公开(公告)号：WO2007053186A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/021209

申请日：2006-05-31

Applicant: LABNOW, INC. ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  MCDEVITT, John, T. ,  CHRISTODOULIDES, Nicolaos, J. ,  FLORIANO, Pierre, N. ,  DOUGLAS, Gary, N. ,  ROGERS, Patrick, E.

Inventor： MCDEVITT, John, T. ,  CHRISTODOULIDES, Nicolaos, J. ,  FLORIANO, Pierre, N. ,  DOUGLAS, Gary, N. ,  ROGERS, Patrick, E.

CPC classification number: G01N21/6456 ,  G01N21/6428 ,  G01N33/56972 ,  G01N2021/6419 ,  G01N2021/6421 ,  Y10T436/112499 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Described herein are methods and compositions for analyte detection with a portable instrument suitable for point-of-care analyses wherein the device may be used for a differential assay of blood components, such as lymphocyte populations or other cell populations, which can be used in diagnosis, and for monitoring treatment of diseases, such as HIV infection. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular-based analyses in conjunction with microsieve-based analysis cartridges.

Abstract translation: 本文描述了用于利用便携式仪器检测分析物的方法和组合物，所述便携式仪器适用于即时分析分析，其中所述装置可用于血液成分的差异分析，例如淋巴细胞群体或其他细胞 可用于诊断的人群以及监测艾滋病毒感染等疾病的治疗。 在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品池，试剂传送系统，流体传送系统，一个或多个通道和/或废物贮存器。 使用便携式仪器可以通过减少操作员与样品分析的接触来减少对操作者的危害。 该设备能够使用基于细胞的分析与基于microsieve的分析盒一起获取诊断信息。

公开(公告)号：WO2005085855A2

公开(公告)日：2005-09-15

申请号：PCT/US2005/006350

申请日：2005-02-28

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  MCDEVITT, John, T. ,  ANSLYN, Eric, V. ,  SHEAR, Jason, B. ,  NEIKIRK, Dean, P. ,  CHRISTODOULIDES, Nick, J. ,  FLORIANO, Pierre, N. ,  MICHAEL-BALLARD, Karri, L.

Inventor： MCDEVITT, John, T. ,  ANSLYN, Eric, V. ,  SHEAR, Jason, B. ,  NEIKIRK, Dean, P. ,  CHRISTODOULIDES, Nick, J. ,  FLORIANO, Pierre, N. ,  MICHAEL-BALLARD, Karri, L.

IPC: G01N33/543

CPC classification number: G01N21/251 ,  B01L3/502715 ,  B01L3/502738 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0688 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6441 ,  Y10S436/809

Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

Abstract translation: 本文描述了与适合于点护理分析的便携式仪器相关的分析物检测装置和方法。 在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。 使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。 该设备能够使用基于细胞和/或基于粒子的分析获得诊断信息，并且可以与基于膜和/或基于粒子的分析盒结合使用。 可以使用基于膜和/或基于粒子的分析系统检测分析物，包括蛋白质和细胞和/或微生物。

公开(公告)号：WO2005085854A1

公开(公告)日：2005-09-15

申请号：PCT/US2005/006077

申请日：2005-02-28

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  MCDEVITT, John, T. ,  CHRISTODOULIDES, Nick, J. ,  FLORIANO, Pierre, N. ,  MICHAEL-BALLARD, Karri, L. ,  BERNARD, Bruce

Inventor： MCDEVITT, John, T. ,  CHRISTODOULIDES, Nick, J. ,  FLORIANO, Pierre, N. ,  MICHAEL-BALLARD, Karri, L. ,  BERNARD, Bruce

IPC: G01N33/543

CPC classification number: G01N21/6456 ,  C12Q1/6816 ,  G01N21/6452 ,  G01N21/6486 ,  G01N33/521 ,  G01N33/5302 ,  G01N2021/0321 ,  Y10S435/808 ,  Y10S436/80 ,  Y10S436/805

Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

Abstract translation: 本文描述了与适合于点护理分析的便携式仪器相关的分析物检测装置和方法。 在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。 使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。 该设备能够使用基于细胞和/或基于粒子的分析获得诊断信息，并且可以与基于膜和/或基于粒子的分析盒结合使用。 可以使用基于膜和/或基于粒子的分析系统检测分析物，包括蛋白质和细胞和/或微生物。

公开(公告)号：WO2005059551A2

公开(公告)日：2005-06-30

申请号：PCT/US2004/041633

申请日：2004-12-13

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  MCDEVITT, John, T. ,  ANSLYN, Eric, V. ,  SHEAR, Jason, B. ,  NEIKIRK, Dean, P. ,  CHRISTODOULIDES, Nick, J.

