公开(公告)号：WO2016109691A1

公开(公告)日：2016-07-07

申请号：PCT/US2015/068101

申请日：2015-12-30

Applicant: ANDREYEV, Boris ,  CIOPYK, Brian ,  DE LA ZERDA, Adam ,  MORAVICK, Keith ,  SWENSON, David ,  LONEY, Gregory ,  CHING, Jesus ,  KELLY, Colin ,  BRIONES, Victor ,  CHU, Steve ,  HUANG, Helen

Inventor： ANDREYEV, Boris ,  CIOPYK, Brian ,  DE LA ZERDA, Adam ,  MORAVICK, Keith ,  SWENSON, David ,  LONEY, Gregory ,  CHING, Jesus ,  KELLY, Colin ,  BRIONES, Victor ,  CHU, Steve ,  HUANG, Helen

IPC: C12P19/34

CPC classification number: B01L3/502715 ,  B01L3/5027 ,  B01L3/5029 ,  B01L3/527 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0681 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0611 ,  B01L2400/0644

Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Abstract translation: 手持式分子诊断测试装置包括壳体，扩增（或PCR）模块和检测模块。 放大模块被配置为接收输入样本，并且定义反应体积。 扩增模块包括加热器，使得扩增模块可以对输入的样品进行聚合酶链式反应（PCR）。 检测模块被配置为接收来自放大模块的输出和被配制为产生指示输入样本内目标扩增子存在的信号的试剂。 放大模块和检测模块集成在外壳内。

公开(公告)号：WO2013034430A1

公开(公告)日：2013-03-14

申请号：PCT/EP2012/066266

申请日：2012-08-21

Applicant: VENTANA MEDICAL SYSTEMS, INC. ,  F. HOFFMANN-LA ROCHE AG ,  HEBERT, Raphael ,  LONEY, Gregory, C. ,  MORAVICK, Keith ,  MORICONI, David ,  TODD, Chris

Inventor： HEBERT, Raphael ,  LONEY, Gregory, C. ,  MORAVICK, Keith ,  MORICONI, David ,  TODD, Chris

IPC: G02B21/24 ,  G02B21/34 ,  G01N35/04

CPC classification number: G01N35/025 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/143 ,  B01L2200/18 ,  B01L2300/021 ,  B01L2300/0822 ,  B01L2300/0841 ,  G02B21/24 ,  G02B21/34

Abstract: A microscope slide holding cassette includes a main body for surrounding and protecting microscopes, and shelves capable of holding the microscope slides. The shelves have support members that extend outwardly in order to support label ends of slides. Catches carried at the end of the support members are capable of limiting movement of the slides during transport of the cassette. To transport slides to different workstations, a pickup device can use a vacuum to pick up a slide without contacting areas of the slide that may have glue. The pickup device can load and unload the cassette. The pickup device can have a low-profile configuration in order to access relatively small spaces for processing flexibility.

Abstract translation: 显微镜载片盒包括用于包围和保护显微镜的主体，以及能够保持显微镜幻灯片的搁板。 搁架具有向外延伸的支撑构件，以支撑滑块的标签端。 在支撑构件的端部承载的抓持器能够限制在盒的传送期间滑块的移动。 为了将幻灯片运送到不同的工作站，拾取装置可以使用真空来拾取滑动件而不接触可能具有胶水的滑块的区域。 拾取装置可以装载和卸载盒式磁带。 拾取装置可以具有薄型结构，以便访问相对较小的空间以便处理灵​​活性。

公开(公告)号：WO2007111651A2

公开(公告)日：2007-10-04

申请号：PCT/US2006042563

申请日：2006-10-31

Applicant: THERANOS INC ,  HOLMES ELIZABETH A ,  ROY SHAUNAK ,  GIBBONS IAN ,  QI SHIZE DANIEL ,  KU EDMOND ,  TODD CHRIS ,  TAKAHASHI MELISSA ,  JOHNSON BRUCE ,  FENTON JEFF ,  MORAVICK KEITH ,  FRENZEL GARY ,  BURD TAMMY

