-
公开(公告)号：WO2010017150A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052617
申请日：2009-08-03
Applicant: ABBOTT LABORATORIES , VASUDEVAN, Anil , BROWN, Brian, S. , KEDDY, Ryan, G. , HOBSON, Adrian, D.
Inventor： VASUDEVAN, Anil , BROWN, Brian, S. , KEDDY, Ryan, G. , HOBSON, Adrian, D.
IPC: A61K31/454 , A61P9/00
CPC classification number: A61K31/437 , C07D471/04
Abstract: Disclosed herein are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein A, X 1 , X 2 , R 1 , R 2 , R 3 , m, n, and p are defined in the specification. Compositions including the compounds which can be useful for inhibiting Rho kinase (ROCK) and methods for using the compositions are also described.
Abstract translation: 本文公开了式（I）化合物或其药学上可接受的盐，其中A，X 1，X 2，R 1，R 2，R 3，m，n和p在本说明书中定义。 还描述了包括可用于抑制Rho激酶（ROCK）的化合物的组合物和使用该组合物的方法。
-
公开(公告)号：WO2008076356A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/025602
申请日：2007-12-14
Applicant: ABBOTT LABORATORIES , HOBSON, Adrian D. , FIX-STENZEL, Shannon , CUSACK, Kevin P. , BREINLINGER, Eric C. , ANSELL, Graham K. , STOFFEL, Robert H.
Inventor： HOBSON, Adrian D. , FIX-STENZEL, Shannon , CUSACK, Kevin P. , BREINLINGER, Eric C. , ANSELL, Graham K. , STOFFEL, Robert H.
CPC classification number: C07D271/07 , C07D271/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
Abstract: Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family receptor activity, in particular by affording a beneficial immunosuppressive effect are disclosed.
Abstract translation: 新型恶二唑化合物，含有这些化合物的药物组合物以及这些化合物或组合物作为G蛋白偶联受体的S1P家族的激动剂或拮抗剂用于治疗与调节S1P家族受体活性有关的疾病的用途，特别是通过提供有益的免疫抑制 效果被公开。
-
公开(公告)号：WO2009011850A3
公开(公告)日：2009-01-22
申请号：PCT/US2008/008645
申请日：2008-07-15
Applicant: ABBOTT LABORATORIES , BREINLINGER, Eric, C. , CUSACK, Kevin, P. , HOBSON, Adrian, D. , LI, Bin , GORDON, Thomas, D. , STOFFEL, Robert, H. , WALLACE, Grier, A. , GRONSGAARD, Pintipa , WANG, Lu , WANG, Lu
Inventor： BREINLINGER, Eric, C. , CUSACK, Kevin, P. , HOBSON, Adrian, D. , LI, Bin , GORDON, Thomas, D. , STOFFEL, Robert, H. , WALLACE, Grier, A. , GRONSGAARD, Pintipa , WANG, Lu , WANG, Lu
IPC: A61K31/42 , A61K31/67 , A61K31/675
Abstract: Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.
-
公开(公告)号：WO2013043826A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056266
申请日：2012-09-20
Applicant: ABBVIE INC. , WISHART, Neil , BONAFOUX, Dominique F. , FRANK, Kristine E. , HOBSON, Adrian D. , KONOPACKI, Donald B, , MARTINEZ, Gloria Y. , WANG, Lu
Inventor： WISHART, Neil , BONAFOUX, Dominique F. , FRANK, Kristine E. , HOBSON, Adrian D. , KONOPACKI, Donald B, , MARTINEZ, Gloria Y. , WANG, Lu
IPC: C07D471/14 , C07D487/14 , A61K31/4985 , A61K31/437 , A61P35/00 , A61P37/00
CPC classification number: C07D487/14 , C07D471/14
Abstract: The invention provides compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫和肿瘤病症。
-
Patent Agency Ranking
公开(公告)号：WO2011079105A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061475
申请日：2010-12-21
Applicant: ABBOTT LABORATORIES , ERICSSON, Anna M. , EDMUNDS, Jeremy J. , HOBSON, Adrian D. , STEWART, Kent D. , WISHART, Neil , WANG, Lei , IHLE, David C. , FERENZ, Catherine R. , DUNSTAN, Theresa A. , WANG, Lu
Inventor： ERICSSON, Anna M. , EDMUNDS, Jeremy J. , HOBSON, Adrian D. , STEWART, Kent D. , WISHART, Neil , WANG, Lei , IHLE, David C. , FERENZ, Catherine R. , DUNSTAN, Theresa A. , WANG, Lu
IPC: C07D265/00
CPC classification number: C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04
Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
-
公开(公告)号：WO2012125797A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029184
申请日：2012-03-15
Applicant: ABBOTT LABORATORIES , CUSACK, Kevin P. , GORDON, Thomas D. , IHLE, David C. , HAYES, Martin E. , BREINLINGER, Eric C. , ERICSSON, Anna M. , LI, Bin , WANG, Lei , MARTINEZ, Gloria Y. , BURCHAT, Andrew , HOBSON, Adrian D. , MULLEN, Kelly D. , FRIEDMAN, Michael , MORYTKO, Michael, J.
