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公开(公告)号:WO2008149115A1
公开(公告)日:2008-12-11
申请号:PCT/GB2008/001961
申请日:2008-06-06
Applicant: THE QUEEN'S UNIVERSITY OF BELFAST , SHAW, Christopher , CHEN, Tianbao , O'ROURKE, Martin , WALKER, Brian , HIRST, David
Inventor: SHAW, Christopher , CHEN, Tianbao , O'ROURKE, Martin , WALKER, Brian , HIRST, David
Abstract: Described is a peptide QUB919, having sequence Lys-Pro-Pro-Pro-Trp-Val-Pro-Val (SEQ ID NO: 1), and fragments or analogues thereof, including reverse peptides thereof, and their novel use as bradykinin receptor antagonists and as anti-angiogenic agents.
Abstract translation: 描述了具有序列Lys-Pro-Pro-Pro-Trp-Val-Pro-Val(SEQ ID NO:1)的肽QUB919及其包含其逆肽的片段或类似物及其作为缓激肽受体拮抗剂的新用途 和作为抗血管生成剂。
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公开(公告)号:WO2005120710A3
公开(公告)日:2007-12-13
申请号:PCT/US2005020049
申请日:2005-06-06
Applicant: IRM LLC , CHANG JIM YUCHEN , MICKLASH KENNETH J II , DOWNS ROBERT CHARLES , MAINQUIST JAMES KEVIN , SHAW CHRISTOPHER M
Inventor: CHANG JIM YUCHEN , MICKLASH KENNETH J II , DOWNS ROBERT CHARLES , MAINQUIST JAMES KEVIN , SHAW CHRISTOPHER M
CPC classification number: B01L3/0293 , B01J2219/00315 , B01J2219/00353 , B01J2219/00355 , B01J2219/0036 , B01J2219/00364 , B01J2219/00389 , B01J2219/004 , B01J2219/00418 , B01J2219/00466 , B01J2219/005 , B01J2219/00527 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/0074 , B01J2219/00743 , B01L3/021 , B01L3/0241 , B01L9/52 , B01L9/523 , B01L2200/025 , B01L2200/0605 , B01L2300/0829 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , G01N35/08 , G01N35/1002 , G01N35/1016 , G01N35/1065
Abstract: The present invention provides dispensing systems that include peristaltic pumps and other pressure sources for the efficient delivery of accurate volumes of fluidic materials into the wells of multi-well containers or onto substrate surfaces. These systems are typically configured to dispense volumes of fluid having substantially uniform densities. Related computer program products and methods of dispensing fluidic materials are also provided.
Abstract translation: 本发明提供了分配系统,其包括蠕动泵和其它压力源,用于将精确体积的流体材料有效地输送到多孔容器的孔中或衬底表面上。 这些系统通常被配置成分配具有基本均匀密度的体积的流体。 还提供了相关的计算机程序产品和分配流体材料的方法。
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公开(公告)号:WO2006130506A3
公开(公告)日:2007-11-22
申请号:PCT/US2006020555
申请日:2006-05-26
Applicant: IRM LLC , SHAW CHRISTOPHER M , DOWNS ROBERT C
Inventor: SHAW CHRISTOPHER M , DOWNS ROBERT C
CPC classification number: B01L1/02 , B01L7/02 , G01N35/0099 , G01N35/025 , G01N2035/0425
Abstract: The invention provides efficiently automated incubation devices that reduce the number of powered moving parts in the devices and the amount of air transfer between environments that are internal and external to the devices. Related systems are also provided.
Abstract translation: 本发明提供了有效的自动化孵化装置,其减少了装置中的动力运动部件的数量以及在装置内部和外部的环境之间的空气传输量。 还提供了相关系统。
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公开(公告)号:WO03056867A3
公开(公告)日:2003-10-02
申请号:PCT/GB0205843
申请日:2002-12-20
Applicant: ORANGE PERSONAL COMM SERV LTD , EALES MICHAEL DAVID , WILLIAMS MICHAEL ANDREW , O'NEILL DOMINIC DESMOND PHELIM , SHAW CHRISTOPHER
Inventor: EALES MICHAEL DAVID , WILLIAMS MICHAEL ANDREW , O'NEILL DOMINIC DESMOND PHELIM , SHAW CHRISTOPHER
IPC: H04Q3/545 , H04Q1/00 , H04Q3/00 , H04W76/04 , H04W88/18 , H04W92/24 , H04L12/58 , H04L29/06 , H04Q7/22 , H04Q7/24
CPC classification number: H04W88/184 , H04Q3/0029 , H04W76/021 , H04W76/027 , H04W88/18 , H04W92/24
Abstract: A mobile telephone network has a function (30) which interacts with the platform (40) or platforms processing a call, event or session to: a) determine the services and/or call handling operations to be applied to the call, event or session; and b) determine if the platform(s) (40) are capable of carrying out the services and/or call handling operations required by the call, event or session. The function may then arrange for the platform (40) to be provided with appropriate data or for the call, event or session to be transferred to another platform.
