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公开(公告)号：WO2010144747A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/038231
申请日：2010-06-10
Applicant: CYNVENIO BIOSYSTEMS, INC. , TUREWICZ, Marek , PAGANO, Paul , DE FUSCO, Andre , SAUVAGEAU, David
Inventor： TUREWICZ, Marek , PAGANO, Paul , DE FUSCO, Andre , SAUVAGEAU, David
IPC: G01N35/08 , G01N33/487 , G01N1/38
CPC classification number: G01N21/11 , B01L3/50273 , B01L3/505 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0809 , B01L2300/0867 , B01L2300/123 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , G01N21/03 , G01N2021/0346 , G01N2021/0364
Abstract: Flexible pouch and flexible cartridge devices for fluid sample processing, related methods of making and using, related manufacturing systems and related instrumentation systems are described. Flexible pouches provide broad advantage in a wide variety of fields by overcoming the need for complex instrumentation, dedicated devices, and relatively high cost in conventional fluid sample devices. Flexible cartridge devices are particularly advantageous in control of fluid handling, rapid adaptation to a number of configurations by the end user, multiple uses for a single configuration, and in cost and ease of manufacture.
Abstract translation: 描述了用于流体样品处理的柔性袋和柔性盒装置，制造和使用的相关方法，相关的制造系统和相关的仪器系统。 柔性袋通过克服复杂仪器，专用设备的需求以及常规流体样品设备中相对较高的成本而在各种领域中提供广泛的优点。 灵活的墨盒装置在流体处理的控制，终端用户对许多配置的快速适应，单一配置的多种用途以及成本和易于制造方面特别有利。
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2.发明申请
公开(公告)号：WO2017161201A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022833
申请日：2017-03-16
Applicant: CYNVENIO BIOSYSTEMS INC.
Inventor： STRAUSS, William M. , NI, Xiaohui
IPC: C12Q1/68
CPC classification number: C12Q1/6827 , C12Q1/6806 , C12Q2600/112 , C12Q2535/122 , C12Q2537/16 , C12Q2543/10
Abstract: Methods for the early detection, enumeration and analysis of circulating tumor cells (CTCs) are disclosed. These methods are useful for cancer screening, development of treatment regimens, and for monitoring for treatment responses, cancer recurrence or the like. Devices that facilitate the early detection, enumeration and analysis of such circulating tumor cells are also provided.
Abstract translation: 公开了用于循环肿瘤细胞（CTC）的早期检测，计数和分析的方法。 这些方法可用于癌症筛查，治疗方案的开发以及监测治疗反应，癌症复发等。 还提供了促进此类循环肿瘤细胞的早期检测，计数和分析的设备。
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公开(公告)号：WO2014018367A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051081
申请日：2013-07-18
Applicant: CYNVENIO BIOSYSTEMS, INC. , STRAUSS, William M.
Inventor： STRAUSS, William M.
CPC classification number: C12Q1/6869 , C12Q1/6848 , C12Q2521/101 , C12Q2527/149 , C12Q2535/122 , C12Q2545/113
Abstract: Provided are methods for validating the presence and character of genomic mutations, particularly single nucleotide polymorphisms (SNPs), by parallel amplification of a portion or the whole genome with at least two different DNA polymerases.
Abstract translation: 提供了通过用至少两种不同DNA聚合酶平行扩增部分或全部基因组来验证基因组突变，特别是单核苷酸多态性（SNP）的存在和特征的方法。
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4.发明申请APPARATUS, SYSTEMS, AND METHODS FOR DNA AMPLIFICATION WITH POST-SEQUENCING DATA FILTERING AND CELL ISOLATION 审中-公开装置，系统和方法DNA扩增后序列数据过滤和细胞分离
公开(公告)号：WO2017136606A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016299
申请日：2017-02-02
Applicant: CYNVENIO BIOSYSTEMS INC.
Inventor： STRAUSS, William M. , GOODMAN, Nathan
CPC classification number: C12Q1/6886 , C12Q1/6806 , C12Q1/6827 , C12Q1/6869 , C12Q2600/156 , G06F19/22 , C12Q2535/122 , C12Q2537/165
Abstract: A heuristic filtering system and method are described for variant DNA within a heterogeneous cell sample. After ion semiconductor sequencing, the amplicons are processed through a series of filters designed to eliminate noise in the variants to provide a clearer set of variant results. Reports are generated, showing both the filtered results and the effects the filters had on the original data.
Abstract translation: 针对异质细胞样本内的变体DNA描述了启发式过滤系统和方法。 离子半导体测序后，通过一系列旨在消除变体中噪声的滤波器处理扩增子，以提供更清晰的变异结果集。 生成报告，显示过滤结果和过滤器对原始数据的影响。
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公开(公告)号：WO2010144747A3
公开(公告)日：2011-03-03
申请号：PCT/US2010038231
申请日：2010-06-10
Applicant: CYNVENIO BIOSYSTEMS INC , TUREWICZ MAREK , PAGANO PAUL , DE FUSCO ANDRE , SAUVAGEAU DAVID
Inventor： TUREWICZ MAREK , PAGANO PAUL , DE FUSCO ANDRE , SAUVAGEAU DAVID
IPC: G01N35/08 , G01N1/38 , G01N33/487
CPC classification number: G01N21/11 , B01L3/50273 , B01L3/505 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0809 , B01L2300/0867 , B01L2300/123 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , G01N21/03 , G01N2021/0346 , G01N2021/0364
Abstract: Flexible pouch and flexible cartridge devices for fluid sample processing, related methods of making and using, related manufacturing systems and related instrumentation systems are described. Flexible pouches provide broad advantage in a wide variety of fields by overcoming the need for complex instrumentation, dedicated devices, and relatively high cost in conventional fluid sample devices. Flexible cartridge devices are particularly advantageous in control of fluid handling, rapid adaptation to a number of configurations by the end user, multiple uses for a single configuration, and in cost and ease of manufacture.
