35/08 , G01N35/10 , G01N2035/00356 , G01N2035/1032 , G01N2035/1034
Abstract: Embodiments of the present invention relate to methods and apparatuses for the discretization and manipulation of sample volumes that is simple, robust, and versatile. It is a fluidic device that partitions a sample by exploiting the interplay between fluidic forces, interfacial tension, channel geometry, and the final stability of the formed droplet and/or discretized volume. These compartmentalized volumes allow for isolation of samples and partitioning into a localized array that can subsequently be manipulated and analyzed. The isolation of the discretized volumes along with the device's inherent portability render our invention versatile for use in many areas, including but not limited to PCR, digital PCR, biological assays for diagnostics and prognostics, cancer diagnosis and prognosis, high throughput screening, single molecule and single cell reactions or assays, the study crystallization and other statistical processes, protein crystallization, drug screening, environmental testing, and the coupling to a wide range of analytical detection techniques for biomedical assays and measurements. The minimal fluid interconnects and simple flow geometry makes the device easy to use and implement, economical to fabricate and operate, and robust in its operations.
Abstract translation: 本发明的实施例涉及用于对样本体积进行离散化和操纵的方法和装置，其简单，稳健且通用。 它是一种流体装置，它通过利用流体力，界面张力，通道几何形状以及形成的液滴和/或离散体积的最终稳定性之间的相互作用来分隔样品。 这些划分的体积允许分离样品并划分为局部阵列，随后可以进行操作和分析。 离散化体积的分离以及设备的固有可移植性使得我们的发明多用于许多领域，包括但不限于PCR，数字PCR，用于诊断和预测的生物测定，癌症诊断和预后，高通量筛选，单分子 和单细胞反应或测定，研究结晶和其他统计过程，蛋白质结晶，药物筛选，环境测试以及与生物医学分析和测量的各种分析检测技术的耦合。 最小的流体互连和简单的流动几何形状使得该设备易于使用和实施，制造和操作经济并且在其操作中稳健。
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公开(公告)号：WO2007021409A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/027099
申请日：2006-07-13
Applicant: UNIVERSITY OF WASHINGTON , CHIU, Daniel, T. , KUO, Jason, S.
Inventor： CHIU, Daniel, T. , KUO, Jason, S.
CPC classification number: G01N1/34 , B01L3/50273 , B01L3/502753 , B01L2200/0668 , B01L2300/0681 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487
Abstract: This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel configured to concurrently allow fluid flow while precluding passage of a target particle or object.
Abstract translation: 本文件尤其公开了一种具有用于流体流动的旁路区域的衬底的方法和系统。 衬底包括多个流体流动通道，每个通道构造成同时允许流体流动，同时排除目标颗粒或物体的通过。
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Patent Agency Ranking
公开(公告)号：WO2004034436A3
公开(公告)日：2005-03-31
申请号：PCT/US0332151
申请日：2003-10-08
Applicant: CELLECTRICON AB , KARLSSON MATTIAS , ORWAR OWE , CHIU DANIEL T
Inventor： KARLSSON MATTIAS , ORWAR OWE , CHIU DANIEL T
CPC classification number: B01J19/0093 , B01J2219/0081 , B01J2219/00891 , B01J2219/0093 , B01J2219/00952 , B01L3/5025 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0487
Abstract: The invention provides integrated systems comprising macroscale devices interfaced with microscale devices and methods for making these systems.
