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    SURFACE CHEMISTRY AND DEPOSITION TECHNIQUES
    2.
    发明申请
    SURFACE CHEMISTRY AND DEPOSITION TECHNIQUES 审中-公开
    表面化学和沉积技术

    公开(公告)号：WO2008097841A2

    公开(公告)日：2008-08-14

    申请号：PCT/US2008/052796

    申请日：2008-02-01

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  STANFORD UNIVERSITY ,  UNIVERSITY OF CHICAGO ,  SCHWARTZ, Jerrod ,  QUAKE, Stephen, R. ,  MRKSICH, Milan

    Inventor： SCHWARTZ, Jerrod ,  QUAKE, Stephen, R. ,  MRKSICH, Milan

    IPC: C12M3/00

    CPC classification number: C12Q1/6874 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T436/143333

    Abstract: Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface attachment features that are spaced apart on the surface such that when the analytes are labeled adjacent analytes are optically resolvable from each other. One way to express this concept is that binding elements should be spaced apart such that the Guassian point spread functions of adjacent labels do not overlap. Another way of expressing this concept is that the surface binding elements should be spaced apart by a distance equal to at least the diffraction limit for an optical label attached to the bound analytes.

    Abstract translation: 提供了具有改进的信噪比特性的标记单分子（分析物）可视化的表面化学。 为了观察，分析物分子结合在表面上间隔开的表面附着特征，使得当分析物被标记为相邻分析物时，彼此是光学可分辨的。 表达这个概念的一种方式是绑定元素应该间隔开，使得相邻标签的古斯分布函数不重叠。 表达这个概念的另一种方式是，表面结合元件应该间隔至少等于连接到结合分析物的光学标签的衍射极限的距离。

    METHOD FOR MANUFACTURING SINGLE WALL CARBON NANOTUBE TIPS
    3.
    发明申请
    METHOD FOR MANUFACTURING SINGLE WALL CARBON NANOTUBE TIPS 审中-公开
    制造单壁碳纳米管提示的方法

    公开(公告)号：WO2005076832A3

    公开(公告)日：2007-09-20

    申请号：PCT/US2005002668

    申请日：2005-02-01

    Applicant: CALIFORNIA INST OF TECHN ,  COLLIER CHARLES PATRICK ,  MA ZIYANG ,  QUAKE STEPHEN R ,  SHAPIRO IAN R ,  WADE LAWRENCE A

    Inventor： COLLIER CHARLES PATRICK ,  MA ZIYANG ,  QUAKE STEPHEN R ,  SHAPIRO IAN R ,  WADE LAWRENCE A

    IPC: G21K7/00 ,  C01B31/02 ,  G01Q10/00 ,  G01Q60/24 ,  G01Q60/38 ,  G01Q70/10 ,  G01Q70/12 ,  G01R3/00

    CPC classification number: C01B32/162 ,  C01B2202/02 ,  C01B2202/34 ,  C01B2202/36 ,  G01Q60/38 ,  G01Q70/12 ,  G01R3/00

    Abstract: A method for fabricating assembled structures. The method includes providing a tip structure, which has a first end, a second end, and a length defined between the first end and the second end. The second end is a free end. The method includes attaching a nano-sized structure along a portion of the length of the tip structure to extend a total length of the tip structure to include the length of the tip structure and a first length associated with the nano-sized structure. The method includes shortening the nano-sized structure from the first length to a second length. The method also includes pushing the nano-sized structure in a direction parallel to the second length to reduce the second length to a third length of the nano-sized structure along the direction parallel to the second length to cause the nano-sized structure to move along a portion of the length of the tip structure.

    Abstract translation: 一种组装结构的制造方法。 该方法包括提供尖端结构，其具有第一端，第二端和限定在第一端和第二端之间的长度。 第二端是自由端。 该方法包括沿着尖端结构的长度的一部分附接纳米尺寸结构以延伸尖端结构的总长度以包括尖端结构的长度和与纳米尺寸结构相关联的第一长度。 该方法包括将纳米尺寸结构从第一长度缩短到第二长度。 该方法还包括沿平行于第二长度的方向推动纳米尺寸结构，以沿平行于第二长度的方向将纳米尺寸结构的第二长度减小到第三长度，以使纳米尺寸结构移动 沿着尖端结构的长度的一部分。

    METHOD FOR MANUFACTURING SINGLE WALL CARBON NANOTUBE TIPS
    5.
    发明申请
    METHOD FOR MANUFACTURING SINGLE WALL CARBON NANOTUBE TIPS 审中-公开
    制造单壁碳纳米管提示的方法

    公开(公告)号：WO2005076832A2

    公开(公告)日：2005-08-25

    申请号：PCT/US2005/002668

    申请日：2005-02-01

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  COLLIER, Charles, Patrick ,  MA, Ziyang ,  QUAKE, Stephen, R. ,  SHAPIRO, Ian, R. ,  WADE, Lawrence, A.

    Inventor： COLLIER, Charles, Patrick ,  MA, Ziyang ,  QUAKE, Stephen, R. ,  SHAPIRO, Ian, R. ,  WADE, Lawrence, A.

    IPC: C01B31/02 ,  G01Q10/00 ,  G01Q60/24 ,  G01Q60/38 ,  G01Q70/10 ,  G01Q70/12 ,  G01R3/00 ,  G21K7/00

    CPC classification number: C01B32/162 ,  C01B2202/02 ,  C01B2202/34 ,  C01B2202/36 ,  G01Q60/38 ,  G01Q70/12 ,  G01R3/00

    Abstract: A method for fabricating assembled structures. The method includes providing a tip structure, which has a first end, a second end, and a length defined between the first end and the second end. The second end is a free end. The method includes attaching a nano-sized structure along a portion of the length of the tip structure to extend a total length of the tip structure to include the length of the tip structure and a first length associated with the nano-sized structure. The method includes shortening the nano-sized structure from the first length to a second length. The method also includes pushing the nano-sized structure in a direction parallel to the second length to reduce the second length to a third length of the nano-sized structure along the direction parallel to the second length to cause the nano-sized structure to move along a portion of the length of the tip structure.