Abstract translation: 描述了用于流体样品处理的柔性袋和柔性盒装置，制造和使用的相关方法，相关的制造系统和相关的仪器系统。 柔性袋通过克服复杂仪器，专用设备的需求以及常规流体样品设备中相对较高的成本而在各种领域中提供广泛的优点。 灵活的墨盒装置在流体处理的控制，终端用户对许多配置的快速适应，单一配置的多种用途以及成本和易于制造方面特别有利。
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Patent Agency Ranking
公开(公告)号：WO2014052875A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/062373
申请日：2013-09-27
Applicant: CYNVENIO BIOSYSTEMS, INC. , STRAUSS, William M.
Inventor： STRAUSS, William M.
CPC classification number: C12Q1/6886 , C12Q2600/156 , C12Q2600/166 , G01N33/545 , G01N33/57484 , G01N33/57492 , G01N2458/00 , G01N2458/10 , G01N2496/80
Abstract: Provided are stimulus-sensitive microparticles and their use, e.g. , in tracking the efficiency of recovery of a rare cell population ( e.g. , circulating tumor cells) from a mixture of cells; and in supplying control nucleic acids to index a molecular assay independent of the rare cell selection steps.
Abstract translation: 提供刺激敏感性微粒及其用途，例如跟踪来自细胞混合物的稀有细胞群（例如循环肿瘤细胞）的回收效率; 以及供应对照核酸以独立于稀有细胞选择步骤来指数分子测定。
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公开(公告)号：WO2010144745A3
公开(公告)日：2011-04-14
申请号：PCT/US2010038229
申请日：2010-06-10
Applicant: CYNVENIO BIOSYSTEMS INC , PAGANO PAUL , ZHANG YANTING , QIAN KAREN , SOH HYONGSOK TOM , DEMPSEY PAUL W , DE FUSCO ANDRE
Inventor： PAGANO PAUL , ZHANG YANTING , QIAN KAREN , SOH HYONGSOK TOM , DEMPSEY PAUL W , DE FUSCO ANDRE
IPC: G01N35/08 , G01N33/487 , G01N33/58
CPC classification number: G01N33/54366 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , G01N1/405 , G01N33/57407 , G01N33/585 , G01N35/0098 , G01N35/1095 , G01N2800/52
Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.
Abstract translation: 本发明一般涉及流体处理，尤其涉及用于颗粒部分的检测，选择，捕集和/或分选的处理流体。 所描述的护套流动装置允许将目标物质与流体样品隔离，同时避免不需要的物质与分离装置的表面的非特异性结合。 描述了细胞，蛋白质和核酸的生物流体处理，检测，分选或选择。 本发明特别用于诊断设置，分析患者的医疗状况，监测和/或调整治疗方案并产生基于细胞的产品。
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公开(公告)号：WO2010144745A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/038229
申请日：2010-06-10
Applicant: CYNVENIO BIOSYSTEMS, INC. , PAGANO, Paul , ZHANG, Yanting , QIAN, Karen , SOH, Hyongsok Tom , DEMPSEY, Paul W. , DE FUSCO, Andre
Inventor： PAGANO, Paul , ZHANG, Yanting , QIAN, Karen , SOH, Hyongsok Tom , DEMPSEY, Paul W. , DE FUSCO, Andre
IPC: G01N35/08 , G01N33/487 , G01N33/58
CPC classification number: G01N33/54366 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2300/0816 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , G01N1/405 , G01N33/57407 , G01N33/585 , G01N35/0098 , G01N35/1095 , G01N2800/52
Abstract: The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoiding non-specific binding of unwanted species to the surfaces of the separation device. Biological fluid processing, detection, sorting or selection of cells, proteins, and nucleic acids is described. The invention finds particular use in diagnostic settings, analyzing a patient's medical condition, monitoring and/or adjusting a therapeutic regimen and producing cell based products.
Abstract translation: 本发明一般涉及流体处理，尤其涉及用于颗粒部分的检测，选择，捕集和/或分选的处理流体。 所描述的护套流动装置允许将目标物质与流体样品隔离，同时避免不需要的物质与分离装置的表面的非特异性结合。 描述了细胞，蛋白质和核酸的生物流体处理，检测，分选或选择。 本发明特别用于诊断设置，分析患者的医疗状况，监测和/或调整治疗方案并产生基于细胞的产品。
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公开(公告)号：WO2014046943A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/059292
申请日：2013-09-11
Applicant: CYNVENIO BIOSYSTEMS, INC. , VAHIDI, Behrad , STRONG, Bernard , FERGUSON, Samuel
Inventor： VAHIDI, Behrad , STRONG, Bernard , FERGUSON, Samuel
CPC classification number: B01L3/563 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2300/12
Abstract: Provided herein are fluid reservoirs or hoppers for controlled delivery of liquid biological sample to a microfluidic device.
Abstract translation: 本文提供了用于将液体生物样品控制递送到微流体装置的流体储存器或料斗。
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公开(公告)号：WO2014046942A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/059291
申请日：2013-09-11
Applicant: CYNVENIO BIOSYSTEMS, INC. , SHARTLE, Robert , VAHIDI, Behrad , STRAUSS, William, M.
Inventor： SHARTLE, Robert , VAHIDI, Behrad , STRAUSS, William, M.
CPC classification number: B01L3/5021 , B01L3/5027 , B01L7/52 , B01L2300/042 , B01L2400/0409
Abstract: Provided are devices for recovery of cells from a microfluidic device.
Abstract translation: 提供了用于从微流体装置回收细胞的装置。
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