Inventor： HOLMES ELIZABETH A ,  ROY SHAUNAK ,  GIBBONS IAN ,  QI SHIZE DANIEL ,  KU EDMOND ,  TODD CHRIS ,  TAKAHASHI MELISSA ,  JOHNSON BRUCE ,  FENTON JEFF ,  MORAVICK KEITH ,  FRENZEL GARY ,  BURD TAMMY

IPC: A61B5/00

CPC classification number: G01N33/5302 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150251 ,  A61B5/150274 ,  A61B5/150282 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150778 ,  A61B5/150786 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15142 ,  A61B5/157 ,  A61B5/412 ,  A61B5/685 ,  G01N33/536 ,  G01N33/573 ,  G01N2333/46 ,  G01N2333/91188 ,  G01N2800/52

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

Abstract translation: 本发明在医疗器械领域。 具体地说，本发明提供允许从生物流体实时检测分析物的便携式医疗装置。 所述方法和装置对于为各种医疗应用提供点护理测试特别有用。

公开(公告)号：WO2018005870A1

公开(公告)日：2018-01-04

申请号：PCT/US2017/040112

申请日：2017-06-29

Applicant: CLICK DIAGNOSTICS, INC. ,  BRIONES, Victor ,  ANDREYEV, Boris ,  LAM, Adrienne C. ,  CIOPYK, Brian ,  HUANG, Helen ,  MORAVICK, Keith ,  KELLY, Colin ,  CHING, Jesus ,  ALBRECHT, Jennifer ,  CENA, Ryan ,  BIBA, Edward ,  HONG, Jonathan

Inventor： BRIONES, Victor ,  ANDREYEV, Boris ,  LAM, Adrienne C. ,  CIOPYK, Brian ,  HUANG, Helen ,  MORAVICK, Keith ,  KELLY, Colin ,  CHING, Jesus ,  ALBRECHT, Jennifer ,  CENA, Ryan ,  BIBA, Edward ,  HONG, Jonathan ,  SWENSON, David D. ,  DE LA ZERDA, Adam ,  LONEY, Gregory C. ,  REVILLA, Valeria

IPC: B01L3/00 ,  B01L7/00 ,  C12N9/12 ,  C12N15/10 ,  C12Q1/68 ,  G01N21/29 ,  G01N30/88

Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).

Abstract translation: 本文公开了用于从生物样品制备核酸分子样品的方法和装置。 这些方法和装置可以执行与标准样品制备方法相似或更好的性能。 使用本文提供的方法和装置制备的核酸分子可用于下游应用，包括聚合酶链式反应（PCR）。

公开(公告)号：WO0132934A3

公开(公告)日：2002-09-12

申请号：PCT/US0041899

申请日：2000-11-03

Applicant: ARCTURUS ENG INC ,  BAER THOMAS M ,  RICHARDSON BRUCE J ,  KITAZAWA CHRIS T ,  BERNS DARREN ,  MORAVICK KEITH E ,  JOHNSON BRUCE A ,  SCHENCK ALAN L ,  BARKER CRAIG S

Inventor： BAER THOMAS M ,  RICHARDSON BRUCE J ,  KITAZAWA CHRIS T ,  BERNS DARREN ,  MORAVICK KEITH E ,  JOHNSON BRUCE A ,  SCHENCK ALAN L ,  BARKER CRAIG S

IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  G01N1/31 ,  G01N35/00 ,  G01N35/10 ,  C12Q1/68 ,  G02B21/34

CPC classification number: B01L3/502 ,  B01L7/52 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2400/0487 ,  G01N1/312 ,  G01N35/0099 ,  G01N35/1004

Abstract: This invention provides a station for rapidly preparing arrayed slides for hybridizations. At least one micro-arrayed slide is inserted into a carrier. A hybridization chamber is formed by a chamber element contacting the slide. The carrier is removably insertable into the station for the carrying out of various steps associated with the pre-hybridization and post-hybridization processes. The station generally includes at least one wash station assembly, a fluid delivery system, a sample delivery system, and a temperature control system.

