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1.发明申请SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR 审中-公开取代的嘧啶衍生物作为组胺H4受体的拮抗剂
公开(公告)号：WO2010108059A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/027904
申请日：2010-03-19
IPC分类号： C07D239/48 , C07D239/84
CPC分类号： C07D401/06 , A61K31/506 , A61K31/517 , A61K45/06 , C07D239/48 , C07D239/84 , C07D239/95 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to substituted heterocyclic compounds of Formula (I) or (XI): or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine H4 receptor inhibitors useful in the treatment of histamine H4 receptor- associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
摘要翻译： 本发明涉及式（I）或（XI）的取代的杂环化合物或其药学上可接受的盐或N-氧化物或季铵盐，其中提供了组成成分，以及它们的组合物和使用方法， 用于治疗组胺H4受体相关病症或疾病或病症的组胺H 4受体抑制剂，包括例如炎性疾病或病症，瘙痒症和疼痛。
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公开(公告)号：WO2008021781A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/075254
申请日：2007-08-06
申请人： INCYTE CORPORATION , ZHUO, Jincong , ZHANG, Colin , XU, Meizhong , QIAN, Ding-Quan , YAO, Wenqing , JALLURI, Ravi Kumar
发明人： ZHUO, Jincong , ZHANG, Colin , XU, Meizhong , QIAN, Ding-Quan , YAO, Wenqing , JALLURI, Ravi Kumar
IPC分类号： C07D487/04 , A61K31/53 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04
摘要： The present invention is directed to [l,2,4]mazolo[4,3-b][l,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. (I)
摘要翻译： 本发明涉及[1,2,4]咪唑并[4,3-b] [1,2,4]三嗪及其药物组合物，它们是诸如c-Met的激酶抑制剂，并且可用于 治疗与激素途径失调相关的癌症和其他疾病。 （一世）
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公开(公告)号：WO2006020598A3
公开(公告)日：2007-01-04
申请号：PCT/US2005028201
申请日：2005-08-09
申请人： INCYTE CORP , YAO WENQING , ZHUO JINCONG , METCALF BRIAN W , QIAN DING-QUAN , LI YUN-LONG
发明人： YAO WENQING , ZHUO JINCONG , METCALF BRIAN W , QIAN DING-QUAN , LI YUN-LONG
IPC分类号： A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D451/06 , C07D211/56 , C07D211/96 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/04
摘要： The present invention relates to inhibitors of 11-ß hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-ß hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
摘要翻译： 本发明涉及11-β羟基类固醇脱氢酶1型抑制剂，盐皮质激素受体（MR）的拮抗剂及其药物组合物。 本发明化合物可用于治疗与11-β羟基类固醇脱氢酶1型和/或醛固酮过量相关疾病的表达或活性有关的各种疾病。
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公开(公告)号：WO2006053024A3
公开(公告)日：2007-07-05
申请号：PCT/US2005040550
申请日：2005-11-09
申请人： INCYTE CORP , YAO WENQING , HE CHUNHONG , ZHUO JINCONG , XU MEIZHONG , ZHANG COLIN , QIAN DING-QUAN , BURNS DAVID , METCALF BRIAN W
发明人： YAO WENQING , HE CHUNHONG , ZHUO JINCONG , XU MEIZHONG , ZHANG COLIN , QIAN DING-QUAN , BURNS DAVID , METCALF BRIAN W
IPC分类号： C07D221/20 , A61K31/438 , C07D471/10
CPC分类号： C07D221/20 , C07D471/10
摘要： The present invention relates to inhibitors of 11-ß hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-ß hydroxyl steroid dehydrogenase type 1and/or diseases associated with aldosterone excess.
