公开(公告)号：WO2009049229A3

公开(公告)日：2009-09-11

申请号：PCT/US2008079610

申请日：2008-10-10

Applicant: BARD INC C R ,  LERDAHL ROBERT G ,  PATHAK CHANDRASHEKHAR P ,  CASANOVA R MICHAEL

Inventor： LERDAHL ROBERT G ,  PATHAK CHANDRASHEKHAR P ,  CASANOVA R MICHAEL

IPC: A61F2/82 ,  A61F2/88 ,  A61L27/06 ,  A61L27/34

CPC classification number: A61F2/966 ,  A61F2/07 ,  A61F2/915 ,  A61F2002/072 ,  A61F2240/001

Abstract: A stent graft is disclosed and can include a stent and a graft engaged with the stent. The graft can include an inner surface and an outer surface. Further, at least one of the inner surface and the outer surface can include a plurality of protrusions as viewed in cross section extending through a longitudinal axis.

Abstract translation: 公开了支架移植物并且可以包括支架和与支架接合的移植物。 移植物可以包括内表面和外表面。 此外，内部表面和外部表面中的至少一个可以包括在穿过纵向轴线延伸的横截面中观察的多个突起。

公开(公告)号：WO2008076973A2

公开(公告)日：2008-06-26

申请号：PCT/US2007/087768

申请日：2007-12-17

Applicant: C.R.BARD INC. ,  TALPADE, Dnyanesh, A. ,  PATHAK, Chandrashekhar, P.

Inventor： TALPADE, Dnyanesh, A. ,  PATHAK, Chandrashekhar, P.

IPC: A61K49/00

CPC classification number: A61B19/54 ,  A61B5/055 ,  A61B5/062 ,  A61B5/064 ,  A61B6/12 ,  A61B8/0833 ,  A61B10/02 ,  A61B90/39 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3925 ,  A61B2090/3966 ,  A61B2090/3995 ,  A61F2250/0098 ,  A61K49/0002 ,  A61K49/0409 ,  A61K49/18 ,  A61K49/222

Abstract: A biopsy marker having radio-opaque properties that are derived in situ, based on a natural a biological response, such as for example, calcification, accumulation or tissue- concentration of a chemical agent so as to provide an imaging contrast. A biodegradable foam such as collagen foam or gelatin foam is embedded with a biological tissue that is susceptible to the calcification. Initially the marker can be imaged using ultrasound, but over time, the embedded material calcifies causing it to become visible under radiation imaging.

Abstract translation: 根据天然生物学反应，例如化学试剂的钙化，积聚或组织浓度，提供原位衍生的具有不透射线性质的活检标记，以提供 成像对比度。 诸如胶原蛋白泡沫或明胶泡沫的生物可降解泡沫嵌入对钙化敏感的生物组织。 最初，可以使用超声波对标记进行成像，但随着时间的推移，嵌入材料钙化，使其在辐射成像下变得可见。

公开(公告)号：WO2006026325A2

公开(公告)日：2006-03-09

申请号：PCT/US2005/030187

申请日：2005-08-24

Applicant: PATHAK, Chandrashekhar, P. ,  THIGLE, Sanjay, M.

Inventor： PATHAK, Chandrashekhar, P. ,  THIGLE, Sanjay, M.

IPC: A61K35/12

CPC classification number: A61L27/16 ,  A61K35/12 ,  A61L27/18 ,  A61L27/24 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3625 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/20 ,  A61L2430/34 ,  A61L2430/40

Abstract: Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio­opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed.

Abstract translation: 公开了新型可植入组织固定方法和组合物。 描述了使用聚合和/或可变长度交联固定的组织的方法和组合物，以及二 - 或聚合物巯基化合物。 还描述了使用可生物降解的交联剂固定组织的方法和组合物。 还描述了用于制备不透射线组织的方法和组合物。 还描述了获得可降解的可植入组织 - 合成的可生物降解的聚合物复合材料的方法和组合物。 还公开了将基本上不溶于水的生物活性化合物掺入可植入组织中的组合物和方法。 还公开了使用膜状可植入组织制备可植入药物递送贴片。 还描述了获得涂覆的可植入组织的组合物和方法。 还公开了医疗应用植入式组织，例如心脏瓣膜生物假体，血管移植物，半月板植入物，药物递送贴片。

公开(公告)号：WO1994024962A1

公开(公告)日：1994-11-10

申请号：PCT/US1994004824

申请日：1994-04-28

Applicant: FOCAL, INC. ,  PATHAK, Chandrashekhar, P. ,  SAWHNEY, Amarpreet, S. ,  HUBBELL, Jeffrey, A. ,  HERMAN, Stephen, J. ,  ROTH, Laurence, A. ,  CAMPBELL, Patrick, K. ,  BERRIGAN, Kevin, M. ,  JARRETT, Peter, K. ,  COURY, Arthur, J.