Abstract translation: 本发明提供了一种用于快速准备用于杂交的阵列幻灯片的站。 至少一个微阵列的幻灯片插入到载体中。 通过与滑块接触的室元件形成杂交室。 载体可移除地插入到站中用于进行与预杂交和杂交后过程相关的各种步骤。 该站通常包括至少一个洗涤站组件，流体输送系统，样品输送系统和温度控制系统。

公开(公告)号：WO0181892A3

公开(公告)日：2002-06-06

申请号：PCT/US0113796

申请日：2001-04-26

Applicant: ARCTURUS ENG INC ,  BAER THOMAS M ,  REAMEY ROBERT H ,  MORAVICK KEITH E ,  HEAD DAVID F ,  RICHARDSON BRUCE J ,  RICHARDSON DERRICK A

Inventor： BAER THOMAS M ,  REAMEY ROBERT H ,  MORAVICK KEITH E ,  HEAD DAVID F ,  RICHARDSON BRUCE J ,  RICHARDSON DERRICK A

IPC: G01N1/28 ,  G01N1/40

CPC classification number: G01N1/30 ,  G01N1/2813 ,  G01N1/40 ,  G01N2001/284 ,  Y10T436/25375 ,  Y10T436/255

Abstract: The present invention generally discloses an extraction system (10) that provides a locale for fluid processing and extraction on a post-microcapture transfer film (28). The extraction system includes a transfer film carrier (12) and an extraction device (14) forming a reservoir. The extraction system (10) selectively excludes regions (90) of the transfer film (28) from the reservoir to advantageously reduce contamination due to matter adhered to the transfer film by non-specific transfer.

Abstract translation: 本发明通常公开了一种提取系统（10），其提供用于后微量捕获转移膜（28）上的流体处理和提取的区域。 提取系统包括转印膜载体（12）和形成储存器的提取装置（14）。 提取系统（10）选择性地从储存器排除转印膜（28）的区域（90），以有利地减少由于通过非特异性转移附着在转印膜上的物质而引起的污染。

公开(公告)号：WO2013030524A1

公开(公告)日：2013-03-07

申请号：PCT/GB2012/000691

申请日：2012-08-30

Applicant: SUPERNOVA DIAGNOSTICS, INC. ,  CAMPBELL, Neil, J. ,  MORAVICK, Keith, Edward ,  RICHARDSON, Bruce, J. ,  BALL, Christopher

Inventor： CAMPBELL, Neil, J. ,  MORAVICK, Keith, Edward ,  RICHARDSON, Bruce, J.

IPC: G01N33/52 ,  G01N33/53 ,  G01N33/558

CPC classification number: G01N33/558 ,  G01N21/8483 ,  G01N33/52 ,  G01N33/53

Abstract: An assay device for testing an analyte comprises a pathway allowing passage of analyte from an application zone to a waste zone. The device includes label material that emits or modifies light and which binds to the analyte. Between the application and waste zones there is a capture zone having capture material for binding any analyte traversing the pathway to the pathway. A first optical filter on one surface of the device allows transmission of light emitted or modified by the label and blocks light of at least one other wavelength range. This enables the device to be illuminated from one surface and light emitted or modified by the label to be detected from the opposite surface. The device may include a second filter allowing shorter wavelength light to reach the label. The device may be viewed using an illuminating reader or held up to a light source for viewing.

Abstract translation: 用于测试分析物的测定装置包括允许分析物从施用区域传递到废物区的途径。 该装置包括发射或修改光并与分析物结合的标签材料。 在应用和废弃区之间存在捕获区，其具有捕获材料，用于将穿过路径的任何分析物结合到路径。 在设备的一个表面上的第一滤光器允许透射由标签发射或修改的光，并且阻挡至少一个其它波长范围的光。 这使得设备能够从一个表面被照射，并且由相对表面上待检测的标签发射或修改的光。 该装置可以包括允许较短波长的光到达标签的第二滤光器。 可以使用照明读取器观看该设备，或者将其保持到光源以供观看。

公开(公告)号：WO2013030523A1

公开(公告)日：2013-03-07

申请号：PCT/GB2012/000690

申请日：2012-08-30

Applicant: SUPERNOVA DIAGNOSTICS INC. ,  CAMPBELL, Neil J. ,  MORAVICK, Keith Edward ,  PENNIMAN, Joseph D. ,  RICHARDSON, Bruce J. ,  BALL, Christopher

Inventor： CAMPBELL, Neil J. ,  MORAVICK, Keith Edward ,  PENNIMAN, Joseph D. ,  RICHARDSON, Bruce J.