Abstract translation: 本发明提供了包括与微型装置接口的宏观装置和用于制造这些系统的方法的集成系统。
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7.发明申请
公开(公告)号：WO0189787A9
公开(公告)日：2003-02-06
申请号：PCT/US0116973
申请日：2001-05-25
Applicant: HARVARD COLLEGE , ANDERSON JANELLE R , CHIU DANIEL T , JACKMAN REBECCA J , CHERNIAVSKAYA OKSANA , MCDONALD COOPER , WHITESIDES GEORGE M
Inventor： ANDERSON JANELLE R , CHIU DANIEL T , JACKMAN REBECCA J , CHERNIAVSKAYA OKSANA , MCDONALD COOPER , WHITESIDES GEORGE M
IPC: G01N37/00 , B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/40 , B29C33/42 , B29C39/02 , B29C39/24 , B29C65/00 , B81B1/00 , B81C1/00 , B82B3/00 , C12M1/34 , B01J4/00
CPC classification number: B01L3/0258 , B01F13/0059 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/405 , B29C33/424 , B29C39/02 , B29C39/24 , B29C66/7373 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/034 , B81C2201/036 , B82Y30/00 , Y10T137/2191 , Y10T137/2224 , Y10T436/2575
Abstract: The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
Abstract translation: 本发明在某些实施方案中提供了改进的微流体系统和用于制造包含一个或多个微流体通道水平的改进的微流体系统的方法。 本发明的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。 根据本发明提供的微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括跨过网络的其它通道的通道，而在交叉点处没有物理交叉点。 本发明的微流体网络可以通过本发明提供的复制模制工艺，利用模具主体，其包括具有通过光刻形成的拓扑特征的表面。 在一些情况下，本发明的微流体网络由单个复制模制层组成，并且在其它情况下由两个，三个或更多个复制模制层组成，以形成整个微流体网络结构。 本发明还描述了使用本发明提供的微流体网络结构的各种新颖应用。
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8.发明申请
公开(公告)号：WO0189787A3
公开(公告)日：2002-05-30
申请号：PCT/US0116973
申请日：2001-05-25
Applicant: HARVARD COLLEGE , ANDERSON JANELLE R , CHIU DANIEL T , JACKMAN REBECCA J , CHERNIAVSKAYA OKSANA , MCDONALD COOPER , WHITESIDES GEORGE M
Inventor： ANDERSON JANELLE R , CHIU DANIEL T , JACKMAN REBECCA J , CHERNIAVSKAYA OKSANA , MCDONALD COOPER , WHITESIDES GEORGE M
IPC: G01N37/00 , B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/40 , B29C33/42 , B29C39/02 , B29C39/24 , B29C65/00 , B81B1/00 , B81C1/00 , B82B3/00 , C12M1/34 , B01J4/00
CPC classification number: B01L3/0258 , B01F13/0059 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/405 , B29C33/424 , B29C39/02 , B29C39/24 , B29C66/7373 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/034 , B81C2201/036 , B82Y30/00 , Y10T137/2191 , Y10T137/2224 , Y10T436/2575
Abstract: The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
Abstract translation: 在某些实施方案中，本发明提供了改进的微流体系统和用于制备包含一个或多个微流体通道水平的改进的微流体系统的方法。 本发明的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。 根据本发明提供的微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括跨过网络的其它通道的通道，而在交叉点处没有物理交叉点。 本发明的微流体网络可以通过本发明提供的复制模制工艺，利用模具主体，其包括具有通过光刻形成的拓扑特征的表面。 在一些情况下，本发明的微流体网络由单个复制模制层组成，并且在其它情况下由两个，三个或更多个复制模制层组成，以形成整个微流体网络结构。 本发明还描述了使用本发明提供的微流体网络结构的各种新颖应用。
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公开(公告)号：WO2012100198A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/022081
申请日：2012-01-20
Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION , CHIU, Daniel T. , FUJIMOTO, Bryant S. , GANSEN, Alexander R. , YEN, Gloria S. , LORENZ, Robert M.
Inventor： CHIU, Daniel T. , FUJIMOTO, Bryant S. , GANSEN, Alexander R. , YEN, Gloria S. , LORENZ, Robert M.
CPC classification number: C12Q1/6851 , C12Q1/6806 , C12Q2527/146 , C12Q2531/113 , C12Q2545/114
Abstract: Methods, devices and systems for performing digital measurements are provided.
Abstract translation:
提供用于执行数字测量的方法，设备和系统。
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公开(公告)号：WO2012054525A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056768
申请日：2011-10-18
Applicant: UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION , CHIU, Daniel T. , WU, Changfeng , ZHANG, Xuanjun , YU, Jiangbo , YE, Fangmao
Inventor： CHIU, Daniel T. , WU, Changfeng , ZHANG, Xuanjun , YU, Jiangbo , YE, Fangmao
CPC classification number: G01N33/588 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/126 , C08G2261/12 , C08G2261/1426 , C08G2261/228 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/54 , C08G2261/72 , C08G2261/94 , C08J3/11 , C08J2327/22 , C09K11/025 , C09K11/06 , C09K2211/1425 , H01L51/0039
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
Abstract translation: 本发明尤其提供了稳定的发色纳米颗粒。 在某些实施方案中，本文提供的发色纳米颗粒用预定数量的官能团合理地官能化。 在某些实施方案中，本文提供的稳定发色纳米粒子用低密度官能团修饰。 在其它实施方案中，本文提供的发色纳米颗粒与一个或多个分子缀合。 本文还提供了用于制备合理官能化的发色纳米颗粒的方法。
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