Inventor： FOCAL, INC.

IPC: A61F02/06

CPC classification number: A61F2/82 ,  A61B2017/22001 ,  A61F2/945 ,  A61F2/95 ,  A61F2210/0047 ,  A61F2220/0008 ,  A61F2250/0098 ,  A61L31/14 ,  B29C35/08 ,  B29C49/00 ,  B29C49/0042 ,  B29C55/24 ,  B29C70/74 ,  B29C2035/0822 ,  B29C2035/0827 ,  B29C2035/0833 ,  B29K2995/006 ,  B29L2023/00 ,  B29L2031/7542 ,  Y10S623/901

Abstract: A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter (10) having a shaping element (12) positioned near its distal end. An emitter (15) provided with light from at least one optical fiber (18) is positioned within the shaping element. The emitter serves to provide a moldable polymeric article (19) positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.

Abstract translation: 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件（12）的导管（10）。 设置有来自至少一个光纤（18）的光的发射器（15）位于成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可模塑聚合物制品（19），从而允许制品在体腔内的期望的治疗部位被加热和模制。

公开(公告)号：WO2011066505A3

公开(公告)日：2011-10-06

申请号：PCT/US2010058205

申请日：2010-11-29

Applicant: PATHAK HOLDINGS LLC ,  PATHAK CHANDRASHEKHAR P ,  PATHAK NIVEDITA C

Inventor： PATHAK CHANDRASHEKHAR P ,  PATHAK NIVEDITA C

IPC: A23L1/212 ,  A23L1/29 ,  A23P1/08

CPC classification number: A23P1/087 ,  A23L19/05 ,  A23L33/115 ,  A23N4/12 ,  A23P20/25

Abstract: Systems and methods for filling a fleshy fruit or vegetable with a filler are described. Embodiments include tool having an expandable member that is expandable to an expanded position to make a cavity in the fruit and collapsible to a collapsed position for withdrawal from the fruit, with the expandable member in the expanded state comprising a cross-section that is larger than the maximum diameter of the tool in the collapsed position. A cavity may be created without substantially affecting the natural visual appearance of the fruit or vegetable. Fillers and filling methods are disclosed.

Abstract translation: 描述了用填充物填充肉质水果或蔬菜的系统和方法。 实施例包括具有可膨胀构件的工具，所述可膨胀构件可膨胀到膨胀位置以在水果中形成空腔并且可塌缩到塌陷位置以从水果中抽出，其中处于膨胀状态的可膨胀构件包括横截面大于 工具在折叠位置的最大直径。 可以在不明显影响水果或蔬菜的自然视觉外观的情况下创建空腔。 公开了填充物和填充方法。

公开(公告)号：WO2011066505A2

公开(公告)日：2011-06-03

申请号：PCT/US2010/058205

申请日：2010-11-29

Applicant: PATHAK HOLDINGS LLC ,  PATHAK, Chandrashekhar, P. ,  PATHAK, Nivedita, C.

Inventor： PATHAK, Chandrashekhar, P. ,  PATHAK, Nivedita, C.

IPC: A23L1/212 ,  A23L1/29 ,  A23P1/08

CPC classification number: A23P1/087 ,  A23L19/05 ,  A23L33/115 ,  A23N4/12 ,  A23P20/25

Abstract: Systems and methods for filling a fleshy fruit or vegetable with a filler are described. Embodiments include tool having an expandable member that is expandable to an expanded position to make a cavity in the fruit and collapsible to a collapsed position for withdrawal from the fruit, with the expandable member in the expanded state comprising a cross-section that is larger than the maximum diameter of the tool in the collapsed position. A cavity may be created without substantially affecting the natural visual appearance of the fruit or vegetable. Fillers and filling methods are disclosed.