IPC: G01N33/543 ,  G01N33/558 ,  G01N33/58

CPC classification number: G01N33/5304 ,  G01N33/5432 ,  G01N33/558 ,  G01N33/586

Abstract: Methods are disclosed for performing a bioassay, comprising activating capsules containing a signal precursor that is hydrolysable from a latent form in which substantially no signal is generated to a form in which it is able to generate a detectable signal, said activating comprising treating said capsules with heat and with an acid or a base catalysing solution, the combination of said heat and the pH of the catalysing solution being such as to hydrolyse said precursor to the form in which it is able to generate a detectable signal.

Abstract translation: 公开了用于进行生物测定的方法，包括活化胶囊，所述胶囊含有信号前体，所述信号前体可潜在地从其中基本上不产生信号的潜在形式到能够产生可检测信号的形式，所述活化包括用 加热和酸或碱催化溶液，所述热和催化溶液的pH的组合使得将所述前体水解成能够产生可检测信号的形式。

公开(公告)号：WO2011106384A1

公开(公告)日：2011-09-01

申请号：PCT/US2011/025871

申请日：2011-02-23

Applicant: GENTURADX, INC. ,  BIRD, Dylan, Hilmer ,  CHING, Jesus ,  JOHNSON, Bruce, A. ,  MORAVICK, Keith, E. ,  RICHARDSON, Bruce

Inventor： BIRD, Dylan, Hilmer ,  CHING, Jesus ,  JOHNSON, Bruce, A. ,  MORAVICK, Keith, E. ,  RICHARDSON, Bruce

IPC: C12M1/24

CPC classification number: B01L7/52 ,  B01F5/12 ,  B01F11/0071 ,  B01F15/0203 ,  B01F15/0237 ,  B01F2015/0221 ,  B01F2215/0037 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50851 ,  B01L3/523 ,  B01L3/527 ,  B01L7/00 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0672 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/1805 ,  B01L2400/0406 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/0633 ,  B01L2400/0644 ,  B01L2400/0683 ,  C12Q1/6806 ,  C12Q1/686 ,  G01N1/38 ,  G01N35/1079 ,  G01N2035/0436 ,  Y10T436/118339 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.

Abstract translation: 提供用于分离生物样品的柱和样品上的下游生物测定。 在一个实施方案中，从生物样品中分离核酸样品，并且例如通过聚合酶链式反应扩增核酸样品。 本文提供的盒还可用于分离非核酸样品，例如蛋白质，并对蛋白质进行下游反应，例如结合测定。 还提供了用于进行下游生物测定和检测测定结果的仪器。

公开(公告)号：WO2007111651A3

公开(公告)日：2007-10-04

申请号：PCT/US2006/042563

申请日：2006-10-31

Applicant: THERANOS, INC. ,  HOLMES, Elizabeth, A. ,  ROY, Shaunak ,  GIBBONS, Ian ,  QI, Shize, Daniel ,  KU, Edmond ,  TODD, Chris ,  TAKAHASHI, Melissa ,  JOHNSON, Bruce ,  FENTON, Jeff ,  MORAVICK, Keith ,  FRENZEL, Gary ,  BURD, Tammy

Inventor： HOLMES, Elizabeth, A. ,  ROY, Shaunak ,  GIBBONS, Ian ,  QI, Shize, Daniel ,  KU, Edmond ,  TODD, Chris ,  TAKAHASHI, Melissa ,  JOHNSON, Bruce ,  FENTON, Jeff ,  MORAVICK, Keith ,  FRENZEL, Gary ,  BURD, Tammy

IPC: C12M3/00

Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.