摘要翻译： 本发明涉及1型11型羟基类固醇脱氢酶抑制剂，盐皮质激素受体（MR）的拮抗剂及其药物组合物。 本发明的化合物可用于治疗与11-β羟基类固醇脱氢酶1型和/或与醛固酮过量相关的疾病的表达或活性相关的各种疾病。
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公开(公告)号：WO2005110992A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/015559
申请日：2005-05-04
申请人： INCYTE CORPORATION , YAO, Wenqing , ZHUO, Jincong , XU, Meizhong , ZHANG, Colin , METCALF, Brian , HE, Chunhong , QIAN, Ding-Quan
发明人： YAO, Wenqing , ZHUO, Jincong , XU, Meizhong , ZHANG, Colin , METCALF, Brian , HE, Chunhong , QIAN, Ding-Quan
IPC分类号： C07D221/00
CPC分类号： C07D207/06 , A61K31/407 , A61K31/4439 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/27 , C07D209/08 , C07D209/42 , C07D209/44 , C07D209/52 , C07D209/62 , C07D209/70 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/66 , C07D211/70 , C07D213/38 , C07D217/06 , C07D217/26 , C07D221/20 , C07D295/185 , C07D333/34 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D493/10 , C07D495/04 , C07D498/20 , C07D513/10
摘要： The present invention relates to inhibitors of 11-ß hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-ß hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
摘要翻译： 本发明涉及1型11型羟基类固醇脱氢酶抑制剂，盐皮质激素受体（MR）的拮抗剂及其药物组合物。 本发明的化合物可用于治疗与11-β羟基类固醇脱氢酶1型和/或与醛固酮过量相关的疾病的表达或活性相关的各种疾病。
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6.发明申请4, 6-DISUBSTITUTED 2-AMINO-PYRIMIDINES AS HISTAMINE H4 RECEPTOR MODULATORS 审中-公开4,6-取代的2-氨基嘧啶作为组胺H4受体调节剂
公开(公告)号：WO2010075270A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/068969
申请日：2009-12-21
发明人： ZHANG, Colin , QIAN, Ding-quan , ZHUO, Jincong , YAO, Wenqing
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , A61K31/506 , A61P29/00 , A61P37/00 , A61P11/06
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted heterocyclic compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine H4 receptor inhibitors/antagonists useful in the treatment of histamine H4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
摘要翻译： 本发明涉及式（I）的取代杂环化合物或其药学上可接受的盐或N-氧化物或季铵盐，其中提供了组成成分，以及它们的组合物和使用方法，它们是组胺H 4受体抑制剂/ 可用于治疗组胺H4受体相关病症或疾病或病症的拮抗剂，包括例如炎性疾病或病症，瘙痒症和疼痛。
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公开(公告)号：WO2007038138A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/036652
申请日：2006-09-20
发明人： YAO, Wenqing , ZHUO, Jincong , QIAN, Ding-Quan
IPC分类号： C07D401/06 , C07D211/56 , C07D401/14 , C07D491/20
CPC分类号： C07D211/56 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D451/06 , C07D471/10 , C07D491/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
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公开(公告)号：WO2006053024A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040550
申请日：2005-11-09
申请人： INCYTE CORPORATION , YAO, Wenqing , HE, Chunhong , ZHUO, Jincong , XU, Meizhong , ZHANG, Colin , QIAN, Ding-Quan , BURNS, David , METCALF, Brian, W.
发明人： YAO, Wenqing , HE, Chunhong , ZHUO, Jincong , XU, Meizhong , ZHANG, Colin , QIAN, Ding-Quan , BURNS, David , METCALF, Brian, W.
IPC分类号： A61K31/52 , A61K31/496 , A61K31/4747 , C07D473/02 , C07D487/04
CPC分类号： C07D221/20 , C07D471/10
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1and/or diseases associated with aldosterone excess.
摘要翻译： 本发明涉及1型11型羟基类固醇脱氢酶抑制剂，盐皮质激素受体（MR）的拮抗剂及其药物组合物。 本发明的化合物可用于治疗与1-β羟基类固醇脱氢酶1型和/或与醛固酮过量相关的疾病的表达或活性相关的各种疾病。
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公开(公告)号：WO2006020598A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028201
申请日：2005-08-09
申请人： INCYTE CORPORATION , YAO, Wenqing , ZHUO, Jincong , METCALF, Brian, W. , QIAN, Ding-Quan , LI, Yanlong
IPC分类号： A61K31/506 , A61K31/4545 , A61K31/454 , C07D417/02 , C07D403/02 , C07D401/02
CPC分类号： C07D451/06 , C07D211/56 , C07D211/96 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/04
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
摘要翻译： 本发明涉及1型11型羟基类固醇脱氢酶抑制剂，盐皮质激素受体（MR）的拮抗剂及其药物组合物。 本发明的化合物可用于治疗与11-β羟基类固醇脱氢酶1型和/或与醛固酮过量相关的疾病的表达或活性相关的各种疾病。
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公开(公告)号：WO2008064157A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/085100
申请日：2007-11-19
申请人： INCYTE CORPORATION , ZHUO, Jincong , METCALF, Brian , XU, Meizhong , HE, Chunhong , ZHANG, Colin , QIAN, Ding-quan , BURNS, David M. , LI, Yunlong , YAO, Wenqing
发明人： ZHUO, Jincong , METCALF, Brian , XU, Meizhong , HE, Chunhong , ZHANG, Colin , QIAN, Ding-quan , BURNS, David M. , LI, Yunlong , YAO, Wenqing
IPC分类号： A61K31/198 , A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4709 , A61K31/53 , C07D403/06
摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
摘要翻译： 本发明涉及咪唑并[1,2-b] [1,2,4]三嗪和咪唑并[1,2-a]嘧啶及其药物组合物，它们是诸如c-Met的激酶抑制剂， 可用于治疗与激酶途径失调相关的癌症和其它疾病。
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