Inventor： MCDEVITT, John, T. ,  ANSLYN, Eric, V. ,  SHEAR, Jason, B. ,  NEIKIRK, Dean, P. ,  CHRISTODOULIDES, Nick, J.

IPC: G01N33/53

CPC classification number: G01N33/5304 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2400/0487 ,  C40B40/10 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/77 ,  G01N33/54313 ,  G01N33/544 ,  G01N33/552 ,  G01N33/6887 ,  G01N33/92 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2201/024 ,  G01N2800/32 ,  Y10S436/807 ,  Y10S436/809

Abstract: A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

Abstract translation: 用于快速表征唾液中分析物的系统。 在一个实施例中，用于检测分析物的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施方案中，一系列化学敏感性颗粒位于空腔内。 当与颗粒偶联的受体与心血管危险因子分析物相互作用并且使用可视化试剂显现颗粒 - 分析物复合物时，颗粒可产生信号。 使用模式识别技术，可以对多分析物流体中的分析物进行表征。 在一个实施例中，多个空腔中的每个空腔被设计成捕获并容纳特定尺寸的颗粒。 可以将柔性突出部定位在每个空腔上以提供颗粒在空腔中的保持。

公开(公告)号：WO2007134191A1

公开(公告)日：2007-11-22

申请号：PCT/US2007/068704

申请日：2007-05-10

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  FLORIANO, Pierre, N. ,  CHRISTODOULIDES, Nicolaos ,  BALLARD, Karri ,  MCDEVITT, John, T.

Inventor： FLORIANO, Pierre, N. ,  CHRISTODOULIDES, Nicolaos ,  BALLARD, Karri ,  MCDEVITT, John, T.

IPC: C12M1/34

CPC classification number: G01N21/8483 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/161 ,  B01L2400/0481 ,  B01L2400/0677 ,  G01N33/56972 ,  G01N2333/70589 ,  G01N2333/70596 ,  Y02A50/58

Abstract: Methods, systems, and apparatus for detecting multiple types of leukocytes in a blood sample material. A fluid or gas sample may pass through a sieve-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the relative distribution of multiple types of white blood cells in the sample.

Abstract translation: 用于检测血液样本材料中多种类型的白细胞的方法，系统和装置。 流体或气体样品可以通过滤筒的基于筛的检测系统。 可以应用检测和分析技术来确定样品中多种类型的白细胞的相对分布。

公开(公告)号：WO2007053186A3

公开(公告)日：2007-07-26

申请号：PCT/US2006021209

申请日：2006-05-31

Applicant: LABNOW INC ,  UNIV TEXAS ,  MCDEVITT JOHN T ,  CHRISTODOULIDES NICOLAOS J ,  FLORIANO PIERRE N ,  DOUGLAS GARY N ,  ROGERS PATRICK E

Inventor： MCDEVITT JOHN T ,  CHRISTODOULIDES NICOLAOS J ,  FLORIANO PIERRE N ,  DOUGLAS GARY N ,  ROGERS PATRICK E

IPC: G01N33/49

CPC classification number: G01N21/6456 ,  G01N21/6428 ,  G01N33/56972 ,  G01N2021/6419 ,  G01N2021/6421 ,  Y10T436/112499 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Described herein are methods and compositions for analyte detection with a portable instrument suitable for point-of-care analyses wherein the device may be used for a differential assay of blood components, such as lymphocyte populations or other cell populations, which can be used in diagnosis, and for monitoring treatment of diseases, such as HIV infection. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular-based analyses in conjunction with microsieve-based analysis cartridges.

Abstract translation: 本文中描述的是用于分析物检测的方法和组合物，其适用于分析点分析，其中该装置可用于血液成分（例如淋巴细胞群体或其它细胞群体）的差异分析，其可用于诊断 ，并用于监测艾滋病毒感染等疾病的治疗。 在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。 使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。 该设备能够使用基于微型的分析结合基于微筛选的分析盒来获得诊断信息。

公开(公告)号：WO2007005666A3

公开(公告)日：2007-03-01

申请号：PCT/US2006025696

申请日：2006-06-30

Applicant: UNIV TEXAS ,  ANSLYN ERIC V ,  MCDEVITT JOHN T ,  SHEAR JASON B ,  NEIKIRK DEAN P ,  WRIGHT AARON T ,  ZHONG ZHENLIN

Inventor： ANSLYN ERIC V ,  MCDEVITT JOHN T ,  SHEAR JASON B ,  NEIKIRK DEAN P ,  WRIGHT AARON T ,  ZHONG ZHENLIN

IPC: G01N33/53

CPC classification number: G01N33/54313 ,  G01N33/54386

Abstract: Methods and systems for detecting the presence of analytes are described. A fluid or gas sample containing one or more analytes may pass through a particle-based sensor array. Detection and analysis techniques may be applied to determine the identity and quantity of the analytes.