    Abstract translation: 一种组装结构的制造方法。 该方法包括提供尖端结构，其具有第一端，第二端和限定在第一端和第二端之间的长度。 第二端是自由端。 该方法包括沿着尖端结构的长度的一部分附接纳米尺寸结构以延伸尖端结构的总长度以包括尖端结构的长度和与纳米尺寸结构相关联的第一长度。 该方法包括将纳米尺寸结构从第一长度缩短到第二长度。 该方法还包括沿平行于第二长度的方向推动纳米尺寸结构，以沿平行于第二长度的方向将纳米尺寸结构的第二长度减小到第三长度，以使纳米尺寸结构移动 沿着尖端结构的长度的一部分。

    MICROFABRICATED RUBBER MICROSCOPE USING SOFT SOLID IMMERSION LENSES
    6.
    发明申请
    MICROFABRICATED RUBBER MICROSCOPE USING SOFT SOLID IMMERSION LENSES 审中-公开
    微胶化橡胶显微镜使用软固体渗透镜

    公开(公告)号：WO2005076773A2

    公开(公告)日：2005-08-25

    申请号：PCT/US2004/026126

    申请日：2004-08-11

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  QUAKE, Stephen, R. ,  GAMBIN, Yann ,  LEGRAND, Oliver

    Inventor： QUAKE, Stephen, R. ,  GAMBIN, Yann ,  LEGRAND, Oliver

    IPC: G02B1/04 ,  G02B21/00 ,  G02B21/33

    CPC classification number: G02B21/33 ,  G02B1/041 ,  G02B21/0008 ,  C08L83/04

    Abstract: Soft lithography with surface tension control is used to microfabricate extremely efficient solid immersion lenses (SILs) out of rubber elastomeric material for use in microscope type applications. In order to counteract the surface tension of the mold material in a negative mold that causes creep on a positive mold, material such as RTV is partially cured before use in order to allow the reticulation of polymer chains to change the viscosity of the uncured material in a controllable manner. In a specific embodiment, the techniques of soft lithography with surface tension control are used to make molded SILs out of the elastomer polydimethylsiloxane. The lenses achieve an NA in the range of 1.25. The principle of compound lens design is used to make the first compound solid immersion lens, which is corrected for higher light gathering ability and has a calculated NA=1.32. An important application of these lenses is integrated optics for microfluidic devices, specifically in a handheld rubber microscope for microfluidic flow cytometry.

    Abstract translation: 使用表面张力控制的软光刻技术可以将非常有效的固体浸没透镜（SIL）从橡胶弹性体材料中微调制成，用于显微镜型应用。 为了抵消在负模具中的模具材料的表面张力，其在正模具上引起蠕变，诸如RTV的材料在使用前被部分固化，以便使聚合物链的网状化以改变未固化材料的粘度 一种可控的方式。 在一个具体的实施方案中，使用表面张力控制的软光刻技术从弹性体聚二甲基硅氧烷中制备模制的SIL。 透镜实现NA在1.25的范围内。 复合透镜设计的原理是用于制造第一个复合固体浸没透镜，其被更正为更高的聚光能力，并且具有计算的NA = 1.32。 这些透镜的重要应用是用于微流体装置的集成光学器件，特别是用于微流体流式细胞术的手持式橡胶显微镜。

    NON-INVASIVE DETERMINATION OF FETAL INHERITANCE OF PARENTAL HAPLOTYPES AT THE GENOME-WIDE SCALE
    10.
    发明申请
    NON-INVASIVE DETERMINATION OF FETAL INHERITANCE OF PARENTAL HAPLOTYPES AT THE GENOME-WIDE SCALE 审中-公开
    非侵入式确定在基因型范围内对家庭幸存者的影响

    公开(公告)号：WO2012078792A3

    公开(公告)日：2012-12-06

    申请号：PCT/US2011063796

    申请日：2011-12-07

    Applicant: UNIV STANFORD ,  QUAKE STEPHEN R ,  FAN HEI-MUN C

    Inventor： QUAKE STEPHEN R ,  FAN HEI-MUN C

    IPC: C12Q1/68

    CPC classification number: C12Q1/6883 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6881 ,  C12Q2521/537 ,  C12Q2537/165 ,  C12Q2600/156 ,  C12Q2600/172 ,  G06F19/18

    Abstract: The present invention provides a method, device and a computer program for haplotyping single cells, such that a sample taken from a pregnant female, without directly sampling the fetus, provides the ability to non-invasively determine the fetal genome. The method can be performed by determining the parental and inherited haplotypes, or can be performed merely on the basis of the mother's genetic information, obtained preferably in a blood or serum sample. The novel device allows for sequence analysis of single chromosomes from a single cell, preferably by partitioning single chromosomes from a metaphase cell into long, thin channels where a sequence analysis can be performed.

    Abstract translation: 本发明提供了用于对单个细胞进行单倍型的方法，装置和计算机程序，使得从怀孕雌性取得的样品，而不直接取样胎儿，提供了非侵入性地确定胎儿基因组的能力。 该方法可以通过确定亲本和遗传单倍体进行，或者可以仅基于母体的遗传信息进行，优选在血液或血清样品中获得。 该新颖的装置允许从单个细胞的单个染色体进行序列分析，优选通过将来自中期细胞的单个染色体分配成可以进行序列分析的长而细的通道。

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