Abstract translation: 移动电话网络具有与平台(40)或处理呼叫,事件或会话的平台交互的功能(30),以便:a)确定要应用于呼叫,事件或会话的服务和/或呼叫处理操作 ; 以及b)确定平台(40)是否能够执行呼叫,事件或会话所需的服务和/或呼叫处理操作。 然后,该功能可以安排将平台(40)提供适当的数据,或者将呼叫,事件或会话传送到另一个平台。
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公开(公告)号:WO2003026267A3
公开(公告)日:2003-03-27
申请号:PCT/GB2002/004262
申请日:2002-09-19
Inventor: WILLIAMS, Michael , SHAW, Christopher
IPC: H04M15/00
Abstract: A computer-implemented method of determining rating data for use in rating a service requested to be provided to a subscriber of a telecommunications system, the method comprising the steps of: storing individual subscriber records relating respectively to individual subscribers of a telecommunications systems. storing, in a subscriber record relating to a subscriber, information for use in determining rating data for use in rating a service requested to be provided to the subscriber, the information identifying one or more parameters of a service; receiving a request to provide a service to the subscriber, and determining rating data for use in rating the requested service in dependence on the information if one or more parameters of the service requested match the service parameters identified in the information.
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公开(公告)号:WO02084312A2
公开(公告)日:2002-10-24
申请号:PCT/US0212109
申请日:2002-04-16
Applicant: SCHLUMBERGER TECHNOLOGIES INC , SHAW CHRISTOPHER , TSAO CHUN-CHENG , LUNDQUIST THEODORE R
Inventor: SHAW CHRISTOPHER , TSAO CHUN-CHENG , LUNDQUIST THEODORE R
IPC: G01R31/302 , G01R31/311 , H01L21/66 , G01R31/00
CPC classification number: G01R31/311 , H01L22/14 , H01L2224/13 , H01L2924/00014 , H01L2924/014 , H01L2924/1305 , H01L2924/00 , H01L2224/0401
Abstract: Methods for integrated circuit diagnosis, characterization or modification using a charged particle beam. In one implementation, the bulk silicon substrate of an integrated circuit is thinned to about 1 to 3 mu m from the deepset well, a voltage is applied to a circuit element that is beneath the outer surface of the thinned substrate. The applied voltage induces an electrical potential on the outer surface, which is detected as a surface feature on the outer surface by its interaction with the charged particle beam.
Abstract translation: 使用带电粒子束进行集成电路诊断,表征或修改的方法。 在一个实施方案中,将集成电路的体硅衬底从深井中减薄至约1至3μm,将电压施加到在薄化衬底的外表面下方的电路元件。 所施加的电压在外表面上引起电位,其通过与带电粒子束的相互作用被检测为外表面上的表面特征。
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公开(公告)号:WO2002062475A1
公开(公告)日:2002-08-15
申请号:PCT/US2002/001536
申请日:2002-01-17
Applicant: IRM LLC , BROCK, Ansgar , SHAW, Christopher, M. , DOWNS, Robert, C.
Inventor: BROCK, Ansgar , SHAW, Christopher, M. , DOWNS, Robert, C.
IPC: B01L3/00
CPC classification number: B01L3/0268 , B01J2219/00369 , B01J2219/00371 , B01J2219/00653 , B01J2219/00691 , B01L2300/0838 , B01L2400/027 , C40B60/14 , Y10T436/2575
Abstract: This invention provides methods and systems for rapidly, accurately and efficiently depositing liquid droplets (130) onto a planar uper surface (117) of sample plate (115) held in sample plate holder (110) which is supported on, or incorporated into, a motion table (105) included in an LC MALDI sample distribution system (100) for MALDI-mass spectrometry sample preparation. System (100) also includes a holding mechanism (118) for holding at least one capillary (125) which terminates at a capillary tip (127) on which droplet (130) is formed. A power supply (135) forms an electric field between sample plate surface (117) and droplet (130) which acts to pull the droplet (130) onto the sample plate (115).