Abstract translation: 描述了用填充物填充肉质水果或蔬菜的系统和方法。 实施方案包括具有可膨胀构件的工具，该可膨胀构件可膨胀到膨胀位置以在水果中形成空腔并且可折叠到收缩位置以从果实中取出，而膨胀状态中的可膨胀构件包括大于 在折叠位置的工具的最大直径。 可以创建空腔而基本上不影响水果或蔬菜的自然视觉外观。 公开了填料和填充方法。

公开(公告)号：WO2008063780A3

公开(公告)日：2008-12-31

申请号：PCT/US2007081261

申请日：2007-10-12

Applicant: BARD INC C R ,  PATHAK CHANDRASHEKHAR P

Inventor： PATHAK CHANDRASHEKHAR P

IPC: B29C67/20 ,  A61F2/06 ,  B29C44/04 ,  B29C44/08

CPC classification number: A61F2/07 ,  A61F2/06 ,  A61F2/82 ,  A61F2002/072 ,  A61F2240/001 ,  A61F2250/0068 ,  B29C47/00 ,  B29C47/0038 ,  B29C47/068 ,  B29C67/202 ,  B29K2027/18 ,  B29K2105/041 ,  B29L2031/753 ,  B29L2031/7542

Abstract: A wall, for example the wall of a vascular graft, has multiple channels within it. The channels may be used to hold drugs or reinforcing fibers. The channels may have a predetermined roughness. The channels may be formed by coextrusion using a soluble material, for example, to define the channels and then dissolving them to open the channels in the extrudate.

Abstract translation: 一个壁，例如血管移植物的壁，在其内部具有多个通道。 通道可以用来容纳药物或增强纤维。 通道可以具有预定的粗糙度。 通道可以通过使用可溶性材料共挤出形成，例如以限定通道，然后溶解它们以打开挤出物中的通道。

公开(公告)号：WO2007127198A2

公开(公告)日：2007-11-08

申请号：PCT/US2007009934

申请日：2007-04-24

Applicant: INCEPT LLC ,  PATHAK CHANDRASHEKHAR P ,  SAWHNEY AMARPREET S

Inventor： PATHAK CHANDRASHEKHAR P ,  SAWHNEY AMARPREET S

IPC: A61K38/39 ,  A61K39/02 ,  A61K39/12 ,  C08G63/91

CPC classification number: A61L24/0005 ,  A61K47/60 ,  A61L24/0031 ,  A61L24/046 ,  A61L24/06 ,  A61L24/108 ,  C08H1/00 ,  C08L89/00 ,  C08L71/02 ,  C08L39/06

Abstract: Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological fluid are blood, plasma, or serum.

Abstract translation: 本公开的一些方面涉及用于交联生物流体的方法，包括将生物流体与交联剂组合以共价交联生物流体内源的蛋白质以形成交联凝胶。 生物流体的实例是血液，血浆或血清。

公开(公告)号：WO2007056761A3

公开(公告)日：2007-05-18

申请号：PCT/US2006/060702

申请日：2006-11-09

Applicant: C.R. BARD INC. ,  CASANOVA, R., Michael ,  PATHAK, Chandrashekhar, P.

Inventor： CASANOVA, R., Michael ,  PATHAK, Chandrashekhar, P.

IPC: A61F2/06

Abstract: A graft device comprising a layer of synthetic non-metallic material having a first surface and a second surface spaced apart from the first surface. The device further, includes a radiopaque marker at least partially embedded in the layer.

公开(公告)号：WO2007030512A2

公开(公告)日：2007-03-15

申请号：PCT/US2006/034671

申请日：2006-09-05

Applicant: C. R. BARD, INC. ,  MCDERMOTT, John, D. ,  CASANOVA, Robert, Michael ,  PATHAK, Chandrashekhar, P

Inventor： MCDERMOTT, John, D. ,  CASANOVA, Robert, Michael ,  PATHAK, Chandrashekhar, P

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61F2/07 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/065 ,  A61F2210/0004 ,  A61F2250/0068 ,  A61L27/16 ,  A61L27/54 ,  A61L31/048 ,  A61L2300/206 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/63 ,  C08L27/18

Abstract: A method of incorporating drugs into an implantable medical device. In one variation, water insoluble drugs are used to form crystals within the porous structure of the device. Upon implantation, the drug crystals dissolve slowly and release the drug into the surrounding tissue. In one example, a water insoluble drug is crystallized within the pores of an ePTFE vascular graft.

Abstract translation: 将药物并入植入式医疗装置的方法。 在一个实施方案中，水不溶性药物用于在装置的多孔结构内形成晶体。 植入后，药物晶体缓慢溶解并将药物释放到周围组织中。 在一个实例中，水不溶性药物在ePTFE血管移植物的孔内结晶。