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1.发明申请COMPOSITIONS AND METHODS FOR IMPROVED ISOPRENE PRODUCTION USING TWO TYPES OF ISPG ENZYMES 审中-公开使用两种类型的ISPG酶的改进的异丙苯生产的组合物和方法
公开(公告)号：WO2012088462A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/066949
申请日：2011-12-22
发明人： MUIR, Rachel, E. , WEYLER, Walter
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/0093 , C12N9/1022 , C12N9/88 , C12N9/90
摘要： The invention provides for compositions and methods for producing isoprene by using recombinantly engineered cells that utilize a system of dual IspG enzymes in addition to isoprene synthase.
摘要翻译： 本发明提供了通过使用除异戊二烯合酶之外利用双重IspG酶系统的重组工程细胞来生产异戊二烯的组合物和方法。
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2.发明申请GEOBACILLUS STEAROTHERMOPHILUS ALPHA-AMYLASE (AMYS) VARIANTS WITH IMPROVED PROPERTIES 审中-公开具有改进性质的GEOBACILLUS STEAROTHERMOPHILUS ALPHA-AMYLASE（AMYS）变种
公开(公告)号：WO2009149130A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046034
申请日：2009-06-02
申请人： DANISCO US INC. , CUEVAS, William, A. , ESTELL, David, A. , HADI, Sura, Hussain , LEE, Sang-Kyu , RAMER, Sandra, W. , SHAW, Andrew , TOPPOZADA, Amr, R. , WEYLER, Walter
发明人： CUEVAS, William, A. , ESTELL, David, A. , HADI, Sura, Hussain , LEE, Sang-Kyu , RAMER, Sandra, W. , SHAW, Andrew , TOPPOZADA, Amr, R. , WEYLER, Walter
CPC分类号： D06M16/003 , C11D3/38609 , C11D3/38618 , C11D3/3869 , C12N9/2417 , C12Y302/01001 , D06L4/40
摘要： Described are variants of a parent alpha-amylase that exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: specific activity, substrate specificity, substrate binding, substrate cleavage, thermal stability, pH-dependent activity, pH-dependent stability, oxidative stability, calcium dependency, pI, and wash performance. The variants are suitable for starch conversion, ethanol production, laundry washing, dish washing, hard surface cleaning, textile desizing, and/or sweetener production.
摘要翻译： 描述了相对于所述亲本α-淀粉酶在下列性质中表现出至少一种变化的亲本α-淀粉酶的变体：比活性，底物特异性，底物结合，底物切割，热稳定性，pH依赖性活性，pH 依赖性稳定性，氧化稳定性，钙依赖性，pI和洗涤性能。 这些变体适用于淀粉转化，乙醇生产，洗衣，洗碗，硬表面清洗，纺织品退浆和/或甜味剂生产。
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公开(公告)号：WO2009100102A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/033027
申请日：2009-02-04
申请人： DANISCO US INC., GENENCOR DIVISION , CASCAO-PEREIRA, Luis , CHANG, Claudine , CHOY, Clement , ESTABROOK, Melodie , JONES, Brian, E. , KELLIS, James, T., Jr. , KOLKMAN, Marc , LEEFLANG, Chris , VROEMEN, Casper , WEYLER, Walter
发明人： CASCAO-PEREIRA, Luis , CHANG, Claudine , CHOY, Clement , ESTABROOK, Melodie , JONES, Brian, E. , KELLIS, James, T., Jr. , KOLKMAN, Marc , LEEFLANG, Chris , VROEMEN, Casper , WEYLER, Walter
IPC分类号： C07K14/435
CPC分类号： C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
摘要： Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
摘要翻译： 描述了具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质的亲本α-淀粉酶的变体（突变体）及其使用方法。
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4.发明申请
公开(公告)号：WO2009098229A3
公开(公告)日：2010-05-27
申请号：PCT/EP2009051268
申请日：2009-02-04
申请人： DANISCO US INC GENENCOR DIV , DANISCO , KRAGH KARSTEN MATTHIAS , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMEN CASPER WILLEM , WEYLER WALTER , PEREIRA LUIS GUSTAVO CASCAO , KELLIS JAMES T
发明人： KRAGH KARSTEN MATTHIAS , CHANG CLAUDINE , ESTABROOK MELODIE , JONES BRIAN , CHOY CLEMENT , KOLKMAN MARC , LEEFLANG CHRIS , VROEMEN CASPER WILLEM , WEYLER WALTER , PEREIRA LUIS GUSTAVO CASCAO , KELLIS JAMES T
CPC分类号： C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
摘要： The present invention relates to the use of a parent AmyTS-23 alpha-amylase as well as variants, which variant has alpha-amylase activity and exhibits altered properties relative to the parent alpha-amylase in the production of food products, such as the use in a baking composition.