Abstract translation: 本发明提供了用于将液滴(130)快速,准确和有效地沉积到样品板(115)上的样品板(115)的平坦表面(117)上的方法和系统, 支持或结合到用于MALDI质谱样品制备的LC MALDI样品分配系统(100)中包括的运动台(105)中。 系统(100)还包括用于保持终止于毛细管尖端(127)处的至少一个毛细管(125)的保持机构(118),毛细管尖端(127)上形成有液滴(130)。 电源(135)在样品板表面(117)和液滴(130)之间形成用于将液滴(130)拉到样品板(115)上的电场。 p>
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公开(公告)号:WO1992019351A1
公开(公告)日:1992-11-12
申请号:PCT/US1992001629
申请日:1992-02-27
Applicant: CONOCO SPECIALTY PRODUCTS INC. , SHAW, Christopher, K. , ROTH, James, R. , SCHUBERT, Mark, F. , HANSEN, Reimer, Z. , WOLFENBERGER, Erick, E. , MAMAGHANI, Mark, H.
Inventor: CONOCO SPECIALTY PRODUCTS INC.
IPC: B01D17/038
CPC classification number: E21B43/34 , B01D17/00 , B01D17/0208 , B01D17/0217 , B01D17/04 , B01D17/12 , C10G33/06
Abstract: An oil/water separation system (116) for separating oil and water components of a suspension formed in an oil/water mixture wherein oil coats solid particles in the mixture to form an oil coated nucleus that is neutrally buoyant to form the suspension. A stream (146) of the suspension is passed through a hydrocyclone (147) wherein the oil is removed from the solids. The solids then pass with the water component through an underflow outlet (15) from the hydrocyclone (147) while the oil component is separately passed from an overflow outlet (145). Water may be added to the stream of the suspension prior to passage into the hydrocyclone (147). A pump (152) may be utilized to mix the added water upstream of the hydrocyclone (147).
Abstract translation: 一种用于分离在油/水混合物中形成的悬浮液的油和水组分的油/水分离系统(116),其中油在混合物中涂覆固体颗粒,以形成中性浮力以形成悬浮液的涂有油的核。 悬浮液的物流(146)通过水力旋流器(147),其中油从固体中除去。 随后,水分离器通过来自水力旋流器(147)的下溢出口(15),同时油分量从溢流出口(145)分开通过。 水可以在进入水力旋流器(147)之前加入到悬浮液流中。 泵(152)可用于混合水力旋流器(147)上游的加入的水。
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公开(公告)号:WO2009053725A3
公开(公告)日:2009-07-30
申请号:PCT/GB2008003637
申请日:2008-10-27
Applicant: UNIV BELFAST , KING S COLLEGE LONDON , SHAW CHRISTOPHER , JONES PETER , PERSAUD SHANTA , CHEN TIANBAO , WALKER BRIAN
Inventor: SHAW CHRISTOPHER , JONES PETER , PERSAUD SHANTA , CHEN TIANBAO , WALKER BRIAN
IPC: C07K14/575 , A61K38/22 , A61P3/00
CPC classification number: A61K31/7004 , A61K38/00 , C07K14/575 , A61K2300/00
Abstract: The invention relates to fragments of Chromogranin A (CgA) derived peptide fragments and their use in methods of therapy, for example in the treatment of diabetes etc. The peptides, for example AL-11, GV-19 and WE-14, are tropic, i.e stimulate release of regulatory substances and may be used in the absence of a stimulatory concentration of glucose.
Abstract translation: 本发明涉及嗜铬粒蛋白A(CgA)衍生的肽片段的片段及其在治疗方法中的用途,例如用于治疗糖尿病等。所述肽,例如AL-11,GV-19和WE-14是热带 即刺激调节物质的释放,并且可以在没有刺激浓度的葡萄糖的情况下使用。
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公开(公告)号:WO2009053725A2
公开(公告)日:2009-04-30
申请号:PCT/GB2008/003637
申请日:2008-10-27
Applicant: THE QUEEN'S UNIVERSITY OF BELFAST , KING'S COLLEGE LONDON , SHAW, Christopher , JONES, Peter , PERSAUD, Shanta , CHEN, Tianbao , WALKER, Brian
Inventor: SHAW, Christopher , JONES, Peter , PERSAUD, Shanta , CHEN, Tianbao , WALKER, Brian
CPC classification number: A61K31/7004 , A61K38/00 , C07K14/575 , A61K2300/00
Abstract: The invention relates to fragments of Chromogranin A (CgA) derived peptide fragments and their use in methods of therapy, for example in the treatment of diabetes etc. The peptides, for example AL-11, GV-19 and WE-14, are tropic, i.e stimulate release of regulatory substances and may be used in the absence of a stimulatory concentration of glucose.
Abstract translation: 本发明涉及嗜铬粒蛋白A(CgA)衍生的肽片段的片段及其在治疗方法中的用途,例如用于治疗糖尿病等。肽例如AL-11,GV-19和WE-14是热带的 ,即刺激调节物质的释放,并且可以在没有葡萄糖的刺激浓度的情况下使用。
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