Inventor： CUSACK, Kevin P. , GORDON, Thomas D. , IHLE, David C. , HAYES, Martin E. , BREINLINGER, Eric C. , ERICSSON, Anna M. , LI, Bin , WANG, Lei , MARTINEZ, Gloria Y. , BURCHAT, Andrew , HOBSON, Adrian D. , MULLEN, Kelly D. , FRIEDMAN, Michael , MORYTKO, Michael, J.
IPC: A01N27/00 , A61K31/015
CPC classification number: C07D213/75 , C07B2200/07 , C07C45/62 , C07C45/72 , C07C45/74 , C07C49/755 , C07D231/54 , C07D235/18 , C07D241/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D453/04 , C07D487/06 , C07D491/20 , C07C49/67
Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
-
公开(公告)号：WO2009011850A2
公开(公告)日：2009-01-22
申请号：PCT/US2008008645
申请日：2008-07-15
Applicant: ABBOTT LAB , BREINLINGER ERIC C , CUSACK KEVIN P , HOBSON ADRIAN D , LI BIN , GORDON THOMAS D , STOFFEL ROBERT H , WALLACE GRIER A , GRONSGAARD PINTIPA , WANG LU
Inventor： BREINLINGER ERIC C , CUSACK KEVIN P , HOBSON ADRIAN D , LI BIN , GORDON THOMAS D , STOFFEL ROBERT H , WALLACE GRIER A , GRONSGAARD PINTIPA , WANG LU
IPC: C07D249/10 , A61K31/415 , A61K31/4196 , A61K31/42 , A61P35/00 , C07D231/14 , C07D261/14 , C07D403/12
CPC classification number: C07D249/10 , C07D231/14 , C07D249/06 , C07D261/14 , C07D261/18 , C07D273/02 , C07D333/36 , C07D333/38 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
Abstract: Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.
Abstract translation: 本文公开了式（I）的新化合物，其中变量如本文所定义。 式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性疾病和疾病以及增殖性疾病如癌症。
-
8.发明申请SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS 审中-公开SPHINGOSINE-1-磷酸酯受体激动剂和拮抗剂化合物
公开(公告)号：WO2008079382A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/026263
申请日：2007-12-21
Applicant: ABBOTT LABORATORIES , WALLACE, Grier A. , BREINLINGER, Eric C. , CUSACK, Kevin P. , FIX-STENZEL, Shannon R. , GORDON, Thomas D. , HOBSON, Adrian D. , HAYES, Martin E. , ANSELL, Graham K. , GRONGSAARD, Pintipa
Inventor： WALLACE, Grier A. , BREINLINGER, Eric C. , CUSACK, Kevin P. , FIX-STENZEL, Shannon R. , GORDON, Thomas D. , HOBSON, Adrian D. , HAYES, Martin E. , ANSELL, Graham K. , GRONGSAARD, Pintipa
IPC: A01N43/50 , A61K31/415
CPC classification number: C07D413/04 , C07C215/38 , C07C215/42 , C07C217/52 , C07C217/74 , C07C229/14 , C07C229/48 , C07C2601/02 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D207/14 , C07D213/30 , C07D263/32 , C07D263/52 , C07D271/06 , C07D307/22 , C07D307/24 , C07D333/16 , C07D491/107 , C07F9/091 , C07F9/301 , C07F9/3808 , C07F9/3826 , C07F9/4006 , C07F9/653 , C07F9/65515 , C07F9/655345
Abstract: The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.
Abstract translation: 本发明涉及作为S1P受体家族的一种或多种单独受体的激动剂或拮抗剂的新颖的，有效的和选择性的药剂。 本发明的化合物可用作治疗与S1P受体家族的各个受体的激动作用或拮抗作用相关的医学病症的治疗剂。
-
9.发明申请AGONISTS AND ANTAGONISTS OF THE S1P5 RECEPTOR, AND METHODS OF USES THEREOF 审中-公开S1P5受体的激素和拮抗剂及其使用方法
公开(公告)号：WO2010093704A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/023768
申请日：2010-02-10
Applicant: ABBOTT LABORATORIES , HARRIS, Christopher, M. , HOBSON, Adrian, D. , WILSON, Noel, S.
Inventor： HARRIS, Christopher, M. , HOBSON, Adrian, D. , WILSON, Noel, S.
CPC classification number: C07D205/04 , C07C69/608 , C07C215/10 , C07C229/14 , C07C229/22 , C07D207/08 , C07D207/16 , C07D207/27 , C07D209/52 , C07D209/82 , C07D211/60 , C07D211/62 , C07D213/64 , C07D239/42 , C07D307/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D417/06 , C07F7/0812
Abstract: Disclosed are compounds that are agonists or antagonists of the S1P 5 receptor, compositions comprising said compounds, and methods of using said compounds and compositions. In certain embodiments, said compounds are 1-benzylazetidine-3-carboxylic acid derivatives. In certain embodiments, said methods relate to the treatment of neuropatic pain and/or a neurodegenerative disorder. In certain embodiments, said compounds may be used in combination with a second therapeutic agent.
Abstract translation: 公开了作为S1P5受体的激动剂或拮抗剂的化合物，包含所述化合物的组合物，以及使用所述化合物和组合物的方法。 在某些实施方案中，所述化合物是1-苄基氮杂环丁烷-3-羧酸衍生物。 在某些实施方案中，所述方法涉及治疗神经性疼痛和/或神经变性疾病。 在某些实施方案中，所述化合物可以与第二治疗剂组合使用。
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.023 seconds)