Abstract translation: 描述了用于检测分析物存在的方法和系统。 含有一种或多种分析物的流体或气体样品可以通过基于粒子的传感器阵列。 可以应用检测和分析技术来确定分析物的身份和数量。

公开(公告)号：WO2007002480A3

公开(公告)日：2007-01-04

申请号：PCT/US2006/024603

申请日：2006-06-23

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  MCDEVITT, John, T. ,  BALLARD, Karri ,  CHRISTODOULIDES, Nicolaos, J. ,  FLORIANO, Pierre, N. ,  SIMMONS, Glennon, W.

Inventor： MCDEVITT, John, T. ,  BALLARD, Karri ,  CHRISTODOULIDES, Nicolaos, J. ,  FLORIANO, Pierre, N. ,  SIMMONS, Glennon, W.

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N35/00

Abstract: Methods, systems, and apparatus for detecting the presence of analytes are described. A fluid or gas sample may pass through a microsieve-based detection system and/or a particle- based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.

公开(公告)号：WO2005059551A3

公开(公告)日：2006-01-12

申请号：PCT/US2004041633

申请日：2004-12-13

Applicant: UNIV TEXAS ,  MCDEVITT JOHN T ,  ANSLYN ERIC V ,  SHEAR JASON B ,  NEIKIRK DEAN P ,  CHRISTODOULIDES NICK J

Inventor： MCDEVITT JOHN T ,  ANSLYN ERIC V ,  SHEAR JASON B ,  NEIKIRK DEAN P ,  CHRISTODOULIDES NICK J

IPC: B01J19/00 ,  B01L3/00 ,  C40B40/10 ,  C40B60/14 ,  G01N21/64 ,  G01N21/77 ,  G01N33/53 ,  G01N33/543 ,  G01N33/544 ,  G01N33/552 ,  G01N33/68 ,  G01N33/92

CPC classification number: G01N33/5304 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2400/0487 ,  C40B40/10 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/77 ,  G01N33/54313 ,  G01N33/544 ,  G01N33/552 ,  G01N33/6887 ,  G01N33/92 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2201/024 ,  G01N2800/32 ,  Y10S436/807 ,  Y10S436/809

Abstract: A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.

Abstract translation: 用于快速表征唾液中分析物的系统。 在一个实施例中，用于检测分析物的系统包括光源，传感器阵列和检测器。 传感器阵列由可以形成多个空腔的支撑构件形成。 在一个实施方案中，一系列化学敏感性颗粒位于空腔内。 当与颗粒偶联的受体与心血管危险因子分析物相互作用并且使用可视化试剂显现颗粒 - 分析物复合物时，颗粒可产生信号。 使用模式识别技术，多分析物流体中的分析物可以被表征。 在一个实施例中，多个空腔的每个空腔被设计成捕获并容纳特定尺寸的颗粒。 可以将柔性突出部定位在每个空腔上以提供颗粒在空腔中的保持。

公开(公告)号：WO2005085796A3

公开(公告)日：2006-01-05

申请号：PCT/US2005006074

申请日：2005-02-28

Applicant: UNIV TEXAS ,  MCDEVITT JOHN T ,  ANSLYN ERIC V ,  SHEAR JASON B ,  NEIKIRK DEAN P ,  CHRISTODOULIDES NICK J ,  MICHAEL-BALLARD KARRI L ,  FLORIANO PIERRE N

Inventor： MCDEVITT JOHN T ,  ANSLYN ERIC V ,  SHEAR JASON B ,  NEIKIRK DEAN P ,  CHRISTODOULIDES NICK J ,  MICHAEL-BALLARD KARRI L ,  FLORIANO PIERRE N

IPC: B01L3/00 ,  G01N21/25 ,  G01N21/64 ,  G01N33/543

CPC classification number: B01L3/502738 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/6428 ,  Y10S436/809

Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.

Abstract translation: 本文描述了与适合于点护理分析的便携式仪器相关的分析物检测装置和方法。 在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。 使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。 该设备能够使用基于细胞和/或基于粒子的分析获得诊断信息，并且可以与基于膜和/或基于粒子的分析盒结合使用。 可以使用基于膜和/或基于粒子的分析系统检测分析物，包括蛋白质和细胞和/或微生物。