摘要翻译： 本发明涉及母体AmyTS-23α-淀粉酶以及变体，其中变体具有α-淀粉酶活性并在食品生产中相对于母体α-淀粉酶具有改变的性质，例如使用 在烘焙组合物中。
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5.发明申请ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE 审中-公开用于改善微生物生产异烟肼的异丙肾上腺素变异体
公开(公告)号：WO2009132220A9
公开(公告)日：2010-05-06
申请号：PCT/US2009041581
申请日：2009-04-23
申请人： DANISCO US INC , GOODYEAR TIRE & RUBBER , CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R , RIFE CHRISTOPHER LEE
发明人： CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R , RIFE CHRISTOPHER LEE
CPC分类号： C12N9/88 , C12P5/007 , C12Y402/03027
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译： 本发明提供包含至少一种具有改善的催化活性和/或溶解度的异戊二烯合酶的方法和组合物。 特别地，本发明提供用于在微生物宿主细胞中增加异戊二烯生产的变体植物异戊二烯合酶。 本发明的生物合成生产的异戊二烯可用于制造橡胶和弹性体。
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6.发明申请ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE 审中-公开用于改善微生物生产异烟肼的异丙肾上腺素变异体
公开(公告)号：WO2009132220A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041581
申请日：2009-04-23
申请人： DANISCO US INC. , THE GOODYEAR TIRE & RUBBER COMPANY , CERVIN, Marguerite, A. , WHITED, Gregory, M. , MIASNIKOV, Andrei , PERES, Caroline, M. , WEYLER, Walter , WELLS, Derek, H. , BOTT, Richard, R.
发明人： CERVIN, Marguerite, A. , WHITED, Gregory, M. , MIASNIKOV, Andrei , PERES, Caroline, M. , WEYLER, Walter , WELLS, Derek, H. , BOTT, Richard, R.
CPC分类号： C12N9/88 , C12P5/007 , C12Y402/03027
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译： 本发明提供包含至少一种具有改进的催化活性和/或溶解度的异戊二烯合酶的方法和组合物。 特别地，本发明提供用于在微生物宿主细胞中增加异戊二烯生产的变体植物异戊二烯合酶。 本发明的生物合成生产的异戊二烯可用于制造橡胶和弹性体。
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7.发明申请
公开(公告)号：WO2006033668A3
公开(公告)日：2007-03-08
申请号：PCT/US2005011821
申请日：2005-04-07
申请人： GENENCOR INT , WEYLER WALTER , HSU AMY KUANG-HUA
发明人： WEYLER WALTER , HSU AMY KUANG-HUA
摘要： The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins, wherein the pckA gene has been modified or deleted. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been modified and/or inactivated (e.g., pckA), and preferably wherein one or more chromosomal genes (e.g., pckA) have been modified and/or deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been modified and/or deleted from a corresponding wild-type Bacillus host chromosome.
摘要翻译： 本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞，其中pckA基因已被修饰或缺失。 特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白质表达的芽孢杆菌属物种，其中一个或多个染色体基因已被修饰和/或失活（例如，pckA），并且优选其中一个或多个 更多的染色体基因（例如，pckA）已经从芽孢杆菌染色体中修饰和/或缺失。 在一些另外的实施方案中，一个或多个本地染色体区已经从相应的野生型芽孢杆菌宿主染色体修饰和/或缺失。
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公开(公告)号：WO2009100102A3
公开(公告)日：2010-04-22
申请号：PCT/US2009033027
申请日：2009-02-04
申请人： DANISCO US INC GENENCOR DIV , CASCAO-PEREIRA LUIS , CHANG CLAUDINE , CHOY CLEMENT , ESTABROOK MELODIE , JONES BRIAN E , KELLIS JAMES T JR , KOLKMAN MARC , LEEFLANG CHRIS , VROEMEN CASPER , WEYLER WALTER
发明人： CASCAO-PEREIRA LUIS , CHANG CLAUDINE , CHOY CLEMENT , ESTABROOK MELODIE , JONES BRIAN E , KELLIS JAMES T JR , KOLKMAN MARC , LEEFLANG CHRIS , VROEMEN CASPER , WEYLER WALTER
CPC分类号： C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
摘要： Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
摘要翻译： 描述了具有α-淀粉酶活性并且相对于母体α-淀粉酶具有改变的性质的亲本α-淀粉酶的变体（突变体）及其使用方法。
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9.发明申请ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE 审中-公开异丙烯合成酶变异体用于改进微生物生产异戊二烯
公开(公告)号：WO2009132220A3
公开(公告)日：2010-01-21
申请号：PCT/US2009041581
申请日：2009-04-23
申请人： DANISCO US INC , GOODYEAR TIRE & RUBBER , CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R
发明人： CERVIN MARGUERITE A , WHITED GREGORY M , MIASNIKOV ANDREI , PERES CAROLINE M , WEYLER WALTER , WELLS DEREK H , BOTT RICHARD R
CPC分类号： C12N9/88 , C12P5/007 , C12Y402/03027
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译： 本发明提供了包含至少一种具有改善的催化活性和/或溶解度的异戊二烯合酶的方法和组合物。 具体而言，本发明提供了用于增加微生物宿主细胞中异戊二烯产生的变异植物异戊二烯合酶。 本发明的生物合成产生的异戊二烯可用于制造橡胶和弹性体。
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10.发明申请
公开(公告)号：WO2008112459A3
公开(公告)日：2008-09-18
申请号：PCT/US2008/055780
申请日：2008-03-04
申请人： DANISCO US INC., GENENCOR DIVISION , CHANG, Claudine , DE NOBEL, Hans , JONES, Brian E. , NAAB, Corey , KOLKMAN, Marc , VROEMEN, Casper , WEYLER, Walter
发明人： CHANG, Claudine , DE NOBEL, Hans , JONES, Brian E. , NAAB, Corey , KOLKMAN, Marc , VROEMEN, Casper , WEYLER, Walter
摘要： Disclosed are variants of the alpha-amylase derived from Bacillus sp. no. 707 compositions comprising said variants and methods of using the variants. The methods of use include methods of cleaning surfaces, laundering textiles, desizing, hydrolyzing biofilms off various substrates, and treating starch (e.g., liquefaction and saccharifrication).
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